All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Jin-Jing Pei, Heiko Braak, Wen-Lin An, Bengt Winblad, Richard F Cowburn, Khalid Iqbal, Inge Grundke-Iqba. Up-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer's disease. Brain research. Molecular brain research. vol 109. issue 1-2. 2003-07-01. PMID:12531514. the abnormal hyperphosphorylation of tau in alzheimer's disease (ad) has been proposed to involve the extracellular-signal-regulated protein kinase (erk) of the mitogen-activated protein (map) kinase family. 2003-07-01 2023-08-12 Not clear
Adam D Cash, Gjumrakch Aliev, Sandra L Siedlak, Akihiko Nunomura, Hisashi Fujioka, Xiongwei Zhu, Arun K Raina, Harry V Vinters, Massimo Tabaton, Anne B Johnson, Manuel Paula-Barbosa, Jesus Avíla, Paul K Jones, Rudy J Castellani, Mark A Smith, George Perr. Microtubule reduction in Alzheimer's disease and aging is independent of tau filament formation. The American journal of pathology. vol 162. issue 5. 2003-06-25. PMID:12707046. microtubule reduction in alzheimer's disease and aging is independent of tau filament formation. 2003-06-25 2023-08-12 Not clear
Adam D Cash, Gjumrakch Aliev, Sandra L Siedlak, Akihiko Nunomura, Hisashi Fujioka, Xiongwei Zhu, Arun K Raina, Harry V Vinters, Massimo Tabaton, Anne B Johnson, Manuel Paula-Barbosa, Jesus Avíla, Paul K Jones, Rudy J Castellani, Mark A Smith, George Perr. Microtubule reduction in Alzheimer's disease and aging is independent of tau filament formation. The American journal of pathology. vol 162. issue 5. 2003-06-25. PMID:12707046. biochemical studies show that phosphorylated tau, like that found in paired helical filaments (phfs), does not promote microtubule assembly leading to the view that phf formation leads to microtubule deficiency in alzheimer's disease (ad). 2003-06-25 2023-08-12 Not clear
Wendy Noble, Vicki Olm, Kazuyuki Takata, Evelyn Casey, O Mary, Jordana Meyerson, Kate Gaynor, John LaFrancois, Lili Wang, Takayuki Kondo, Peter Davies, Mark Burns, Veeranna, Ralph Nixon, Dennis Dickson, Yasuji Matsuoka, Michael Ahlijanian, Lit-Fui Lau, Karen Duf. Cdk5 is a key factor in tau aggregation and tangle formation in vivo. Neuron. vol 38. issue 4. 2003-06-25. PMID:12765608. tau aggregation is a common feature of neurodegenerative diseases such as alzheimer's disease, and hyperphosphorylation of tau has been implicated as a fundamental pathogenic mechanism in this process. 2003-06-25 2023-08-12 mouse
Christopher J Phiel, Christina A Wilson, Virginia M-Y Lee, Peter S Klei. GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides. Nature. vol 423. issue 6938. 2003-06-18. PMID:12761548. since gsk-3 also phosphorylates tau protein, the principal component of neurofibrillary tangles, inhibition of gsk-3alpha offers a new approach to reduce the formation of both amyloid plaques and neurofibrillary tangles, two pathological hallmarks of alzheimer's disease. 2003-06-18 2023-08-12 mouse
Alex Mitchell, Nick Brindl. CSF phosphorylated tau--does it constitute an accurate biological test for Alzheimer's disease? International journal of geriatric psychiatry. vol 18. issue 5. 2003-06-13. PMID:12766916. csf phosphorylated tau--does it constitute an accurate biological test for alzheimer's disease? 2003-06-13 2023-08-12 Not clear
Tetsuaki Arai, Kenji Ikeda, Haruhiko Akiyama, Kuniaki Tsuchiya, Shuji Iritani, Koichi Ishiguro, Saburo Yagishita, Tatsuro Oda, Toshinari Odawara, Eizo Isek. Different immunoreactivities of the microtubule-binding region of tau and its molecular basis in brains from patients with Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration. Acta neuropathologica. vol 105. issue 5. 2003-06-06. PMID:12677450. different immunoreactivities of the microtubule-binding region of tau and its molecular basis in brains from patients with alzheimer's disease, pick's disease, progressive supranuclear palsy and corticobasal degeneration. 2003-06-06 2023-08-12 Not clear
Tetsuaki Arai, Kenji Ikeda, Haruhiko Akiyama, Kuniaki Tsuchiya, Shuji Iritani, Koichi Ishiguro, Saburo Yagishita, Tatsuro Oda, Toshinari Odawara, Eizo Isek. Different immunoreactivities of the microtubule-binding region of tau and its molecular basis in brains from patients with Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration. Acta neuropathologica. vol 105. issue 5. 2003-06-06. PMID:12677450. the microtubule-associated protein tau accumulates as cytoplasmic inclusions in alzheimer's disease (ad), pick's disease (pid), progressive supranuclear palsy (psp) and corticobasal degeneration (cbd). 2003-06-06 2023-08-12 Not clear
Cheng-Xin Gong, Jian-Zhi Wang, Khalid Iqbal, Inge Grundke-Iqba. Inhibition of protein phosphatase 2A induces phosphorylation and accumulation of neurofilaments in metabolically active rat brain slices. Neuroscience letters. vol 340. issue 2. 2003-05-29. PMID:12668248. in alzheimer disease (ad) brain neurofilaments (nf) in addition to tau are hyperphosphorylated and accumulated and the activity of the phosphoprotein phosphatase 2a (pp2a) is compromised. 2003-05-29 2023-08-12 rat
T Chris Gamblin, Robert W Berry, Lester I Binde. Tau polymerization: role of the amino terminus. Biochemistry. vol 42. issue 7. 2003-05-07. PMID:12590615. the abnormal polymerization of the tau molecule into insoluble filaments is a seminal event in the neurodegenerative process underlying alzheimer's disease. 2003-05-07 2023-08-12 Not clear
Alberto Gómez-Ramos, Javier Díaz-Nido, Mark A Smith, George Perry, Jesús Avil. Effect of the lipid peroxidation product acrolein on tau phosphorylation in neural cells. Journal of neuroscience research. vol 71. issue 6. 2003-05-07. PMID:12605413. a hallmark of several neurodegenerative disorders, including alzheimer's disease and tauopathies, is the hyperphosphorylation of the microtubule-associated protein tau. 2003-05-07 2023-08-12 mouse
Alberto Gómez-Ramos, Javier Díaz-Nido, Mark A Smith, George Perry, Jesús Avil. Effect of the lipid peroxidation product acrolein on tau phosphorylation in neural cells. Journal of neuroscience research. vol 71. issue 6. 2003-05-07. PMID:12605413. these results support the view that oxidative stress and subsequent formation of lipid peroxidation products may contribute to tau protein phosphorylation in alzheimer's disease and tauopathies. 2003-05-07 2023-08-12 mouse
Trey Sunderland, Gary Linker, Nadeem Mirza, Karen T Putnam, David L Friedman, Lida H Kimmel, Judy Bergeson, Guy J Manetti, Matthew Zimmermann, Brian Tang, John J Bartko, Robert M Cohe. Decreased beta-amyloid1-42 and increased tau levels in cerebrospinal fluid of patients with Alzheimer disease. JAMA. vol 289. issue 16. 2003-05-06. PMID:12709467. decreased beta-amyloid1-42 and increased tau levels in cerebrospinal fluid of patients with alzheimer disease. 2003-05-06 2023-08-12 Not clear
C Q Zhu, X D Ca. [Regulatory effect of tiaoxin recipe drug serum on animal's Alzheimer disease related tau protein phosphorylation]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 21. issue 11. 2003-04-30. PMID:12575378. [regulatory effect of tiaoxin recipe drug serum on animal's alzheimer disease related tau protein phosphorylation]. 2003-04-30 2023-08-12 Not clear
C Q Zhu, X D Ca. [Regulatory effect of tiaoxin recipe drug serum on animal's Alzheimer disease related tau protein phosphorylation]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 21. issue 11. 2003-04-30. PMID:12575378. to study the regulatory effect and possible mechanism of tiaoxin recipe (txr) on animal's alzheimer disease related tau protein phosphorylation. 2003-04-30 2023-08-12 Not clear
V Meske, F Albert, D Richter, J Schwarze, T G Oh. Blockade of HMG-CoA reductase activity causes changes in microtubule-stabilizing protein tau via suppression of geranylgeranylpyrophosphate formation: implications for Alzheimer's disease. The European journal of neuroscience. vol 17. issue 1. 2003-04-28. PMID:12534972. blockade of hmg-coa reductase activity causes changes in microtubule-stabilizing protein tau via suppression of geranylgeranylpyrophosphate formation: implications for alzheimer's disease. 2003-04-28 2023-08-12 rat
V Meske, F Albert, D Richter, J Schwarze, T G Oh. Blockade of HMG-CoA reductase activity causes changes in microtubule-stabilizing protein tau via suppression of geranylgeranylpyrophosphate formation: implications for Alzheimer's disease. The European journal of neuroscience. vol 17. issue 1. 2003-04-28. PMID:12534972. our data demonstrate that lovastatin concentrations able to suppress not only cholesterol but also geranylgeranylpyrophosphate formation may evoke phosphorylation of tau reminiscent of preclinical early stages of alzheimer's disease and, when prolonged, apoptosis. 2003-04-28 2023-08-12 rat
Katsuji Kobayashi, Hiroyuki Nakano, Masahiro Hayashi, Masao Shimazaki, Yuken Fukutani, Kazuo Sasaki, Kaoru Sugimori, Yoshifumi Koshin. Association of phosphorylation site of tau protein with neuronal apoptosis in Alzheimer's disease. Journal of the neurological sciences. vol 208. issue 1-2. 2003-04-28. PMID:12639720. association of phosphorylation site of tau protein with neuronal apoptosis in alzheimer's disease. 2003-04-28 2023-08-12 Not clear
Lubica Vechterova, Eva Kontsekova, Norbert Zilka, Miroslav Ferencik, Rivka Ravid, Michal Nova. DC11: a novel monoclonal antibody revealing Alzheimer's disease-specific tau epitope. Neuroreport. vol 14. issue 1. 2003-04-25. PMID:12544837. dc11: a novel monoclonal antibody revealing alzheimer's disease-specific tau epitope. 2003-04-25 2023-08-12 Not clear
Lubica Vechterova, Eva Kontsekova, Norbert Zilka, Miroslav Ferencik, Rivka Ravid, Michal Nova. DC11: a novel monoclonal antibody revealing Alzheimer's disease-specific tau epitope. Neuroreport. vol 14. issue 1. 2003-04-25. PMID:12544837. using tau protein extracts from alzheimer's disease (ad) brain tissue, we generated a monoclonal antibody (mab dc11) which decorated neurofibrillary pathology in brain derived from ad patients on immunohistochemistry, and which lacked reactivity with healthy brain tissue. 2003-04-25 2023-08-12 Not clear