| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dorothea Böken, Dezerae Cox, Melanie Burke, Jeff Y L Lam, Taxiarchis Katsinelos, John S Danial, Emre Fertan, William A McEwan, James B Rowe, David Klenerma. Single-Molecule Characterization and Super-Resolution Imaging of Alzheimer's Disease-Relevant Tau Aggregates in Human Samples. Angewandte Chemie (International ed. in English). 2024-03-24. PMID:38523073. |
hyperphosphorylation and aggregation of the protein tau play key roles in the development of alzheimer's disease (ad). |
2024-03-24 |
2024-03-27 |
human |
| Tohidul Islam, Hlin Kvartsberg, Anuradha Sehrawat, Przemysław R Kac, Bruno Becker, Maria Olsson, Eric E Abrahamson, Henrik Zetterberg, Milos D Ikonomovic, Kaj Blennow, Thomas K Karikar. Novel ultrasensitive immunoassay for the selective quantification of tau oligomers and related soluble aggregates. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-03-23. PMID:38520322. |
tau aggregation into paired helical filaments and neurofibrillary tangles is characteristic of alzheimer's disease (ad) and related disorders. |
2024-03-23 |
2024-03-26 |
Not clear |
| Takuya Oshima, Mandy S J Kater, Christiaan F M Huffels, Evelyn M Wesseling, Jinte Middeldorp, Elly M Hol, Mark H G Verheijen, August B Smit, Erik W G M Boddeke, Bart J L Egge. Early amyloid-induced changes in microglia gene expression in male APP/PS1 mice. Journal of neuroscience research. vol 102. issue 3. 2024-03-22. PMID:38515329. |
alzheimer's disease (ad) is a progressive neurodegenerative disease and the most common cause of dementia, characterized by deposition of extracellular amyloid-beta (aβ) aggregates and intraneuronal hyperphosphorylated tau. |
2024-03-22 |
2024-03-24 |
mouse |
| Jingji Wang, Yilan Zhen, Jun Yang, Shaojie Yang, Guoqi Zh. Recognizing Alzheimer's disease from perspective of oligodendrocytes: Phenomena or pathogenesis? CNS neuroscience & therapeutics. vol 30. issue 3. 2024-03-22. PMID:38516808. |
accumulation of amyloid beta, tau hyperphosphorylation, and microglia activation are the three highly acknowledged pathological factors of alzheimer's disease (ad). |
2024-03-22 |
2024-03-24 |
Not clear |
| Jiaxin Yue, Yonggang Sh. Uncovering Heterogeneity in Alzheimer's Disease from Graphical Modeling of the Tau Spatiotemporal Topography. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. vol 14224. 2024-03-21. PMID:38510994. |
uncovering heterogeneity in alzheimer's disease from graphical modeling of the tau spatiotemporal topography. |
2024-03-21 |
2024-03-23 |
human |
| Jiaxin Yue, Yonggang Sh. Uncovering Heterogeneity in Alzheimer's Disease from Graphical Modeling of the Tau Spatiotemporal Topography. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. vol 14224. 2024-03-21. PMID:38510994. |
growing evidence from post-mortem and in vivo studies have demonstrated the substantial variability of tau pathology spreading patterns in alzheimer's disease(ad). |
2024-03-21 |
2024-03-23 |
human |
| Tabassum Khair Barbhuiya, Dulari K Jayarathna, Raechelle Gilmour, Caroline Smet-Nocca, Neha S Gandh. Characterization of Posttranslationally Modified PHF-1 Tau Peptides Using Gaussian Accelerated Molecular Dynamics Simulation. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512658. |
the microtubule-associated protein, tau, is an intrinsically disordered protein that plays a crucial role in neurodegenerative diseases like alzheimer's disease. |
2024-03-21 |
2024-03-24 |
Not clear |
| David Horsley, Janet E Rickard, Thomas Vorley, Matilda F Leeper, Claude M Wischik, Charles R Harringto. Assays for the Screening and Characterization of Tau Aggregation Inhibitors. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512662. |
aggregation of tau protein is a pathological hallmark of alzheimer's disease and other neurodegenerative tauopathies. |
2024-03-21 |
2024-03-24 |
Not clear |
| Subashchandrabose Chinnathambi, Tushar Dube. Photo-Excited Dyes: Emerging Technique Against Tau Protein Aggregation. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512663. |
tau aggregates are considered a pathological hallmark of alzheimer's disease. |
2024-03-21 |
2024-03-24 |
Not clear |
| Subashchandrabose Chinnathambi, Tushar Dube. Photo-Excited Dyes: Emerging Technique Against Tau Protein Aggregation. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512663. |
the screening of molecules against tau aggregation is a novel strategy for alzheimer's disease. |
2024-03-21 |
2024-03-24 |
Not clear |
| Subashchandrabose Chinnathambi, Tushar Dube. Photo-Excited Dyes: Emerging Technique Against Tau Protein Aggregation. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512663. |
in recent studies, the photo-excited dyes showed an inhibitory effect on alzheimer's disease-related tau protein aggregation and toxicity. |
2024-03-21 |
2024-03-24 |
Not clear |
| Hariharakrishnan Chidambaram, Smita Eknath Desale, Subashchandrabose Chinnathamb. Interaction of Tau with G-Protein-Coupled Purinergic P2Y12 Receptor by Molecular Docking and Molecular Dynamic Simulation. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512659. |
alzheimer's disease, a progressive neurological disorder, is characterized by the accumulation of neurofibrillary tangles and senile plaques by tau and amyloid-β, respectively, in the brain microenvironment. |
2024-03-21 |
2024-03-24 |
Not clear |
| Yanxian Li. Preparation of Tau Condensates by Liquid-Liquid Phase Separation to Study Tau Amyloid Aggregation. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512667. |
amyloid aggregation of tau is a hallmark of alzheimer's disease and other neurodegenerative diseases. |
2024-03-21 |
2024-03-24 |
Not clear |
| Léa El Hajjar, Clarisse Bridot, Marine Nguyen, François-Xavier Cantrelle, Isabelle Landrieu, Caroline Smet-Nocc. The O-GlcNAc Modification of Recombinant Tau Protein and Characterization of the O-GlcNAc Pattern for Functional Study. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512671. |
in neurodegenerative disorders referred to as tauopathies including alzheimer's disease, tau is abnormally hyperphosphorylated and forms fibrillar inclusions in neurons progressing throughout different brain area during the course of the disease. |
2024-03-21 |
2024-03-24 |
mouse |
| Smita Eknath Desale, Hariharakrishnan Chidambaram, Subashchandrabose Chinnathamb. Biochemical and Biophysical Characterization of Tau and α-Linolenic Acid Vesicles In Vitro. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512668. |
alzheimer's disease (ad) is characterized by the abnormal accumulation of disordered protein, that is, extracellular senile plaques of amyloid-β (aβ) and intracellular neurofibrillary tangles of tau. |
2024-03-21 |
2024-03-24 |
Not clear |
| Parissa Fereydouni-Forouzandeh, Geoffrey Canet, Sofia Diego-Diàz, Emma Rocaboy, Serena Petry, Robert A Whittington, Emmanuel Plane. Western Blot of Tau Protein from Mouse Brains Extracts: How to Avoid Signal Artifacts. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512673. |
in alzheimer's disease and other neurodegenerative diseases known as tauopathies, tau undergoes several abnormal post-translational modifications including hyperphosphorylation, conformational changes, oligomerization, and aggregation. |
2024-03-21 |
2024-03-24 |
mouse |
| Christopher A Ayoub, Khadijah I Moore, Jeff Kure. Quantification of Methylation and Phosphorylation Stoichiometry. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512670. |
tauopathies including alzheimer's disease (ad) are neurodegenerative disorders accompanied by the conversion of functional forms of the microtubule associated protein tau into non-functional aggregates. |
2024-03-21 |
2024-03-24 |
Not clear |
| Geoffrey Canet, Emma Rocaboy, Sofia Diego-Diàz, Robert A Whittington, Carl Julien, Emmanuel Plane. Methods for Biochemical Isolation of Insoluble Tau in Rodent Models of Tauopathies. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512674. |
the intracellular accumulation of microtubule-associated protein tau is a characteristic feature of tauopathies, a group of neurodegenerative diseases including alzheimer's disease. |
2024-03-21 |
2024-03-24 |
mouse |
| Kristen E Fun. Measuring Antibody-Mediated Tau Fibril Uptake in Microglia by Flow Cytometry. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512680. |
microtubule-associated protein tau is an intracellular protein that self-aggregates into neurofibrillary tangles in alzheimer's disease and many other neurodegenerative diseases. |
2024-03-21 |
2024-03-24 |
Not clear |
| Katharina Schindowsk. Differential Regulation of Neurotrophic Factors During Pathogenic Tau-Aggregation in a Tau Transgenic Mouse Model for Alzheimer's Disease: A Protocol for Double-Labeling mRNA by In Situ Hybridization and Protein Epitopes by Immunohistochemistry. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512677. |
differential regulation of neurotrophic factors during pathogenic tau-aggregation in a tau transgenic mouse model for alzheimer's disease: a protocol for double-labeling mrna by in situ hybridization and protein epitopes by immunohistochemistry. |
2024-03-21 |
2024-03-24 |
mouse |