| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Norbert Zilka, Peter Filipcik, Peter Koson, Lubica Fialova, Rostislav Skrabana, Monika Zilkova, Gabriela Rolkova, Eva Kontsekova, Michal Nova. Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo. FEBS letters. vol 580. issue 15. 2006-08-08. PMID:16753151. |
truncated tau protein is the characteristic feature of human sporadic alzheimer's disease. |
2006-08-08 |
2023-08-12 |
human |
| Norbert Zilka, Peter Filipcik, Peter Koson, Lubica Fialova, Rostislav Skrabana, Monika Zilkova, Gabriela Rolkova, Eva Kontsekova, Michal Nova. Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo. FEBS letters. vol 580. issue 15. 2006-08-08. PMID:16753151. |
furthermore, biochemical analysis of neurofibrillary changes revealed that massive sarcosyl insoluble tau complexes consisted of human alzheimer's tau and endogenous rat tau in ratio 1:1 including characteristic alzheimer's disease (ad)-specific proteins (a68). |
2006-08-08 |
2023-08-12 |
human |
| Marcela K Sjöberg, Elena Shestakova, Zeyni Mansuroglu, Ricardo B Maccioni, Eliette Bonnefo. Tau protein binds to pericentromeric DNA: a putative role for nuclear tau in nucleolar organization. Journal of cell science. vol 119. issue Pt 10. 2006-08-03. PMID:16638814. |
since nuclear tau has also been found in neurons from patients with alzheimer's disease (ad), aberrant nuclear tau could affect the nucleolar organization during the course of ad. |
2006-08-03 |
2023-08-12 |
human |
| Yong-Jie Zhang, Ya-Fei Xu, Ying-Hua Liu, Jun Yin, Hong-Lian Li, Qun Wang, Jian-Zhi Wan. Peroxynitrite induces Alzheimer-like tau modifications and accumulation in rat brain and its underlying mechanisms. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 20. issue 9. 2006-07-31. PMID:16816118. |
to investigate the upstream effector that led to tau hyperphosphorylation, nitration, and accumulation as seen in alzheimer's disease brain, and the underlying mechanisms, we bilaterally injected sin-1, a recognized peroxynitrite donor, into the hippocampus of rat brain. |
2006-07-31 |
2023-08-12 |
rat |
| Angela M Boutte, Randall L Woltjer, Lisa J Zimmerman, Sheryl L Stamer, Kathleen S Montine, Michael V Manno, Patrick J Cimino, Daniel C Liebler, Thomas J Montin. Selectively increased oxidative modifications mapped to detergent-insoluble forms of Abeta and beta-III tubulin in Alzheimer's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 20. issue 9. 2006-07-31. PMID:16816122. |
deleterious post-translational modifications (ptms) to the neuronal cytoskeleton are a proposed mechanistic link between accumulation of amyloid (a) beta peptides and subsequent abnormalities of tau and neurodegeneration in alzheimer's disease (ad). |
2006-07-31 |
2023-08-12 |
Not clear |
| Alberto Gómez-Ramos, Jorge Domínguez, Delia Zafra, Helena Corominola, Ramon Gomis, Joan J Guinovart, Jesús Avil. Inhibition of GSK3 dependent tau phosphorylation by metals. Current Alzheimer research. vol 3. issue 2. 2006-07-28. PMID:16611012. |
one of the main pathological characteristics of alzheimer's disease is the presence in the brain of the patients of an aberrant structure, the paired helical filaments, composed of hyperphosphorylated tau. |
2006-07-28 |
2023-08-12 |
Not clear |
| Alberto Gómez-Ramos, Jorge Domínguez, Delia Zafra, Helena Corominola, Ramon Gomis, Joan J Guinovart, Jesús Avil. Inhibition of GSK3 dependent tau phosphorylation by metals. Current Alzheimer research. vol 3. issue 2. 2006-07-28. PMID:16611012. |
thus, the mechanism for tau phosphorylation could be important to clarify those pathological features in alzheimer's disease. |
2006-07-28 |
2023-08-12 |
Not clear |
| Cheng-Xin Gong, Fei Liu, Inge Grundke-Iqbal, Khalid Iqba. Impaired brain glucose metabolism leads to Alzheimer neurofibrillary degeneration through a decrease in tau O-GlcNAcylation. Journal of Alzheimer's disease : JAD. vol 9. issue 1. 2006-07-28. PMID:16627930. |
impaired brain glucose metabolism leads to alzheimer neurofibrillary degeneration through a decrease in tau o-glcnacylation. |
2006-07-28 |
2023-08-12 |
human |
| Cheng-Xin Gong, Fei Liu, Inge Grundke-Iqbal, Khalid Iqba. Impaired brain glucose metabolism leads to Alzheimer neurofibrillary degeneration through a decrease in tau O-GlcNAcylation. Journal of Alzheimer's disease : JAD. vol 9. issue 1. 2006-07-28. PMID:16627930. |
neurofibrillary degeneration characterized by abnormal hyperphosphorylation and aggregation of tau in affected neurons is directly associated with dementia symptoms and plays a pivotal role in the pathogenesis of alzheimer disease (ad) and related tauopathies. |
2006-07-28 |
2023-08-12 |
human |
| Jian-zhi Wang, Ze-fen Wan. Role of melatonin in Alzheimer-like neurodegeneration. Acta pharmacologica Sinica. vol 27. issue 1. 2006-07-27. PMID:16364209. |
alzheimer disease (ad), an age-related neurodegenerative disorder with progressive loss of memory and deterioration of comprehensive cognition, is characterized by extracellular senile plaques of aggregated beta-amyloid (abeta), and intracellular neurofibrillary tangles that contain hyperphosphorylated tau protein. |
2006-07-27 |
2023-08-12 |
Not clear |
| Jesús Avil. Tau phosphorylation and aggregation in Alzheimer's disease pathology. FEBS letters. vol 580. issue 12. 2006-07-27. PMID:16529745. |
tau phosphorylation and aggregation in alzheimer's disease pathology. |
2006-07-27 |
2023-08-12 |
Not clear |
| Jesús Avil. Tau phosphorylation and aggregation in Alzheimer's disease pathology. FEBS letters. vol 580. issue 12. 2006-07-27. PMID:16529745. |
in this article i shall review how tau phosphorylation and aggregation participates in alzheimer's disease (ad) and other tauopathies. |
2006-07-27 |
2023-08-12 |
Not clear |
| Patrizia Formichi, Carla Battisti, Elena Radi, Antonio Federic. Cerebrospinal fluid tau, A beta, and phosphorylated tau protein for the diagnosis of Alzheimer's disease. Journal of cellular physiology. vol 208. issue 1. 2006-07-26. PMID:16447254. |
cerebrospinal fluid tau, a beta, and phosphorylated tau protein for the diagnosis of alzheimer's disease. |
2006-07-26 |
2023-08-12 |
Not clear |
| SeungYong Yoon, JungEun Choi, Jae-Wan Huh, Onyou Hwang, DongHou Ki. Calpain activation in okadaic-acid-induced neurodegeneration. Neuroreport. vol 17. issue 7. 2006-07-26. PMID:16641670. |
okadaic acid, a protein phosphatase-2a inhibitor, has been used in alzheimer's disease research models to increase tau phosphorylation and induce neuronal death. |
2006-07-26 |
2023-08-12 |
Not clear |
| Xue Zhang, Feng Li, Ayelen Bulloj, Yun-Wu Zhang, Gang Tong, Zhuohua Zhang, Francesca-Fang Liao, Huaxi X. Tumor-suppressor PTEN affects tau phosphorylation, aggregation, and binding to microtubules. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 20. issue 8. 2006-07-19. PMID:16645045. |
neurofibrillary tangles (nfts), consisting of abnormally hyperphosphorylated tau, are implicated in the pathogenesis of several neurodegenerative diseases including alzheimer's disease (ad). |
2006-07-19 |
2023-08-12 |
Not clear |
| Martin von Bergen, Stefan Barghorn, Shirley A Müller, Marcus Pickhardt, Jacek Biernat, Eva-Maria Mandelkow, Peter Davies, Ueli Aebi, Eckhard Mandelko. The core of tau-paired helical filaments studied by scanning transmission electron microscopy and limited proteolysis. Biochemistry. vol 45. issue 20. 2006-07-19. PMID:16700555. |
in alzheimer's disease and frontotemporal dementias the microtubule-associated protein tau forms intracellular paired helical filaments (phfs). |
2006-07-19 |
2023-08-12 |
Not clear |
| Martin von Bergen, Stefan Barghorn, Shirley A Müller, Marcus Pickhardt, Jacek Biernat, Eva-Maria Mandelkow, Peter Davies, Ueli Aebi, Eckhard Mandelko. The core of tau-paired helical filaments studied by scanning transmission electron microscopy and limited proteolysis. Biochemistry. vol 45. issue 20. 2006-07-19. PMID:16700555. |
tau filaments assembled from the three repeat domain have a mass per length (mpl) of approximately 60 kda/nm and filaments from full-length tau (htau40deltak280 mutant) have approximately 160 kda/nm, compared with approximately 130 kda/nm for phfs from alzheimer's brain. |
2006-07-19 |
2023-08-12 |
Not clear |
| Alejandra del C Alonso, Bin Li, Inge Grundke-Iqbal, Khalid Iqba. Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 23. 2006-07-19. PMID:16735465. |
accumulation of abnormally hyperphosphorylated tau (p-tau) in the form of tangles of paired helical filaments and/or straight filaments is one of the hallmarks of alzheimer's disease (ad) and other tauopathies. |
2006-07-19 |
2023-08-12 |
Not clear |
| A K Wallin, K Blennow, N Andreasen, L Mintho. CSF biomarkers for Alzheimer's Disease: levels of beta-amyloid, tau, phosphorylated tau relate to clinical symptoms and survival. Dementia and geriatric cognitive disorders. vol 21. issue 3. 2006-07-18. PMID:16391474. |
csf biomarkers for alzheimer's disease: levels of beta-amyloid, tau, phosphorylated tau relate to clinical symptoms and survival. |
2006-07-18 |
2023-08-12 |
Not clear |
| A K Wallin, K Blennow, N Andreasen, L Mintho. CSF biomarkers for Alzheimer's Disease: levels of beta-amyloid, tau, phosphorylated tau relate to clinical symptoms and survival. Dementia and geriatric cognitive disorders. vol 21. issue 3. 2006-07-18. PMID:16391474. |
cerebrospinal fluid (csf) samples from 21 patients with a clinical diagnosis of alzheimer's disease (ad) participating in a 5-year treatment study with the choline esterase inhibitor tacrin were retrospectively analyzed for the contents of beta-amyloid (abeta42), total tau (t-tau) and phosphorylated tau (p-tau). |
2006-07-18 |
2023-08-12 |
Not clear |