| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gail V W Johnso. Tau phosphorylation and proteolysis: insights and perspectives. Journal of Alzheimer's disease : JAD. vol 9. issue 3 Suppl. 2006-10-19. PMID:16914862. |
in this article we give a brief history of our initial findings and then discuss subsequent studies from our laboratory, as well as others, on tau proteolysis and modulation by phosphorylation and how these findings contribute to our understanding of the posttranslational processing of tau in alzheimer's disease. |
2006-10-19 |
2023-08-12 |
Not clear |
| Kenneth S Kosi. Traveling the tau pathway: a personal account. Journal of Alzheimer's disease : JAD. vol 9. issue 3 Suppl. 2006-10-19. PMID:16914863. |
studies of the tau protein and its pathological fate as a neurofibrillary tangle have been a pillar of alzheimer's disease research. |
2006-10-19 |
2023-08-12 |
Not clear |
| Virginia M-Y Lee, John Q Trojanowsk. Progress from Alzheimer's tangles to pathological tau points towards more effective therapies now. Journal of Alzheimer's disease : JAD. vol 9. issue 3 Suppl. 2006-10-19. PMID:16914864. |
progress from alzheimer's tangles to pathological tau points towards more effective therapies now. |
2006-10-19 |
2023-08-12 |
human |
| Maria Grazia Spillantini, Jill R Murrell, Michel Goedert, Martin Farlow, Aaron Klug, Bernardino Ghett. Mutations in the tau gene (MAPT) in FTDP-17: the family with Multiple System Tauopathy with Presenile Dementia (MSTD). Journal of Alzheimer's disease : JAD. vol 9. issue 3 Suppl. 2006-10-19. PMID:16914875. |
work in 1980s and early 1990s established that the microtubule-associated protein tau is the major component of the paired helical filament of alzheimer's disease. |
2006-10-19 |
2023-08-12 |
Not clear |
| Michael Pirchl, Josef Marksteiner, Christian Humpe. Effects of acidosis on brain capillary endothelial cells and cholinergic neurons: relevance to vascular dementia and Alzheimer's disease. Neurological research. vol 28. issue 6. 2006-10-19. PMID:16945219. |
alzheimer's disease is a progressive brain disorder which is neuropathologically characterized by an increased number of beta-amyloid plaques, tau pathology and synapse loss. |
2006-10-19 |
2023-08-12 |
Not clear |
| Johannes Brettschneider, Axel Petzold, Daniel Schottle, Annett Claus, Matthias Riepe, Hayrettin Tuman. The neurofilament heavy chain (NfH) in the cerebrospinal fluid diagnosis of Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 21. issue 5-6. 2006-10-17. PMID:16484807. |
attempting to improve the cerebrospinal fluid (csf) diagnosis of alzheimer's disease (ad), the neurofilament heavy chain isoform, nfh(smi35) was compared to other csf markers [total tau, phospho-tau, amyloid beta 1-42 (abeta42), the ratio of amyloid beta fragments abeta42/abeta40 (abeta ratio)]. |
2006-10-17 |
2023-08-12 |
Not clear |
| L Pennanen, D P Wolfer, R M Nitsch, J Göt. Impaired spatial reference memory and increased exploratory behavior in P301L tau transgenic mice. Genes, brain, and behavior. vol 5. issue 5. 2006-10-16. PMID:16879631. |
the neuropathological hallmark shared between alzheimer's disease (ad) and familial frontotemporal dementia (ftdp-17) are neurofibrillary tangles (nft) which are composed of filamentous aggregates of the microtubule-associated protein tau. |
2006-10-16 |
2023-08-12 |
mouse |
| Florian Plattner, Marco Angelo, K Peter Gies. The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation. The Journal of biological chemistry. vol 281. issue 35. 2006-10-10. PMID:16803897. |
hyperphosphorylation of the microtubule-associated protein tau is a characteristic feature of neurodegenerative tauopathies including alzheimer disease. |
2006-10-10 |
2023-08-12 |
mouse |
| Lian-Xiu Zhou, Zhi-Yang Zeng, Jin-Tang Du, Yu-Fen Zhao, Yan-Mei L. The self-assembly ability of the first microtubule-binding repeat from tau and its modulation by phosphorylation. Biochemical and biophysical research communications. vol 348. issue 2. 2006-10-10. PMID:16889747. |
aggregation of abnormally phosphorylated tau in the form of tangs of paired helical filaments (phfs) is one of the hallmarks of alzheimer's disease (ad) and other tauopathies. |
2006-10-10 |
2023-08-12 |
Not clear |
| H Bartosik-Psujek, Z Stelmasia. The CSF levels of total-tau and phosphotau in patients with relapsing-remitting multiple sclerosis. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 3. 2006-10-03. PMID:15997419. |
total-tau protein is considered the marker of axon damage whereas the abnormally phosphorylated tau forms are mainly associated with alzheimer's disease. |
2006-10-03 |
2023-08-12 |
Not clear |
| Annica Johansson, Henrik Zetterberg, Anna Håkansson, Hans Nissbrandt, Kaj Blenno. TAU haplotype and the Saitohin Q7R gene polymorphism do not influence CSF Tau in Alzheimer's disease and are not associated with frontotemporal dementia or Parkinson's disease. Neuro-degenerative diseases. vol 2. issue 1. 2006-10-03. PMID:16909000. |
tau haplotype and the saitohin q7r gene polymorphism do not influence csf tau in alzheimer's disease and are not associated with frontotemporal dementia or parkinson's disease. |
2006-10-03 |
2023-08-12 |
human |
| Annica Johansson, Henrik Zetterberg, Anna Håkansson, Hans Nissbrandt, Kaj Blenno. TAU haplotype and the Saitohin Q7R gene polymorphism do not influence CSF Tau in Alzheimer's disease and are not associated with frontotemporal dementia or Parkinson's disease. Neuro-degenerative diseases. vol 2. issue 1. 2006-10-03. PMID:16909000. |
the corresponding protein shows a similar tissue expression to tau, which is involved in many neurodegenerative disorders including alzheimer's disease (ad), frontotemporal dementia (ftd) and parkinson's disease (pd). |
2006-10-03 |
2023-08-12 |
human |
| Da-yu Yu, Jing Luo, Fan Bu, Gao-jie Song, Lai-qun Zhang, Qun We. Inhibition of calcineurin by infusion of CsA causes hyperphosphorylation of tau and is accompanied by abnormal behavior in mice. Biological chemistry. vol 387. issue 7. 2006-10-03. PMID:16913847. |
injection of csa led to enhanced phosphorylation of tau at ser-262 (12e8 site), ser-198, ser-199, and/or ser-202 (tau-1 site) and ser-396 and/or ser-404 (phf-1 site), as well as to impaired spatial memory, which are two characteristic features of alzheimer's disease. |
2006-10-03 |
2023-08-12 |
mouse |
| Shinji Sato, Ronald L Cerny, James L Buescher, Tsuneya Ikez. Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation. Journal of neurochemistry. vol 98. issue 5. 2006-10-03. PMID:16923168. |
neurofibrillary tangles, which are major pathological hallmarks of alzheimer's disease (ad), are composed of paired helical filaments (phfs) containing hyperphosphorylated tau. |
2006-10-03 |
2023-08-12 |
human |
| Ignacio Mateo, Jon Infante, Javier Llorca, Eloy Rodríguez, José Berciano, Onofre Combarro. Association between glycogen synthase kinase-3beta genetic polymorphism and late-onset Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 21. issue 4. 2006-09-26. PMID:16428884. |
aberrant phosphorylated tau is the major component of the neurofibrillary tangles in alzheimer's disease (ad) brains. |
2006-09-26 |
2023-08-12 |
human |
| Mary L Michaelis, G Georg, H Telikepalli, M McIntosh, R A Rajewsk. Ongoing in vivo studies with cytoskeletal drugs in tau transgenic mice. Current Alzheimer research. vol 3. issue 3. 2006-09-25. PMID:16842098. |
most drug discovery efforts for alzheimer's disease (ad) have focused on prevention or clearance of beta-amyloid (abeta) fibrils or oligomers, with far less attention to prevention of tau abnormalities that lead to neurofibrillary tangles (nfts). |
2006-09-25 |
2023-08-12 |
mouse |
| Ze-Fen Wang, Hong-Lian Li, Xia-Chun Li, Qi Zhang, Qing Tian, Qun Wang, Huaxi Xu, Jian-Zhi Wan. Effects of endogenous beta-amyloid overproduction on tau phosphorylation in cell culture. Journal of neurochemistry. vol 98. issue 4. 2006-09-21. PMID:16762022. |
alzheimer's disease is characterized by beta-amyloid (abeta) overproduction and tau hyperphosphorylation. |
2006-09-21 |
2023-08-12 |
mouse |
| Jürgen Götz, Lars M Ittner, Stefan Kin. Do axonal defects in tau and amyloid precursor protein transgenic animals model axonopathy in Alzheimer's disease? Journal of neurochemistry. vol 98. issue 4. 2006-09-21. PMID:16787410. |
do axonal defects in tau and amyloid precursor protein transgenic animals model axonopathy in alzheimer's disease? |
2006-09-21 |
2023-08-12 |
mouse |
| Cristina d'Abramo, Roberta Ricciarelli, Maria A Pronzato, Peter Davie. Troglitazone, a peroxisome proliferator-activated receptor-gamma agonist, decreases tau phosphorylation in CHOtau4R cells. Journal of neurochemistry. vol 98. issue 4. 2006-09-21. PMID:16787414. |
a 24 h treatment with troglitazone significantly reduced phosphorylation of tau at ser202 and ser396/404, residues of early and later stages of neurofibrillary tangle accumulation in alzheimer's disease and other neurodegenerative disorders. |
2006-09-21 |
2023-08-12 |
Not clear |
| Kim N Green, Lauren M Billings, Benno Roozendaal, James L McGaugh, Frank M LaFerl. Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 35. 2006-09-21. PMID:16943563. |
glucocorticoids increase amyloid-beta and tau pathology in a mouse model of alzheimer's disease. |
2006-09-21 |
2023-08-12 |
mouse |