| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Luisa Diomede, Elisa R Zanier, Federico Moro, Gloria Vegliante, Laura Colombo, Luca Russo, Alfredo Cagnotto, Carmina Natale, Federica Marta Xodo, Ada De Luigi, Michele Mosconi, Marten Beeg, Marcella Catania, Giacomina Rossi, Fabrizio Tagliavini, Giuseppe Di Fede, Mario Salmon. Aβ1-6 Molecular psychiatry. 2023-05-17. PMID:37198260. |
aβ1-6 alzheimer's disease (ad), the leading cause of dementia in older adults, is a double proteinopathy characterized by amyloid-β (aβ) and tau pathology. |
2023-05-17 |
2023-08-14 |
Not clear |
| Laia Montoliu-Gaya, Andréa L Benedet, Cécile Tissot, Agathe Vrillon, Nicholas J Ashton, Wagner S Brum, Juan Lantero-Rodriguez, Jenna Stevenson, Johanna Nilsson, Mathias Sauer, Nesrine Rahmouni, Gunnar Brinkmalm, Firoza Z Lussier, Tharick A Pascoal, Ingmar Skoog, Silke Kern, Henrik Zetterberg, Claire Paquet, Johan Gobom, Pedro Rosa-Neto, Kaj Blenno. Mass spectrometric simultaneous quantification of tau species in plasma shows differential associations with amyloid and tau pathologies. Nature aging. 2023-05-17. PMID:37198279. |
blood phosphorylated tau (p-tau) biomarkers, at differing sites, demonstrate high accuracy to detect alzheimer's disease (ad). |
2023-05-17 |
2023-08-14 |
human |
| Peter A Ljubenkov, Gil D Rabinovic. Silencing tau to treat early Alzheimer's disease. Nature medicine. 2023-05-17. PMID:37198457. |
silencing tau to treat early alzheimer's disease. |
2023-05-17 |
2023-08-14 |
Not clear |
| Rommani Mondal, Yasmin K Sandhu, Vallabhi M Kamalia, Brooke A Delaney, Amina U Syed, Grace A H Nguyen, Taylor R Moran, Roz R Limpengco, Christopher Liang, Jogeshwar Mukherje. Measurement of Aβ Amyloid Plaques and Tau Protein in Postmortem Human Alzheimer's Disease Brain by Autoradiography Using [ Biomedicines. vol 11. issue 4. 2023-05-16. PMID:37189652. |
measurement of aβ amyloid plaques and tau protein in postmortem human alzheimer's disease brain by autoradiography using [ high-resolution scans of immunohistochemical (ihc) stains of alzheimer's disease (ad) brain slices and radioligand autoradiography both provide information about the distribution of aβ plaques and tau, the two common proteinopathies in ad. |
2023-05-16 |
2023-08-14 |
human |
| Alex Zabala-Findlay, Lewis K Penny, Richard A Lofthouse, Andrew J Porter, Soumya Palliyil, Charles R Harrington, Claude M Wischik, Mohammad Arasto. Utility of Blood-Based Tau Biomarkers for Mild Cognitive Impairment and Alzheimer's Disease: Systematic Review and Meta-Analysis. Cells. vol 12. issue 8. 2023-05-16. PMID:37190093. |
utility of blood-based tau biomarkers for mild cognitive impairment and alzheimer's disease: systematic review and meta-analysis. |
2023-05-16 |
2023-08-14 |
Not clear |
| Batbayar Tumurbaatar, Anna Fracassi, Pietro Scaduto, Jutatip Guptarak, Randall Woltjer, Daniel Jupiter, Giulio Taglialatel. Preserved autophagy in cognitively intact non-demented individuals with Alzheimer's neuropathology. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-05-16. PMID:37191183. |
growing evidence supports that dysfunctional autophagy, the major cell mechanism responsible for removing protein aggregates and a route of clearance for tau in healthy neurons, is a major finding in demented alzheimer's disease (ad) patients. |
2023-05-16 |
2023-08-14 |
Not clear |
| Caitlin Tice, Huaqing Zhao, Dianne Langfor. Single nucleotide polymorphisms in aquaporin-4 associate with cognitive impairment status in people with HIV. Journal of neurovirology. 2023-05-16. PMID:37191905. |
a key contributor to cognitive impairment in hiv and in alzheimer's disease (ad) is formation and accumulation of aberrant proteins including hyperphosphorylated tau (ptau). |
2023-05-16 |
2023-08-14 |
human |
| Martí Colom-Cadena, Caitlin Davies, Sònia Sirisi, Ji-Eun Lee, Elizabeth M Simzer, Makis Tzioras, Marta Querol-Vilaseca, Érika Sánchez-Aced, Ya Yin Chang, Kristjan Holt, Robert I McGeachan, Jamie Rose, Jane Tulloch, Lewis Wilkins, Colin Smith, Teodora Andrian, Olivia Belbin, Sílvia Pujals, Mathew H Horrocks, Alberto Lleó, Tara L Spires-Jone. Synaptic oligomeric tau in Alzheimer's disease - A potential culprit in the spread of tau pathology through the brain. Neuron. 2023-05-16. PMID:37192625. |
synaptic oligomeric tau in alzheimer's disease - a potential culprit in the spread of tau pathology through the brain. |
2023-05-16 |
2023-08-14 |
mouse |
| Martí Colom-Cadena, Caitlin Davies, Sònia Sirisi, Ji-Eun Lee, Elizabeth M Simzer, Makis Tzioras, Marta Querol-Vilaseca, Érika Sánchez-Aced, Ya Yin Chang, Kristjan Holt, Robert I McGeachan, Jamie Rose, Jane Tulloch, Lewis Wilkins, Colin Smith, Teodora Andrian, Olivia Belbin, Sílvia Pujals, Mathew H Horrocks, Alberto Lleó, Tara L Spires-Jone. Synaptic oligomeric tau in Alzheimer's disease - A potential culprit in the spread of tau pathology through the brain. Neuron. 2023-05-16. PMID:37192625. |
in alzheimer's disease, fibrillar tau pathology accumulates and spreads through the brain and synapses are lost. |
2023-05-16 |
2023-08-14 |
mouse |
| Martí Colom-Cadena, Caitlin Davies, Sònia Sirisi, Ji-Eun Lee, Elizabeth M Simzer, Makis Tzioras, Marta Querol-Vilaseca, Érika Sánchez-Aced, Ya Yin Chang, Kristjan Holt, Robert I McGeachan, Jamie Rose, Jane Tulloch, Lewis Wilkins, Colin Smith, Teodora Andrian, Olivia Belbin, Sílvia Pujals, Mathew H Horrocks, Alberto Lleó, Tara L Spires-Jone. Synaptic oligomeric tau in Alzheimer's disease - A potential culprit in the spread of tau pathology through the brain. Neuron. 2023-05-16. PMID:37192625. |
here we used sub-diffraction-limit microscopy to study synaptic tau accumulation in postmortem temporal and occipital cortices of human alzheimer's and control donors. |
2023-05-16 |
2023-08-14 |
mouse |
| Martí Colom-Cadena, Caitlin Davies, Sònia Sirisi, Ji-Eun Lee, Elizabeth M Simzer, Makis Tzioras, Marta Querol-Vilaseca, Érika Sánchez-Aced, Ya Yin Chang, Kristjan Holt, Robert I McGeachan, Jamie Rose, Jane Tulloch, Lewis Wilkins, Colin Smith, Teodora Andrian, Olivia Belbin, Sílvia Pujals, Mathew H Horrocks, Alberto Lleó, Tara L Spires-Jone. Synaptic oligomeric tau in Alzheimer's disease - A potential culprit in the spread of tau pathology through the brain. Neuron. 2023-05-16. PMID:37192625. |
thus, specifically reducing oligomeric tau at synapses may be a promising therapeutic strategy for alzheimer's disease. |
2023-05-16 |
2023-08-14 |
mouse |
| Carlos A Saura, Arnaldo Parra-Dama. Is phosphorylated tau a good biomarker of synapse pathology in Alzheimer's disease? Brain communications. vol 5. issue 3. 2023-05-15. PMID:37180989. |
is phosphorylated tau a good biomarker of synapse pathology in alzheimer's disease? |
2023-05-15 |
2023-08-14 |
Not clear |
| Tyler S Saunders, Francesca E Pozzolo, Amanda Heslegrave, Declan King, Robert I McGeachan, Maxwell P Spires-Jones, Sarah E Harris, Craig Ritchie, Graciela Muniz-Terrera, Ian J Deary, Simon R Cox, Henrik Zetterberg, Tara L Spires-Jone. Predictive blood biomarkers and brain changes associated with age-related cognitive decline. Brain communications. vol 5. issue 3. 2023-05-15. PMID:37180996. |
growing evidence supports the use of plasma levels of tau phosphorylated at threonine 181, amyloid-β, neurofilament light and glial fibrillary acidic protein as promising biomarkers for alzheimer's disease. |
2023-05-15 |
2023-08-14 |
human |
| Tyler S Saunders, Francesca E Pozzolo, Amanda Heslegrave, Declan King, Robert I McGeachan, Maxwell P Spires-Jones, Sarah E Harris, Craig Ritchie, Graciela Muniz-Terrera, Ian J Deary, Simon R Cox, Henrik Zetterberg, Tara L Spires-Jone. Predictive blood biomarkers and brain changes associated with age-related cognitive decline. Brain communications. vol 5. issue 3. 2023-05-15. PMID:37180996. |
several forms of tau phosphorylated at threonine 181 have been shown to contribute to synapse degeneration in alzheimer's disease, which correlates closely with cognitive decline in this form of dementia, but to date, there have not been investigations of whether tau phosphorylated at threonine 181 is found in synapses in alzheimer's disease or healthy ageing brain. |
2023-05-15 |
2023-08-14 |
human |
| Riyadh Ahmed Atto Al-Shuaeeb, H R Abd El-Mageed, Shimaa Ahmed, Hussein S Mohamed, Zeinab S Hamza, Md Oliullah Rafi, Iqrar Ahmad, Harun Pate. Journal of biomolecular structure & dynamics. 2023-05-15. PMID:37184133. |
mark4 has been associated with tau protein phosphorylation and, consequently, alzheimer's disease. |
2023-05-15 |
2023-08-14 |
Not clear |
| Sneha Kumari, Rishika Dhapola, Dibbanti HariKrishna Redd. Apoptosis in Alzheimer's disease: insight into the signaling pathways and therapeutic avenues. Apoptosis : an international journal on programmed cell death. 2023-05-15. PMID:37186274. |
alzheimer's disease (ad) is characterized by the accumulation of hyperphosphorylated tau and amyloid-β (aβ) protein resulting in synaptic loss and apoptosis. |
2023-05-15 |
2023-08-14 |
Not clear |
| Patrick Oeckl, Shorena Janelidze, Steffen Halbgebauer, Erik Stomrud, Sebastian Palmqvist, Markus Otto, Oskar Hansso. Higher plasma β-synuclein indicates early synaptic degeneration in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-05-15. PMID:37186338. |
β-synuclein is an emerging synaptic blood biomarker for alzheimer's disease (ad) but differences in β-synuclein levels in preclinical ad and its association with amyloid and tau pathology have not yet been studied. |
2023-05-15 |
2023-08-14 |
Not clear |
| Julie P Merchant, Kuixi Zhu, Marc Y R Henrion, Syed S A Zaidi, Branden Lau, Sara Moein, Melissa L Alamprese, Richard V Pearse, David A Bennett, Nilüfer Ertekin-Taner, Tracy L Young-Pearse, Rui Chan. Predictive network analysis identifies JMJD6 and other potential key drivers in Alzheimer's disease. Communications biology. vol 6. issue 1. 2023-05-15. PMID:37188718. |
our work thus identifies robust neuronal key drivers of the alzheimer's-associated network state which may represent therapeutic targets with relevance to both amyloid and tau pathology in alzheimer's disease. |
2023-05-15 |
2023-08-14 |
human |
| Suyue Zhong, Jinwang Ye, Yunsong Deng, Mohan Zhang, Miaozhan Zou, Xuanbao Yao, Shifeng Xia. Quercetagitrin Inhibits Tau Accumulation and Reverses Neuroinflammation and Cognitive Deficits in P301S-Tau Transgenic Mice. Molecules (Basel, Switzerland). vol 28. issue 9. 2023-05-14. PMID:37175376. |
intracellular tau accumulation is a hallmark pathology of alzheimer's disease (ad) and other tauopathies. |
2023-05-14 |
2023-08-14 |
mouse |
| Yuxing Xia, Brach M Bell, Benoit I Giasso. Tau Lysine Pseudomethylation Regulates Microtubule Binding and Enhances Prion-like Tau Aggregation. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37175990. |
alzheimer's disease (ad) and frontotemporal dementia (ftd) can be classified as tauopathies, which are a group of neurodegenerative diseases that develop toxic tau aggregates in specific brain regions. |
2023-05-14 |
2023-08-14 |
Not clear |