| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yi-Gang Che. Specific tau phosphorylation sites in hippocampus correlate with impairment of step-down inhibitory avoidance task in rats. Behavioural brain research. vol 158. issue 2. 2005-04-19. PMID:15698894. |
microtubule associated protein tau is abnormally phosphorylated in alzheimer's disease (ad) and aggregates as paired helical filaments (phfs) in neurofibrillary tangles (nfts), which are one of the pathological signatures of ad and their presence correlates with severity of dementia. |
2005-04-19 |
2023-08-12 |
rat |
| Tetsuaki Arai, Jian-Ping Guo, Patrick L McGee. Proteolysis of non-phosphorylated and phosphorylated tau by thrombin. The Journal of biological chemistry. vol 280. issue 7. 2005-04-18. PMID:15542598. |
the microtubule-associated protein tau aggregates intracellularly by unknown mechanisms in alzheimer's disease and other tauopathies. |
2005-04-18 |
2023-08-12 |
human |
| Tetsuaki Arai, Jian-Ping Guo, Patrick L McGee. Proteolysis of non-phosphorylated and phosphorylated tau by thrombin. The Journal of biological chemistry. vol 280. issue 7. 2005-04-18. PMID:15542598. |
furthermore, paired helical filament tau prepared from alzheimer's disease brain was more resistant to thrombin proteolysis than following dephosphorylation by alkaline phosphatase. |
2005-04-18 |
2023-08-12 |
human |
| Ya-Li Zheng, Sashi Kesavapany, Maneth Gravell, Rebecca S Hamilton, Manfred Schubert, Niranjana Amin, Wayne Albers, Philip Grant, Harish C Pan. A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons. The EMBO journal. vol 24. issue 1. 2005-04-18. PMID:15592431. |
the extracellular aggregation of amyloid beta (abeta) peptides and the intracellular hyperphosphorylation of tau at specific epitopes are pathological hallmarks of neurodegenerative diseases such as alzheimer's disease (ad). |
2005-04-18 |
2023-08-12 |
Not clear |
| Su Jeon Shin, Sung-Eun Lee, Jung Hyun Boo, Mihyang Kim, Young-Dae Yoon, Su-il Kim, Inhee Mook-Jun. Profiling proteins related to amyloid deposited brain of Tg2576 mice. Proteomics. vol 4. issue 11. 2005-04-13. PMID:15378736. |
alzheimer's disease (ad) is an age-related neurodegenerative disorder that is characterized by the extracellular deposition of beta-amyloid and intracellular hyperphosphorylation of tau in the cortex and hippocampus of the brain. |
2005-04-13 |
2023-08-12 |
mouse |
| Fei Liu, Khalid Iqbal, Inge Grundke-Iqbal, Sandra Rossie, Cheng-Xin Gon. Dephosphorylation of tau by protein phosphatase 5: impairment in Alzheimer's disease. The Journal of biological chemistry. vol 280. issue 3. 2005-04-13. PMID:15546861. |
dephosphorylation of tau by protein phosphatase 5: impairment in alzheimer's disease. |
2005-04-13 |
2023-08-12 |
human |
| Fei Liu, Khalid Iqbal, Inge Grundke-Iqbal, Sandra Rossie, Cheng-Xin Gon. Dephosphorylation of tau by protein phosphatase 5: impairment in Alzheimer's disease. The Journal of biological chemistry. vol 280. issue 3. 2005-04-13. PMID:15546861. |
pp5 dephosphorylated tau at all 12 alzheimer's disease (ad)-associated abnormal phosphorylation sites studied, with different efficiency toward each site. |
2005-04-13 |
2023-08-12 |
human |
| David Eliezer, Patrick Barré, Muris Kobaslija, Dylan Chan, Xiaohua Li, Lauren Heen. Residual structure in the repeat domain of tau: echoes of microtubule binding and paired helical filament formation. Biochemistry. vol 44. issue 3. 2005-04-12. PMID:15654759. |
the microtubule-associated protein tau is found aggregated into paired helical filaments in the intraneuronal neurofibrillary tangle deposits of victims of alzheimer's disease (ad) and other related dementias. |
2005-04-12 |
2023-08-12 |
Not clear |
| A Boldyrev, E Bulygina, A Makhr. Glutamate receptors modulate oxidative stress in neuronal cells. A mini-review. Neurotoxicity research. vol 6. issue 7-8. 2005-04-08. PMID:15639790. |
selective dysfunction of mglu ii receptors may also lead to abnormal protein phosphorylation (i.e., tau phosphorylation), culminating in neurodegenerative disorders (i.e., alzheimer disease). |
2005-04-08 |
2023-08-12 |
human |
| Sayuri Taniguchi, Nobuyuki Suzuki, Masami Masuda, Shin-ichi Hisanaga, Takeshi Iwatsubo, Michel Goedert, Masato Hasegaw. Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins. The Journal of biological chemistry. vol 280. issue 9. 2005-04-07. PMID:15611092. |
tau protein is the major component of the intraneuronal filamentous inclusions that constitute defining neuropathological characteristics of alzheimer's disease and other tauopathies. |
2005-04-07 |
2023-08-12 |
Not clear |
| Peleg M Horowitz, Kristina R Patterson, Angela L Guillozet-Bongaarts, Matthew R Reynolds, Christopher A Carroll, Susan T Weintraub, David A Bennett, Vincent L Cryns, Robert W Berry, Lester I Binde. Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 36. 2005-04-05. PMID:15356202. |
early n-terminal changes and caspase-6 cleavage of tau in alzheimer's disease. |
2005-04-05 |
2023-08-12 |
Not clear |
| Peleg M Horowitz, Kristina R Patterson, Angela L Guillozet-Bongaarts, Matthew R Reynolds, Christopher A Carroll, Susan T Weintraub, David A Bennett, Vincent L Cryns, Robert W Berry, Lester I Binde. Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 36. 2005-04-05. PMID:15356202. |
alzheimer's disease (ad) is a progressive amnestic dementia that involves post-translational hyperphosphorylation, enzymatic cleavage, and conformational alterations of the microtubule-associated protein tau. |
2005-04-05 |
2023-08-12 |
Not clear |
| Peleg M Horowitz, Kristina R Patterson, Angela L Guillozet-Bongaarts, Matthew R Reynolds, Christopher A Carroll, Susan T Weintraub, David A Bennett, Vincent L Cryns, Robert W Berry, Lester I Binde. Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 36. 2005-04-05. PMID:15356202. |
collectively, these results suggest a role for caspase-6 and n-terminal truncation of tau during neurofibrillary tangle evolution and the progression of alzheimer's disease. |
2005-04-05 |
2023-08-12 |
Not clear |
| Taizo Taniguchi, Miho Sumida, Shuko Hiraoka, Koji Tomoo, Tomoko Kakehi, Katsuhiko Minoura, Shigeru Sugiyama, Koji Inaka, Toshimasa Ishida, Naoaki Saito, Chikako Tanak. Effects of different anti-tau antibodies on tau fibrillogenesis: RTA-1 and RTA-2 counteract tau aggregation. FEBS letters. vol 579. issue 6. 2005-04-01. PMID:15733848. |
tau is the major antigenic component of neurofibrillary pathology in tauopathy, including alzheimer's disease. |
2005-04-01 |
2023-08-12 |
Not clear |
| Mihaela Necula, Jeff Kure. Site-specific pseudophosphorylation modulates the rate of tau filament dissociation. FEBS letters. vol 579. issue 6. 2005-04-01. PMID:15733856. |
hyperphosphorylation of tau is of fundamental importance for neurofibrillary lesion development in alzheimer's disease, but the mechanisms through which it acts are not clear. |
2005-04-01 |
2023-08-12 |
Not clear |
| R Rademakers, M Cruts, C van Broeckhove. The role of tau (MAPT) in frontotemporal dementia and related tauopathies. Human mutation. vol 24. issue 4. 2005-03-31. PMID:15365985. |
abnormal filamentous tau deposits have been reported as a pathological characteristic in several other neurodegenerative diseases, including frontotemporal dementia, pick disease, alzheimer disease, argyrophilic grain disease, progressive supranuclear palsy, and corticobasal degeneration. |
2005-03-31 |
2023-08-12 |
mouse |
| Natalia Csokova, Rostislav Skrabana, Hans-Dieter Liebig, Anna Mederlyova, Peter Kontsek, Michal Nova. Rapid purification of truncated tau proteins: model approach to purification of functionally active fragments of disordered proteins, implication for neurodegenerative diseases. Protein expression and purification. vol 35. issue 2. 2005-03-29. PMID:15135415. |
truncated tau is of great interest because of its important role in neurofibrillary pathogenesis in alzheimer's disease (ad). |
2005-03-29 |
2023-08-12 |
Not clear |
| Carl W Cotman, Wayne W Poon, Robert A Rissman, Mathew Blurton-Jone. The role of caspase cleavage of tau in Alzheimer disease neuropathology. Journal of neuropathology and experimental neurology. vol 64. issue 2. 2005-03-29. PMID:15751224. |
the role of caspase cleavage of tau in alzheimer disease neuropathology. |
2005-03-29 |
2023-08-12 |
mouse |
| Salvatore Oddo, Antonella Caccamo, Kim N Green, Kevin Liang, Levina Tran, Yiling Chen, Frances M Leslie, Frank M LaFerl. Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 8. 2005-03-24. PMID:15705720. |
chronic nicotine administration exacerbates tau pathology in a transgenic model of alzheimer's disease. |
2005-03-24 |
2023-08-12 |
mouse |
| Marcus Pickhardt, Zuzana Gazova, Martin von Bergen, Inna Khlistunova, Yipeng Wang, Antje Hascher, Eva-Maria Mandelkow, Jacek Biernat, Eckhard Mandelko. Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells. The Journal of biological chemistry. vol 280. issue 5. 2005-03-22. PMID:15525637. |
anthraquinones inhibit tau aggregation and dissolve alzheimer's paired helical filaments in vitro and in cells. |
2005-03-22 |
2023-08-12 |
Not clear |