All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Nisha Job, Venkatesan S Thimmakondu, Krishnan Thirumoorth. In Silico Drug Design and Analysis of Dual Amyloid-Beta and Tau Protein-Aggregation Inhibitors for Alzheimer's Disease Treatment. Molecules (Basel, Switzerland). vol 28. issue 3. 2023-02-11. PMID:36771052. in silico drug design and analysis of dual amyloid-beta and tau protein-aggregation inhibitors for alzheimer's disease treatment. 2023-02-11 2023-08-14 Not clear
Courtney J Mycroft-West, Anthony J Devlin, Lynsay C Cooper, Scott E Guimond, Patricia Procter, Gavin J Miller, Marco Guerrini, David G Fernig, Edwin A Yates, Marcelo A Lima, Mark A Skidmor. A sulphated glycosaminoglycan extract from Placopecten magellanicus inhibits the Alzheimer's disease β-site amyloid precursor protein cleaving enzyme 1 (BACE-1). Carbohydrate research. vol 525. 2023-02-11. PMID:36773398. in addition, heparin has been shown to exert favourable bioactivities through a number of pathophysiological pathways involved in the disease processes of alzheimer's disease including inflammation, oxidative stress, tau phosphorylation and amyloid peptide generation. 2023-02-11 2023-08-14 cattle
Daiki Nakatsu, Rina Kunishige, Yuki Taguchi, Naeko Shinozaki-Narikawa, Kishiko Osaka, Kayo Yokomizo, Mami Ishida, Shunsuke Takei, Shoko Yamasaki, Keita Hagiya, Kotaro Hattori, Tadashi Tsukamoto, Masayuki Murata, Fumi Kan. BMP4-SMAD1/5/9-RUNX2 pathway activation inhibits neurogenesis and oligodendrogenesis in Alzheimer's patients' iPSCs in senescence-related conditions. Stem cell reports. 2023-02-10. PMID:36764297. in addition to increasing β-amyloid plaque deposition and tau tangle formation, inhibition of neurogenesis has recently been observed in alzheimer's disease (ad). 2023-02-10 2023-08-14 Not clear
Claira Sohn, Jiacheng Ma, William J Ray, Bess Fros. Pathogenic tau decreases nuclear tension in cultured neurons. Frontiers in aging. vol 4. 2023-02-09. PMID:36756194. neurodegenerative tauopathies, including alzheimer's disease, are pathologically defined by the presence of aggregated forms of tau protein in brains of affected individuals. 2023-02-09 2023-08-14 human
Claira Sohn, Jiacheng Ma, William J Ray, Bess Fros. Pathogenic tau decreases nuclear tension in cultured neurons. Frontiers in aging. vol 4. 2023-02-09. PMID:36756194. based on the known function of the nucleus as a mechanosensor, as well as the high incidence of nuclear pleomorphism in human alzheimer's disease and related tauopathies, we investigated the effects of pathogenic tau on nuclear tension. 2023-02-09 2023-08-14 human
Lindsay A Welikovitch, Simon Dujardin, Amy R Dunn, Analiese R Fernandes, Anita Khasnavis, Lori B Chibnik, Catherine C Kaczorowski, Bradley T Hyma. Rate of tau propagation is a heritable disease trait in genetically diverse mouse strains. iScience. vol 26. issue 2. 2023-02-09. PMID:36756365. the speed and scope of cognitive deterioration in alzheimer's disease is highly associated with the advancement of tau neurofibrillary lesions across brain networks. 2023-02-09 2023-08-14 mouse
Miaomiao Wang, Gan Tang, Congfa Zhou, Hongmin Guo, Zihui Hu, Qixing Hu, Guilin L. Revisiting the intersection of microglial activation and neuroinflammation in Alzheimer's disease from the perspective of ferroptosis. Chemico-biological interactions. 2023-02-09. PMID:36758888. alzheimer's disease (ad) is a neurodegenerative disorder characterized by chronic neuroinflammation with amyloid beta-protein deposition and hyperphosphorylated tau protein. 2023-02-09 2023-08-14 Not clear
Ann C McKee, Thor D Stein, Bertrand R Huber, John F Crary, Kevin Bieniek, Dennis Dickson, Victor E Alvarez, Jonathan D Cherry, Kurt Farrell, Morgane Butler, Madeline Uretsky, Bobak Abdolmohammadi, Michael L Alosco, Yorghos Tripodis, Jesse Mez, Daniel H Daneshva. Chronic traumatic encephalopathy (CTE): criteria for neuropathological diagnosis and relationship to repetitive head impacts. Acta neuropathologica. 2023-02-09. PMID:36759368. the pathology of cte is unique, characterized by a pathognomonic lesion consisting of a perivascular accumulation of neuronal phosphorylated tau (p-tau) variably alongside astrocytic aggregates at the depths of the cortical sulci, and a distinctive molecular structural configuration of p-tau fibrils that is unlike the changes observed with aging, alzheimer's disease, or any other tauopathy. 2023-02-09 2023-08-14 Not clear
Yue Cai, Jing Du, Anqi Li, Yalin Zhu, Linsen Xu, Kun Sun, Shaohua Ma, Tengfei Gu. Initial levels of β-amyloid and tau deposition have distinct effects on longitudinal tau accumulation in Alzheimer's disease. Alzheimer's research & therapy. vol 15. issue 1. 2023-02-08. PMID:36750884. initial levels of β-amyloid and tau deposition have distinct effects on longitudinal tau accumulation in alzheimer's disease. 2023-02-08 2023-08-14 Not clear
Yue Cai, Jing Du, Anqi Li, Yalin Zhu, Linsen Xu, Kun Sun, Shaohua Ma, Tengfei Gu. Initial levels of β-amyloid and tau deposition have distinct effects on longitudinal tau accumulation in Alzheimer's disease. Alzheimer's research & therapy. vol 15. issue 1. 2023-02-08. PMID:36750884. to better assist with the design of future clinical trials for alzheimer's disease (ad) and aid in our understanding of the disease's symptomatology, it is essential to clarify what roles β-amyloid (aβ) plaques and tau tangles play in longitudinal tau accumulation inside and outside the medial temporal lobe (mtl) as well as how age, sex, apolipoprotein e (apoe) ε4 (apoe-ε4), and klotho-vs heterozygosity (kl-vs 2023-02-08 2023-08-14 Not clear
Renata Guedes de Jesus Gonçalves, Juliana Ferreira Vasques, Almir Jordão da Silva-Junior, Fernanda Gubert, Rosalia Mendez-Oter. Mesenchymal stem cell- and extracellular vesicle-based therapies for Alzheimer's disease: progress, advantages, and challenges. Neural regeneration research. vol 18. issue 8. 2023-02-08. PMID:36751774. for decades, the search for disease-modifying therapies has focused on the two main alzheimer's disease histopathological hallmarks, seeking to prevent, mitigate, or clear the formation of extracellular aggregates of β-amyloid peptide and intracellular neurofibrillary tangles of tau protein, although without clinical success. 2023-02-08 2023-08-14 Not clear
Guo-Liang Chen, Kai Sun, Xi-Zhe Liu, Kui-Leung Tong, Zi-Juan Chen, Lu Yu, Ning-Ning Chen, Shao-Yu Li. Inhibiting tau protein improves the recovery of spinal cord injury in rats by alleviating neuroinflammation and oxidative stress. Neural regeneration research. vol 18. issue 8. 2023-02-08. PMID:36751813. tau inhibition is considered effective therapy for many central nervous system diseases, including traumatic brain injury and alzheimer's disease. 2023-02-08 2023-08-14 rat
Zhenyi Hu, Po-Han Chen, Wenxue Li, Todd Douglas, John Hines, Yansheng Liu, Craig M Crew. Targeted Dephosphorylation of Tau by Phosphorylation Targeting Chimeras (PhosTACs) as a Therapeutic Modality. Journal of the American Chemical Society. 2023-02-08. PMID:36753634. hyperphosphorylation of the microtubule-associated protein tau plays an important pathological role in the development of alzheimer's disease and other tauopathies. 2023-02-08 2023-08-14 Not clear
Ying-Ying Yang, Yan-Tao Ren, Meng-Yu Jia, Chen-Yang Bai, Xiu-Ting Liang, Hui-Ling Gao, Man-Li Zhong, Tao Wang, Chuang Gu. The human islet amyloid polypeptide reduces hippocampal tauopathy and behavioral impairments in P301S mice without inducing neurotoxicity or seeding amyloid aggregation. Experimental neurology. 2023-02-07. PMID:36750170. recent evidence suggests that human islet amyloid polypeptide (h-iapp) accumulates in the brains of alzheimer's disease (ad) patients and may interact with aβ or microtubule associated protein tau to associate with the neurodegenerative process. 2023-02-07 2023-08-14 mouse
Rohit Shukla, Anuj Kumar, David J Kelvin, Tiratha Raj Sing. Disruption of DYRK1A-induced hyperphosphorylation of amyloid-beta and tau protein in Alzheimer's disease: An integrative molecular modeling approach. Frontiers in molecular biosciences. vol 9. 2023-02-06. PMID:36741918. disruption of dyrk1a-induced hyperphosphorylation of amyloid-beta and tau protein in alzheimer's disease: an integrative molecular modeling approach. 2023-02-06 2023-08-14 Not clear
Jasmeet Pannu Hayes, Meghan E Pierce, Emma Brown, David Salat, Mark W Logue, Julie Constantinescu, Kate Valerio, Mark W Miller, Richard Sherva, Bertrand Russell Huber, William Milberg, Regina McGlinche. Genetic Risk for Alzheimer Disease and Plasma Tau Are Associated With Accelerated Parietal Cortex Thickness Change in Middle-Aged Adults. Neurology. Genetics. vol 9. issue 1. 2023-02-06. PMID:36742995. genetic risk for alzheimer disease and plasma tau are associated with accelerated parietal cortex thickness change in middle-aged adults. 2023-02-06 2023-08-14 Not clear
Jasmeet Pannu Hayes, Meghan E Pierce, Emma Brown, David Salat, Mark W Logue, Julie Constantinescu, Kate Valerio, Mark W Miller, Richard Sherva, Bertrand Russell Huber, William Milberg, Regina McGlinche. Genetic Risk for Alzheimer Disease and Plasma Tau Are Associated With Accelerated Parietal Cortex Thickness Change in Middle-Aged Adults. Neurology. Genetics. vol 9. issue 1. 2023-02-06. PMID:36742995. neuroimaging and biomarker studies in alzheimer disease (ad) have shown well-characterized patterns of cortical thinning and altered biomarker concentrations of tau and β-amyloid (aβ). 2023-02-06 2023-08-14 Not clear
Bin Wang, Xiaofang Zhong, Lauren Fields, Haiyan Lu, Zexin Zhu, Lingjun L. Structural Proteomic Profiling of Cerebrospinal Fluids to Reveal Novel Conformational Biomarkers for Alzheimer's Disease. Journal of the American Society for Mass Spectrometry. 2023-02-06. PMID:36745855. alzheimer's disease (ad) is the most common representation of dementia, with brain pathological hallmarks of protein abnormal aggregation, such as with amyloid beta and tau protein. 2023-02-06 2023-08-14 human
Steven S Hou, Joyce Yang, Jeong Heon Lee, Yeseo Kwon, Maria Calvo-Rodriguez, Kai Bao, Sung Ahn, Satoshi Kashiwagi, Anand T N Kumar, Brian J Bacskai, Hak Soo Cho. Near-infrared fluorescence lifetime imaging of amyloid-β aggregates and tau fibrils through the intact skull of mice. Nature biomedical engineering. 2023-02-06. PMID:36747008. in transgenic mouse models of alzheimer's disease, we compare the performance of zw800-1c with that of the two spectrally similar heptamethine fluorophores zw800-1a and indocyanine green, and show that zw800-1c undergoes a longer fluorescence-lifetime shift when bound to amyloid-β and tau aggregates than when circulating in blood vessels. 2023-02-06 2023-08-14 mouse
Kathrin Wenger, Arthur Viode, Christoph N Schlaffner, Patrick van Zalm, Long Cheng, Tammy Dellovade, Xavier Langlois, Anthony Bannon, Rui Chang, Theresa R Connors, Derek Oakley, Bernhard Renard, Juri Rappsilber, Bradley Hyman, Hanno Steen, Judith A Stee. Common mouse models of tauopathy reflect early but not late human disease. Molecular neurodegeneration. vol 18. issue 1. 2023-02-03. PMID:36732784. mouse models that overexpress human mutant tau (p301s and p301l) are commonly used in preclinical studies of alzheimer's disease (ad) and while several drugs showed therapeutic effects in these mice, they were ineffective in humans. 2023-02-03 2023-08-14 mouse