All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Yuh-Jiin I Jong, Stephanie R Ford, Kuljeet Seehra, Victor Brian Malave, Nancy Lewis Baenzige. Alzheimer's disease skin fibroblasts selectively express a bradykinin signaling pathway mediating tau protein Ser phosphorylation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 17. issue 15. 2004-01-06. PMID:14563691. increased ser phosphorylation of tau microtubule-associated protein in the brain is an early feature of alzheimer's disease (ad) that precedes progression of the disease to frank neuronal disruption. 2004-01-06 2023-08-12 Not clear
Pankajavalli Ramakrishnan, Dennis W Dickson, Peter Davie. Pin1 colocalization with phosphorylated tau in Alzheimer's disease and other tauopathies. Neurobiology of disease. vol 14. issue 2. 2004-01-06. PMID:14572447. pin1 colocalization with phosphorylated tau in alzheimer's disease and other tauopathies. 2004-01-06 2023-08-12 Not clear
L Parnetti, A Lanari, E Saggese, C Spaccatini, V Galla. Cerebrospinal fluid biochemical markers in early detection and in differential diagnosis of dementia disorders in routine clinical practice. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 24. issue 3. 2004-01-06. PMID:14598086. measurement of total tau and amyloid beta1-42 (ab42) in cerebrospinal fluid (csf) improves diagnostic accuracy of alzheimer's disease (ad). 2004-01-06 2023-08-12 Not clear
Jeffrey L Cumming. Toward a molecular neuropsychiatry of neurodegenerative diseases. Annals of neurology. vol 54. issue 2. 2004-01-05. PMID:12891666. alzheimer's disease is a triple proteinopathy with abnormalities of a-beta, tau, and alpha-synculein leading to a complex behavioral phenotype. 2004-01-05 2023-08-12 Not clear
Thor D Stein, Jeffrey A Johnso. Genetic programming by the proteolytic fragments of the amyloid precursor protein: somewhere between confusion and clarity. Reviews in the neurosciences. vol 14. issue 4. 2003-12-29. PMID:14640319. mice engineered to overexpress disease-causing mutant amyloid precursor proteins (app) display plaque deposition, but lack the hyperphosphorylated tau and massive neuronal loss characteristic of alzheimer's disease (ad). 2003-12-29 2023-08-12 mouse
Abraham Fisher, Zipora Pittel, Rachel Haring, Nira Bar-Ner, Michal Kliger-Spatz, Niva Natan, Inbal Egozi, Hagar Sonego, Itzhak Marcovitch, Rachel Brandei. M1 muscarinic agonists can modulate some of the hallmarks in Alzheimer's disease: implications in future therapy. Journal of molecular neuroscience : MN. vol 20. issue 3. 2003-12-23. PMID:14501019. m1 muscarinic receptors (m1 machrs) play a role in an apparent linkage of three major hallmarks of alzheimer's disease (ad): beta-amyloid (abeta) peptide; tau hyperphosphorylation and paired helical filaments (phfs); and loss of cholinergic function conducive to cognitive impairments. 2003-12-23 2023-08-12 mouse
Fortunato Battaglia, Fabrizio Trinchese, Shumin Liu, Sean Walter, Ralph A Nixon, Ottavio Aranci. Calpain inhibitors, a treatment for Alzheimer's disease: position paper. Journal of molecular neuroscience : MN. vol 20. issue 3. 2003-12-23. PMID:14501020. calpains modulate processes that govern the function and metabolism of proteins key to the pathogenesis of alzheimer's disease, including tau and amyloid precursor protein. 2003-12-23 2023-08-12 mouse
A Cedazo-Mínguez, B O Popescu, J M Blanco-Millán, S Akterin, J-J Pei, B Winblad, R F Cowbur. Apolipoprotein E and beta-amyloid (1-42) regulation of glycogen synthase kinase-3beta. Journal of neurochemistry. vol 87. issue 5. 2003-12-18. PMID:14622095. glycogen synthase kinase-3beta (gsk-3beta) is implicated in regulating apoptosis and tau protein hyperphosphorylation in alzheimer's disease (ad). 2003-12-18 2023-08-12 human
Alexei R Koudinov, Natalia V Koudinov. Cholesterol, synaptic function and Alzheimer's disease. Pharmacopsychiatry. vol 36 Suppl 2. 2003-12-10. PMID:14574623. moreover, changes in the neurochemistry of amyloid beta, tau, neuronal cytoskeleton, and oxidative stress reactions due to alzheimer's likely represent physiological transitory mechanisms that aim to compensate impaired brain cholesterol dynamics and/or associated neurotransmission and synaptic plasticity failure. 2003-12-10 2023-08-12 rat
T G Ohm, S Treiber-Held, R Distl, F Glöckner, B Schönheit, M Tamanai, V Mesk. Cholesterol and tau protein--findings in Alzheimer's and Niemann Pick C's disease. Pharmacopsychiatry. vol 36 Suppl 2. 2003-12-10. PMID:14574625. cholesterol and tau protein--findings in alzheimer's and niemann pick c's disease. 2003-12-10 2023-08-12 mouse
J Wang, Z Wei, Q Wang, I Grundke-Iqbal, K Iqba. [Association of microtubule promoting and binding activity of tau with its phosphorylation sites]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 22. issue 2. 2003-12-04. PMID:12903511. to explore the association between the abnormal phosphorylation sites found in alzheimer disease (ad) tau and the inhibition of its biological activity. 2003-12-04 2023-08-12 Not clear
Thomas Timm, Xiao-Yu Li, Jacek Biernat, Jian Jiao, Eckhard Mandelkow, Joel Vandekerckhove, Eva-Maria Mandelko. MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1. The EMBO journal. vol 22. issue 19. 2003-11-24. PMID:14517247. the sites are prominent in tau from alzheimer's disease brains. 2003-11-24 2023-08-12 Not clear
Esther M Ingram, Maria G Spillantin. Tau gene mutations: dissecting the pathogenesis of FTDP-17. Trends in molecular medicine. vol 8. issue 12. 2003-11-17. PMID:12470988. abnormal filamentous tau deposits constitute a major defining characteristic of several neurodegenerative diseases, including alzheimer's disease. 2003-11-17 2023-08-12 Not clear
Esther M Ingram, Maria G Spillantin. Tau gene mutations: dissecting the pathogenesis of FTDP-17. Trends in molecular medicine. vol 8. issue 12. 2003-11-17. PMID:12470988. although the presence of tau pathology correlates with the symptoms of alzheimer's disease, there was no genetic evidence linking tau to neurodegeneration until recently. 2003-11-17 2023-08-12 Not clear
Zhiming Suo, Min Wu, Bruce A Citron, Robert E Palazzo, Barry W Festof. Rapid tau aggregation and delayed hippocampal neuronal death induced by persistent thrombin signaling. The Journal of biological chemistry. vol 278. issue 39. 2003-11-17. PMID:12821672. tau hyperphosphorylation, leading to self-aggregation, is widely held to underlie the neurofibrillary degeneration found in alzheimer's disease (ad) and other tauopathies. 2003-11-17 2023-08-12 Not clear
Katsutoshi Furukawa, Yue Wang, Pamela J Yao, Weiming Fu, Mark P Mattson, Yasuto Itoyama, Hiroshi Onodera, Ian D'Souza, Parvone H Poorkaj, Thomas D Bird, Gerard D Schellenber. Alteration in calcium channel properties is responsible for the neurotoxic action of a familial frontotemporal dementia tau mutation. Journal of neurochemistry. vol 87. issue 2. 2003-11-06. PMID:14511120. tau, a microtubule binding protein, is not only a major component of neurofibrillary tangles in alzheimer's disease, but also a causative gene for hereditary frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17). 2003-11-06 2023-08-12 Not clear
Onofre Combarros, Lucía Rodero, Jon Infante, Enrique Palacio, Javier Llorca, Carlos Fernández-Viadero, Nicolás Peña, José Bercian. Age-dependent association between the Q7R polymorphism in the Saitohin gene and sporadic Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 16. issue 3. 2003-11-05. PMID:12826738. a vigorous controversy exists over whether tau tangles or amyloid-beta plaques are the primary cause of neurodegeneration in alzheimer's disease (ad), and it is not well established whether genetic variation in tau is associated with ad. 2003-11-05 2023-08-12 human
Hoau-Yan Wang, Weiwei Li, Nancy J Benedetti, Daniel H S Le. Alpha 7 nicotinic acetylcholine receptors mediate beta-amyloid peptide-induced tau protein phosphorylation. The Journal of biological chemistry. vol 278. issue 34. 2003-10-29. PMID:12801934. the alzheimer's disease pathogenic peptide, beta-amyloid42 (a beta 42), induces tau protein phosphorylation. 2003-10-29 2023-08-12 human
Hoau-Yan Wang, Weiwei Li, Nancy J Benedetti, Daniel H S Le. Alpha 7 nicotinic acetylcholine receptors mediate beta-amyloid peptide-induced tau protein phosphorylation. The Journal of biological chemistry. vol 278. issue 34. 2003-10-29. PMID:12801934. because hyperphosphorylated tau is a consistent component of neurofibrillary tangles, a pathological hallmark of alzheimer's disease, we investigated the signaling molecules involved in a beta 42-induced tau phosphorylation. 2003-10-29 2023-08-12 human
Brian C Kraemer, Bin Zhang, James B Leverenz, James H Thomas, John Q Trojanowski, Gerard D Schellenber. Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 17. 2003-10-29. PMID:12872001. aggregated tau is seen in numerous other neurodegenerative diseases, including alzheimer's disease (ad). 2003-10-29 2023-08-12 human