| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniel B Hier, Sima Azizi, Matthew S Thimgan, Donald C Wunsc. Tau kinetics in Alzheimer's disease. Frontiers in aging neuroscience. vol 14. 2022-11-28. PMID:36437992. |
the kinetic model predicts that an increase in the neuronal tau synthesis rate or a decrease in tau catabolism rate best accounts for observed increases in tau levels in the brain, csf, and plasma found in alzheimer's disease. |
2022-11-28 |
2023-08-14 |
Not clear |
| Daniel B Hier, Sima Azizi, Matthew S Thimgan, Donald C Wunsc. Tau kinetics in Alzheimer's disease. Frontiers in aging neuroscience. vol 14. 2022-11-28. PMID:36437992. |
furthermore, the model predicts that increases in brain half-life of tau in alzheimer's disease should be attributed to decreased tau catabolism and not to increased tau synthesis. |
2022-11-28 |
2023-08-14 |
Not clear |
| b' Jian-Guo Li, Benjamin E Blass, Domenico Pratic\\xc3\\xb. Beneficial Effect of a Small Pharmacologic Chaperone on the Established Alzheimer\'s Disease Phenotype. Journal of Alzheimer\'s disease : JAD. 2022-11-28. PMID:36442197.' |
downregulation of its recognition core proteins, such as vps35, is present in alzheimer's disease (ad) brain, whereas its normalization prevents the development of ad pathology in a transgenic model with amyloid-β deposits and tau tangles. |
2022-11-28 |
2023-08-14 |
Not clear |
| Li-Tian Hu, Xiao-Yong Xie, Gui-Feng Zhou, Qi-Xin Wen, Li Song, Biao Luo, Xiao-Juan Deng, Qiu-Ling Pan, Guo-Jun Che. HMGCS2-Induced Autophagic Degradation of Tau Involves Ketone Body and ANKRD24. Journal of Alzheimer's disease : JAD. 2022-11-28. PMID:36442191. |
accumulation of hyperphosphorylated tau (ptau) contributes to the formation of neurofibrillary tangles in alzheimer's disease (ad), and targeting tau/ptau metabolism has emerged as a therapeutic approach. |
2022-11-28 |
2023-08-14 |
Not clear |
| Asokan Prema, Arokiasamy Justin Thenmozhi, Thamilarasan Manivasagam, Musthafa Mohamed Essa, Gilles J Guillemi. Erratum to: Fenugreek Seed Powder Attenuated Aluminum Chloride-Induced Tau Pathology, Oxidative Stress, and Inflammation in a Rat Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2022-11-28. PMID:36442226. |
erratum to: fenugreek seed powder attenuated aluminum chloride-induced tau pathology, oxidative stress, and inflammation in a rat model of alzheimer's disease. |
2022-11-28 |
2023-08-14 |
rat |
| Alessandra Dos Santos, Fernanda Cardoso Teixeira, Daniel Schuch da Silva, Tayná Amaral Veleda, Julia Eisenhart de Mello, Karina Pereira Luduvico, Rejane Giacomelli Tavares, Francieli Moro Stefanello, Wilson Cunico Filho, Roselia Maria Spanevell. Thiazolidin-4-one prevents against memory deficits, increase in phosphorylated tau protein, oxidative damage and cholinergic dysfunction in Alzheimer disease model: comparison with donepezil drug. Brain research bulletin. 2022-11-28. PMID:36442692. |
thiazolidin-4-one prevents against memory deficits, increase in phosphorylated tau protein, oxidative damage and cholinergic dysfunction in alzheimer disease model: comparison with donepezil drug. |
2022-11-28 |
2023-08-14 |
rat |
| Anna Atlante, Giuseppina Amadoro, Valentina Latina, Daniela Valent. Therapeutic Potential of Targeting Mitochondria for Alzheimer's Disease Treatment. Journal of clinical medicine. vol 11. issue 22. 2022-11-26. PMID:36431219. |
alzheimer's disease (ad), a chronic and progressive neurodegenerative disease, is characterized by memory and cognitive impairment and by the accumulation in the brain of abnormal proteins, more precisely beta-amyloid (β-amyloid or aβ) and tau proteins. |
2022-11-26 |
2023-08-14 |
Not clear |
| Anna Steward, Davina Biel, Matthias Brendel, Anna Dewenter, Sebastian Roemer, Anna Rubinski, Ying Luan, Martin Dichgans, Michael Ewers, Nicolai Franzmeie. Functional network segregation is associated with attenuated tau spreading in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-11-26. PMID:36433865. |
functional network segregation is associated with attenuated tau spreading in alzheimer's disease. |
2022-11-26 |
2023-08-14 |
Not clear |
| Anna Steward, Davina Biel, Matthias Brendel, Anna Dewenter, Sebastian Roemer, Anna Rubinski, Ying Luan, Martin Dichgans, Michael Ewers, Nicolai Franzmeie. Functional network segregation is associated with attenuated tau spreading in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-11-26. PMID:36433865. |
lower network segregation is associated with accelerated cognitive decline in alzheimer's disease (ad), yet it is unclear whether less segregated brain networks facilitate connectivity-mediated tau spreading. |
2022-11-26 |
2023-08-14 |
Not clear |
| Mehboob Hoque, Arijit Samanta, Syed Sahajada Mahafujul Alam, Torki A Zughaibi, Mohammad Amjad Kamal, Shams Tabre. Nanomedicine-based immunotherapy for Alzheimer's Disease. Neuroscience and biobehavioral reviews. 2022-11-26. PMID:36435391. |
alzheimer's disease (ad) is the most prevalent neurodegenerative disease caused by the deposition of amyloid β (aβ) fibrils forming extracellular plaques and the development of neurofibrillary tangles (nft) of intracellular hyperphosphorylated tau protein. |
2022-11-26 |
2023-08-14 |
Not clear |
| Zdeněk Fiša. Linking the Amyloid, Tau, and Mitochondrial Hypotheses of Alzheimer's Disease and Identifying Promising Drug Targets. Biomolecules. vol 12. issue 11. 2022-11-24. PMID:36421690. |
linking the amyloid, tau, and mitochondrial hypotheses of alzheimer's disease and identifying promising drug targets. |
2022-11-24 |
2023-08-14 |
Not clear |
| Shuai Zhao, Ziqi Fan, Xinyi Zhang, Zheyu Li, Ting Shen, Kaicheng Li, Yaping Yan, Yunfeng Yuan, Jiali Pu, Jun Tian, Zhirong Liu, Yanxing Chen, Baorong Zhan. Metformin Attenuates Tau Pathology in Tau-Seeded PS19 Mice. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2022-11-24. PMID:36422837. |
accumulation of neurofibrillary tangles (nfts) composed of hyperphosphorylated tau is a histopathological hallmark of alzheimer's disease (ad) and related tauopathies. |
2022-11-24 |
2023-08-14 |
mouse |
| Gøril Rolfseng Grøntvedt, Sigrid Botne Sando, Camilla Lauridsen, Geir Bråthen, Linda R White, Øyvind Salvesen, Dag Aarsland, Erik Hessen, Tormod Fladby, Knut Waterloo, Katja Scheffle. Association of Klotho Protein Levels and KL-VS Heterozygosity With Alzheimer Disease and Amyloid and Tau Burden. JAMA network open. vol 5. issue 11. 2022-11-22. PMID:36413367. |
association of klotho protein levels and kl-vs heterozygosity with alzheimer disease and amyloid and tau burden. |
2022-11-22 |
2023-08-14 |
Not clear |
| Heikki Lukkarinen, Aleksi Vanninen, Ina Tesseur, Darrel Pemberton, Peter Van Der Ark, Tarja Kokkola, Sanna-Kaisa Herukka, Tuomas Rauramaa, Mikko Hiltunen, Kaj Blennow, Henrik Zetterberg, Ville Leinone. Concordance of Alzheimer's Disease-Related Biomarkers Between Intraventricular and Lumbar Cerebrospinal Fluid in Idiopathic Normal Pressure Hydrocephalus. Journal of Alzheimer's disease : JAD. 2022-11-21. PMID:36404546. |
alzheimer's disease cerebrospinal fluid (csf) biomarkers amyloid-β 1-42 (aβ42), total tau (t-tau), and phosphorylated tau 181 (p-tau181) are widely used. |
2022-11-21 |
2023-08-14 |
Not clear |
| Jianhao Bai, Zhongqi Wan, Minli Wang, Xue Wu, Tianyu Wang, Yuanyuan Zhang, Yawen Xue, Hong Xu, Qing Pen. Association of cognitive function with Neurofilament light chain in the aqueous humor of human eye. Frontiers in aging neuroscience. vol 14. 2022-11-21. PMID:36408096. |
to evaluate the predictive clinical role of neurofilament light chain (nfl), amyloid-β (aβ), glial fibrillary acidic protein (gfap), and phosphorylated tau at threonine 181 (p-tau181) proteins in human aqueous humor (ah) and quantify the retinal macular microvascular parameters by optical coherence tomography angiography (octa) as early diagnostic markers of alzheimer's disease (ad). |
2022-11-21 |
2023-08-14 |
human |
| M I Holubiec, M Gellert, E M Hanschman. Redox signaling and metabolism in Alzheimer's disease. Frontiers in aging neuroscience. vol 14. 2022-11-21. PMID:36408110. |
alzheimer's disease (ad) is a neurodegenerative pathology linked to both, abnormal amyloid precursor protein (app) processing, generating aβ peptide, and tau hyperphosphorylation and aggregation. |
2022-11-21 |
2023-08-14 |
Not clear |
| Daniel Lee, Virginia M-Y Lee, Seong Kwon Hu. Manipulation of the diet-microbiota-brain axis in Alzheimer's disease. Frontiers in neuroscience. vol 16. 2022-11-21. PMID:36408394. |
several studies investigating the pathogenesis of alzheimer's disease have identified various interdependent constituents contributing to the exacerbation of the disease, including aβ plaque formation, tau protein hyperphosphorylation, neurofibrillary tangle accumulation, glial inflammation, and the eventual loss of proper neural plasticity. |
2022-11-21 |
2023-08-14 |
human |
| Sumra Malik, G A Miana, Athar Ata, Madiha Kanwal, Saima Maqsood, Imran Malik, Zartashia Kazm. Synthesis, characterization, in-silico, and pharmacological evaluation of new 2-amino-6‑trifluoromethoxy benzothiazole derivatives. Bioorganic chemistry. vol 130. 2022-11-21. PMID:36410112. |
alzheimer's disease (ad), a relentless neurodegenerative disorder, is still waiting for safer profile drugs, risk factors affecting ad's pathogenesis include aβ accumulation, tau protein hyperphosphorylation, and neuroinflammation. |
2022-11-21 |
2023-08-14 |
Not clear |
| Nastaran Karimi, Feyza Bayram Çatak, Ebru Arslan, Amene Saghazadeh, Nima Rezae. Tau immunotherapy in Alzheimer's disease and progressive supranuclear palsy. International immunopharmacology. vol 113. issue Pt B. 2022-11-21. PMID:36410182. |
tau immunotherapy in alzheimer's disease and progressive supranuclear palsy. |
2022-11-21 |
2023-08-14 |
Not clear |
| Gillian Carling, Wenjie Luo, Li Ga. Friend turned foe: TREM2 agonist in battles against tau. The Journal of experimental medicine. vol 220. issue 1. 2022-11-18. PMID:36399126. |
med.https://doi.org/10.1084/jem.20220654) find that chronic trem2 activation by al002a antibody exacerbates the seeding and spread of pathological tau, enhances the disease-associated microglial signature, and increases neurite dystrophy in 5xfad mice seeded with alzheimer's disease tau. |
2022-11-18 |
2023-08-14 |
mouse |