All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Joo-Hee Lee, Nivethasri Lakshmana Perumal, Sehee Kwon, Hee-Cheol Kim, Na-Hyun Ahn, Su-Bin Choi, Eunjin Hwang, Hyoryeong Song, David R Elmaleh, Aryun Kim, Woong-Suk Yang, Cheorl-Ho Kim, Byeong-Churl Jang, Sungwoon Choi, Seung-Hoon Yan. The derivatives of cromolyn ameliorate the abnormal misfolding of amyloid proteins and neuroinflammation in the neural cells. Current medicinal chemistry. 2023-01-25. PMID:36694324. the representative symptom of alzheimer's disease (ad) has mainly been mentioned to be misfolding of amyloid proteins, such as amyloid-beta (aβ) and tau protein. 2023-01-25 2023-08-14 Not clear
Aleksandra Parka, Caroline Degel, Jakob Dreyer, Ulrike Richter, Benjamin Hall, Jesper F Bastlund, Bettina Laursen, Maiken Nedergaard, Florence Sotty, Paolo Bott. Early impairments of visually-driven neuronal ensemble dynamics in the rTg4510 tauopathy mouse model. Neurobiology of disease. vol 178. 2023-01-25. PMID:36696792. tau protein pathology is a hallmark of many neurodegenerative diseases, including alzheimer's disease or frontotemporal dementia. 2023-01-25 2023-08-14 mouse
Federico Verde, Edoardo Nicolò Aiello, Eleonora Giacopuzzi Grigoli, Ilaria Milone, Antonella Dubini, Antonia Ratti, Barbara Poletti, Nicola Ticozzi, Vincenzo Silan. CSF Aβ40 and P-Tau181 Might Differentiate Atypical from Typical AD Phenotypes: Preliminary Evidence. Neuro-degenerative diseases. vol 22. issue 2. 2023-01-23. PMID:36108600. this study aimed at testing whether csf levels of amyloid β42 (aβ42), aβ40, total tau, and phosphorylated tau (p-tau181) individually contribute to the identification of atypical phenotypes among a retrospective cohort of probable alzheimer's disease (ad) patients diagnosed by means of the ratio between aβ42 and aβ40 (aβ42/40). 2023-01-23 2023-08-16 Not clear
Pei-Hao Chen, Sang-I Lin, Ying-Yi Liao, Wei-Ling Hsu, Fang-Yu Chen. Corrigendum: Associations between blood-based biomarkers of Alzheimer's disease with cognition in motoric cognitive risk syndrome: A pilot study using plasma Aβ42 and total tau. Frontiers in aging neuroscience. vol 14. 2023-01-23. PMID:36688149. corrigendum: associations between blood-based biomarkers of alzheimer's disease with cognition in motoric cognitive risk syndrome: a pilot study using plasma aβ42 and total tau. 2023-01-23 2023-08-14 Not clear
Giulia Montalto, Roberta Ricciarell. Tau, tau kinases, and tauopathies: An updated overview. BioFactors (Oxford, England). 2023-01-23. PMID:36688478. however, hyperphosphorylated tau aggregates into paired helical filaments, the main constituents of neurofibrillary tangles found in the brains of patients with alzheimer's disease and other tauopathies. 2023-01-23 2023-08-14 Not clear
Jingxin Chen, Wanyao Ma, Jiangchuan Yu, Xi Wang, Hongling Qian, Ping Li, Haiqiong Ye, Yue Han, Zhengding Su, Meng Gao, Yongqi Huan. (-)-Epigallocatechin-3-gallate, a Polyphenol from Green Tea, Regulates the Liquid-Liquid Phase Separation of Alzheimer's-Related Protein Tau. Journal of agricultural and food chemistry. 2023-01-23. PMID:36688583. the microtubule-associated protein tau is involved in alzheimer's disease and other tauopathies. 2023-01-23 2023-08-14 Not clear
Laura Schnöder, Wenqiang Quan, Ye Yu, Inge Tomic, Qinghua Luo, Wenlin Hao, Guoping Peng, Dong Li, Klaus Fassbender, Yang Li. Deficiency of IKKβ in neurons ameliorates Alzheimer's disease pathology in APP- and tau-transgenic mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 37. issue 2. 2023-01-23. PMID:36688823. in alzheimer's disease (ad) brain, inflammatory activation regulates protein levels of amyloid-β-peptide (aβ) and phosphorylated tau (p-tau), as well as neurodegeneration; however, the regulatory mechanisms remain unclear. 2023-01-23 2023-08-14 mouse
Xingrong Peng, Rongcan Luo, Xiaoqian Ran, Yarong Guo, Yong-Gang Yao, Minghua Qi. Ganoapplins A and B with an unprecedented 6/6/6/5/6-fused pentacyclic skeleton from Ganoderma inhibit Tau pathology through activating autophagy. Bioorganic chemistry. vol 132. 2023-01-22. PMID:36682148. furthermore, their roles in activating autophagy were investigated and the cellular assays showed that 1 and 2 can inhibit tau pathology by inducing autophagy, suggesting their potential against alzheimer's disease (ad). 2023-01-22 2023-08-14 Not clear
Antoine Leuzy, Niklas Mattsson-Carlgren, Nicholas C Cullen, Erik Stomrud, Sebastian Palmqvist, Renaud La Joie, Leonardo Iaccarino, Henrik Zetterberg, Gil Rabinovici, Kaj Blennow, Shorena Janelidze, Oskar Hansso. Robustness of CSF Aβ42/40 and Aβ42/P-tau181 measured using fully automated immunoassays to detect AD-related outcomes. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-01-21. PMID:36681387. this study investigated the comparability of cerebrospinal fluid (csf) cutoffs for elecsys immunoassays for amyloid beta (aβ)42/aβ40 or aβ42/phosphorylated tau (p-tau)181 and the effects of measurement variability when predicting alzheimer's disease (ad)-related outcomes (i.e., aβ-positron emission tomography [pet] visual read and ad neuropathology). 2023-01-21 2023-08-14 Not clear
Viet Hoang Man, Xibing He, Jie Gao, Junmei Wan. Phosphorylation of Tau R2 Repeat Destabilizes Its Binding to Microtubules: A Molecular Dynamics Simulation Study. ACS chemical neuroscience. 2023-01-20. PMID:36669127. there are in total 85 potential phosphorylation sites in a full-length tau protein, and about half of them are abnormal as they occur in tau of alzheimer's disease (ad) brain only. 2023-01-20 2023-08-14 Not clear
Binal Kuber, Mitisha Fadnavis, Bappaditya Chatterje. Role of Angiotensin Receptor Blockers in the context of Alzheimer's Disease. Fundamental & clinical pharmacology. 2023-01-19. PMID:36654189. in pre-clinical studies of alzheimer's disease, it was recently found that inhibition of angiotensin-converting enzyme (ace) and blocking of the angiotensin ii receptors reduce symptoms of neurodegeneration, aβ plaque development, and tau hyperphosphorylation. 2023-01-19 2023-08-14 Not clear
Amira Ben Hassine, Noureddine Raouafi, Felismina T C Moreir. Novel biomimetic Prussian blue nanocubes-based biosensor for Tau-441 protein detection. Journal of pharmaceutical and biomedical analysis. vol 226. 2023-01-19. PMID:36657353. tau protein is a promising biomarker for early diagnosis of alzheimer's disease. 2023-01-19 2023-08-14 cattle
Georgina Perez-Garcia, Mesude Bicak, Jean-Vianney Haure-Mirande, Gissel M Perez, Alena Otero-Pagan, Miguel A Gama Sosa, Rita De Gasperi, Mary Sano, Carrolee Barlow, Fred H Gage, Benjamin Readhead, Michelle E Ehrlich, Sam Gandy, Gregory A Elde. BCI-838, an orally active mGluR2/3 receptor antagonist pro-drug, rescues learning behavior deficits in the PS19 MAPT Neuroscience letters. 2023-01-19. PMID:36657633. bci-838, an orally active mglur2/3 receptor antagonist pro-drug, rescues learning behavior deficits in the ps19 mapt tauopathies are a heterogeneous group of neurodegenerative disorders that are clinically and pathologically distinct from alzheimer's disease (ad) having tau inclusions in neurons and/or glia as their most prominent neuropathological feature. 2023-01-19 2023-08-14 Not clear
Han Kyu Na, Han-Kyeol Kim, Hye Sun Lee, Mina Park, Jae Hoon Lee, Young Hoon Ryu, Hanna Cho, Chul Hyoung Lyo. Role of Enlarged Perivascular Space in the Temporal Lobe in Cerebral Amyloidosis. Annals of neurology. 2023-01-18. PMID:36651566. although growing evidence suggests that perivascular space (pvs) serves as a clearance route for amyloid and tau, the association between enlarged pvs (epvs) and alzheimer's disease are highly inconsistent across studies. 2023-01-18 2023-08-14 Not clear
Anish Kapadia, Krish Billimoria, Prarthna Desai, James T Grist, Chris Heyn, Pejman Maralani, Sean Symons, Fulvio Zaccagn. Hypoperfusion Precedes Tau Deposition in the Entorhinal Cortex: A Retrospective Evaluation of ADNI-2 Data. Journal of clinical neurology (Seoul, Korea). 2023-01-17. PMID:36647226. tau deposition in the entorhinal cortex is the earliest pathological feature of alzheimer's disease (ad). 2023-01-17 2023-08-14 Not clear
Mingxi Dang, Qian Chen, Xiaobin Zhao, Kewei Chen, Xin Li, Junying Zhang, Jie Lu, Lin Ai, Yaojing Chen, Zhanjun Zhan. Tau as a biomarker of cognitive impairment and neuropsychiatric symptom in Alzheimer's disease. Human brain mapping. vol 44. issue 2. 2023-01-17. PMID:36647262. tau as a biomarker of cognitive impairment and neuropsychiatric symptom in alzheimer's disease. 2023-01-17 2023-08-14 Not clear
Javaria Baig, Jangampalli Adi Pradeepkiran, P Hemachandra Redd. Methods to Study Mitochondria: Techniques Used to Study the Effects of Age-Related Diseases Including Alzheimer's. Current protocols. vol 3. issue 1. 2023-01-17. PMID:36648280. most of these techniques have been performed in vitro (in human and mouse neuronal cell lines transfected with mutant amyloid precursor protein or tau protein cdnas) and in vivo (in brain tissues from different mouse models of alzheimer's and other neurological diseases). 2023-01-17 2023-08-14 mouse
Z Qiu, H Zhang, M Xia, J Gu, K Guo, H Wang, C Mia. Programmed Death of Microglia in Alzheimer's Disease: Autophagy, Ferroptosis, and Pyroptosis. The journal of prevention of Alzheimer's disease. vol 10. issue 1. 2023-01-15. PMID:36641613. alzheimer's disease (ad) is a neurodegenerative disorder characterized by progressive cognitive decline, amyloid-β (aβ) plaques and the formation of neurofibrillary tangles (nfts) composed of hyperphosphorylated tau. 2023-01-15 2023-08-14 Not clear
Mingming Yang, Rongrong Qi, Yuxiao Liu, Xin Shen, Yulou Zhao, Nana Jin, Ruozhen Wu, Fei Liu, Jianlan G. Casein Kinase 1δ Phosphorylates TDP-43 and Suppresses Its Function in Tau mRNA Processing. Journal of Alzheimer's disease : JAD. 2023-01-15. PMID:36641675. neurofibrillary tangles aggregated from anomalous hyperphosphorylated tau is a hallmark of alzheimer's disease (ad). 2023-01-15 2023-08-14 Not clear
Susan Barendrecht, An Schreurs, Stefanie Geissler, Victor Sabanov, Victoria Ilse, Vera Rieckmann, Rico Eichentopf, Anja Künemund, Benjamin Hietel, Sebastian Wussow, Katrin Hoffmann, Kerstin Körber-Ferl, Ravi Pandey, Gregory W Carter, Hans-Ulrich Demuth, Max Holzer, Steffen Roßner, Stephan Schilling, Christoph Preuss, Detlef Balschun, Holger Cyni. A novel human tau knock-in mouse model reveals interaction of Abeta and human tau under progressing cerebral amyloidosis in 5xFAD mice. Alzheimer's research & therapy. vol 15. issue 1. 2023-01-14. PMID:36641439. hyperphosphorylation and intraneuronal aggregation of the microtubule-associated protein tau is a major pathological hallmark of alzheimer's disease (ad) brain. 2023-01-14 2023-08-14 mouse