| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G V Johnson, S M Jenkin. Tau protein in normal and Alzheimer's disease brain. Journal of Alzheimer's disease : JAD. vol 1. issue 4-5. 2004-05-04. PMID:12214128. |
finally, speculation as to the relationship between abnormal processing of tau, other subcellular abnormalities seen in alzheimer's disease, and the pathological causes of the disease are discussed. |
2004-05-04 |
2023-08-12 |
Not clear |
| G V Johnson, J A Hartiga. Tau protein in normal and Alzheimer's disease brain: an update. Journal of Alzheimer's disease : JAD. vol 1. issue 4-5. 2004-05-04. PMID:12214129. |
tau protein in normal and alzheimer's disease brain: an update. |
2004-05-04 |
2023-08-12 |
Not clear |
| G V Johnson, J A Hartiga. Tau protein in normal and Alzheimer's disease brain: an update. Journal of Alzheimer's disease : JAD. vol 1. issue 4-5. 2004-05-04. PMID:12214129. |
tau is a microtubule-associated protein that, in a hyperphosphorylated form, comprises the main component of the paired helical filaments and neurofibrillary tangles found in alzheimer's disease (ad) brain. |
2004-05-04 |
2023-08-12 |
Not clear |
| T Chris Gamblin, Robert W Berry, Lester I Binde. Modeling tau polymerization in vitro: a review and synthesis. Biochemistry. vol 42. issue 51. 2004-05-04. PMID:14690409. |
here we discuss the advantages and disadvantages of the various techniques used to model tau polymerization and the discoveries arising from these techniques that have led to a better structural understanding of tau polymerization in relation to alzheimer's disease and other tauopathies. |
2004-05-04 |
2023-08-12 |
Not clear |
| Shirley B Shelton, Pavan Krishnamurthy, Gail V W Johnso. Effects of cyclin-dependent kinase-5 activity on apoptosis and tau phosphorylation in immortalized mouse brain cortical cells. Journal of neuroscience research. vol 76. issue 1. 2004-05-04. PMID:15048935. |
previous studies suggest that cdk5 is proapoptotic and contributes to tau hyperphosphorylation and neurodegeneration in alzheimer's disease. |
2004-05-04 |
2023-08-12 |
mouse |
| Hiroyuki Nakano, Katsuji Kobayashi, Kaoru Sugimori, Masao Shimazaki, Kenji Miyazu, Masahiro Hayashi, Hisakazu Furut. Regional analysis of differently phosphorylated tau proteins in brains from patients with Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 17. issue 3. 2004-05-03. PMID:14739532. |
regional analysis of differently phosphorylated tau proteins in brains from patients with alzheimer's disease. |
2004-05-03 |
2023-08-12 |
Not clear |
| Hiroyuki Nakano, Katsuji Kobayashi, Kaoru Sugimori, Masao Shimazaki, Kenji Miyazu, Masahiro Hayashi, Hisakazu Furut. Regional analysis of differently phosphorylated tau proteins in brains from patients with Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 17. issue 3. 2004-05-03. PMID:14739532. |
neurofibrillary tangles (nft) in alzheimer's disease (ad) are composed of abnormally phosphorylated tau proteins. |
2004-05-03 |
2023-08-12 |
Not clear |
| Virginia M-Y Lee, Benoit I Giasson, John Q Trojanowsk. More than just two peas in a pod: common amyloidogenic properties of tau and alpha-synuclein in neurodegenerative diseases. Trends in neurosciences. vol 27. issue 3. 2004-05-03. PMID:15036877. |
intracytoplasmic filamentous aggregates, such as neurofibrillary tangles in alzheimer's disease and lewy bodies in parkinson's disease, are composed of the proteins tau and alpha-synuclein, respectively. |
2004-05-03 |
2023-08-12 |
Not clear |
| Allan S Wagman, Kirk W Johnson, Dirksen E Bussier. Discovery and development of GSK3 inhibitors for the treatment of type 2 diabetes. Current pharmaceutical design. vol 10. issue 10. 2004-04-30. PMID:15078145. |
gsk3's association with neuronal apoptosis and hyper-phosphorylation of tau make this kinase an attractive therapeutic target for neurodegenerative conditions such as head trauma, stroke and alzheimer's disease. |
2004-04-30 |
2023-08-12 |
Not clear |
| Chris Conrad, Cintia Vianna, Christian Schultz, Dietmar R Thal, Estifanos Ghebremedhin, Jack Lenz, Heiko Braak, Peter Davie. Molecular evolution and genetics of the Saitohin gene and tau haplotype in Alzheimer's disease and argyrophilic grain disease. Journal of neurochemistry. vol 89. issue 1. 2004-04-26. PMID:15030402. |
molecular evolution and genetics of the saitohin gene and tau haplotype in alzheimer's disease and argyrophilic grain disease. |
2004-04-26 |
2023-08-12 |
mouse |
| Markus Tolnay, Alphonse Probs. The neuropathological spectrum of neurodegenerative tauopathies. IUBMB life. vol 55. issue 6. 2004-04-22. PMID:12938731. |
abundant neurofibrillary lesions made of abnormal and hyperphosphorylated microtubule-associated protein tau constitute one of the defining neuropathological features of alzheimer's disease. |
2004-04-22 |
2023-08-12 |
Not clear |
| Peter Schönknecht, Johannes Pantel, Tobias Hartmann, Egon Werle, Martin Volkmann, Marco Essig, Michael Amann, Nadja Zanabili, Hubertus Bardenheuer, Aoife Hunt, Johannes Schröde. Cerebrospinal fluid tau levels in Alzheimer's disease are elevated when compared with vascular dementia but do not correlate with measures of cerebral atrophy. Psychiatry research. vol 120. issue 3. 2004-04-21. PMID:14561434. |
cerebrospinal fluid tau levels in alzheimer's disease are elevated when compared with vascular dementia but do not correlate with measures of cerebral atrophy. |
2004-04-21 |
2023-08-12 |
Not clear |
| Peter Schönknecht, Johannes Pantel, Tobias Hartmann, Egon Werle, Martin Volkmann, Marco Essig, Michael Amann, Nadja Zanabili, Hubertus Bardenheuer, Aoife Hunt, Johannes Schröde. Cerebrospinal fluid tau levels in Alzheimer's disease are elevated when compared with vascular dementia but do not correlate with measures of cerebral atrophy. Psychiatry research. vol 120. issue 3. 2004-04-21. PMID:14561434. |
increased tau levels are a well-established finding in alzheimer's disease (ad). |
2004-04-21 |
2023-08-12 |
Not clear |
| Victor M Miller, Cynthia M Gouvion, Beverly L Davidson, Henry L Paulso. Targeting Alzheimer's disease genes with RNA interference: an efficient strategy for silencing mutant alleles. Nucleic acids research. vol 32. issue 2. 2004-04-21. PMID:14754988. |
tau and amyloid precursor protein (app) are key proteins in the pathogenesis of sporadic and inherited alzheimer's disease. |
2004-04-21 |
2023-08-12 |
Not clear |
| Dorota Religa, Bengt Winbla. Therapeutic strategies for Alzheimer's disease based on new molecular mechanisms. Acta neurobiologiae experimentalis. vol 63. issue 4. 2004-04-19. PMID:15053264. |
alzheimer's disease (ad)--the main cause of dementia--is characterized by the presence of neuritic plaques containing the amyloid-beta peptide (a beta) and an intraneuronal accumulation of tubule-associated protein called tau. |
2004-04-19 |
2023-08-12 |
Not clear |
| Isao Nishimura, Yufeng Yang, Bingwei L. PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila. Cell. vol 116. issue 5. 2004-04-13. PMID:15006350. |
multisite hyperphosphorylation of tau has been implicated in the pathogenesis of neurodegenerative diseases including alzheimer's disease (ad). |
2004-04-13 |
2023-08-12 |
drosophila_melanogaster |
| R Rademakers, B Dermaut, K Peeters, M Cruts, P Heutink, A Goate, C Van Broeckhove. Tau (MAPT) mutation Arg406Trp presenting clinically with Alzheimer disease does not share a common founder in Western Europe. Human mutation. vol 22. issue 5. 2004-04-12. PMID:14517953. |
tau (mapt) mutation arg406trp presenting clinically with alzheimer disease does not share a common founder in western europe. |
2004-04-12 |
2023-08-12 |
Not clear |
| Allal Boutajangout, Michèle Authelet, Véronique Blanchard, N Touchet, Gunter Tremp, Laurent Pradier, Jean-Pierre Brio. Characterisation of cytoskeletal abnormalities in mice transgenic for wild-type human tau and familial Alzheimer's disease mutants of APP and presenilin-1. Neurobiology of disease. vol 15. issue 1. 2004-04-07. PMID:14751770. |
characterisation of cytoskeletal abnormalities in mice transgenic for wild-type human tau and familial alzheimer's disease mutants of app and presenilin-1. |
2004-04-07 |
2023-08-12 |
mouse |
| J-J Hauw, C Hausser-Hauw, C Duyckaert. [Neuropathology of tauopathies and synucleinopathies, and neuroanatomy of sleep disorders: meeting the challenge]. Revue neurologique. vol 159. issue 11 Suppl. 2004-04-02. PMID:14646802. |
in contrast to alzheimer's disease, where abnormal tau containing cells are mainly neurones, in the other disorders, both neurones and glial cells are affected. |
2004-04-02 |
2023-08-12 |
human |
| Hideki Shimura, Daniel Schwartz, Steven P Gygi, Kenneth S Kosi. CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival. The Journal of biological chemistry. vol 279. issue 6. 2004-04-01. PMID:14612456. |
the microtubule-binding protein tau has been implicated in the neurofibrillary pathology of alzheimer's disease. |
2004-04-01 |
2023-08-12 |
human |