| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Petr Novak, Branislav Kovacech, Stanislav Katina, Reinhold Schmidt, Philip Scheltens, Eva Kontsekova, Stefan Ropele, Lubica Fialova, Milica Kramberger, Natalia Paulenka-Ivanovova, Miroslav Smisek, Jozef Hanes, Eva Stevens, Andrej Kovac, Stanislav Sutovsky, Vojtech Parrak, Peter Koson, Michal Prcina, Jaroslav Galba, Martin Cente, Tomas Hromadka, Peter Filipcik, Juraj Piestansky, Maria Samcova, Carmen Prenn-Gologranc, Roman Sivak, Lutz Froelich, Michal Fresser, Martin Rakusa, John Harrison, Jakub Hort, Markus Otto, Duygu Tosun, Matej Ondrus, Bengt Winblad, Michal Novak, Norbert Zilk. ADAMANT: a placebo-controlled randomized phase 2 study of AADvac1, an active immunotherapy against pathological tau in Alzheimer's disease. Nature aging. vol 1. issue 6. 2023-04-28. PMID:37117834. |
alzheimer's disease (ad) pathology is partly characterized by accumulation of aberrant forms of tau protein. |
2023-04-28 |
2023-08-14 |
Not clear |
| Nader Morshed, Meelim J Lee, Felicia H Rodriguez, Douglas A Lauffenburger, Diego Mastroeni, Forest M Whit. Quantitative phosphoproteomics uncovers dysregulated kinase networks in Alzheimer's disease. Nature aging. vol 1. issue 6. 2023-04-28. PMID:37117831. |
alzheimer's disease (ad) is a form of dementia characterized by amyloid-β plaques and tau neurofibrillary tangles that progressively disrupt neural circuits in the brain. |
2023-04-28 |
2023-08-14 |
Not clear |
| Joana B Pereira, Shorena Janelidze, Olof Strandberg, Christopher D Whelan, Henrik Zetterberg, Kaj Blennow, Sebastian Palmqvist, Erik Stomrud, Niklas Mattsson-Carlgren, Oskar Hansso. Microglial activation protects against accumulation of tau aggregates in nondemented individuals with underlying Alzheimer's disease pathology. Nature aging. vol 2. issue 12. 2023-04-28. PMID:37118533. |
microglial activation protects against accumulation of tau aggregates in nondemented individuals with underlying alzheimer's disease pathology. |
2023-04-28 |
2023-08-14 |
Not clear |
| Joana B Pereira, Shorena Janelidze, Olof Strandberg, Christopher D Whelan, Henrik Zetterberg, Kaj Blennow, Sebastian Palmqvist, Erik Stomrud, Niklas Mattsson-Carlgren, Oskar Hansso. Microglial activation protects against accumulation of tau aggregates in nondemented individuals with underlying Alzheimer's disease pathology. Nature aging. vol 2. issue 12. 2023-04-28. PMID:37118533. |
the role of microglia in tau accumulation is currently unclear but could provide an important insight into the mechanisms underlying alzheimer's disease (ad) |
2023-04-28 |
2023-08-14 |
Not clear |
| Luying Qiao, Yang Shen, Guangzhi Li, Guanglei Lv, Chunxia L. Hypochlorous Acid-Activated UCNPs-LMB/VQIVYK Multifunctional Nanosystem for Alzheimer's Disease Treatment. Journal of functional biomaterials. vol 14. issue 4. 2023-04-27. PMID:37103297. |
the development of nanosystems, which can photooxygenate amyloid-β (aβ), detect the tau protein, and inhibit effectively the tau aggregation, is increasingly important in the diagnosis and therapy of alzheimer's disease (ad). |
2023-04-27 |
2023-08-14 |
Not clear |
| Seyed Hani Hojjati, Tracy A Butler, Gloria C Chiang, Christian Habeck, Arindam RoyChoudhury, Farnia Feiz, Jacob Shteingart, Siddharth Nayak, Sindy Ozoria, Antonio Fernández, Yaakov Stern, José A Luchsinger, Davangere P Devanand, Qolamreza R Razligh. Distinct and joint effects of low and high levels of Aβ and tau deposition on cortical thickness. NeuroImage. Clinical. vol 38. 2023-04-27. PMID:37104927. |
alzheimer's disease (ad) is defined by the presence of amyloid-β (aβ),tau, and neurodegeneration (atn framework) in the human cerebral cortex. |
2023-04-27 |
2023-08-14 |
human |
| Julia C Gambardella, Wyatt Schoephoerster, Viktoriya Bondarenko, Brian S Yandell, Marina E Embor. Expression of tau and phosphorylated tau in the brain of normal and hemiparkinsonian rhesus macaques. The Journal of comparative neurology. 2023-04-26. PMID:37098996. |
in neurodegenerative disorders termed "tauopathies," like alzheimer's and parkinson's disease, tau becomes hyperphosphorylated and forms intracellular inclusions. |
2023-04-26 |
2023-08-14 |
human |
| Jiaying Lu, Zizhao Ju, Min Wang, Xun Sun, Chenhao Jia, Ling Li, Weiqi Bao, Huiwei Zhang, Fangyang Jiao, Huamei Lin, Tzu-Chen Yen, Ruixue Cui, Xiaoli Lan, Qianhua Zhao, Yihui Guan, Chuantao Zu. Feasibility of European radiology. 2023-04-26. PMID:37099173. |
feasibility of quantification of tau accumulation using positron emission tomography (pet) is critical for the diagnosis of alzheimer's disease (ad). |
2023-04-26 |
2023-08-14 |
Not clear |
| Yue Sun, Changgui Li, Jinping Wang, Hu Sh. New Hypothesis Insight of Structural Properties on Four Tau Peptide Fragments in Alzheimer's Disease: Origin from the Histidine Behaviors. Chemistry (Weinheim an der Bergstrasse, Germany). 2023-04-25. PMID:37096391. |
new hypothesis insight of structural properties on four tau peptide fragments in alzheimer's disease: origin from the histidine behaviors. |
2023-04-25 |
2023-08-14 |
Not clear |
| Fei Liu, Ruozhen Wu, Nana Jin, Dandan Chu, Jianlan Gu, Yunn Chyn Tung, Zhihao Hu, Cheng-Xin Gong, Khalid Iqba. Two simple assays for assessing the seeding activity of proteopathic tau. Frontiers in aging neuroscience. vol 15. 2023-04-24. PMID:37091523. |
the regional distribution of neurofibrillary tangles of hyperphosphorylated tau aggregates is associated with the progression of alzheimer's disease (ad). |
2023-04-24 |
2023-08-14 |
Not clear |
| Asgeir Kobro-Flatmoen, Claudia Battistin, Rajeevkumar Raveendran Nair, Christiana Bjorkli, Belma Skender, Cliff Kentros, Gunnar Gouras, Menno P Witte. Lowering levels of reelin in entorhinal cortex layer II-neurons results in lowered levels of intracellular amyloid-β. Brain communications. vol 5. issue 2. 2023-04-24. PMID:37091586. |
projection neurons in the anteriolateral part of entorhinal cortex layer ii are the predominant cortical site for hyper-phosphorylation of tau and formation of neurofibrillary tangles in prodromal alzheimer's disease. |
2023-04-24 |
2023-08-14 |
rat |
| Catherine J Mummery, Anne Börjesson-Hanson, Daniel J Blackburn, Everard G B Vijverberg, Peter Paul De Deyn, Simon Ducharme, Michael Jonsson, Anja Schneider, Juha O Rinne, Albert C Ludolph, Ralf Bodenschatz, Holly Kordasiewicz, Eric E Swayze, Bethany Fitzsimmons, Laurence Mignon, Katrina M Moore, Chris Yun, Tiffany Baumann, Dan Li, Daniel A Norris, Rebecca Crean, Danielle L Graham, Ellen Huang, Elena Ratti, C Frank Bennett, Candice Junge, Roger M Lan. Tau-targeting antisense oligonucleotide MAPT Nature medicine. 2023-04-24. PMID:37095250. |
tau-targeting antisense oligonucleotide mapt tau plays a key role in alzheimer's disease (ad) pathophysiology, and accumulating evidence suggests that lowering tau may reduce this pathology. |
2023-04-24 |
2023-08-14 |
Not clear |
| Jessica Brown, Elena Camporesi, Juan Lantero-Rodriguez, Maria Olsson, Alice Wang, Blanca Medem, Henrik Zetterberg, Kaj Blennow, Thomas K Karikari, Mark Wall, Emily Hil. Tau in cerebrospinal fluid induces neuronal hyperexcitability and alters hippocampal theta oscillations. Acta neuropathologica communications. vol 11. issue 1. 2023-04-24. PMID:37095572. |
alzheimer's disease (ad) and other tauopathies are characterized by the aggregation of tau into soluble and insoluble forms (including tangles and neuropil threads). |
2023-04-24 |
2023-08-14 |
mouse |
| Lydia Reinhardt, Fabrizio Musacchio, Maria Bichmann, Annika Behrendt, Ebru Ercan-Herbst, Juliane Stein, Isabelle Becher, Per Haberkant, Julia Mader, David C Schöndorf, Melanie Schmitt, Jürgen Korffmann, Peter Reinhardt, Christian Pohl, Mikhail Savitski, Corinna Klein, Laura Gasparini, Martin Fuhrmann, Dagmar E Ehrnhoefe. Dual truncation of tau by caspase-2 accelerates its CHIP-mediated degradation. Neurobiology of disease. 2023-04-22. PMID:37086756. |
intraneuronal aggregates of the microtubule binding protein tau are a hallmark of different neurodegenerative diseases including alzheimer's disease (ad). |
2023-04-22 |
2023-08-14 |
mouse |
| Marina Célestine, Muriel Jacquier-Sarlin, Eve Borel, Fanny Petit, Jean-Baptiste Perot, Anne-Sophie Hérard, Luc Bousset, Alain Buisson, Marc Dhenai. Long term worsening of amyloid pathology, cerebral function, and cognition after a single inoculation of beta-amyloid seeds with Osaka mutation. Acta neuropathologica communications. vol 11. issue 1. 2023-04-22. PMID:37087498. |
alzheimer's disease (ad) is characterized by intracerebral deposition of abnormal proteinaceous assemblies made of amyloid-β (aß) peptides or tau proteins. |
2023-04-22 |
2023-08-14 |
Not clear |
| Anika Wuestefeld, Alexa Pichet Binette, David Berron, Nicola Spotorno, Danielle van Westen, Erik Stomrud, Niklas Mattsson-Carlgren, Olof Strandberg, Ruben Smith, Sebastian Palmqvist, Trevor Glenn, Svenja Moes, Michael Honer, Konstantinos Arfanakis, Lisa L Barnes, David A Bennett, Julie A Schneider, Laura E M Wisse, Oskar Hansso. Age-related and amyloid-beta-independent tau deposition and its downstream effects. Brain : a journal of neurology. 2023-04-21. PMID:37082959. |
the associations between age and cortical volume or thickness were partially mediated via tau in regions with early alzheimer's disease pathology, i.e., early tau and/or amyloid-beta pathology (subiculum/brodmann area 35/precuneus/posterior cingulate). |
2023-04-21 |
2023-08-14 |
Not clear |
| Anika Wuestefeld, Alexa Pichet Binette, David Berron, Nicola Spotorno, Danielle van Westen, Erik Stomrud, Niklas Mattsson-Carlgren, Olof Strandberg, Ruben Smith, Sebastian Palmqvist, Trevor Glenn, Svenja Moes, Michael Honer, Konstantinos Arfanakis, Lisa L Barnes, David A Bennett, Julie A Schneider, Laura E M Wisse, Oskar Hansso. Age-related and amyloid-beta-independent tau deposition and its downstream effects. Brain : a journal of neurology. 2023-04-21. PMID:37082959. |
these results have implications for our understanding of the spreading of tau outside the medial temporal lobe, also in the context of alzheimer's disease. |
2023-04-21 |
2023-08-14 |
Not clear |
| Lan-Ting Zhou, Dan Liu, Hui-Cong Kang, Lu Lu, He-Zhou Huang, Wen-Qing Ai, Yang Zhou, Man-Fei Deng, Hao Li, Zhi-Qiang Liu, Wei-Feng Zhang, Ya-Zhuo Hu, Zhi-Tao Han, Hong-Hong Zhang, Jian-Jun Jia, Avijite Kumer Sarkar, Saldin Sharaydeh, Jie Wang, Heng-Ye Man, Marcel Schilling, Lars Bertram, Youming Lu, Ziyuan Guo, Ling-Qiang Zh. Tau pathology epigenetically remodels the neuron-glial cross-talk in Alzheimer's disease. Science advances. vol 9. issue 16. 2023-04-21. PMID:37083538. |
tau pathology epigenetically remodels the neuron-glial cross-talk in alzheimer's disease. |
2023-04-21 |
2023-08-14 |
mouse |
| Lan-Ting Zhou, Dan Liu, Hui-Cong Kang, Lu Lu, He-Zhou Huang, Wen-Qing Ai, Yang Zhou, Man-Fei Deng, Hao Li, Zhi-Qiang Liu, Wei-Feng Zhang, Ya-Zhuo Hu, Zhi-Tao Han, Hong-Hong Zhang, Jian-Jun Jia, Avijite Kumer Sarkar, Saldin Sharaydeh, Jie Wang, Heng-Ye Man, Marcel Schilling, Lars Bertram, Youming Lu, Ziyuan Guo, Ling-Qiang Zh. Tau pathology epigenetically remodels the neuron-glial cross-talk in Alzheimer's disease. Science advances. vol 9. issue 16. 2023-04-21. PMID:37083538. |
how neurons manipulate the neuron-astrocyte interaction under pathological conditions, such as hyperphosphorylated tau, a pathological hallmark in alzheimer's disease (ad), remains elusive. |
2023-04-21 |
2023-08-14 |
mouse |
| Riheb Jabeur, Caroline Corbel, Pascal Loyer, Annabelle Le Parc, Adélaide Le Grand, Arnaud Comte, Stéphane Bach, Gwenaëlle André-Leroux, Olivier Sire, Hedi Ben Mansour, Véronique Le Till. Identification of Novel Compounds Inhibiting the Kinase Activity of the CDK5/p25 Complex via Direct Binding to p25. Biochemistry. 2023-04-19. PMID:37074084. |
tamoxifen, the gold standard drug for endocrine therapy for breast cancer, modulates the phosphorylation status of the tau protein in alzheimer's disease by inhibiting cdk5 kinase activity. |
2023-04-19 |
2023-08-14 |
Not clear |