Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
A Rahman, I Grundke-Iqbal, K Iqba. PP2B isolated from human brain preferentially dephosphorylates Ser-262 and Ser-396 of the Alzheimer disease abnormally hyperphosphorylated tau. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 2. 2006-08-16. PMID:15959850. |
we quantitated the dephosphorylation of various sites of alzheimer disease abnormally hyperphosphorylated tau by pp2b purified from six (three alzheimer and three control) autopsied human brains. |
2006-08-16 |
2023-08-12 |
human |
A Rahman, I Grundke-Iqbal, K Iqba. PP2B isolated from human brain preferentially dephosphorylates Ser-262 and Ser-396 of the Alzheimer disease abnormally hyperphosphorylated tau. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 2. 2006-08-16. PMID:15959850. |
estimated by dot-blot analyses, the purified pp2b (on average from six brains) dephosphorylated alzheimer tau at ps199, pt217, ps262, ps396 and ps422 by 38%, 32%, 63%, 78%, and 32%, respectively. |
2006-08-16 |
2023-08-12 |
human |
Brian C Kraemer, Jack K Burgess, Jin H Chen, James H Thomas, Gerard D Schellenber. Molecular pathways that influence human tau-induced pathology in Caenorhabditis elegans. Human molecular genetics. vol 15. issue 9. 2006-08-16. PMID:16600994. |
in ftdp-17, alzheimer's disease, and other tauopathies, aggregated hyper-phosphorylated tau forms the neurofibrillary tangles characteristic of these disorders. |
2006-08-16 |
2023-08-12 |
human |
Muhammad Omar Chohan, Sabiha Khatoon, Inge-Grundke Iqbal, Khalid Iqba. Involvement of I2PP2A in the abnormal hyperphosphorylation of tau and its reversal by Memantine. FEBS letters. vol 580. issue 16. 2006-08-14. PMID:16806196. |
the activity of protein phosphatase (pp)-2a, which regulates tau phosphorylation, is compromised in alzheimer disease brain. |
2006-08-14 |
2023-08-12 |
Not clear |
Qingfeng Ma, Yanmei Li, Jintang Du, Huadong Liu, Kenji Kanazawa, Tadashi Nemoto, Hiroshi Nakanishi, Yufen Zha. Copper binding properties of a tau peptide associated with Alzheimer's disease studied by CD, NMR, and MALDI-TOF MS. Peptides. vol 27. issue 4. 2006-08-11. PMID:16225961. |
copper binding properties of a tau peptide associated with alzheimer's disease studied by cd, nmr, and maldi-tof ms. we have previously reported the copper binding properties of r3 peptide (residues 318-335: vtskcgslgnihhkpggg, according to the longest tau protein) derived from the third repeat microtubule-binding domain of water-soluble tau protein. |
2006-08-11 |
2023-08-12 |
Not clear |
Ian Churche. Tau therapeutic strategies for the treatment of Alzheimer's disease. Current topics in medicinal chemistry. vol 6. issue 6. 2006-08-11. PMID:16712493. |
tau therapeutic strategies for the treatment of alzheimer's disease. |
2006-08-11 |
2023-08-12 |
Not clear |
Ian Churche. Tau therapeutic strategies for the treatment of Alzheimer's disease. Current topics in medicinal chemistry. vol 6. issue 6. 2006-08-11. PMID:16712493. |
the two classical pathological hallmarks of alzheimer's disease are deposits of aggregated beta-amyloid (abeta) peptide and neurofibrillary tangles composed of hyperphosphorylated tau protein. |
2006-08-11 |
2023-08-12 |
Not clear |
Ian Churche. Tau therapeutic strategies for the treatment of Alzheimer's disease. Current topics in medicinal chemistry. vol 6. issue 6. 2006-08-11. PMID:16712493. |
in addition to abeta pathology, an invariant trait of alzheimer's disease, disruption of tau processing is a necessary event in the neurotoxic cascade which eventually leads to neuronal death and subsequent dementia. |
2006-08-11 |
2023-08-12 |
Not clear |
Ian Churche. Tau therapeutic strategies for the treatment of Alzheimer's disease. Current topics in medicinal chemistry. vol 6. issue 6. 2006-08-11. PMID:16712493. |
in addition to this pathogenic hyperphosphorylation, tau dissociates from microtubules and self-aggregates to form insoluble oligomers which progress to the macroscopic tangles evident in post mortem alzheimer's disease tissue. |
2006-08-11 |
2023-08-12 |
Not clear |
Ian Churche. Tau therapeutic strategies for the treatment of Alzheimer's disease. Current topics in medicinal chemistry. vol 6. issue 6. 2006-08-11. PMID:16712493. |
this review will describe the tau-related etiology of alzheimer's disease and other tauopathies as well as the therapeutic strategies to inhibit the hyperphosphorylation of tau. |
2006-08-11 |
2023-08-12 |
Not clear |
Mikio Shoj. [Alzheimer's disease as brain amyloidosis: diagnosis using cerebrospinal fluid abeta and tau]. Rinsho byori. The Japanese journal of clinical pathology. vol 54. issue 5. 2006-08-11. PMID:16789421. |
[alzheimer's disease as brain amyloidosis: diagnosis using cerebrospinal fluid abeta and tau]. |
2006-08-11 |
2023-08-12 |
Not clear |
Norbert Zilka, Peter Filipcik, Peter Koson, Lubica Fialova, Rostislav Skrabana, Monika Zilkova, Gabriela Rolkova, Eva Kontsekova, Michal Nova. Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo. FEBS letters. vol 580. issue 15. 2006-08-08. PMID:16753151. |
truncated tau from sporadic alzheimer's disease suffices to drive neurofibrillary degeneration in vivo. |
2006-08-08 |
2023-08-12 |
human |
Norbert Zilka, Peter Filipcik, Peter Koson, Lubica Fialova, Rostislav Skrabana, Monika Zilkova, Gabriela Rolkova, Eva Kontsekova, Michal Nova. Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo. FEBS letters. vol 580. issue 15. 2006-08-08. PMID:16753151. |
truncated tau protein is the characteristic feature of human sporadic alzheimer's disease. |
2006-08-08 |
2023-08-12 |
human |
Norbert Zilka, Peter Filipcik, Peter Koson, Lubica Fialova, Rostislav Skrabana, Monika Zilkova, Gabriela Rolkova, Eva Kontsekova, Michal Nova. Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo. FEBS letters. vol 580. issue 15. 2006-08-08. PMID:16753151. |
furthermore, biochemical analysis of neurofibrillary changes revealed that massive sarcosyl insoluble tau complexes consisted of human alzheimer's tau and endogenous rat tau in ratio 1:1 including characteristic alzheimer's disease (ad)-specific proteins (a68). |
2006-08-08 |
2023-08-12 |
human |
Marcela K Sjöberg, Elena Shestakova, Zeyni Mansuroglu, Ricardo B Maccioni, Eliette Bonnefo. Tau protein binds to pericentromeric DNA: a putative role for nuclear tau in nucleolar organization. Journal of cell science. vol 119. issue Pt 10. 2006-08-03. PMID:16638814. |
since nuclear tau has also been found in neurons from patients with alzheimer's disease (ad), aberrant nuclear tau could affect the nucleolar organization during the course of ad. |
2006-08-03 |
2023-08-12 |
human |
Yong-Jie Zhang, Ya-Fei Xu, Ying-Hua Liu, Jun Yin, Hong-Lian Li, Qun Wang, Jian-Zhi Wan. Peroxynitrite induces Alzheimer-like tau modifications and accumulation in rat brain and its underlying mechanisms. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 20. issue 9. 2006-07-31. PMID:16816118. |
to investigate the upstream effector that led to tau hyperphosphorylation, nitration, and accumulation as seen in alzheimer's disease brain, and the underlying mechanisms, we bilaterally injected sin-1, a recognized peroxynitrite donor, into the hippocampus of rat brain. |
2006-07-31 |
2023-08-12 |
rat |
Angela M Boutte, Randall L Woltjer, Lisa J Zimmerman, Sheryl L Stamer, Kathleen S Montine, Michael V Manno, Patrick J Cimino, Daniel C Liebler, Thomas J Montin. Selectively increased oxidative modifications mapped to detergent-insoluble forms of Abeta and beta-III tubulin in Alzheimer's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 20. issue 9. 2006-07-31. PMID:16816122. |
deleterious post-translational modifications (ptms) to the neuronal cytoskeleton are a proposed mechanistic link between accumulation of amyloid (a) beta peptides and subsequent abnormalities of tau and neurodegeneration in alzheimer's disease (ad). |
2006-07-31 |
2023-08-12 |
Not clear |
Alberto Gómez-Ramos, Jorge Domínguez, Delia Zafra, Helena Corominola, Ramon Gomis, Joan J Guinovart, Jesús Avil. Inhibition of GSK3 dependent tau phosphorylation by metals. Current Alzheimer research. vol 3. issue 2. 2006-07-28. PMID:16611012. |
one of the main pathological characteristics of alzheimer's disease is the presence in the brain of the patients of an aberrant structure, the paired helical filaments, composed of hyperphosphorylated tau. |
2006-07-28 |
2023-08-12 |
Not clear |
Alberto Gómez-Ramos, Jorge Domínguez, Delia Zafra, Helena Corominola, Ramon Gomis, Joan J Guinovart, Jesús Avil. Inhibition of GSK3 dependent tau phosphorylation by metals. Current Alzheimer research. vol 3. issue 2. 2006-07-28. PMID:16611012. |
thus, the mechanism for tau phosphorylation could be important to clarify those pathological features in alzheimer's disease. |
2006-07-28 |
2023-08-12 |
Not clear |
Cheng-Xin Gong, Fei Liu, Inge Grundke-Iqbal, Khalid Iqba. Impaired brain glucose metabolism leads to Alzheimer neurofibrillary degeneration through a decrease in tau O-GlcNAcylation. Journal of Alzheimer's disease : JAD. vol 9. issue 1. 2006-07-28. PMID:16627930. |
impaired brain glucose metabolism leads to alzheimer neurofibrillary degeneration through a decrease in tau o-glcnacylation. |
2006-07-28 |
2023-08-12 |
human |