| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiyoen Kim, Maria de Haro, Ismael Al-Ramahi, Lorena Laura Garaicoechea, Hyun-Hwan Jeong, Jun Young Sonn, Bakhos Tadros, Zhandong Liu, Juan Botas, Huda Yahya Zoghb. Evolutionarily conserved regulators of tau identify targets for new therapies. Neuron. 2023-01-07. PMID:36610398. |
tauopathies are neurodegenerative diseases that involve the pathological accumulation of tau proteins; in this family are alzheimer disease, corticobasal degeneration, and chronic traumatic encephalopathy, among others. |
2023-01-07 |
2023-08-14 |
mouse |
| Jiyoen Kim, Maria de Haro, Ismael Al-Ramahi, Lorena Laura Garaicoechea, Hyun-Hwan Jeong, Jun Young Sonn, Bakhos Tadros, Zhandong Liu, Juan Botas, Huda Yahya Zoghb. Evolutionarily conserved regulators of tau identify targets for new therapies. Neuron. 2023-01-07. PMID:36610398. |
this study thus identifies several points of intervention to reduce tau levels and demonstrates that reduction of tau levels via regulation of this pathway is a viable therapeutic strategy for alzheimer disease and other tauopathies. |
2023-01-07 |
2023-08-14 |
mouse |
| Wang Liao, Haoyu Luo, Yuting Ruan, Yingren Mai, Chongxu Liu, Jiawei Chen, Shaoqing Yang, Aiguo Xuan, Jun Li. Identification of candidate genes associated with clinical onset of Alzheimer's disease. Frontiers in neuroscience. vol 16. 2023-01-06. PMID:36605552. |
alzheimer's disease (ad) is the most common type of dementia, with its pathology like beta-amyloid and phosphorylated tau beginning several years before the clinical onset. |
2023-01-06 |
2023-08-14 |
Not clear |
| Elizabeth Ochoa, Paulino Ramirez, Elias Gonzalez, Jasmine De Mange, William J Ray, Kevin F Bieniek, Bess Fros. Pathogenic tau-induced transposable element-derived dsRNA drives neuroinflammation. Science advances. vol 9. issue 1. 2023-01-06. PMID:36608133. |
deposition of tau protein aggregates in the brain of affected individuals is a defining feature of "tauopathies," including alzheimer's disease. |
2023-01-06 |
2023-08-14 |
mouse |
| Elizabeth Ochoa, Paulino Ramirez, Elias Gonzalez, Jasmine De Mange, William J Ray, Kevin F Bieniek, Bess Fros. Pathogenic tau-induced transposable element-derived dsRNA drives neuroinflammation. Science advances. vol 9. issue 1. 2023-01-06. PMID:36608133. |
we find that dsrna and dsrna sensing machinery are elevated in astrocytes of postmortem brain tissue from patients with alzheimer's disease and progressive supranuclear palsy and in brains of tau transgenic mice. |
2023-01-06 |
2023-08-14 |
mouse |
| John R Dickson, Matthew P Frosch, Bradley T Hyma. Altered localization of nucleoporin 98 in primary tauopathies. Brain communications. vol 5. issue 1. 2023-01-05. PMID:36601621. |
nucleoporin 98 is a nuclear pore complex component that is mislocalized in alzheimer's disease and the alteration in nucleoporin 98 has been attributed to tau. |
2023-01-05 |
2023-08-14 |
Not clear |
| John R Dickson, Matthew P Frosch, Bradley T Hyma. Altered localization of nucleoporin 98 in primary tauopathies. Brain communications. vol 5. issue 1. 2023-01-05. PMID:36601621. |
in the context of prior research demonstrating nucleoporin 98 mislocalization in alzheimer's disease and an interaction between tau and nucleoporin 98, these results further support the hypothesis that pathological tau may contribute to nucleoporin 98 mislocalization. |
2023-01-05 |
2023-08-14 |
Not clear |
| Thamires Naela Cardoso Magalhães, Raphael Fernandes Casseb, Christian Luiz Baptista Gerbelli, Luciana Ramalho Pimentel-Siva, Mateus Henrique Nogueira, Camila Vieira Ligo Teixeira, Ana Flávia Mac Knight Carletti, Thiago Junqueira Ribeiro de Rezende, Helena Passarelli Giroud Joaquim, Leda Leme Talib, Orestes Vicente Forlenza, Fernando Cendes, Marcio Luiz Figueredo Balthaza. Whole-brain DTI parameters associated with tau protein and hippocampal volume in Alzheimer's disease. Brain and behavior. 2023-01-05. PMID:36601694. |
whole-brain dti parameters associated with tau protein and hippocampal volume in alzheimer's disease. |
2023-01-05 |
2023-08-14 |
Not clear |
| Mervat Hassan, Hisham Ismail, Olfat Hammam, Abdullrahman Elsayed, Othman Othman, Sohair Al. Natural inhibitors for acetylcholinesterase and autophagy modulators as effective antagonists for tau and β-amyloid in Alzheimer's rat model. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2023-01-03. PMID:36594248. |
natural inhibitors for acetylcholinesterase and autophagy modulators as effective antagonists for tau and β-amyloid in alzheimer's rat model. |
2023-01-03 |
2023-08-14 |
rat |
| Yu Zou, Lulu Guan, Jingwang Tan, Bote Qi, Ying Wang, Qingwen Zhang, Yunxiang Su. Atomistic Insights into the Inhibitory Mechanism of Tyrosine Phosphorylation against the Aggregation of Human Tau Fragment PHF6. The journal of physical chemistry. B. 2023-01-03. PMID:36594671. |
abnormal aggregation of the microtubule-associated protein tau into intracellular fibrillary inclusions is characterized as the hallmark of tauopathies, including alzheimer's disease and chronic traumatic encephalopathy. |
2023-01-03 |
2023-08-14 |
human |
| b' \\xc5\\x9eenay G\\xc3\\xb6r\\xc3\\xbcc\\xc3\\xbc Y\\xc4\\xb1lmaz, Salam Almasri, Yasemin Yuyucu Karabulut, Murat Korkmaz, \\xc3\\x96znur Bucak, Sibel O\\xc4\\x9fuzkan Balc\\xc4\\xb. Okadaic Acid-Induced Alzheimer\'s in Rat Brain: Phytochemical Cucurbitacin E Contributes to Memory Gain by Reducing TAU Protein Accumulation. Omics : a journal of integrative biology. 2023-01-03. PMID:36594931.' |
okadaic acid-induced alzheimer's in rat brain: phytochemical cucurbitacin e contributes to memory gain by reducing tau protein accumulation. |
2023-01-03 |
2023-08-14 |
rat |
| b' \\xc5\\x9eenay G\\xc3\\xb6r\\xc3\\xbcc\\xc3\\xbc Y\\xc4\\xb1lmaz, Salam Almasri, Yasemin Yuyucu Karabulut, Murat Korkmaz, \\xc3\\x96znur Bucak, Sibel O\\xc4\\x9fuzkan Balc\\xc4\\xb. Okadaic Acid-Induced Alzheimer\'s in Rat Brain: Phytochemical Cucurbitacin E Contributes to Memory Gain by Reducing TAU Protein Accumulation. Omics : a journal of integrative biology. 2023-01-03. PMID:36594931.' |
alzheimer's disease (ad) is a neurodegenerative disease characterized by progressive memory loss and cognitive decline, with hallmark pathologies related to amyloid beta (aβ) and tau. |
2023-01-03 |
2023-08-14 |
rat |
| Allegra Kawles, Grace Minogue, Antonia Zouridakis, Rachel Keszycki, Nathan Gill, Caren Nassif, Christina Coventry, Hui Zhang, Emily Rogalski, Margaret E Flanagan, Rudolph Castellani, Eileen H Bigio, M Marsel Mesulam, Changiz Geula, Tamar Gefe. Differential vulnerability of the dentate gyrus to tauopathies in dementias. Acta neuropathologica communications. vol 11. issue 1. 2023-01-03. PMID:36597124. |
the dentate gyrus (dg), a key hippocampal subregion in memory processing, generally resists phosphorylated tau accumulation in the amnestic dementia of the alzheimer's type due to alzheimer's disease (dat-ad), but less is known about the susceptibility of the dg to other tauopathies. |
2023-01-03 |
2023-08-14 |
human |
| Christina B Young, Emily Johns, Gabriel Kennedy, Michael E Belloy, Philip S Insel, Michael D Greicius, Reisa A Sperling, Keith A Johnson, Kathleen L Poston, Elizabeth C Mormin. APOE effects on regional tau in preclinical Alzheimer's disease. Molecular neurodegeneration. vol 18. issue 1. 2023-01-03. PMID:36597122. |
apoe effects on regional tau in preclinical alzheimer's disease. |
2023-01-03 |
2023-08-14 |
human |
| Ya-Nan Lv, Yu Cui, Bo Zhang, Shu-Ming Huan. Sleep deficiency promotes Alzheimer's disease development and progression. Frontiers in neurology. vol 13. 2023-01-02. PMID:36588906. |
sleep deficiency was found to be associated with oxidative stress, β-amyloid protein deposition, tau hyperphosphorylation, and neuroinflammation, which are known to increase the risk for alzheimer's disease. |
2023-01-02 |
2023-08-14 |
Not clear |
| Ningtian Ma, Yuyang Liang, Lingyun Yue, Pu Liu, Yuxia Xu, Cuiqing Zh. The identities of insulin signaling pathway are affected by overexpression of Tau and its phosphorylation form. Frontiers in aging neuroscience. vol 14. 2023-01-02. PMID:36589543. |
hyperphosphorylated tau formed neurofibrillary tangles was one of the major neuropathological hallmarks of alzheimer's disease (ad). |
2023-01-02 |
2023-08-14 |
Not clear |
| Alexandra Milani, Markus Morawski, Ingo Bechman. Inter-hemispherical comparison of tau-pathology in the human temporal lobe. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. 2023-01-02. PMID:36592871. |
alzheimer's disease (ad) is characterized histopathologically by hyperphosphorylated and aggregated tau and amyloid plaques. |
2023-01-02 |
2023-08-14 |
human |
| Teresa H Evering, Jez L Marston, Li Gan, Douglas F Nixo. Transposable elements and Alzheimer's disease pathogenesis. Trends in neurosciences. 2023-01-01. PMID:36588011. |
alzheimer's disease (ad) is characterized by the pathological accumulation of amyloid β (aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated tau. |
2023-01-01 |
2023-08-14 |
Not clear |
| Deepti Putcha, Yuta Katsumi, Michael Brickhouse, Ryn Flaherty, David H Salat, Alexandra Touroutoglou, Bradford C Dickerso. Gray to white matter signal ratio as a novel biomarker of neurodegeneration in Alzheimer's disease. NeuroImage. Clinical. vol 37. 2022-12-31. PMID:36586361. |
alzheimer's disease (ad) is characterized neuropathologically by β-amyloid (aβ) plaques, hyperphosphorylated tau neurofibrillary tangles, and neurodegeneration, which lead to a phenotypically heterogeneous cognitive-behavioral dementia syndrome. |
2022-12-31 |
2023-08-14 |
Not clear |
| Jiasi Yu, Dan Wu, Yanan Zhao, Linli Guo, Ping Li. Study on multi-target effects of PIMPC on Aβ/Cu Brain research. 2022-12-31. PMID:36586663. |
study on multi-target effects of pimpc on aβ/cu glycogen synthase kinase-3 (gsk-3), a key role in the pathogenesis of alzheimer's disease (ad), has been linked with the formation of β-amyloid (aβ), tubulin-associated unit (tau) protein phosphorylation and apoptosis. |
2022-12-31 |
2023-08-14 |
Not clear |