Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Gary W Arendash, Jada Lewis, Ralph E Leighty, Eileen McGowan, Jennifer R Cracchiolo, Mike Hutton, Marcos F Garci. Multi-metric behavioral comparison of APPsw and P301L models for Alzheimer's disease: linkage of poorer cognitive performance to tau pathology in forebrain. Brain research. vol 1012. issue 1-2. 2004-08-17. PMID:15158158. |
multi-metric behavioral comparison of appsw and p301l models for alzheimer's disease: linkage of poorer cognitive performance to tau pathology in forebrain. |
2004-08-17 |
2023-08-12 |
mouse |
Fumitaka Oyama, Svetlana Kotliarova, Akihiro Harada, Mamoru Ito, Haruko Miyazaki, Yoshito Ueyama, Nobutaka Hirokawa, Nobuyuki Nukina, Yasuo Ihar. Gem GTPase and tau: morphological changes induced by gem GTPase in cho cells are antagonized by tau. The Journal of biological chemistry. vol 279. issue 26. 2004-08-13. PMID:15087445. |
tau is also the major component of paired helical filaments found in brains affected by alzheimer's disease. |
2004-08-13 |
2023-08-12 |
mouse |
Dennis W Dickso. Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect? The Journal of clinical investigation. vol 114. issue 1. 2004-08-02. PMID:15232608. |
in alzheimer disease both extracellular amyloid deposits and intracellular amyloid beta protein may activate caspases, leading to cleavage of nuclear and cytoskeletal proteins, including tau protein. |
2004-08-02 |
2023-08-12 |
Not clear |
Robert A Rissman, Wayne W Poon, Mathew Blurton-Jones, Salvatore Oddo, Reidun Torp, Michael P Vitek, Frank M LaFerla, Troy T Rohn, Carl W Cotma. Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. The Journal of clinical investigation. vol 114. issue 1. 2004-08-02. PMID:15232619. |
caspase-cleavage of tau is an early event in alzheimer disease tangle pathology. |
2004-08-02 |
2023-08-12 |
mouse |
Anne Jämsä, Kristina Hasslund, Richard F Cowburn, Anders Bäckström, Mervi Vasäng. The retinoic acid and brain-derived neurotrophic factor differentiated SH-SY5Y cell line as a model for Alzheimer's disease-like tau phosphorylation. Biochemical and biophysical research communications. vol 319. issue 3. 2004-07-30. PMID:15184080. |
the retinoic acid and brain-derived neurotrophic factor differentiated sh-sy5y cell line as a model for alzheimer's disease-like tau phosphorylation. |
2004-07-30 |
2023-08-12 |
human |
Anne Jämsä, Kristina Hasslund, Richard F Cowburn, Anders Bäckström, Mervi Vasäng. The retinoic acid and brain-derived neurotrophic factor differentiated SH-SY5Y cell line as a model for Alzheimer's disease-like tau phosphorylation. Biochemical and biophysical research communications. vol 319. issue 3. 2004-07-30. PMID:15184080. |
the paired helical filaments of highly phosphorylated tau protein are the main components of neurofibrillary tangles (nft) in alzheimer's disease (ad). |
2004-07-30 |
2023-08-12 |
human |
Teresa García, David Ja. [Phosphorylation of tau and Alzheimer's disease]. Gaceta medica de Mexico. vol 140. issue 3. 2004-07-27. PMID:15259345. |
[phosphorylation of tau and alzheimer's disease]. |
2004-07-27 |
2023-08-12 |
Not clear |
Teresa García, David Ja. [Phosphorylation of tau and Alzheimer's disease]. Gaceta medica de Mexico. vol 140. issue 3. 2004-07-27. PMID:15259345. |
under these circumstances tau begins to aggregate into neurofibrillary tangles (nfts) complexes which are pathological hallmarks of alzheimer's disease together with senile plaques. |
2004-07-27 |
2023-08-12 |
Not clear |
Marcin Sadowski, Joanna Pankiewicz, Henrieta Scholtzova, Yong-sheng Li, David Quartermain, Karen Duff, Thomas Wisniewsk. Links between the pathology of Alzheimer's disease and vascular dementia. Neurochemical research. vol 29. issue 6. 2004-07-26. PMID:15176482. |
the major neuropathological lesions defining alzheimer's disease (ad) include neurofibrillary tangles and amyloid plaques, which are mainly composed of abnormally phosphorylated tau and amyloid-beta (a beta), respectively. |
2004-07-26 |
2023-08-12 |
mouse |
Guibin Li, Haishan Yin, Jeff Kure. Casein kinase 1 delta phosphorylates tau and disrupts its binding to microtubules. The Journal of biological chemistry. vol 279. issue 16. 2004-07-22. PMID:14761950. |
tau hyperphosphorylation precedes neuritic lesion formation in alzheimer's disease, suggesting it participates in the tau fibrillization reaction pathway. |
2004-07-22 |
2023-08-12 |
human |
Guibin Li, Haishan Yin, Jeff Kure. Casein kinase 1 delta phosphorylates tau and disrupts its binding to microtubules. The Journal of biological chemistry. vol 279. issue 16. 2004-07-22. PMID:14761950. |
candidate tau protein kinases include members of the casein kinase 1 (ck1) family of phosphotransferases, which are highly overexpressed in alzheimer's disease brain and colocalize with neuritic and granulovacuolar lesions. |
2004-07-22 |
2023-08-12 |
human |
Guibin Li, Haishan Yin, Jeff Kure. Casein kinase 1 delta phosphorylates tau and disrupts its binding to microtubules. The Journal of biological chemistry. vol 279. issue 16. 2004-07-22. PMID:14761950. |
these results suggest that ckidelta phosphorylates tau at sites that modulate tau/microtubule binding, and that the expression pattern of ckidelta in alzheimer's disease is consistent with it playing an important role in tau aggregation. |
2004-07-22 |
2023-08-12 |
human |
Ratan V Bhat, Samantha L Budd Haeberlein, Jesús Avil. Glycogen synthase kinase 3: a drug target for CNS therapies. Journal of neurochemistry. vol 89. issue 6. 2004-07-22. PMID:15189333. |
the most exciting of the possibilities of gsk3 lies within the treatment of alzheimer's disease (ad) where abnormal increases in gsk3 levels and activity have been associated with neuronal death, paired helical filament tau formation and neurite retraction as well as a decline in cognitive performance. |
2004-07-22 |
2023-08-12 |
Not clear |
Takeshi Kawarabayashi, Mikio Shoji, Linda H Younkin, Lin Wen-Lang, Dennis W Dickson, Tetsuro Murakami, Etsuro Matsubara, Koji Abe, Karen Hsiao Ashe, Steven G Younki. Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 15. 2004-07-21. PMID:15084661. |
dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein e and phosphorylated tau accumulation in the tg2576 mouse model of alzheimer's disease. |
2004-07-21 |
2023-08-12 |
mouse |
Alberto Gómez-Ramos, Xabier Abad, Mónica López Fanarraga, Ratan Bhat, Juan Carlos Zabala, Jesús Avil. Expression of an altered form of tau in Sf9 insect cells results in the assembly of polymers resembling Alzheimer's paired helical filaments. Brain research. vol 1007. issue 1-2. 2004-07-19. PMID:15064135. |
expression of an altered form of tau in sf9 insect cells results in the assembly of polymers resembling alzheimer's paired helical filaments. |
2004-07-19 |
2023-08-12 |
Not clear |
Alberto Gómez-Ramos, Xabier Abad, Mónica López Fanarraga, Ratan Bhat, Juan Carlos Zabala, Jesús Avil. Expression of an altered form of tau in Sf9 insect cells results in the assembly of polymers resembling Alzheimer's paired helical filaments. Brain research. vol 1007. issue 1-2. 2004-07-19. PMID:15064135. |
tau is the main component of the paired helical filaments (phfs), aberrant structures that develop in the brain of alzheimer's disease (ad) patients and other tauopathies like frontotemporal dementia and parkinsonism associated to chromosome 17 (ftdp-17). |
2004-07-19 |
2023-08-12 |
Not clear |
Liang Li, Amitabha Sengupta, Niloufar Haque, Inge Grundke-Iqbal, Khalid Iqba. Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration. FEBS letters. vol 566. issue 1-3. 2004-07-16. PMID:15147906. |
memantine inhibits and reverses the alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration. |
2004-07-16 |
2023-08-12 |
rat |
Piotr Lewczuk, Hermann Esselmann, Markus Otto, Juan Manuel Maler, Andreas Wolfram Henkel, Maria Kerstin Henkel, Oliver Eikenberg, Christof Antz, Wolf-Rainer Krause, Udo Reulbach, Johannes Kornhuber, Jens Wiltfan. Neurochemical diagnosis of Alzheimer's dementia by CSF Abeta42, Abeta42/Abeta40 ratio and total tau. Neurobiology of aging. vol 25. issue 3. 2004-07-15. PMID:15123331. |
neurochemical diagnosis of alzheimer's dementia by csf abeta42, abeta42/abeta40 ratio and total tau. |
2004-07-15 |
2023-08-12 |
human |
Piotr Lewczuk, Hermann Esselmann, Markus Otto, Juan Manuel Maler, Andreas Wolfram Henkel, Maria Kerstin Henkel, Oliver Eikenberg, Christof Antz, Wolf-Rainer Krause, Udo Reulbach, Johannes Kornhuber, Jens Wiltfan. Neurochemical diagnosis of Alzheimer's dementia by CSF Abeta42, Abeta42/Abeta40 ratio and total tau. Neurobiology of aging. vol 25. issue 3. 2004-07-15. PMID:15123331. |
cerebrospinal fluid (csf) concentrations of amyloid beta peptides ending at positions 42 and 40 (abeta42 and abeta40, respectively), and total tau (ttau) protein were measured by elisa in order to compare their accuracy in discriminating patients with alzheimer's disease (ad, n = 22), non-alzheimer dementia (nad, n = 11) and control subjects (con, n=35). |
2004-07-15 |
2023-08-12 |
human |
Muralidhar L Hegde, Suram Anitha, Kallur S Latha, Mohammed S Mustak, Reuven Stein, Rivka Ravid, K S Jagannatha Ra. First evidence for helical transitions in supercoiled DNA by amyloid Beta Peptide (1-42) and aluminum: a new insight in understanding Alzheimer's disease. Journal of molecular neuroscience : MN. vol 22. issue 1-2. 2004-07-12. PMID:14742907. |
previously, we evidenced a b --> z helical change in alzheimer's brain genomic dna, leading to a hypothesis that alzheimer's disease (ad) etiological factors such as aluminum (al), amyloid beta (abeta) peptide, and tau might play a role in modulating dna topology. |
2004-07-12 |
2023-08-12 |
Not clear |