| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Frederique J Hart de Ruyter, Tjado H J Morrema, Jurre den Haan, Jos W R Twisk, Johannes F de Boer, Philip Scheltens, Baayla D C Boon, Dietmar R Thal, Annemieke J Rozemuller, Frank D Verbraak, Femke H Bouwman, Jeroen J M Hoozeman. Correction to: Phosphorylated tau in the retina correlates with tau pathology in the brain in Alzheimer's disease and primary tauopathies. Acta neuropathologica. 2022-12-23. PMID:36562817. |
correction to: phosphorylated tau in the retina correlates with tau pathology in the brain in alzheimer's disease and primary tauopathies. |
2022-12-23 |
2023-08-14 |
Not clear |
| Preetpal Kaur, Alisha Khera, Hema K Alajangi, Akanksha Sharma, Pradeep K Jaiswal, Gurpal Singh, Ravi P Barnwa. Role of Tau in Various Tauopathies, Treatment Approaches, and Emerging Role of Nanotechnology in Neurodegenerative Disorders. Molecular neurobiology. 2022-12-23. PMID:36562884. |
aberrant tau phosphorylation causes tau to dissociate from the microtubules and clump together in the cytosol to form neurofibrillary tangles (nfts), which lead to the progression of neurodegenerative disorders including alzheimer's disease (ad) and other tauopathies. |
2022-12-23 |
2023-08-14 |
Not clear |
| Xibing He, Viet Hoang Man, Jie Gao, Junmei Wan. Investigation of the Structure of Full-Length Tau Proteins with Coarse-Grained and All-Atom Molecular Dynamics Simulations. ACS chemical neuroscience. 2022-12-23. PMID:36563129. |
tau proteins not only have many important biological functions but also are associated with several neurodegenerative diseases, such as parkinson's disease and alzheimer's disease (ad). |
2022-12-23 |
2023-08-14 |
Not clear |
| Andreia Ferreira, Ines Royaux, Jian Liu, Zhangjie Wang, Guowei Su, Diederik Moechars, Nico Callewaert, Louis De Muync. The 3-O sulfation of heparan sulfate proteoglycans contributes to the cellular internalization of tau aggregates. BMC molecular and cell biology. vol 23. issue 1. 2022-12-23. PMID:36564747. |
considering the high correlation between the functional decline in alzheimer's disease (ad) and the propagation of aggregated tau protein, many research efforts are focused on determining the underlying molecular mechanisms of tau spreading. |
2022-12-23 |
2023-08-14 |
Not clear |
| Liliana Diaz-Gomez, Andres E Gutierrez-Rodriguez, Alejandra Martinez-Maldonado, Jose Luna-Muñoz, Jose A Cantoral-Ceballos, Miguel A Ontiveros-Torre. Interpretable Classification of Tauopathies with a Convolutional Neural Network Pipeline Using Transfer Learning and Validation against Post-Mortem Clinical Cases of Alzheimer's Disease and Progressive Supranuclear Palsy. Current issues in molecular biology. vol 44. issue 12. 2022-12-22. PMID:36547067. |
we propose a convolutional neural network pipeline for the classification of tau pathology of alzheimer's disease and progressive supranuclear palsy by analyzing post-mortem immunofluorescence images with different tau biomarkers performed with models generated with the architecture resnet-ift using transfer learning. |
2022-12-22 |
2023-08-14 |
Not clear |
| Liliana Diaz-Gomez, Andres E Gutierrez-Rodriguez, Alejandra Martinez-Maldonado, Jose Luna-Muñoz, Jose A Cantoral-Ceballos, Miguel A Ontiveros-Torre. Interpretable Classification of Tauopathies with a Convolutional Neural Network Pipeline Using Transfer Learning and Validation against Post-Mortem Clinical Cases of Alzheimer's Disease and Progressive Supranuclear Palsy. Current issues in molecular biology. vol 44. issue 12. 2022-12-22. PMID:36547067. |
we demonstrated that our design was able to classify diseases with an accuracy of 98.41% on average whilst providing an interpretation concerning the proper classification involving different structural patterns in the immunoreactivity of the tau protein in nfts present in the brains of patients with progressive supranuclear palsy and alzheimer's disease. |
2022-12-22 |
2023-08-14 |
Not clear |
| Guanying You, Jinyi Yao, Qiong Liu, Nan L. The Strategies for Treating "Alzheimer's Disease": Insulin Signaling May Be a Feasible Target. Current issues in molecular biology. vol 44. issue 12. 2022-12-22. PMID:36547082. |
alzheimer's disease (ad) is a neurodegenerative disorder characterized by senile plaques formed by amyloid-beta (aβ) extracellularly and neurofibrillary tangles (nfts) formed by hyperphosphorylated tau protein intracellularly. |
2022-12-22 |
2023-08-14 |
Not clear |
| Catalina Novoa, Paulina Salazar, Pedro Cisternas, Camila Gherardelli, Roberto Vera-Salazar, Juan M Zolezzi, Nibaldo C Inestros. Inflammation context in Alzheimer's disease, a relationship intricate to define. Biological research. vol 55. issue 1. 2022-12-22. PMID:36550479. |
alzheimer's disease (ad), the most common form of dementia, is characterized by the accumulation of amyloid β (aβ) and hyperphosphorylated tau protein aggregates. |
2022-12-22 |
2023-08-14 |
Not clear |
| Joel Simrén, Wagner S Brum, Nicholas J Ashton, Andrea L Benedet, Thomas K Karikari, Hlin Kvartsberg, Emma Sjons, Firoza Z Lussier, Mira Chamoun, Jenna Stevenson, Robert Hopewell, Vanessa Pallen, Keqiang Ye, Tharick A Pascoal, Henrik Zetterberg, Pedro Rosa-Neto, Kaj Blenno. CSF tau368/total-tau ratio reflects cognitive performance and neocortical tau better compared to p-tau181 and p-tau217 in cognitively impaired individuals. Alzheimer's research & therapy. vol 14. issue 1. 2022-12-21. PMID:36544221. |
cerebrospinal fluid (csf) tau biomarkers are reliable diagnostic markers for alzheimer's disease (ad). |
2022-12-21 |
2023-08-14 |
Not clear |
| Qianyun Chen, Jill Abrigo, Min Deng, Lin Shi, Yi-Xiang Wang, Winnie Chiu Wing Ch. Diffusion Changes in Hippocampal Cingulum in Early Biologically Defined Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2022-12-19. PMID:36530082. |
diagnosis of alzheimer's disease (ad) was recently shifted from clinical to biological construct to reflect underlying neuropathological status, where amyloid deposition designated patients to the ad continuum, and additional tau positivity represented ad. |
2022-12-19 |
2023-08-14 |
Not clear |
| Xin Wang, Iris Broce, Kacie D Deters, Chun Chieh Fan, Sarah Jane Bank. Identification of Sex-Specific Genetic Variants Associated With Tau PET. Neurology. Genetics. vol 8. issue 6. 2022-12-19. PMID:36530928. |
important sex differences exist in tau pathology along the alzheimer disease (ad) continuum, with women showing enhanced tau deposition compared with men, especially during the mild cognitive impairment (mci) phase. |
2022-12-19 |
2023-08-14 |
Not clear |
| Itzhak Fische. Evolutionary perspective of Big tau structure: 4a exon variants of MAPT. Frontiers in molecular neuroscience. vol 15. 2022-12-19. PMID:36533137. |
tau plays important roles in modulating microtubule dynamics, axonal transport, synaptic plasticity, and dna repair, and has also been associated with neurodegenerative diseases (tauopathies) including alzheimer's disease and frontotemporal dementia. |
2022-12-19 |
2023-08-14 |
human |
| Justin Ralph Welden, Giorgi Margvelani, Karol Andrea Arizaca Maquera, Bhavani Gudlavalleti, Sandra C Miranda Sardón, Alexandre Rosa Campos, Noémie Robil, Daniel C Lee, Alvaro G Hernandez, Wang-Xia Wang, Jing Di, Pierre de la Grange, Peter T Nelson, Stefan Stam. RNA editing of microtubule-associated protein tau circular RNAs promotes their translation and tau tangle formation. Nucleic acids research. 2022-12-19. PMID:36533443. |
aggregation of the microtubule-associated protein tau characterizes tauopathies, including alzheimer's disease and frontotemporal lobar degeneration (ftld-tau). |
2022-12-19 |
2023-08-14 |
human |
| Tyler Reed Bell, Jeremy A Elman, Asad Beck, Christine Fennema-Notestine, Daniel E Gustavson, Donald J Hagler, Amy J Jack, Michael J Lyons, Olivia K Puckett, Rosemary Toomey, Carol E Franz, William S Kreme. Rostral-middle locus coeruleus integrity and subjective cognitive decline in early old age. Journal of the International Neuropsychological Society : JINS. 2022-12-16. PMID:36524301. |
abnormal tau, a hallmark alzheimer's disease (ad) pathology, may appear in the locus coeruleus (lc) decades before ad symptom onset. |
2022-12-16 |
2023-08-14 |
Not clear |
| Hongtao Shen, Tianzhen Zhang, Yao Ji, Yu Zhang, Yongxiang Wang, Yuling Jiang, Xiongjin Chen, Qiuhao Liang, Kefeng Wu, Yunfeng Li, Xingyu Lu, Lili Cui, Bin Zhao, Yan Wan. GRK5 Deficiency in the Hippocampus Leads to Cognitive Impairment via Abnormal Microglial Alterations. Molecular neurobiology. 2022-12-16. PMID:36525154. |
here, we reported that mice with reduced grk5 in the hippocampus exhibit cognitive impairment and some alzheimer's disease (ad)-related molecular pathologies, such as significant neuronal damage and loss, enhanced tau protein phosphorylation, and increased levels of aβ peptides in the hippocampus. |
2022-12-16 |
2023-08-14 |
mouse |
| Thomas F Tropea, Teresa Waligorska, Sharon X Xie, Ilya M Nasrallah, Katheryn A Q Cousins, John Q Trojanowski, Murray Grossman, David J Irwin, Daniel Weintraub, Edward B Lee, David A Wolk, Alice S Chen-Plotkin, Leslie M Sha. Plasma phosphorylated tau181 predicts cognitive and functional decline. Annals of clinical and translational neurology. 2022-12-15. PMID:36518085. |
to determine if plasma tau phosphorylated at threonine 181 (p-tau181) distinguishes pathology-confirmed alzheimer's disease (ad) from normal cognition (nc) adults, to test if p-tau181 predicts cognitive and functional decline, and to validate findings in an external cohort. |
2022-12-15 |
2023-08-14 |
Not clear |
| Sung-Hyun Kim, Key-Hwan Lim, Sumin Yang, Jae-Yeol Jo. Boosting of tau protein aggregation by CD40 and CD48 gene expression in Alzheimer's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 37. issue 1. 2022-12-15. PMID:36520044. |
boosting of tau protein aggregation by cd40 and cd48 gene expression in alzheimer's disease. |
2022-12-15 |
2023-08-14 |
mouse |
| Laurel A Becket. Alzheimer's-related brain damage shows sex-specific links with risk factors. PLoS biology. vol 20. issue 12. 2022-12-14. PMID:36516115. |
alzheimer's disease is marked by brain damage from tau and amyloid aggregates, particularly to the hippocampus and the default network. |
2022-12-14 |
2023-08-14 |
Not clear |
| Masanori Kurihara, Hiroki Komatsu, Renpei Sengoku, Mari Shibukawa, Satoru Morimoto, Tomoyasu Matsubara, Akira Arakawa, Makoto Orita, Kenji Ishibashi, Akihiko Mitsutake, Shota Shibata, Hiroyuki Ishiura, Kaori Adachi, Kensuke Ohse, Keiko Hatano, Ryoko Ihara, Mana Higashihara, Yasushi Nishina, Aya Midori Tokumaru, Kenji Ishii, Yuko Saito, Shigeo Murayama, Kazutomi Kanemaru, Atsushi Iwat. CSF P-Tau181 and Other Biomarkers in Patients With Neuronal Intranuclear Inclusion Disease. Neurology. 2022-12-14. PMID:36517236. |
csf tau phosphorylated at threonine 181 (p-tau181) is a widely used biomarker for alzheimer's disease (ad) and has recently been regarded to reflect amyloid-beta and/or p-tau deposition in the ad brain. |
2022-12-14 |
2023-08-14 |
Not clear |
| Chloé Savignac, Sylvia Villeneuve, AmanPreet Badhwar, Karin Saltoun, Kimia Shafighi, Chris Zajner, Vaibhav Sharma, Sarah A Gagliano Taliun, Sali Farhan, Judes Poirier, Danilo Bzdo. APOE alleles are associated with sex-specific structural differences in brain regions affected in Alzheimer's disease and related dementia. PLoS biology. vol 20. issue 12. 2022-12-13. PMID:36512526. |
alzheimer's disease is marked by intracellular tau aggregates in the medial temporal lobe (mtl) and extracellular amyloid aggregates in the default network (dn). |
2022-12-13 |
2023-08-14 |
human |