| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Robyn A Halverson, Jada Lewis, Shanti Frausto, Mike Hutton, Nancy A Mum. Tau protein is cross-linked by transglutaminase in P301L tau transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 5. 2005-09-13. PMID:15689560. |
several lines of evidence suggest that transglutaminase may cross-link tau into stable, insoluble aggregates, leading to the formation of nfts in alzheimer's disease and progressive supranuclear palsy. |
2005-09-13 |
2023-08-12 |
mouse |
| Robyn A Halverson, Jada Lewis, Shanti Frausto, Mike Hutton, Nancy A Mum. Tau protein is cross-linked by transglutaminase in P301L tau transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 5. 2005-09-13. PMID:15689560. |
cross-linked, phosphorylated tau from p301l tau transgenic mice runs as high-molecular mass aggregates on western blots, similar to cross-linked tau from paired helical filaments of alzheimer's disease. |
2005-09-13 |
2023-08-12 |
mouse |
| Clive Ballard, Christopher Morris, Rajesh Kalaria, Ian McKeith, Robert Perry, Elaine Perr. The k variant of the butyrylcholinesterase gene is associated with reduced phosphorylation of tau in dementia patients. Dementia and geriatric cognitive disorders. vol 19. issue 5-6. 2005-09-01. PMID:15802910. |
we examined the relationship between the k variant of buche and the severity of deposits of amyloid (abeta(1-42)) and phosphorylated tau in the temporal cortex (ba36) of 30 prospectively studied autopsy-diagnosed dementia (alzheimer's disease and dementia with lewy bodies) patients. |
2005-09-01 |
2023-08-12 |
Not clear |
| Guo-Gang Xu, Yan-Qiu Deng, Shi-Jie Liu, Hong-Lian Li, Jian-Zhi Wan. Prolonged Alzheimer-like tau hyperphosphorylation induced by simultaneous inhibition of phosphoinositol-3 kinase and protein kinase C in N2a cells. Acta biochimica et biophysica Sinica. vol 37. issue 5. 2005-08-23. PMID:15880264. |
we conclude that the simultaneous inhibition of pi3k and pkc can induce gsk-3 overactivation, and further strengthen and prolong the alzheimer-like tau hyperphosphorylation in n2a cells, suggesting the establishment of a cell model with early pathological events of alzheimer's disease. |
2005-08-23 |
2023-08-12 |
rat |
| J P Jia, R Meng, Y X Sun, W J Sun, X M Ji, L F Ji. Cerebrospinal fluid tau, Abeta1-42 and inflammatory cytokines in patients with Alzheimer's disease and vascular dementia. Neuroscience letters. vol 383. issue 1-2. 2005-08-22. PMID:15936505. |
cerebrospinal fluid tau, abeta1-42 and inflammatory cytokines in patients with alzheimer's disease and vascular dementia. |
2005-08-22 |
2023-08-12 |
Not clear |
| J P Jia, R Meng, Y X Sun, W J Sun, X M Ji, L F Ji. Cerebrospinal fluid tau, Abeta1-42 and inflammatory cytokines in patients with Alzheimer's disease and vascular dementia. Neuroscience letters. vol 383. issue 1-2. 2005-08-22. PMID:15936505. |
in this study we aimed to evaluate the possibility of using cerebrospinal fluid (csf) tau, abeta(1-42) and inflammatory cytokines for diagnosis of alzheimer's disease (ad) and vascular dementia (vd). |
2005-08-22 |
2023-08-12 |
Not clear |
| Marco D Mukrasch, Jacek Biernat, Martin von Bergen, Christian Griesinger, Eckhard Mandelkow, Markus Zweckstette. Sites of tau important for aggregation populate {beta}-structure and bind to microtubules and polyanions. The Journal of biological chemistry. vol 280. issue 26. 2005-08-16. PMID:15855160. |
the aggregation of the microtubule-associated tau protein and formation of "neurofibrillary tangles" is one of the hallmarks of alzheimer disease. |
2005-08-16 |
2023-08-12 |
Not clear |
| Mihaela Necula, Jeff Kure. A static laser light scattering assay for surfactant-induced tau fibrillization. Analytical biochemistry. vol 333. issue 2. 2005-08-15. PMID:15450794. |
here the utility of static laser light scattering for quantitative assay of anionic micelle-induced protein fibrillization was characterized using tau protein, the major component of neurofibrillary lesions of alzheimer's disease. |
2005-08-15 |
2023-08-12 |
Not clear |
| Johannes Attems, Felix Lintner, Kurt A Jellinge. Olfactory involvement in aging and Alzheimer's disease: an autopsy study. Journal of Alzheimer's disease : JAD. vol 7. issue 2. 2005-08-15. PMID:15851853. |
olfactory dysfunction and tau pathology in the olfactory bulb increase with the severity of alzheimer's disease. |
2005-08-15 |
2023-08-12 |
Not clear |
| Johannes Attems, Felix Lintner, Kurt A Jellinge. Olfactory involvement in aging and Alzheimer's disease: an autopsy study. Journal of Alzheimer's disease : JAD. vol 7. issue 2. 2005-08-15. PMID:15851853. |
130 autopsy cases (81 female, 49 male, aged 61-102, mean 82.48 +/- 4.35 sd) years, underwent a standardized neuropathological assessment with immunohistochemical study of tau pathology in the olfactory bulb and nerve and of alzheimer's disease using established criteria including braak staging. |
2005-08-15 |
2023-08-12 |
Not clear |
| Johannes Attems, Felix Lintner, Kurt A Jellinge. Olfactory involvement in aging and Alzheimer's disease: an autopsy study. Journal of Alzheimer's disease : JAD. vol 7. issue 2. 2005-08-15. PMID:15851853. |
these data confirm previous studies demonstrating abundant tau pathology in the olfactory system in all definite alzheimer's disease cases, in two-thirds of limbic alzheimer's disease, and in almost one-third of non-demented elderly persons with braak stage 2. |
2005-08-15 |
2023-08-12 |
Not clear |
| Zheng-Hui Hu, Xiao-Chuan Wang, Li-Yun Li, Mai-Li Liu, Rong Liu, Zhiqun Ling, Qing Tian, Xiao-Wei Tang, Yi-Gen Wu, Jian-Zhi Wan. Correlation of behavior changes and BOLD signal in Alzheimer-like rat model. Acta biochimica et biophysica Sinica. vol 36. issue 12. 2005-08-08. PMID:15592647. |
to explore a potential means for the early diagnosis of alzheimer disease, we studied the relationship of resting t2* signal and tau hyperphosphorylation/spatial memory deficit. |
2005-08-08 |
2023-08-12 |
rat |
| Claire Lafay-Chebassier, Marc Paccalin, Guylène Page, Stéphanie Barc-Pain, Marie Christine Perault-Pochat, Roger Gil, Laurent Pradier, Jacques Hugo. mTOR/p70S6k signalling alteration by Abeta exposure as well as in APP-PS1 transgenic models and in patients with Alzheimer's disease. Journal of neurochemistry. vol 94. issue 1. 2005-08-08. PMID:15953364. |
in alzheimer's disease, neuropathological hallmarks include the accumulation of beta-amyloid peptides (abeta) in senile plaques, phosphorylated tau in neurofibrillary tangles and neuronal death. |
2005-08-08 |
2023-08-12 |
mouse |
| Luisa Fasulo, Gabriele Ugolini, Antonino Cattane. Apoptotic effect of caspase-3 cleaved tau in hippocampal neurons and its potentiation by tau FTDP-mutation N279K. Journal of Alzheimer's disease : JAD. vol 7. issue 1. 2005-08-02. PMID:15750210. |
in addition to mutation at genetic level, a number of post-translational modifications of tau occur in tauopathies, including abnormal phosphorylation and aberrant proteolysis described in alzheimer's disease (ad). |
2005-08-02 |
2023-08-12 |
human |
| Maile R Brown, Vimala Bondada, Jeffery N Keller, Jeffery Thorpe, James W Gedde. Proteasome or calpain inhibition does not alter cellular tau levels in neuroblastoma cells or primary neurons. Journal of Alzheimer's disease : JAD. vol 7. issue 1. 2005-08-02. PMID:15750211. |
impaired tau catabolism may contribute to tau accumulation and aggregation in alzheimer's disease and neurofibrillary tangle formation. |
2005-08-02 |
2023-08-12 |
human |
| Wendy Noble, Emmanuel Planel, Cindy Zehr, Vicki Olm, Jordana Meyerson, Farhana Suleman, Kate Gaynor, Lili Wang, John LaFrancois, Boris Feinstein, Mark Burns, Pavan Krishnamurthy, Yi Wen, Ratan Bhat, Jada Lewis, Dennis Dickson, Karen Duf. Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 19. 2005-08-01. PMID:15867159. |
neurofibrillary tangles composed of hyperphosphorylated, aggregated tau are a common pathological feature of tauopathies, including alzheimer's disease. |
2005-08-01 |
2023-08-12 |
mouse |
| Wendy Noble, Emmanuel Planel, Cindy Zehr, Vicki Olm, Jordana Meyerson, Farhana Suleman, Kate Gaynor, Lili Wang, John LaFrancois, Boris Feinstein, Mark Burns, Pavan Krishnamurthy, Yi Wen, Ratan Bhat, Jada Lewis, Dennis Dickson, Karen Duf. Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 19. 2005-08-01. PMID:15867159. |
lithium administration also resulted in significantly lower levels of phosphorylation at several epitopes of tau known to be hyperphosphorylated in alzheimer's disease and significantly reduced levels of aggregated, insoluble tau. |
2005-08-01 |
2023-08-12 |
mouse |
| Stefan Barghorn, Jacek Biernat, Eckhard Mandelko. Purification of recombinant tau protein and preparation of Alzheimer-paired helical filaments in vitro. Methods in molecular biology (Clifton, N.J.). vol 299. 2005-07-28. PMID:15980594. |
investigating the fundamentals of tau polymerization is indispensable for identifying inhibitory conditions or compounds preventing phf formation, which may slow down or even stop the degeneration of neurons in alzheimer's disease. |
2005-07-28 |
2023-08-12 |
Not clear |
| Martin von Bergen, Li Li, Eckhard Mandelko. Intrinsic fluorescent detection of tau conformation and aggregation. Methods in molecular biology (Clifton, N.J.). vol 299. 2005-07-28. PMID:15980601. |
the polymerization of the microtubule-associated protein tau into paired helical filaments (phfs) is one of the hallmarks of alzheimer's disease. |
2005-07-28 |
2023-08-12 |
Not clear |
| Sébastien Feuillette, Olivier Blard, Magalie Lecourtois, Thierry Frébourg, Dominique Campion, Cécile Dumanchi. Tau is not normally degraded by the proteasome. Journal of neuroscience research. vol 80. issue 3. 2005-07-26. PMID:15795929. |
ubiquitinated tau-positive inclusions have been reported in brains of alzheimer's disease patients, but involvement of the ubiquitin-dependent proteasomal system in tau degradation remains controversial. |
2005-07-26 |
2023-08-12 |
human |