| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Julian R Thorpe, Sabrina Mosaheb, Lida Hashemzadeh-Bonehi, Nigel J Cairns, John E Kay, Simon J Morley, Stuart L Rulte. Shortfalls in the peptidyl-prolyl cis-trans isomerase protein Pin1 in neurons are associated with frontotemporal dementias. Neurobiology of disease. vol 17. issue 2. 2004-12-21. PMID:15474361. |
we, and others, have shown that tau hyperphosphorylation in the neurofibrillary tangles (nfts) of alzheimer disease (ad) is associated with redirection of the predominantly nuclear pin1 to the cytoplasm and with pin1 shortfalls throughout subcellular compartments. |
2004-12-21 |
2023-08-12 |
Not clear |
| Andrea Caricasole, Agata Copani, Filippo Caraci, Eleonora Aronica, Annemieke J Rozemuller, Alessandra Caruso, Marianna Storto, Giovanni Gaviraghi, Georg C Terstappen, Ferdinando Nicolett. Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 26. 2004-12-16. PMID:15229249. |
we used primary cultures of cortical neurons to examine the relationship between beta-amyloid toxicity and hyperphosphorylation of the tau protein, the biochemical substrate for neurofibrillary tangles of alzheimer's brain. |
2004-12-16 |
2023-08-12 |
Not clear |
| Gerard Drewe. MARKing tau for tangles and toxicity. Trends in biochemical sciences. vol 29. issue 10. 2004-12-02. PMID:15450610. |
in the brains of individuals with alzheimer's disease, tau is hyperphosphorylated and aggregated into intraneuronal deposits called neurofibrillary tangles (nfts). |
2004-12-02 |
2023-08-12 |
Not clear |
| Takashi Konno, Shigetoshi Oiki, Kazuhiro Hasegawa, Hironobu Naik. Anionic contribution for fibrous maturation of protofibrillar assemblies of the human tau repeat domain in a fluoroalcohol solution. Biochemistry. vol 43. issue 42. 2004-12-02. PMID:15491168. |
tau protein forms fibrous aggregates in the brain of patients with alzheimer's disease. |
2004-12-02 |
2023-08-12 |
human |
| Eva-Maria Mandelkow, Edda Thies, Bernhard Trinczek, Jacek Biernat, Eckard Mandelko. MARK/PAR1 kinase is a regulator of microtubule-dependent transport in axons. The Journal of cell biology. vol 167. issue 1. 2004-11-22. PMID:15466480. |
we report here a mechanism whereby microtubule associated proteins (maps) represent obstacles to motors which can be regulated by microtubule affinity regulating kinase (mark)/par-1, a family of kinases that is known for its involvement in establishing cell polarity and in phosphorylating tau protein during alzheimer neurodegeneration. |
2004-11-22 |
2023-08-12 |
Not clear |
| A Boutajangout, A Boom, K Leroy, J P Brio. Expression of tau mRNA and soluble tau isoforms in affected and non-affected brain areas in Alzheimer's disease. FEBS letters. vol 576. issue 1-2. 2004-11-19. PMID:15474035. |
expression of tau mrna and soluble tau isoforms in affected and non-affected brain areas in alzheimer's disease. |
2004-11-19 |
2023-08-12 |
human |
| A Boutajangout, A Boom, K Leroy, J P Brio. Expression of tau mRNA and soluble tau isoforms in affected and non-affected brain areas in Alzheimer's disease. FEBS letters. vol 576. issue 1-2. 2004-11-19. PMID:15474035. |
in alzheimer's disease (ad), selective expression of tau isoforms might underlie the susceptibility of different brain areas to develop neurofibrillary tangles and this pattern might change in the disease. |
2004-11-19 |
2023-08-12 |
human |
| Pierre R Burkhard, Roxane Fournier, Bernadette Mermillod, Karl-Heinz Krause, Constantin Bouras, Irmgard Irminge. Cerebrospinal fluid tau and Abeta42 concentrations in healthy subjects: delineation of reference intervals and their limitations. Clinical chemistry and laboratory medicine. vol 42. issue 4. 2004-11-16. PMID:15147150. |
many limitations and conflicting results have cast serious doubts on the validity of cerebrospinal fluid tau and abeta42 levels for the biological diagnosis of alzheimer's disease, particularly extreme variations of the reference limits found by unrelated groups as a consequence of different reference populations used. |
2004-11-16 |
2023-08-12 |
human |
| Eva Carro, Ignacio Torres-Alema. The role of insulin and insulin-like growth factor I in the molecular and cellular mechanisms underlying the pathology of Alzheimer's disease. European journal of pharmacology. vol 490. issue 1-3. 2004-11-03. PMID:15094079. |
furthermore, insulin and igf-i are potent neuroprotective factors and can regulate levels of phosphorylated tau, a major component of neurofibrillary tangles found in alzheimer's brains. |
2004-11-03 |
2023-08-12 |
Not clear |
| Michael Hutton, Eileen McGowa. Clearing tau pathology with Abeta immunotherapy--reversible and irreversible stages revealed. Neuron. vol 43. issue 3. 2004-11-02. PMID:15294135. |
the report by oddo and colleagues in this issue of neuron demonstrates for the first time that clearance of amyloid also results in the removal of early-stage tau pathology in mice that develop both amyloid plaques and neurofibrillary tangles (nft), the two hallmark lesions of alzheimer's disease (ad). |
2004-11-02 |
2023-08-12 |
mouse |
| Naruhiko Sahara, Irving E Vega, Takashi Ishizawa, Jada Lewis, Eileen McGowan, Michael Hutton, Dennis Dickson, Shu-Hui Ye. Phosphorylated p38MAPK specific antibodies cross-react with sarkosyl-insoluble hyperphosphorylated tau proteins. Journal of neurochemistry. vol 90. issue 4. 2004-10-28. PMID:15287888. |
neurofibrillary tangles (nft) accumulated in alzheimer's diseases and related disorders contain hyperphosphorylated tau and display immunoreactivity for active forms of various kinases. |
2004-10-28 |
2023-08-12 |
mouse |
| Atsushi Watanabe, Won-Kyoung Hong, Naoshi Dohmae, Koji Takio, Maho Morishima-Kawashima, Yasuo Ihar. Molecular aging of tau: disulfide-independent aggregation and non-enzymatic degradation in vitro and in vivo. Journal of neurochemistry. vol 90. issue 6. 2004-10-27. PMID:15341514. |
smearing from high-molecular-mass regions to low-molecular-mass regions on western blot is the most striking observation of the tau making up paired helical filaments in brain tissues affected by alzheimer's disease. |
2004-10-27 |
2023-08-12 |
Not clear |
| Atsushi Watanabe, Won-Kyoung Hong, Naoshi Dohmae, Koji Takio, Maho Morishima-Kawashima, Yasuo Ihar. Molecular aging of tau: disulfide-independent aggregation and non-enzymatic degradation in vitro and in vivo. Journal of neurochemistry. vol 90. issue 6. 2004-10-27. PMID:15341514. |
similar degradation products starting from the bulky residues next to asparaginyl residues were found in the smeared tau in vivo partially purified from the homogenates from alzheimer's disease brains. |
2004-10-27 |
2023-08-12 |
Not clear |
| Michael A Rogawsk. What is the rationale for new treatment strategies in Alzheimer's disease? CNS spectrums. vol 9. issue 7 Suppl 5. 2004-10-18. PMID:15241294. |
alzheimer's disease (ad) is characterized by the abnormal extracellular accumulation of amyloid beta-peptide (abeta) into neuritic plaques and the intraneuronal aggregation of the microtubule-associated protein tau to form neurofibrillary tangles. |
2004-10-18 |
2023-08-12 |
Not clear |
| Kumar Sambamurti, Ann-Charlotte Granholm, Mark S Kindy, Narayan R Bhat, Nigel H Greig, Debomoy K Lahiri, Jacobo E Mintze. Cholesterol and Alzheimer's disease: clinical and experimental models suggest interactions of different genetic, dietary and environmental risk factors. Current drug targets. vol 5. issue 6. 2004-10-14. PMID:15270198. |
alzheimer's disease (ad) is a progressive senile dementia characterized by deposition of a 4 kda peptide of 39-42 residues known as amyloid beta-peptide (abeta) in the form of senile plaques and the microtubule associated protein tau as paired helical filaments. |
2004-10-14 |
2023-08-12 |
Not clear |
| Joshua M Shulman, Mel B Fean. Genetic modifiers of tauopathy in Drosophila. Genetics. vol 165. issue 3. 2004-10-05. PMID:14668378. |
in alzheimer's disease and related disorders, the microtubule-associated protein tau is abnormally hyperphosphorylated and aggregated into neurofibrillary tangles. |
2004-10-05 |
2023-08-12 |
drosophila_melanogaster |
| Andreas Fellgiebel, Thomas Siessmeier, Armin Scheurich, Georg Winterer, Peter Bartenstein, Lutz G Schmidt, Matthias J Mülle. Association of elevated phospho-tau levels with Alzheimer-typical 18F-fluoro-2-deoxy-D-glucose positron emission tomography findings in patients with mild cognitive impairment. Biological psychiatry. vol 56. issue 4. 2004-09-30. PMID:15312816. |
phosphorylated tau protein in cerebrospinal fluid and even more decrements of cerebral glucose metabolism in parietal, temporal, or cingulate regions have shown favorable specificity for the diagnosis of alzheimer dementia and could be useful supplementary tools to determine alzheimer pathology in early stages. |
2004-09-30 |
2023-08-12 |
Not clear |
| Chihiro Yoshizaki, Mariko Tsukane, Takashi Yamauch. Overexpression of tau leads to the stimulation of neurite outgrowth, the activation of caspase 3 activity, and accumulation and phosphorylation of tau in neuroblastoma cells on cAMP treatment. Neuroscience research. vol 49. issue 4. 2004-09-27. PMID:15236861. |
to explore changes to the tau molecule in alzheimer's disease, we studied the effect of tau expression in stably transfected neuroblastoma x glioma hybrid ng108-15 cells (tau cells). |
2004-09-27 |
2023-08-12 |
Not clear |
| Chihiro Yoshizaki, Mariko Tsukane, Takashi Yamauch. Overexpression of tau leads to the stimulation of neurite outgrowth, the activation of caspase 3 activity, and accumulation and phosphorylation of tau in neuroblastoma cells on cAMP treatment. Neuroscience research. vol 49. issue 4. 2004-09-27. PMID:15236861. |
these observations have implications for the cellular causes of alzheimer's disease where the accumulation and mislocation of tau occur concomitant with neuronal degeneration. |
2004-09-27 |
2023-08-12 |
Not clear |
| Magnus Sjögren, Elisabet Englun. Negative neurofilament light and tau immunostaining in frontotemporal dementia. Dementia and geriatric cognitive disorders. vol 17. issue 4. 2004-09-24. PMID:15178951. |
we investigated the immunohistochemical stainability of phosphorylated tau and the light (nfl), intermediate (nfm), and heavy (nfh) neurofilament proteins in postmortem brain tissue from 8 patients with frontotemporal dementia (ftd), for comparison with 6 patients with alzheimer's disease (ad), and 6 normal controls. |
2004-09-24 |
2023-08-12 |
Not clear |