| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Makis Tzioras, Robert I McGeachan, Claire S Durrant, Tara L Spires-Jone. Synaptic degeneration in Alzheimer disease. Nature reviews. Neurology. 2022-12-13. PMID:36513730. |
alzheimer disease (ad) is characterized by progressive cognitive decline in older individuals accompanied by the presence of two pathological protein aggregates - amyloid-β and phosphorylated tau - in the brain. |
2022-12-13 |
2023-08-14 |
Not clear |
| Sara Kim, Seonggyun Han, Soo-Ah Cho, Kwangsik Nho, Insong Koh, Younghee Le. Brain Region-Dependent Alternative Splicing of Alzheimer Disease (AD)-Risk Genes Is Associated With Neuropathological Features in AD. International neurourology journal. vol 26. issue Suppl 2. 2022-12-12. PMID:36503215. |
alzheimer disease (ad) is one of the most complex diseases and is characterized by ad-related neuropathological features, including accumulation of amyloid-β plaques and tau neurofibrillary tangles. |
2022-12-12 |
2023-08-14 |
Not clear |
| Vani Jangra, Jeshnu Topl. Can Alzheimer's Disease Be Secondary to Type-2 Diabetes Mellitus? Cureus. vol 14. issue 11. 2022-12-12. PMID:36505102. |
thirdly, several pathological research has also shown that beta-amyloid plaques, hyperphosphorylated tau protein, and brain shrinkage, particularly in the hippocampus, are shared brain lesions between insulin and alzheimer's disease. in light of this, type 2 diabetes mellitus may be viewed as a liability for dementia and alzheimer's disease. |
2022-12-12 |
2023-08-14 |
human |
| Etienne Aumont, Cyntia Tremblay, Stéphanie Levert, David A Bennett, Frédéric Calon, Nicole Lecler. Evidence of Filamin A loss of solubility at the prodromal stage of neuropathologically-defined Alzheimer's disease. Frontiers in aging neuroscience. vol 14. 2022-12-12. PMID:36506473. |
alzheimer's disease (ad) is a multifactorial disorder diagnosed through the assessment of amyloid-beta (aβ) and tau protein depositions. |
2022-12-12 |
2023-08-14 |
Not clear |
| Joseph Therriault, Marie Vermeiren, Stijn Servaes, Cécile Tissot, Nicholas J Ashton, Andréa Lessa Benedet, Thomas K Karikari, Juan Lantero-Rodriguez, Wagner S Brum, Firoza Z Lussier, Gleb Bezgin, Jenna Stevenson, Nesrine Rahmouni, Peter Kunach, Yi-Ting Wang, Jaime Fernandez-Arias, Kely Quispialaya Socualaya, Arthur C Macedo, João Pedro Ferrari-Souza, Pâmela C L Ferreira, Bruna Bellaver, Douglas T Leffa, Eduardo R Zimmer, Paolo Vitali, Jean-Paul Soucy, Gallen Triana-Baltzer, Hartmuth C Kolb, Tharick A Pascoal, Paramita Saha-Chaudhuri, Serge Gauthier, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Net. Association of Phosphorylated Tau Biomarkers With Amyloid Positron Emission Tomography vs Tau Positron Emission Tomography. JAMA neurology. 2022-12-12. PMID:36508198. |
the recent proliferation of phosphorylated tau (p-tau) biomarkers has raised questions about their preferential association with the hallmark pathologies of alzheimer disease (ad): amyloid-β plaques and tau neurofibrillary tangles. |
2022-12-12 |
2023-08-14 |
Not clear |
| Wen Yang, Qing-Qing Xu, Qiuju Yuan, Yan-Fang Xian, Zhi-Xiu Li. Sulforaphene, a CDK5 Inhibitor, attenuates cognitive deficits in a transgenic mouse model of Alzheimer's disease via reducing Aβ Deposition, tau hyperphosphorylation and synaptic dysfunction. International immunopharmacology. vol 114. 2022-12-12. PMID:36508924. |
sulforaphene, a cdk5 inhibitor, attenuates cognitive deficits in a transgenic mouse model of alzheimer's disease via reducing aβ deposition, tau hyperphosphorylation and synaptic dysfunction. |
2022-12-12 |
2023-08-14 |
mouse |
| In Gyoung Ju, Su Young Son, Seungmin Lee, Hyeri Im, Eugene Huh, Hyeyoon Eo, Jin Gyu Choi, Mi Won Sohn, Sung-Vin Yim, Sun Yeou Kim, Dong-Hyun Kim, Choong Hwan Lee, Myung Sook O. Protective effects of CCL01 against Aβ-induced neurotoxicity in 5xFAD transgenic mouse model of Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 158. 2022-12-12. PMID:36508997. |
alzheimer's disease (ad) is the most common dementia characterized by the excessive accumulation of amyloid-beta (aβ) and tau aggregates, as well as neuronal damage and neuroinflammation. |
2022-12-12 |
2023-08-14 |
mouse |
| Johan Gobom, Andréa L Benedet, Niklas Mattsson-Carlgren, Laia Montoliu-Gaya, Nina Schultz, Nicholas J Ashton, Shorena Janelidze, Stijn Servaes, Mathias Sauer, Tharick A Pascoal, Thomas K Karikari, Juan Lantero-Rodriguez, Gunnar Brinkmalm, Henrik Zetterberg, Oskar Hansson, Pedro Rosa-Neto, Kaj Blenno. Antibody-free measurement of cerebrospinal fluid tau phosphorylation across the Alzheimer's disease continuum. Molecular neurodegeneration. vol 17. issue 1. 2022-12-12. PMID:36510321. |
antibody-free measurement of cerebrospinal fluid tau phosphorylation across the alzheimer's disease continuum. |
2022-12-12 |
2023-08-14 |
Not clear |
| Johan Gobom, Andréa L Benedet, Niklas Mattsson-Carlgren, Laia Montoliu-Gaya, Nina Schultz, Nicholas J Ashton, Shorena Janelidze, Stijn Servaes, Mathias Sauer, Tharick A Pascoal, Thomas K Karikari, Juan Lantero-Rodriguez, Gunnar Brinkmalm, Henrik Zetterberg, Oskar Hansson, Pedro Rosa-Neto, Kaj Blenno. Antibody-free measurement of cerebrospinal fluid tau phosphorylation across the Alzheimer's disease continuum. Molecular neurodegeneration. vol 17. issue 1. 2022-12-12. PMID:36510321. |
alzheimer's disease is characterized by an abnormal increase of phosphorylated tau (ptau) species in the csf. |
2022-12-12 |
2023-08-14 |
Not clear |
| Kseniya B Varshavskaya, Vladimir A Mitkevich, Alexander A Makarov, Evgeny P Baryki. Synthetic, Cell-Derived, Brain-Derived, and Recombinant β-Amyloid: Modelling Alzheimer's Disease for Research and Drug Development. International journal of molecular sciences. vol 23. issue 23. 2022-12-11. PMID:36499362. |
alzheimer's disease (ad) is the most common cause of dementia in the elderly, characterised by the accumulation of senile plaques and tau tangles, neurodegeneration, and neuroinflammation in the brain. |
2022-12-11 |
2023-08-14 |
Not clear |
| Alicia Leikin-Frenkel, Michal Schnaider Beeri, Itzik Coope. How Alpha Linolenic Acid May Sustain Blood-Brain Barrier Integrity and Boost Brain Resilience against Alzheimer's Disease. Nutrients. vol 14. issue 23. 2022-12-11. PMID:36501121. |
cognitive decline, the primary clinical phenotype of alzheimer's disease (ad), is currently attributed mainly to amyloid and tau protein deposits. |
2022-12-11 |
2023-08-14 |
Not clear |
| Tianqing Liu, Yuying Li, Yan Wang, Xiao-Xin Yan, Jiapei Dai, Mengchao Cu. Discovery and evaluation of aza-fused tricyclic derivatives for detection of Tau pathology in Alzheimer's disease. European journal of medicinal chemistry. vol 246. 2022-12-09. PMID:36493618. |
discovery and evaluation of aza-fused tricyclic derivatives for detection of tau pathology in alzheimer's disease. |
2022-12-09 |
2023-08-14 |
Not clear |
| Tianqing Liu, Yuying Li, Yan Wang, Xiao-Xin Yan, Jiapei Dai, Mengchao Cu. Discovery and evaluation of aza-fused tricyclic derivatives for detection of Tau pathology in Alzheimer's disease. European journal of medicinal chemistry. vol 246. 2022-12-09. PMID:36493618. |
for various neurodegenerative diseases, including alzheimer's disease (ad), the abnormal aggregation of tau is not only the predominant contributing factor but also a major biomarker for disease diagnosis. |
2022-12-09 |
2023-08-14 |
Not clear |
| Frederique J Hart de Ruyter, Tjado H J Morrema, Jurre den Haan, Jos W R Twisk, Johannes F de Boer, Philip Scheltens, Baayla D C Boon, Dietmar R Thal, Annemieke J Rozemuller, Frank D Verbraak, Femke H Bouwman, Jeroen J M Hoozeman. Phosphorylated tau in the retina correlates with tau pathology in the brain in Alzheimer's disease and primary tauopathies. Acta neuropathologica. 2022-12-08. PMID:36480077. |
phosphorylated tau in the retina correlates with tau pathology in the brain in alzheimer's disease and primary tauopathies. |
2022-12-08 |
2023-08-14 |
Not clear |
| Frederique J Hart de Ruyter, Tjado H J Morrema, Jurre den Haan, Jos W R Twisk, Johannes F de Boer, Philip Scheltens, Baayla D C Boon, Dietmar R Thal, Annemieke J Rozemuller, Frank D Verbraak, Femke H Bouwman, Jeroen J M Hoozeman. Phosphorylated tau in the retina correlates with tau pathology in the brain in Alzheimer's disease and primary tauopathies. Acta neuropathologica. 2022-12-08. PMID:36480077. |
accumulation of phosphorylated tau (p-tau) in the brain is a pathological feature characteristic for alzheimer's disease (ad) and primary tauopathies. |
2022-12-08 |
2023-08-14 |
Not clear |
| Marine Denechaud, Sarah Geurs, Thomas Comptdaer, Séverine Bégard, Alejandro Garcia-Núñez, Louis-Adrien Pechereau, Thomas Bouillet, Yannick Vermeiren, Peter P De Deyn, Romain Perbet, Vincent Deramecourt, Claude-Alain Maurage, Michiel Vanderhaegen, Sebastiaan Vanuytven, Bruno Lefebvre, Elke Bogaert, Nicole Déglon, Thierry Voet, Morvane Colin, Luc Buée, Bart Dermaut, Marie-Christine Gala. Tau promotes oxidative stress-associated cycling neurons in S phase as a pro-survival mechanism: possible implication for Alzheimer's disease. Progress in neurobiology. 2022-12-08. PMID:36481386. |
tau promotes oxidative stress-associated cycling neurons in s phase as a pro-survival mechanism: possible implication for alzheimer's disease. |
2022-12-08 |
2023-08-14 |
Not clear |
| Marine Denechaud, Sarah Geurs, Thomas Comptdaer, Séverine Bégard, Alejandro Garcia-Núñez, Louis-Adrien Pechereau, Thomas Bouillet, Yannick Vermeiren, Peter P De Deyn, Romain Perbet, Vincent Deramecourt, Claude-Alain Maurage, Michiel Vanderhaegen, Sebastiaan Vanuytven, Bruno Lefebvre, Elke Bogaert, Nicole Déglon, Thierry Voet, Morvane Colin, Luc Buée, Bart Dermaut, Marie-Christine Gala. Tau promotes oxidative stress-associated cycling neurons in S phase as a pro-survival mechanism: possible implication for Alzheimer's disease. Progress in neurobiology. 2022-12-08. PMID:36481386. |
multiple lines of evidence have linked oxidative stress, tau pathology and neuronal cell cycle re-activation to alzheimer's disease (ad). |
2022-12-08 |
2023-08-14 |
Not clear |
| Madhu Ramesh, Chenikkayala Balachandra, Prayasee Baruah, Thimmaiah Govindaraj. Cyclic dipeptide-based small molecules modulate zinc-mediated liquid-liquid phase separation of tau. Journal of peptide science : an official publication of the European Peptide Society. 2022-12-06. PMID:36471564. |
recently, the tau protein responsible for alzheimer's disease (ad) and other tauopathies is shown to phase separate into condensates in vitro and in vivo. |
2022-12-06 |
2023-08-14 |
Not clear |
| Jianfeng Wu, Yi Su, Wenhui Zhu, Negar Jalili Mallak, Natasha Lepore, Eric M Reiman, Richard J Caselli, Paul M Thompson, Kewei Chen, Yalin Wan. Improved Prediction of Amyloid-β and Tau Burden Using Hippocampal Surface Multivariate Morphometry Statistics and Sparse Coding. Journal of Alzheimer's disease : JAD. 2022-12-04. PMID:36463452. |
amyloid-β (aβ) plaques and tau protein tangles in the brain are the defining 'a' and 't' hallmarks of alzheimer's disease (ad), and together with structural atrophy detectable on brain magnetic resonance imaging (mri) scans as one of the neurodegenerative ('n') biomarkers comprise the "atn framework" of ad. |
2022-12-04 |
2023-08-14 |
Not clear |
| Ruxin Zhang, Yanrong Song, Xuefeng S. Necroptosis and Alzheimer's Disease: Pathogenic Mechanisms and Therapeutic Opportunities. Journal of Alzheimer's disease : JAD. 2022-12-04. PMID:36463451. |
the keywords in the search included: "necroptosis", "alzheimer's disease", "signaling pathways", "aβ", aβo", "tau", "p-tau", "neuronal death", "bbb damage", "neuroinflammation", "microglia", "mitochondrial dysfunction", "granulovacuolar degeneration", "synaptic loss", "axonal degeneration", "nec-1", "nec-1s", "gsk872", "nsa", "oga", "ripk1", "ripk3", and "mlkl". |
2022-12-04 |
2023-08-14 |
Not clear |