| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Matthew R Reynolds, Thomas J Lukas, Robert W Berry, Lester I Binde. Peroxynitrite-mediated tau modifications stabilize preformed filaments and destabilize microtubules through distinct mechanisms. Biochemistry. vol 45. issue 13. 2006-05-16. PMID:16566606. |
alzheimer's disease (ad) is a progressive amnestic dementia typified by abnormal modifications of the microtubule (mt)-associated tau protein that promote its pathological self-assembly and displacement from the mt lattice. |
2006-05-16 |
2023-08-12 |
Not clear |
| Ping Han, Fei Dou, Feng Li, Xue Zhang, Yun-Wu Zhang, Hui Zheng, Stuart A Lipton, Huaxi Xu, Francesca-Fang Lia. Suppression of cyclin-dependent kinase 5 activation by amyloid precursor protein: a novel excitoprotective mechanism involving modulation of tau phosphorylation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 50. 2006-05-11. PMID:16354912. |
alzheimer's disease is cytopathologically characterized by loss of synapses and neurons, neuritic amyloid plaques consisting of beta-amyloid (abeta) peptides, and neurofibrillary tangles consisting of hyperphosphorylated tau protein in susceptible brain regions. |
2006-05-11 |
2023-08-12 |
mouse |
| Stephen D Ginsberg, Shaoli Che, Scott E Counts, Elliott J Mufso. Shift in the ratio of three-repeat tau and four-repeat tau mRNAs in individual cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease. Journal of neurochemistry. vol 96. issue 5. 2006-05-11. PMID:16478530. |
shift in the ratio of three-repeat tau and four-repeat tau mrnas in individual cholinergic basal forebrain neurons in mild cognitive impairment and alzheimer's disease. |
2006-05-11 |
2023-08-12 |
human |
| Stephen D Ginsberg, Shaoli Che, Scott E Counts, Elliott J Mufso. Shift in the ratio of three-repeat tau and four-repeat tau mRNAs in individual cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease. Journal of neurochemistry. vol 96. issue 5. 2006-05-11. PMID:16478530. |
in the current study, single cell gene expression profiling was coupled with custom-designed cdna array analysis to evaluate tau expression and other cytoskeletal elements within individual neuronal populations in patients with no cognitive impairment (nci), mild cognitive impairment (mci), and alzheimer's disease (ad). |
2006-05-11 |
2023-08-12 |
human |
| Chad A Dickey, Judith Dunmore, Bingwei Lu, Ji-Wu Wang, Wing C Lee, Adeela Kamal, Francis Burrows, Christopher Eckman, Michael Hutton, Leonard Petrucell. HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 20. issue 6. 2006-05-08. PMID:16464956. |
neurofibrillary tangles (nfts) are a characteristic neuropathological feature of alzheimer's disease (ad), and molecular chaperones appear to be involved in the removal of disease-associated hyperphosphorylated tau, a primary component of nfts. |
2006-05-08 |
2023-08-12 |
Not clear |
| Yoshitaka Tatebayashi, Emmanuel Planel, De-Hua Chui, Shinji Sato, Tomohiro Miyasaka, Naruhiko Sahara, Miyuki Murayama, Naomi Kikuchi, Katsuji Yoshioka, Ravid Rivka, Akihiko Takashim. c-jun N-terminal kinase hyperphosphorylates R406W tau at the PHF-1 site during mitosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 20. issue 6. 2006-05-08. PMID:16478768. |
tauopathies such as alzheimer disease (ad) probably involve a type of phosphorylation imbalance causing the accumulation of abnormally hyperphosphorylated tau in neurons and/or glias. |
2006-05-08 |
2023-08-12 |
Not clear |
| Hanae Nakashima, Takeshi Ishihara, Pilar Suguimoto, Osamu Yokota, Etsuko Oshima, Aki Kugo, Seishi Terada, Takashi Hamamura, John Q Trojanowski, Virginia M-Y Lee, Shigetoshi Kurod. Chronic lithium treatment decreases tau lesions by promoting ubiquitination in a mouse model of tauopathies. Acta neuropathologica. vol 110. issue 6. 2006-05-05. PMID:16228182. |
we tested this hypothesis and showed that long-term administration of lithium at relatively low therapeutic concentrations to transgenic mice that recapitulate alzheimer's disease (ad)-like tau pathologies reduces tau lesions, primarily by promoting their ubiquitination rather than by inhibiting tau phosphorylation. |
2006-05-05 |
2023-08-12 |
mouse |
| Brit Mollenhauer, Mirko Bibl, Jens Wiltfang, Petra Steinacker, Barbara Ciesielczyk, Karin Neubert, Claudia Trenkwalder, Markus Ott. Total tau protein, phosphorylated tau (181p) protein, beta-amyloid(1-42), and beta-amyloid(1-40) in cerebrospinal fluid of patients with dementia with Lewy bodies. Clinical chemistry and laboratory medicine. vol 44. issue 2. 2006-05-05. PMID:16475906. |
for tau protein and beta-amyloid(1-42) in cerebrospinal fluid (csf), promising results for the diagnosis of alzheimer's disease (ad) have been reported; however, their differential diagnostic spectrum is limited, as was recently shown for dementia with lewy bodies (dlb) and for ad. |
2006-05-05 |
2023-08-12 |
Not clear |
| Kentaro Tanemura, Du-Hua Chui, Tetsuya Fukuda, Miyuki Murayama, Jung-Mi Park, Takumi Akagi, Yoshitaka Tatebayashi, Tomohiro Miyasaka, Tetsuya Kimura, Tsutomu Hashikawa, Yuka Nakano, Takashi Kudo, Masatoshi Takeda, Akihiko Takashim. Formation of tau inclusions in knock-in mice with familial Alzheimer disease (FAD) mutation of presenilin 1 (PS1). The Journal of biological chemistry. vol 281. issue 8. 2006-05-04. PMID:16377636. |
formation of tau inclusions in knock-in mice with familial alzheimer disease (fad) mutation of presenilin 1 (ps1). |
2006-05-04 |
2023-08-12 |
mouse |
| Tong Li, Hemant K Paude. Glycogen synthase kinase 3beta phosphorylates Alzheimer's disease-specific Ser396 of microtubule-associated protein tau by a sequential mechanism. Biochemistry. vol 45. issue 10. 2006-05-03. PMID:16519507. |
glycogen synthase kinase 3beta phosphorylates alzheimer's disease-specific ser396 of microtubule-associated protein tau by a sequential mechanism. |
2006-05-03 |
2023-08-12 |
Not clear |
| Tong Li, Hemant K Paude. Glycogen synthase kinase 3beta phosphorylates Alzheimer's disease-specific Ser396 of microtubule-associated protein tau by a sequential mechanism. Biochemistry. vol 45. issue 10. 2006-05-03. PMID:16519507. |
phosphorylation of tau on s(396) was suggested to be a key step in the development of neurofibrillary pathology in alzheimer's disease brain [bramblett, g. t., goedert, m., jacks, r., merrick, s. e., trojanowski, j. q., and lee, v. m.-y. |
2006-05-03 |
2023-08-12 |
Not clear |
| G J Biessels, L J Kappell. Increased risk of Alzheimer's disease in Type II diabetes: insulin resistance of the brain or insulin-induced amyloid pathology? Biochemical Society transactions. vol 33. issue Pt 5. 2006-05-02. PMID:16246041. |
insulin also regulates the metabolism of beta-amyloid and tau, the building blocks of amyloid plaques and neurofibrillary tangles, the neuropathological hallmarks of alzheimer's disease. |
2006-05-02 |
2023-08-12 |
Not clear |
| E Tortosa, J Avila, M Pére. Acetylsalicylic acid decreases tau phosphorylation at serine 422. Neuroscience letters. vol 396. issue 1. 2006-04-28. PMID:16386371. |
tau protein pathology in alzheimer's disease is characterized by the hyperphosphorylation of tau at some specific sites. |
2006-04-28 |
2023-08-12 |
Not clear |
| Sumihiro Maeda, Naruhiko Sahara, Yuko Saito, Shigeo Murayama, Atsushi Ikai, Akihiko Takashim. Increased levels of granular tau oligomers: an early sign of brain aging and Alzheimer's disease. Neuroscience research. vol 54. issue 3. 2006-04-28. PMID:16406150. |
increased levels of granular tau oligomers: an early sign of brain aging and alzheimer's disease. |
2006-04-28 |
2023-08-12 |
Not clear |
| Lucia Pastorino, Anyang Sun, Pei-Jung Lu, Xiao Zhen Zhou, Martin Balastik, Greg Finn, Gerburg Wulf, Jormay Lim, Shi-Hua Li, Xiaojiang Li, Weiming Xia, Linda K Nicholson, Kun Ping L. The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production. Nature. vol 440. issue 7083. 2006-04-28. PMID:16554819. |
neuropathological hallmarks of alzheimer's disease are neurofibrillary tangles composed of tau and neuritic plaques comprising amyloid-beta peptides (abeta) derived from amyloid precursor protein (app), but their exact relationship remains elusive. |
2006-04-28 |
2023-08-12 |
mouse |
| D I Orellana, R A Quintanilla, C Gonzalez-Billault, R B Maccion. Role of the JAKs/STATs pathway in the intracellular calcium changes induced by interleukin-6 in hippocampal neurons. Neurotoxicity research. vol 8. issue 3-4. 2006-04-27. PMID:16371324. |
additional studies indicate that the increase in cytosolic calcium induces tau protein hyperphosphorylation, as revealed by using specific antibodies against alzheimer phosphoepitopes. |
2006-04-27 |
2023-08-12 |
rat |
| Toshihisa Tanaka, Kenji Isoe-Wada, Hidenaga Yamamori, Kiyoko Kato, Begum Nurun Nessa, Golam Md Sadik, Masatoshi Taked. Neurobiological studies of dementia--biological markers and neuroprotective strategies for Alzheimer disease. Acta neurologica Taiwanica. vol 15. issue 1. 2006-04-27. PMID:16599295. |
tau protein and amyloid s (abeta), two major components of neuropathology in alzheimer disease (ad), have been applied for establishment of more useful biomarkers and therapeutic approaches. |
2006-04-27 |
2023-08-12 |
Not clear |
| Patrice Delobel, Isabelle Lavenir, Bernardino Ghetti, Max Holzer, Michel Goeder. Cell-cycle markers in a transgenic mouse model of human tauopathy: increased levels of cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1. The American journal of pathology. vol 168. issue 3. 2006-04-19. PMID:16507903. |
recent evidence has suggested that an abnormal reactivation of the cell cycle may precede and cause the hyperphosphorylation and filament formation of tau protein in alzheimer's disease and other tauopathies. |
2006-04-19 |
2023-08-12 |
mouse |
| Paula I Moreira, Mark A Smith, Xiongwei Zhu, Maria S Santos, Catarina R Oliveira, George Perr. Therapeutic potential of oxidant mechanisms in Alzheimer's disease. Expert review of neurotherapeutics. vol 4. issue 6. 2006-04-14. PMID:15853526. |
evidence indicates that in the initial phase of alzheimer's disease development, amyloid-beta deposition and hyperphosphorylated tau, hallmarks of the disease, are consequences of oxidative stress. |
2006-04-14 |
2023-08-12 |
Not clear |
| John Q Trojanowski, Amos B Smith, Donna Huryn, Virginia M-Y Le. Microtubule-stabilising drugs for therapy of Alzheimer's disease and other neurodegenerative disorders with axonal transport impairments. Expert opinion on pharmacotherapy. vol 6. issue 5. 2006-04-14. PMID:15934894. |
moreover, in sporadic neurodegenerative disorders such as alzheimer's disease (ad), pathological alterations of the mt-binding protein tau are linked to impaired axonal transport and brain degeneration. |
2006-04-14 |
2023-08-12 |
human |