Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Brendan P Lucey, Haiyan Liu, Cristina D Toedebusch, David Freund, Tiara Redrick, Samir L Chahin, Kwasi G Mawuenyega, James G Bollinger, Vitaliy Ovod, Nicolas R Barthélemy, Randall J Batema. Suvorexant acutely decreases tau phosphorylation and Aβ in the human CNS. Annals of neurology. 2023-03-10. PMID:36897120. |
in alzheimer's disease, hyperphosphorylated tau is associated with formation of insoluble paired helical filaments that aggregate as neurofibrillary tau tangles and are associated with neuronal loss and cognitive symptoms. |
2023-03-10 |
2023-08-14 |
mouse |
Ryan K Betters, Emma Luhmann, Amy C Gottschalk, Zhen Xu, Mallory R Shin, Christopher P Ptak, Kimberly L Fiock, Lilliana C Radoshevich, Marco M Heft. Characterization of the Tau Interactome in Human Brain Reveals Isoform-Dependent Interaction with 14-3-3 Family Proteins. eNeuro. 2023-03-10. PMID:36898832. |
despite exhibiting tau phosphorylation similar to alzheimer disease, the human fetal brain is remarkably resilient to tau aggregation and toxicity. |
2023-03-10 |
2023-08-14 |
human |
Ryan K Betters, Emma Luhmann, Amy C Gottschalk, Zhen Xu, Mallory R Shin, Christopher P Ptak, Kimberly L Fiock, Lilliana C Radoshevich, Marco M Heft. Characterization of the Tau Interactome in Human Brain Reveals Isoform-Dependent Interaction with 14-3-3 Family Proteins. eNeuro. 2023-03-10. PMID:36898832. |
to identify potential mechanisms for this resilience, we used co-immunoprecipitation with mass spectrometry to characterize the tau interactome in human fetal, adult, and alzheimer disease brains. |
2023-03-10 |
2023-08-14 |
human |
Ryan K Betters, Emma Luhmann, Amy C Gottschalk, Zhen Xu, Mallory R Shin, Christopher P Ptak, Kimberly L Fiock, Lilliana C Radoshevich, Marco M Heft. Characterization of the Tau Interactome in Human Brain Reveals Isoform-Dependent Interaction with 14-3-3 Family Proteins. eNeuro. 2023-03-10. PMID:36898832. |
differentially interacting proteins were enriched for 14-3-3 domains, and we found that the 14-3-3-β, η, and γ isoforms interacted with phosphorylated tau in alzheimer disease but not the fetal brain. |
2023-03-10 |
2023-08-14 |
human |
Ryan K Betters, Emma Luhmann, Amy C Gottschalk, Zhen Xu, Mallory R Shin, Christopher P Ptak, Kimberly L Fiock, Lilliana C Radoshevich, Marco M Heft. Characterization of the Tau Interactome in Human Brain Reveals Isoform-Dependent Interaction with 14-3-3 Family Proteins. eNeuro. 2023-03-10. PMID:36898832. |
our findings suggest that there are isoform-driven differences between the phospho-tau interactome in fetal and alzheimer disease brain, including differences in interaction with the critical 14-3-3 family of protein chaperones, which may explain, in part, the resilience of fetal brain to tau toxicity. |
2023-03-10 |
2023-08-14 |
human |
Emma M Coomans, Jori Tomassen, Rik Ossenkoppele, Betty M Tijms, Luigi Lorenzini, Mara Ten Kate, Lyduine E Collij, Fiona Heeman, Roos M Rikken, Sophie M van der Landen, Marijke E den Hollander, Sandeep S V Golla, Maqsood Yaqub, Albert D Windhorst, Frederik Barkhof, Philip Scheltens, Eco J C de Geus, Pieter Jelle Visser, Bart N M van Berckel, Anouk den Brabe. Genetically identical twin-pair difference models support the amyloid cascade hypothesis. Brain : a journal of neurology. 2023-03-09. PMID:36892415. |
the amyloid cascade hypothesis has strongly impacted the alzheimer's disease research agenda and clinical trial designs over the past decades, but precisely how amyloid-β pathology initiates the aggregation of neocortical tau remains unclear. |
2023-03-09 |
2023-08-14 |
Not clear |
Prabhu Rajaiah Prince, Janine Hochmair, Hévila Brognaro, Susanna Gevorgyan, Maximilian Franck, Robin Schubert, Kristina Lorenzen, Selin Yazici, Eckhard Mandelkow, Susanne Wegmann, Christian Betze. Initiation and modulation of Tau protein phase separation by the drug suramin. Scientific reports. vol 13. issue 1. 2023-03-09. PMID:36894559. |
aggregated tau is the main component of neurofibrillary tangles observed in alzheimer's disease. |
2023-03-09 |
2023-08-14 |
Not clear |
Mohammed D Rajab, Emmanuel Jammeh, Teruka Taketa, Carol Brayne, Fiona E Matthews, Li Su, Paul G Ince, Stephen B Wharton, Dennis Wan. Assessment of Alzheimer-related pathologies of dementia using machine learning feature selection. Alzheimer's research & therapy. vol 15. issue 1. 2023-03-09. PMID:36895019. |
we first tested alzheimer's disease and tau markers and then other neuropathologies associated with dementia. |
2023-03-09 |
2023-08-14 |
Not clear |
Michael A Kelberman, Jacki M Rorabaugh, Claire R Anderson, Alexia Marriott, Seth D DePuy, Kurt Rasmussen, Katharine E McCann, Jay M Weiss, David Weinshenke. Age-dependent dysregulation of locus coeruleus firing in a transgenic rat model of Alzheimer's disease. Neurobiology of aging. vol 125. 2023-03-08. PMID:36889122. |
hyperphosphorylated tau in the locus coeruleus (lc) is ubiquitous in prodromal alzheimer's disease (ad), and lc neurons degenerate as ad progresses. |
2023-03-08 |
2023-08-14 |
rat |
Aditya Singh, Vaseem Ahamad Ansari, Tarique Mahmood, Farogh Ahsan, Rufaida Wasim, Mohammad Shariq, Saba Parveen, Shubhrat Maheshwar. Receptor for Advanced Glycation End Products: Dementia and Cognitive Impairment. Drug research. 2023-03-08. PMID:36889338. |
the pathophysiological processes of dementia and cognitive impairment are linked to advanced glycation end products (ages) and their receptor (rage).the neurofibrillary tangles (nfts) of abnormally hyperphosphorylated tau protein and senile plaques (sps), which are brought on by amyloid beta (aβ) deposition, are the hallmarks of alzheimer's disease (ad), a progressive neurodegenerative condition. |
2023-03-08 |
2023-08-14 |
Not clear |
Xiaoying Chen, Maria Firulyova, Melissa Manis, Jasmin Herz, Igor Smirnov, Ekaterina Aladyeva, Chanung Wang, Xin Bao, Mary Beth Finn, Hao Hu, Irina Shchukina, Min Woo Kim, Carla M Yuede, Jonathan Kipnis, Maxim N Artyomov, Jason D Ulrich, David M Holtzma. Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy. Nature. 2023-03-08. PMID:36890231. |
extracellular deposition of amyloid-β as neuritic plaques and intracellular accumulation of hyperphosphorylated, aggregated tau as neurofibrillary tangles are two of the characteristic hallmarks of alzheimer's disease |
2023-03-08 |
2023-08-14 |
Not clear |
Mona-Lisa Malarte, Per-Göran Gillberg, Amit Kumar, Nenad Bogdanovic, Laëtitia Lemoine, Agneta Nordber. Correction: Discriminative binding of tau PET tracers PI2620, MK6240 and RO948 in Alzheimer's disease, corticobasal degeneration and progressive supranuclear palsy brains. Molecular psychiatry. 2023-03-08. PMID:36890300. |
correction: discriminative binding of tau pet tracers pi2620, mk6240 and ro948 in alzheimer's disease, corticobasal degeneration and progressive supranuclear palsy brains. |
2023-03-08 |
2023-08-14 |
Not clear |
Masaomi Miyamoto, Chio Okuyama, Shinya Kagawa, Kuninori Kusano, Masaaki Takahashi, Keisuke Takahata, Ming-Kuei Jang, Hiroshi Yamauch. Radiation dosimetry and pharmacokinetics of the tau PET tracer florzolotau (18F) in healthy Japanese subjects. Annals of nuclear medicine. 2023-03-08. PMID:36890399. |
florzolotau (18f) (florzolotau, apn-1607, pm-pbb3) has been shown to be a probe for tau fibrils in an animal model and patients with alzheimer's disease and those with non-alzheimer's disease tauopathies. |
2023-03-08 |
2023-08-14 |
human |
Adrian Beckmann, Paulino Ramirez, Maria Gamez, Elias Gonzalez, Jasmine De Mange, Kevin F Bieniek, William J Ray, Bess Fros. Moesin is an effector of tau-induced actin overstabilization, cell cycle activation, and neurotoxicity in Alzheimer's disease. iScience. vol 26. issue 3. 2023-03-07. PMID:36879821. |
multiple lines of evidence suggest that abortive cell cycle activation is a consequence of pathogenic forms of tau, a protein that drives neurodegeneration in alzheimer's disease and related "tauopathies." |
2023-03-07 |
2023-08-14 |
mouse |
Siwen Li, Chi Him Poon, Zhigang Zhang, Ming Yue, Ruijun Chen, Yalun Zhang, Md Farhad Hossain, Yining Pan, Jun Zhao, Lei Rong, Leung Wing Chu, Yat Fung Shea, Ekaterina Rogaeva, Jie Tu, Peter St George-Hyslop, Lee Wei Lim, You-Qiang Son. MicroRNA-128 suppresses tau phosphorylation and reduces amyloid-beta accumulation by inhibiting the expression of GSK3β, APPBP2, and mTOR in Alzheimer's disease. CNS neuroscience & therapeutics. 2023-03-07. PMID:36880288. |
microrna-128 suppresses tau phosphorylation and reduces amyloid-beta accumulation by inhibiting the expression of gsk3β, appbp2, and mtor in alzheimer's disease. |
2023-03-07 |
2023-08-14 |
Not clear |
Siwen Li, Chi Him Poon, Zhigang Zhang, Ming Yue, Ruijun Chen, Yalun Zhang, Md Farhad Hossain, Yining Pan, Jun Zhao, Lei Rong, Leung Wing Chu, Yat Fung Shea, Ekaterina Rogaeva, Jie Tu, Peter St George-Hyslop, Lee Wei Lim, You-Qiang Son. MicroRNA-128 suppresses tau phosphorylation and reduces amyloid-beta accumulation by inhibiting the expression of GSK3β, APPBP2, and mTOR in Alzheimer's disease. CNS neuroscience & therapeutics. 2023-03-07. PMID:36880288. |
alzheimer's disease (ad) is characterized by the abnormal accumulation of hyperphosphorylated tau proteins and amyloid-beta (aβ) peptides. |
2023-03-07 |
2023-08-14 |
Not clear |
Weihua Jin, Chenghui Lu, Yanan Zhu, Jing Zhao, Wenjing Zhang, Lianchun Wang, Robert J Linhardt, Chunyu Wang, Fuming Zhan. Fucoidans inhibited tau interaction and cellular uptake. Carbohydrate polymers. vol 299. 2023-03-06. PMID:36876791. |
tau spreading in alzheimer's disease is mediated by cell surface heparan sulfate (hs). |
2023-03-06 |
2023-08-14 |
mouse |
Nicholas J Ashton, Marion Moseby-Knappe, Andrea L Benedet, Lana Grötschel, Juan Lantero-Rodriguez, Thomas K Karikari, Christian Hassager, Matt P Wise, Pascal Stammet, Jesper Kjaergaard, Hans Friberg, Niklas Nielsen, Tobias Cronberg, Henrik Zetterberg, Kaj Blenno. Alzheimer Disease Blood Biomarkers in Patients With Out-of-Hospital Cardiac Arrest. JAMA neurology. 2023-03-06. PMID:36877496. |
blood phosphorylated tau (p-tau) and amyloid-β peptides (aβ) are promising peripheral biomarkers of alzheimer disease (ad) pathology. |
2023-03-06 |
2023-08-14 |
Not clear |
Takuya Murata, Genta Ito, Naoko Utsunomiya-Tat. Site-specific amino acid D-isomerization of Tau R2 and R3 peptides changes the fibril morphology, resulting in attenuation of Tau aggregation inhibitor potency. Biochemical and biophysical research communications. vol 654. 2023-03-06. PMID:36878036. |
tau, a microtubule-binding protein, is a major component of neurofibrillary tangles in the brains of alzheimer's disease patients. |
2023-03-06 |
2023-08-14 |
Not clear |
Takuya Murata, Genta Ito, Naoko Utsunomiya-Tat. Site-specific amino acid D-isomerization of Tau R2 and R3 peptides changes the fibril morphology, resulting in attenuation of Tau aggregation inhibitor potency. Biochemical and biophysical research communications. vol 654. 2023-03-06. PMID:36878036. |
tau aggregation following fibril formation induces alzheimer's disease pathogenesis. |
2023-03-06 |
2023-08-14 |
Not clear |