All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Julia Eisenhardt de Mello, Fernanda Cardoso Teixeira, Alessandra Dos Santos, Karina Luduvico, Mayara Sandrielly Soares de Aguiar, William Borges Domingues, Vinicius Farias Campos, Rejane Giacomelli Tavares, Augusto Schneider, Francieli Moro Stefanello, Roselia Maria Spanevell. Treatment with Blackberry Extract and Metformin in Sporadic Alzheimer's Disease Model: Impact on Memory, Inflammation, Redox Status, Phosphorylated Tau Protein and Insulin Signaling. Molecular neurobiology. 2024-03-02. PMID:38430352. treatment with blackberry extract and metformin in sporadic alzheimer's disease model: impact on memory, inflammation, redox status, phosphorylated tau protein and insulin signaling. 2024-03-02 2024-03-04 rat
Wei Wang, Wen-Qing Zheng, Xian Du, Shi-Cai Chen, Yan-Han Chen, Qing-Yang Ma, Hao Wang, Shan Gao, Rui Tan, Han-Ting Zhang, Yan-Meng Zhou, Fang-Fang Zhan. Chronic pain exacerbates memory impairment and pathology of Aβ and tau by upregulating IL-1β and p-65 signaling in a mouse model of Alzheimer's disease. Brain research. 2024-03-02. PMID:38430996. chronic pain exacerbates memory impairment and pathology of aβ and tau by upregulating il-1β and p-65 signaling in a mouse model of alzheimer's disease. 2024-03-02 2024-03-06 mouse
Elena Rodriguez-Vieitez, Amit Kumar, Mona-Lisa Malarte, Konstantinos Ioannou, Filipa M Rocha, Konstantinos Chioti. Imaging Neuroinflammation: Quantification of Astrocytosis in a Multitracer PET Approach. Methods in molecular biology (Clifton, N.J.). vol 2785. 2024-03-01. PMID:38427196. alzheimer's disease (ad) - the most common neurodegenerative disorder - is characterized by a complex neuropathology involving the deposition of extracellular amyloid-β (aβ) plaques and intracellular neurofibrillary tangles (nfts) of hyperphosphorylated tau proteins, accompanied by the activation of glial cells, i.e., astrocytes and microglia, and neuroinflammatory response, leading to neurodegeneration and cognitive dysfunction. 2024-03-01 2024-03-03 Not clear
Hariharakrishnan Chidambaram, Smita Eknath Desale, Tazeen Qureshi, Subashchandrabose Chinnathamb. Microglial Uptake of Extracellular Tau by Actin-Mediated Phagocytosis. Methods in molecular biology (Clifton, N.J.). vol 2761. 2024-03-01. PMID:38427240. in alzheimer's disease, microglia get activated to phagocytose damaged neurons, extracellular amyoid-β, and tau deposits. 2024-03-01 2024-03-03 Not clear
YouJin Lee, Eric M Morro. Quantitative Measurement of Tau Aggregation in Genetically Modified Rats with Neurodegeneration. Methods in molecular biology (Clifton, N.J.). vol 2761. 2024-03-01. PMID:38427245. also, certain rat models can represent deposition of tau, which is one of the key pathological features of alzheimer's diseases and tauopathies. 2024-03-01 2024-03-03 mouse
Smita Eknath Desale, Hariharakrishnan Chidambaram, Tazeen Qureshi, Subashchandrabose Chinnathamb. Internalization and Endosomal Trafficking of Extracellular Tau in Microglia Improved by α-Linolenic Acid. Methods in molecular biology (Clifton, N.J.). vol 2761. 2024-03-01. PMID:38427241. alzheimer's disease (ad) is distinguished by extracellular accumulation of amyloid-beta plaques and intracellular neurofibrillary tangles of tau. 2024-03-01 2024-03-03 Not clear
Abhay Kumar Singh, Karthikeyan Selvarasu, Siva Sundara Kumar Durairaja. Isolation and Detection of Pathological Tau Species in a Tauopathy Mouse Model. Methods in molecular biology (Clifton, N.J.). vol 2761. 2024-03-01. PMID:38427247. tau protein in alzheimer's disease (ad) and tauopathies becomes insoluble due to hyperphosphorylation, conformational alterations, and aggregation. 2024-03-01 2024-03-03 mouse
Abhay Kumar Singh, Karthikeyan Selvarasu, Siva Sundara Kumar Durairaja. Isolation and Detection of Pathological Tau Species in a Tauopathy Mouse Model. Methods in molecular biology (Clifton, N.J.). vol 2761. 2024-03-01. PMID:38427247. additionally, the study employs immunohistochemistry to visualize and quantify the pathological tau species in the brain tissue of transgenic mice, aiming to identify and analyze pathological tau species such as hyperphosphorylated tau to further our understanding of tauopathies such as alzheimer's disease. 2024-03-01 2024-03-03 mouse
Philippe Verwaerde, Cécilia Estrella, Stéphane Burlet, Mathieu Barrier, Andrée-Anne Marotte, Gilbert Clinck. First-In-Human Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses of AZP2006, A Synthetic Compound for the Treatment of Alzheimer's Disease and Related Diseases. Journal of Alzheimer's disease : JAD. 2024-03-01. PMID:38427472. alzheimer's disease (ad) and progressive supranuclear palsy (psp) are major neurodegenerative conditions with tau pathology in common but distinct symptoms-ad involves cognitive decline while psp affects balance and eye movement. 2024-03-01 2024-03-04 Not clear
Einar M Sigurdsso. Tau Immunotherapies for Alzheimer's Disease and Related Tauopathies: Status of Trials and Insights from Preclinical Studies. Journal of Alzheimer's disease : JAD. 2024-03-01. PMID:38427486. tau immunotherapies for alzheimer's disease and related tauopathies: status of trials and insights from preclinical studies. 2024-03-01 2024-03-04 Not clear
Einar M Sigurdsso. Tau Immunotherapies for Alzheimer's Disease and Related Tauopathies: Status of Trials and Insights from Preclinical Studies. Journal of Alzheimer's disease : JAD. 2024-03-01. PMID:38427486.  the tau protein undergoes pathological changes in alzheimer's disease and other tauopathies that eventually lead to functional impairments. 2024-03-01 2024-03-04 Not clear
Einar M Sigurdsso. Tau Immunotherapies for Alzheimer's Disease and Related Tauopathies: Status of Trials and Insights from Preclinical Studies. Journal of Alzheimer's disease : JAD. 2024-03-01. PMID:38427486. this view is based on the significant although modest efficacy of some antibodies targeting amyloid-β in alzheimer's disease and the fact that tau pathology correlates much better with the degree of dementia than amyloid-β lesions. 2024-03-01 2024-03-04 Not clear
Einar M Sigurdsso. Tau Immunotherapies for Alzheimer's Disease and Related Tauopathies: Status of Trials and Insights from Preclinical Studies. Journal of Alzheimer's disease : JAD. 2024-03-01. PMID:38427486. in alzheimer's disease, clearing pathological tau may therefore improve function later in the disease process than when removing amyloid-β. 2024-03-01 2024-03-04 Not clear
Shawn C C Hsueh, Mark Nijland, Adekunle Aina, Steven S Plotki. Cyclization Scaffolding for Improved Vaccine Immunogen Stability: Application to Tau Protein in Alzheimer's Disease. Journal of chemical information and modeling. 2024-03-01. PMID:38427576. cyclization scaffolding for improved vaccine immunogen stability: application to tau protein in alzheimer's disease. 2024-03-01 2024-03-04 Not clear
Lannah S Abasi, Nesreen Elathram, Manasi Movva, Amar Deep, Kevin D Corbett, Galia T Debelouchin. Phosphorylation regulates tau's phase separation behavior and interactions with chromatin. Communications biology. vol 7. issue 1. 2024-03-01. PMID:38429335. tau is a microtubule-associated protein often found in neurofibrillary tangles (nfts) in the brains of patients with alzheimer's disease. 2024-03-01 2024-03-04 Not clear
Arpan Dey, Aditi Verma, Uchit Bhaskar, Bidyut Sarkar, Mamata Kallianpur, Vicky Vishvakarma, Anand Kant Das, Kanchan Garai, Odity Mukherjee, Kunihiko Ishii, Tahei Tahara, Sudipta Mait. A Toxicogenic Interaction between Intracellular Amyloid-β and Apolipoprotein-E. ACS chemical neuroscience. 2024-02-29. PMID:38421952. a toxicogenic interaction between intracellular amyloid-β and apolipoprotein-e. alzheimer's disease (ad) is associated with the aggregation of amyloid β (aβ) and tau proteins. 2024-02-29 2024-03-03 rat
Veerle van Gils, Marianna Rizzo, Jade Côte, Wolfgang Viechtbauer, Giuseppe Fanelli, Jordi Salas-Salvadó, Theresa Wimberley, Mònica Bulló, Fernando Fernandez-Aranda, Søren Dalsgaard, Pieter Jelle Visser, Willemijn J Jansen, Stephanie J B Vo. The association of glucose metabolism measures and diabetes status with Alzheimer's disease biomarkers of amyloid and tau: a systematic review and meta-analysis. Neuroscience and biobehavioral reviews. 2024-02-29. PMID:38423195. the association of glucose metabolism measures and diabetes status with alzheimer's disease biomarkers of amyloid and tau: a systematic review and meta-analysis. 2024-02-29 2024-03-03 Not clear
Sujin Kim, Soo Jung Shin, Yunkwon Nam, Yong Ho Park, Byeong-Hyeon Kim, Hyun Ha Park, Vijay Kumar, Doo-Han Yoo, Yong Yook Lee, Hyang-Sook Hoe, Minho Moo. Korean red ginseng polysaccharide as a potential therapeutic agent targeting tau pathology in Alzheimer's disease. International journal of biological macromolecules. 2024-02-29. PMID:38423419. korean red ginseng polysaccharide as a potential therapeutic agent targeting tau pathology in alzheimer's disease. 2024-02-29 2024-03-03 mouse
Sujin Kim, Soo Jung Shin, Yunkwon Nam, Yong Ho Park, Byeong-Hyeon Kim, Hyun Ha Park, Vijay Kumar, Doo-Han Yoo, Yong Yook Lee, Hyang-Sook Hoe, Minho Moo. Korean red ginseng polysaccharide as a potential therapeutic agent targeting tau pathology in Alzheimer's disease. International journal of biological macromolecules. 2024-02-29. PMID:38423419. tau pathology is stronger associated with cognitive decline in patients with alzheimer's disease (ad) than amyloid beta (aβ) pathology. 2024-02-29 2024-03-03 mouse
Lars Tatenhorst, Fabian Maass, Hannah Paul, Vivian Dambeck, Mathias Bähr, Rosanna Dono, Paul Lingo. Glypican-4 serum levels are associated with cognitive dysfunction and vascular risk factors in Parkinson's disease. Scientific reports. vol 14. issue 1. 2024-02-29. PMID:38424123. initially described as supporting functionality of synapses via glutamate receptors during cns development, glypican 4 (gpc-4) also plays a role in the context of dementia via tau hyperphosphorylation in alzheimer's disease, which is also a co-pathology in parkinson's disease dementia. 2024-02-29 2024-03-03 human