Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Jianzhi Wang, Xiaochuan Wang, Rong Liu, Qun Wang, Inge Grundke-Iqbal, Khalid Iqba. In vitro analysis of tau phosphorylation sites and its biological activity. Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih. vol 17. issue 1. 2004-02-24. PMID:12894878. |
to explore the association between the abnormal phosphorylation sites found in alzheimer disease (ad) tau and the inhibition of its biological activity. |
2004-02-24 |
2023-08-12 |
Not clear |
Jerzy Leszek, Krzysztof Małyszczak, Barbara Janicka, Andrzej Kiejna, Andrzej Wia. Total tau in cerebrospinal fluid differentiates Alzheimer's disease from vascular dementia. Medical science monitor : international medical journal of experimental and clinical research. vol 9. issue 11. 2004-02-20. PMID:14586274. |
total tau in cerebrospinal fluid differentiates alzheimer's disease from vascular dementia. |
2004-02-20 |
2023-08-12 |
Not clear |
Cheng-Xin Gong, Fei Liu, Guoxin Wu, Sandra Rossie, Jerzy Wegiel, Liang Li, Inge Grundke-Iqbal, Khalid Iqba. Dephosphorylation of microtubule-associated protein tau by protein phosphatase 5. Journal of neurochemistry. vol 88. issue 2. 2004-02-17. PMID:14690518. |
we found that this phosphatase dephosphorylated recombinant tau phosphorylated with camp-dependent protein kinase and glycogen synthase kinase-3beta, as well as abnormally hyperphosphorylated tau isolated from brains of patients with alzheimer's disease. |
2004-02-17 |
2023-08-12 |
human |
Cheng-Xin Gong, Fei Liu, Guoxin Wu, Sandra Rossie, Jerzy Wegiel, Liang Li, Inge Grundke-Iqbal, Khalid Iqba. Dephosphorylation of microtubule-associated protein tau by protein phosphatase 5. Journal of neurochemistry. vol 88. issue 2. 2004-02-17. PMID:14690518. |
these results suggest that pp5 plays a role in the dephosphorylation of tau and might be involved in the molecular pathogenesis of alzheimer's disease. |
2004-02-17 |
2023-08-12 |
human |
Harald Hampel, Katharina Buerger, Raymond Zinkowski, Stefan J Teipel, Alexander Goernitz, Niels Andreasen, Magnus Sjoegren, John DeBernardis, Daniel Kerkman, Koichi Ishiguro, Hideto Ohno, Eugeen Vanmechelen, Hugo Vanderstichele, Cheryl McCulloch, Hans-Jurgen Moller, Peter Davies, Kaj Blenno. Measurement of phosphorylated tau epitopes in the differential diagnosis of Alzheimer disease: a comparative cerebrospinal fluid study. Archives of general psychiatry. vol 61. issue 1. 2004-02-17. PMID:14706948. |
measurement of phosphorylated tau epitopes in the differential diagnosis of alzheimer disease: a comparative cerebrospinal fluid study. |
2004-02-17 |
2023-08-12 |
Not clear |
Harald Hampel, Katharina Buerger, Raymond Zinkowski, Stefan J Teipel, Alexander Goernitz, Niels Andreasen, Magnus Sjoegren, John DeBernardis, Daniel Kerkman, Koichi Ishiguro, Hideto Ohno, Eugeen Vanmechelen, Hugo Vanderstichele, Cheryl McCulloch, Hans-Jurgen Moller, Peter Davies, Kaj Blenno. Measurement of phosphorylated tau epitopes in the differential diagnosis of Alzheimer disease: a comparative cerebrospinal fluid study. Archives of general psychiatry. vol 61. issue 1. 2004-02-17. PMID:14706948. |
abnormal hyperphosphorylation of the microtubule-associated protein tau and its incorporation into neurofibrillary tangles are major hallmarks of the pathogenesis of alzheimer disease (ad). |
2004-02-17 |
2023-08-12 |
Not clear |
Sébastien B Lavoie, Alexandra L Albert, Michel Vincen. [Unexpected roles of the peptidyl-prolyl cis/trans isomerase Pin1]. Medecine sciences : M/S. vol 19. issue 12. 2004-02-10. PMID:14691750. |
pin1 also targets tau, a protein forming part of hte neuronal cytoskeleton which is hyper-phosphorylated in patients suffering from alzheimer's disease (ad). |
2004-02-10 |
2023-08-12 |
human |
Yoshiyuki Yoshimura, Tatsuya Ichinose, Takashi Yamauch. Phosphorylation of tau protein to sites found in Alzheimer's disease brain is catalyzed by Ca2+/calmodulin-dependent protein kinase II as demonstrated tandem mass spectrometry. Neuroscience letters. vol 353. issue 3. 2004-02-09. PMID:14665412. |
phosphorylation of tau protein to sites found in alzheimer's disease brain is catalyzed by ca2+/calmodulin-dependent protein kinase ii as demonstrated tandem mass spectrometry. |
2004-02-09 |
2023-08-12 |
human |
Yoshiyuki Yoshimura, Tatsuya Ichinose, Takashi Yamauch. Phosphorylation of tau protein to sites found in Alzheimer's disease brain is catalyzed by Ca2+/calmodulin-dependent protein kinase II as demonstrated tandem mass spectrometry. Neuroscience letters. vol 353. issue 3. 2004-02-09. PMID:14665412. |
these results suggested that camkii is involved in the phosphorylation of tau in alzheimer's disease brain. |
2004-02-09 |
2023-08-12 |
human |
Richard M Kostrzewa, Juan Segura-Aguila. Novel mechanisms and approaches in the study of neurodegeneration and neuroprotection. a review. Neurotoxicity research. vol 5. issue 6. 2004-02-02. PMID:14715440. |
although alzheimer's disease (ad) has features of a continuous spectrum of neural and functional decline, in vivo pet imaging and and functional magnetic resonance imaging, indicate that ad can be staged into an early phase treatable by inhibitors of beta and gamma secretase; and a late phase which may be more amenable to treatment by drugs that prevent or reverse tau phosphorylation. |
2004-02-02 |
2023-08-12 |
human |
Niels Andreasen, Magnus Sjögren, Kaj Blenno. CSF markers for Alzheimer's disease: total tau, phospho-tau and Abeta42. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 4. issue 4. 2004-01-28. PMID:14608585. |
csf markers for alzheimer's disease: total tau, phospho-tau and abeta42. |
2004-01-28 |
2023-08-12 |
Not clear |
Shi Jie Liu, Ai Hong Zhang, Hong Lian Li, Qun Wang, Heng Mei Deng, William J Netzer, Huaxi Xu, Jian Zhi Wan. Overactivation of glycogen synthase kinase-3 by inhibition of phosphoinositol-3 kinase and protein kinase C leads to hyperphosphorylation of tau and impairment of spatial memory. Journal of neurochemistry. vol 87. issue 6. 2004-01-26. PMID:14713290. |
neurofibrillary tangles (nfts) consisting of the hyperphosphorylated microtubule-associated protein tau are a defining pathological characteristic of alzheimer's disease (ad). |
2004-01-26 |
2023-08-12 |
rat |
Benoit I Giasson, Virginia M-Y Lee, John Q Trojanowsk. Interactions of amyloidogenic proteins. Neuromolecular medicine. vol 4. issue 1-2. 2004-01-21. PMID:14528052. |
however, intracytoplasmic amyloid aggregates, such as neurofibrillary tangles in alzheimer's disease and lewy bodies in parkinson's disease, are composed of the proteins tau and alpha-synuclein, respectively. |
2004-01-21 |
2023-08-12 |
Not clear |
Fatma J Ekinci, Daniela Ortiz, Thomas B She. Okadaic acid mediates tau phosphorylation via sustained activation of the L-voltage-sensitive calcium channel. Brain research. Molecular brain research. vol 117. issue 2. 2004-01-20. PMID:14559148. |
accumulation of phosphorylated isoforms of the microtubule-associated protein tau is one hallmark of affected neurons in alzheimer's disease (ad). |
2004-01-20 |
2023-08-12 |
human |
Mark Wagner, Gordon Teichner, David L Bachma. Diagnostic challenges of using CSF assay of tau and beta-amyloid(42) in atypical degenerative dementias of the Alzheimer type. Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists. vol 18. issue 8. 2004-01-20. PMID:14609583. |
diagnostic challenges of using csf assay of tau and beta-amyloid(42) in atypical degenerative dementias of the alzheimer type. |
2004-01-20 |
2023-08-12 |
Not clear |
Ulrich Gärtner, Martina K Brückner, Sabine Krug, Stefanie Schmetsdorf, Matthias Staufenbiel, Thomas Arend. Amyloid deposition in APP23 mice is associated with the expression of cyclins in astrocytes but not in neurons. Acta neuropathologica. vol 106. issue 6. 2004-01-16. PMID:12923647. |
alzheimer's disease (ad) is a neurodegenerative disorder characterized by the intracellular accumulation of highly phosphorylated tau protein, the extracellular formation of amyloid plaques and a significant loss of neurons. |
2004-01-16 |
2023-08-12 |
mouse |
M Schumacher, S Weill-Engerer, P Liere, F Robert, R J M Franklin, L M Garcia-Segura, J J Lambert, W Mayo, R C Melcangi, A Parducz, U Suter, C Carelli, E E Baulieu, Y Akw. Steroid hormones and neurosteroids in normal and pathological aging of the nervous system. Progress in neurobiology. vol 71. issue 1. 2004-01-16. PMID:14611864. |
in alzheimer's patients, there was a general trend toward lower levels of neurosteroids in different brain regions, and neurosteroid levels were negatively correlated with two biochemical markers of alzheimer's disease, the phosphorylated tau protein and the beta-amyloid peptides. |
2004-01-16 |
2023-08-12 |
human |
Ester Angulo, Vicent Casadó, Josefa Mallol, Enric I Canela, Francesc Viñals, Isidre Ferrer, Carmen Lluis, Rafael Franc. A1 adenosine receptors accumulate in neurodegenerative structures in Alzheimer disease and mediate both amyloid precursor protein processing and tau phosphorylation and translocation. Brain pathology (Zurich, Switzerland). vol 13. issue 4. 2004-01-12. PMID:14655750. |
a1 adenosine receptors accumulate in neurodegenerative structures in alzheimer disease and mediate both amyloid precursor protein processing and tau phosphorylation and translocation. |
2004-01-12 |
2023-08-12 |
human |
Xiang-You Hu, Song Qin, Ya-Ping Lu, Rivka Ravid, Dick F Swaab, Jiang-Ning Zho. Decreased estrogen receptor-alpha expression in hippocampal neurons in relation to hyperphosphorylated tau in Alzheimer patients. Acta neuropathologica. vol 106. issue 3. 2004-01-09. PMID:12819990. |
decreased estrogen receptor-alpha expression in hippocampal neurons in relation to hyperphosphorylated tau in alzheimer patients. |
2004-01-09 |
2023-08-12 |
Not clear |
Christopher M Clark, Sharon Xie, Jesse Chittams, Douglas Ewbank, Elaine Peskind, Douglas Galasko, John C Morris, Daniel W McKeel, Martin Farlow, Sharon L Weitlauf, Joseph Quinn, Jeffrey Kaye, David Knopman, Hiroyuki Arai, Rachelle S Doody, Charles DeCarli, Susan Leight, Virginia M-Y Lee, John Q Trojanowsk. Cerebrospinal fluid tau and beta-amyloid: how well do these biomarkers reflect autopsy-confirmed dementia diagnoses? Archives of neurology. vol 60. issue 12. 2004-01-07. PMID:14676043. |
tau and beta-amyloid (abeta) are proposed diagnostic biomarkers for alzheimer disease (ad). |
2004-01-07 |
2023-08-12 |
human |