All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Lei Gao, Kerry L Tucker, Athena Andreadi. Transcriptional regulation of the mouse microtubule-associated protein tau. Biochimica et biophysica acta. vol 1681. issue 2-3. 2005-03-09. PMID:15627509. the microtubule-associated protein (map) tau is found primarily in neurons and errors in its regulation are associated with alzheimer's disease and other neurodegenerative disorders. 2005-03-09 2023-08-12 mouse
Xiaomei Liao, Yingchun Zhang, Yipeng Wang, Jianzhi Wan. The effect of cdk-5 overexpression on tau phosphorylation and spatial memory of rat. Science in China. Series C, Life sciences. vol 47. issue 3. 2005-03-04. PMID:15524282. in alzheimer's disease (ad), hyperphosphorylation of tau may be the underlying mechanism for the cytoskeletal abnormalities and neuronal death. 2005-03-04 2023-08-12 rat
Rani Kunjithapatham, Fabiana Y Oliva, Urmi Doshi, Mar Pérez, Jesus Avila, Victor Muño. Role for the alpha-helix in aberrant protein aggregation. Biochemistry. vol 44. issue 1. 2005-03-04. PMID:15628855. tau is a natively unfolded protein that binds to microtubules and forms aggregates in alzheimer's disease. 2005-03-04 2023-08-12 Not clear
Masato Hasegaw. [Frontotemporal dementia: tau mutations, deposition, and molecular mechanisms of neuronal cell death]. Rinsho shinkeigaku = Clinical neurology. vol 44. issue 11. 2005-03-04. PMID:15651320. in sporadic tauopathies, decreased levels of 3r tau mrna were detected not only in severely affected cases with progressive supranuclear palsy or corticobasal degeneration but also in cases with alzheimer's disease or pick's disease. 2005-03-04 2023-08-12 Not clear
Jesús Mendieta, Miguel A Fuertes, Rani Kunjishapatham, Ismael Santa-María, Francisco J Moreno, Carlos Alonso, Federico Gago, Victor Muñoz, Jesús Avila, Félix Hernánde. Phosphorylation modulates the alpha-helical structure and polymerization of a peptide from the third tau microtubule-binding repeat. Biochimica et biophysica acta. vol 1721. issue 1-3. 2005-03-01. PMID:15652175. paired helical filaments (phfs) isolated from patients with alzheimer's disease (ad) mainly consist of the microtubule-associated protein tau in a hyperphosphorylated form. 2005-03-01 2023-08-12 Not clear
I Ferre. Stress kinases involved in tau phosphorylation in Alzheimer's disease, tauopathies and APP transgenic mice. Neurotoxicity research. vol 6. issue 6. 2005-03-01. PMID:15658002. stress kinases involved in tau phosphorylation in alzheimer's disease, tauopathies and app transgenic mice. 2005-03-01 2023-08-12 mouse
I Ferre. Stress kinases involved in tau phosphorylation in Alzheimer's disease, tauopathies and APP transgenic mice. Neurotoxicity research. vol 6. issue 6. 2005-03-01. PMID:15658002. hyperphosphorylation and accumulation of tau in neurons (and glial cells) is one of the main pathologic hallmarks in alzheimer's disease (ad) and other tauopathies, including pick's disease (pid), progressive supranuclear palsy, corticobasal degeneration, argyrophilic grain disease and familial frontotemporal dementia and parkinsonism linked to chromosome 17 due to mutations in the tau gene (ftdp-17-tau). 2005-03-01 2023-08-12 mouse
Anja Schneider, Gilda Wright Araújo, Katarina Trajkovic, Martin M Herrmann, Doron Merkler, Eva-Maria Mandelkow, Robert Weissert, Mikael Simon. Hyperphosphorylation and aggregation of tau in experimental autoimmune encephalomyelitis. The Journal of biological chemistry. vol 279. issue 53. 2005-02-25. PMID:15494405. hyperphosphorylation and pathological aggregation of microtubule-associated protein tau is a common feature of many neurodegenerative diseases with axonal degeneration including alzheimer's disease. 2005-02-25 2023-08-12 rat
Anja Schneider, Gilda Wright Araújo, Katarina Trajkovic, Martin M Herrmann, Doron Merkler, Eva-Maria Mandelkow, Robert Weissert, Mikael Simon. Hyperphosphorylation and aggregation of tau in experimental autoimmune encephalomyelitis. The Journal of biological chemistry. vol 279. issue 53. 2005-02-25. PMID:15494405. we have therefore analyzed tau phosphorylation, solubility and distribution in the brainstem of rats with experimental autoimmune encephalomyelitis (eae), an animal model of ms. tau was hyperphosphorylated at several sites also phosphorylated in alzheimer's disease and became partially detergent-insoluble in eae brains. 2005-02-25 2023-08-12 rat
Satyabrata Kar, Stephen P M Slowikowski, David Westaway, Howard T J Moun. Interactions between beta-amyloid and central cholinergic neurons: implications for Alzheimer's disease. Journal of psychiatry & neuroscience : JPN. vol 29. issue 6. 2005-02-23. PMID:15644984. the brain of an individual with alzheimer's disease exhibits extracellular plaques of aggregated beta-amyloid protein (abeta), intracellular neurofibrillary tangles that contain hyperphosphorylated tau protein and a profound loss of basal forebrain cholinergic neurons that innervate the hippocampus and the neocortex. 2005-02-23 2023-08-12 Not clear
Satyabrata Kar, Stephen P M Slowikowski, David Westaway, Howard T J Moun. Interactions between beta-amyloid and central cholinergic neurons: implications for Alzheimer's disease. Journal of psychiatry & neuroscience : JPN. vol 29. issue 6. 2005-02-23. PMID:15644984. understanding the functional interrelations between abeta peptides, cholinergic neurons and tau phosphorylation will unravel the biologic events that precede neurodegeneration and may lead to the development of more effective pharmacotherapies for alzheimer's disease. 2005-02-23 2023-08-12 Not clear
Li Sun, XiaoChuang Wang, Shengyuan Liu, Quan Wang, JianZhi Wang, Malika Bennecib, Cheng-Xin Gong, Amitabha Sengupta, Inge Grundke-Iqbal, Khalid Iqba. Bilateral injection of isoproterenol into hippocampus induces Alzheimer-like hyperphosphorylation of tau and spatial memory deficit in rat. FEBS letters. vol 579. issue 1. 2005-02-17. PMID:15620722. the abnormal hyperphosphorylation of tau protein is one of the hallmarks of alzheimer disease and other tauopathies; as yet the exact role of various tau kinases in this pathology is not fully understood. 2005-02-17 2023-08-12 rat
Hanna Rosenmann, Zeev Meiner, Esther Kahana, Zoja Aladjem, Gideon Friedman, Arie Ben-Yehuda, Tal Grenader, Eli Wertman, Oded Abramsk. An association study of a polymorphism in the heparan sulfate proteoglycan gene (perlecan, HSPG2) and Alzheimer's disease. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 128B. issue 1. 2005-02-16. PMID:15211644. accumulating evidence indicates that the heparan-sulfate-proteoglycan (perlecan, hspg2), as well as other specific proteoglycans, are involved in amyloidogenesis and tau aggregation in alzheimer's disease (ad). 2005-02-16 2023-08-12 Not clear
Dan-Ling Wang, Zhi-Qun Ling, Fu-Yuan Cao, Ling-Qiang Zhu, Jian-Zhi Wan. Melatonin attenuates isoproterenol-induced protein kinase A overactivation and tau hyperphosphorylation in rat brain. Journal of pineal research. vol 37. issue 1. 2005-02-10. PMID:15230863. hyperphosphorylation of microtubule-associated protein tau at specific sites is a recognized pathological process in alzheimer's disease (ad), and protein kinase a (pka) is a crucial kinase in ad-like tau hyperphosphorylation. 2005-02-10 2023-08-12 rat
Mihaela Necula, Jeff Kure. Pseudophosphorylation and glycation of tau protein enhance but do not trigger fibrillization in vitro. The Journal of biological chemistry. vol 279. issue 48. 2005-02-07. PMID:15364924. alzheimer's disease is defined in part by the intraneuronal aggregation of tau protein into filamentous lesions. 2005-02-07 2023-08-12 Not clear
Shi Jie Liu, Jia Yu Zhang, Hong Lian Li, Zheng Yu Fang, Qun Wang, Heng Mei Deng, Cheng Xin Gong, Inge Grundke-Iqbal, Khalid Iqbal, Jian Zhi Wan. Tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain. The Journal of biological chemistry. vol 279. issue 48. 2005-02-07. PMID:15375165. microtubule-associated protein tau is abnormally hyperphosphorylated in alzheimer's disease (ad) and other tauopathies and is believed to lead to neurodegeneration in this family of diseases. 2005-02-07 2023-08-12 rat
Ian D'Souza, Gerard D Schellenber. Regulation of tau isoform expression and dementia. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615630. pathological tau causes neuronal loss in alzheimer's disease (ad) and a diverse group of disorders called the frontotemporal dementias (ftd), which are two of the most common forms of dementia and afflict more than 10% of the elderly population. 2005-02-03 2023-08-12 Not clear
George S Bloom, Ke Ren, Charles G Glab. Cultured cell and transgenic mouse models for tau pathology linked to beta-amyloid. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615631. the two histopathological signatures of alzheimer's disease (ad) are amyloid plaques and neurofibrillary tangles, prompting speculation that a causal relationship exists between the respective building blocks of these abnormal brain structures: the beta-amyloid peptides (abeta) and the neuron-enriched microtubule-associated protein called tau. 2005-02-03 2023-08-12 mouse
Li-Wen Ko, Michael DeTure, Naruhiko Sahara, Rifki Chihab, Irving E Vega, Shu-Hui Ye. Recent advances in experimental modeling of the assembly of tau filaments. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615632. intracellular assembly of microtubule-associated protein tau into filamentous inclusions is central to alzheimer's disease and related disorders collectively known as tauopathies. 2005-02-03 2023-08-12 human
Bradley T Hyman, Jean C Augustinack, Martin Ingelsso. Transcriptional and conformational changes of the tau molecule in Alzheimer's disease. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615634. transcriptional and conformational changes of the tau molecule in alzheimer's disease. 2005-02-03 2023-08-12 Not clear