All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Martin von Bergen, Stefan Barghorn, Jacek Biernat, Eva-Maria Mandelkow, Eckhard Mandelko. Tau aggregation is driven by a transition from random coil to beta sheet structure. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615635. the abnormal aggregation of the microtubule associated protein tau into paired helical filaments (phfs) is one the hallmarks of alzheimer's disease. 2005-02-03 2023-08-12 Not clear
Jeff Kuret, Carmen N Chirita, Erin E Congdon, Theresa Kannanayakal, Guibin Li, Mihaela Necula, Haishan Yin, Qi Zhon. Pathways of tau fibrillization. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615636. here we review the parallels between the sequential progression of tau fibrillization observed macroscopically in alzheimer's disease (ad) lesions and the pathway of tau aggregation observed in vitro with purified tau preparations. 2005-02-03 2023-08-12 Not clear
Nicolas Sergeant, André Delacourte, Luc Bué. Tau protein as a differential biomarker of tauopathies. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615637. a direct correlation has been established between the regional brain distribution of tau pathology and clinical symptoms; for instance progressive involvement of neocortical areas is well correlated to the severity of dementia in alzheimer's disease, overall suggesting that pathological tau proteins are reliable marker of the neurodegenerative process. 2005-02-03 2023-08-12 Not clear
Nicolas Sergeant, André Delacourte, Luc Bué. Tau protein as a differential biomarker of tauopathies. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615637. they would hopefully find their application against alzheimer's disease but also in all neurological disorders for which a dysfunction of tau biology has been identified. 2005-02-03 2023-08-12 Not clear
Khalid Iqbal, Alejandra del C Alonso, She Chen, M Omar Chohan, Ezzat El-Akkad, Cheng-Xin Gong, Sabiha Khatoon, Bin Li, Fei Liu, Abdur Rahman, Hitoshi Tanimukai, Inge Grundke-Iqba. Tau pathology in Alzheimer disease and other tauopathies. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615638. tau pathology in alzheimer disease and other tauopathies. 2005-02-03 2023-08-12 Not clear
Quan Liu, Hyoung-gon Lee, Kazuhiro Honda, Sandra L Siedlak, Peggy L R Harris, Adam D Cash, Xiongwei Zhu, Jesús Avila, Akihiko Nunomura, Atsushi Takeda, Mark A Smith, George Perr. Tau modifiers as therapeutic targets for Alzheimer's disease. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615639. tau modifiers as therapeutic targets for alzheimer's disease. 2005-02-03 2023-08-12 Not clear
Lester I Binder, Angela L Guillozet-Bongaarts, Francisco Garcia-Sierra, Robert W Berr. Tau, tangles, and Alzheimer's disease. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615640. tau, tangles, and alzheimer's disease. 2005-02-03 2023-08-12 Not clear
Virginia M-Y Lee, Theresa K Kenyon, John Q Trojanowsk. Transgenic animal models of tauopathies. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615643. tauopathies are a group of neurodegenerative disorders that include alzheimer's disease, frontotemporal dementia with parkinsonism linked to chromosome 17 (ftdp-17) and other related diseases with prominent tau pathology. 2005-02-03 2023-08-12 mouse
Stuart C Feinstein, Leslie Wilso. Inability of tau to properly regulate neuronal microtubule dynamics: a loss-of-function mechanism by which tau might mediate neuronal cell death. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615645. interest in the microtubule-associated protein tau stems from its critical roles in neural development and maintenance, as well as its role in alzheimer's, ftdp-17 and related neurodegenerative diseases. 2005-02-03 2023-08-12 Not clear
William H Stoothoff, Gail V W Johnso. Tau phosphorylation: physiological and pathological consequences. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615646. the microtubule-associated protein tau, abundant in neurons, has gained notoriety due to the fact that it is deposited in cells as fibrillar lesions in numerous neurodegenerative diseases, and most notably alzheimer's disease. 2005-02-03 2023-08-12 Not clear
William H Stoothoff, Gail V W Johnso. Tau phosphorylation: physiological and pathological consequences. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615646. given the increasing evidence that a disruption in the normal phosphorylation state of tau plays a key role in the pathogenic events that occur in alzheimer's disease and other neurodegenerative conditions, it is of crucial importance that the protein kinases and phosphatases that regulate tau phosphorylation in vivo as well as the signaling cascades that regulate them be identified. 2005-02-03 2023-08-12 Not clear
Kenneth S Kosik, Hideki Shimur. Phosphorylated tau and the neurodegenerative foldopathies. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615647. many studies have implicated phosphorylated tau in the alzheimer disease process. 2005-02-03 2023-08-12 Not clear
Roland Brandt, Monika Hundelt, Neelam Shahan. Tau alteration and neuronal degeneration in tauopathies: mechanisms and models. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615650. the review begins with a discussion about similarities and differences in tau alteration in paradigmatic tauopathies such as frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17) and alzheimer's disease (ad). 2005-02-03 2023-08-12 Not clear
Xiao-Qing Li, Deng Chen, Zhen-Xin Zhang, Qiu-Ming Qu, Jun-Wu Zhan. Association between cathepsin D polymorphism and Alzheimer's disease in a Chinese Han population. Dementia and geriatric cognitive disorders. vol 18. issue 2. 2005-02-02. PMID:15211064. ctsd may play a role in alzheimer's disease (ad) through cleaving the amyloid precursor protein into beta-amyloid peptide and degrading tau protein into fragments. 2005-02-02 2023-08-12 Not clear
Trey Sunderland, Nadeem Mirza, Karen T Putnam, Gary Linker, Deepa Bhupali, Rob Durham, Holly Soares, Lida Kimmel, David Friedman, Judy Bergeson, Gyorgy Csako, James A Levy, John J Bartko, Robert M Cohe. Cerebrospinal fluid beta-amyloid1-42 and tau in control subjects at risk for Alzheimer's disease: the effect of APOE epsilon4 allele. Biological psychiatry. vol 56. issue 9. 2005-01-31. PMID:15522251. cerebrospinal fluid beta-amyloid1-42 and tau in control subjects at risk for alzheimer's disease: the effect of apoe epsilon4 allele. 2005-01-31 2023-08-12 human
Trey Sunderland, Nadeem Mirza, Karen T Putnam, Gary Linker, Deepa Bhupali, Rob Durham, Holly Soares, Lida Kimmel, David Friedman, Judy Bergeson, Gyorgy Csako, James A Levy, John J Bartko, Robert M Cohe. Cerebrospinal fluid beta-amyloid1-42 and tau in control subjects at risk for Alzheimer's disease: the effect of APOE epsilon4 allele. Biological psychiatry. vol 56. issue 9. 2005-01-31. PMID:15522251. cerebrospinal fluid (csf) measures of beta-amyloid(1-42) and tau are linked with the known neuropathology of alzheimer's disease (ad). 2005-01-31 2023-08-12 human
Sarah L Lambourne, Lynda A Sellers, Toby G Bush, Shewly K Choudhury, Piers C Emson, Yoo-Hun Suh, Lawrence S Wilkinso. Increased tau phosphorylation on mitogen-activated protein kinase consensus sites and cognitive decline in transgenic models for Alzheimer's disease and FTDP-17: evidence for distinct molecular processes underlying tau abnormalities. Molecular and cellular biology. vol 25. issue 1. 2005-01-18. PMID:15601849. increased tau phosphorylation on mitogen-activated protein kinase consensus sites and cognitive decline in transgenic models for alzheimer's disease and ftdp-17: evidence for distinct molecular processes underlying tau abnormalities. 2005-01-18 2023-08-12 mouse
Sarah L Lambourne, Lynda A Sellers, Toby G Bush, Shewly K Choudhury, Piers C Emson, Yoo-Hun Suh, Lawrence S Wilkinso. Increased tau phosphorylation on mitogen-activated protein kinase consensus sites and cognitive decline in transgenic models for Alzheimer's disease and FTDP-17: evidence for distinct molecular processes underlying tau abnormalities. Molecular and cellular biology. vol 25. issue 1. 2005-01-18. PMID:15601849. abnormal tau phosphorylation occurs in several neurodegenerative disorders, including alzheimer's disease (ad) and frontotemporal dementia with parkinsonism linked to chromosome 17 (ftdp-17). 2005-01-18 2023-08-12 mouse
C-A Maurage, T Bussière, N Sergeant, A Ghesteem, D Figarella-Branger, M-M Ruchoux, J-F Pellissier, A Delacourt. Tau aggregates are abnormally phosphorylated in inclusion body myositis and have an immunoelectrophoretic profile distinct from other tauopathies. Neuropathology and applied neurobiology. vol 30. issue 6. 2005-01-13. PMID:15541003. in the present study, we have investigated by immunohistochemistry and immunoblotting analysis the presence of tau proteins in muscle biopsy samples from patients with s-ibm and other myopathies with rimmed vacuoles, using newly developed antibodies raised against tau protein epitopes found in alzheimer's disease brain. 2005-01-13 2023-08-12 Not clear
Mihaela Necula, Jeff Kure. Electron microscopy as a quantitative method for investigating tau fibrillization. Analytical biochemistry. vol 329. issue 2. 2005-01-11. PMID:15158482. fibrillization of tau protein is a hallmark lesion in alzheimer's disease. 2005-01-11 2023-08-12 Not clear