| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nastaran Karimi, Feyza Bayram Çatak, Ebru Arslan, Amene Saghazadeh, Nima Rezae. Tau immunotherapy in Alzheimer's disease and progressive supranuclear palsy. International immunopharmacology. vol 113. issue Pt B. 2022-11-21. PMID:36410182. |
tau immunotherapy in alzheimer's disease and progressive supranuclear palsy. |
2022-11-21 |
2023-08-14 |
Not clear |
| Gillian Carling, Wenjie Luo, Li Ga. Friend turned foe: TREM2 agonist in battles against tau. The Journal of experimental medicine. vol 220. issue 1. 2022-11-18. PMID:36399126. |
med.https://doi.org/10.1084/jem.20220654) find that chronic trem2 activation by al002a antibody exacerbates the seeding and spread of pathological tau, enhances the disease-associated microglial signature, and increases neurite dystrophy in 5xfad mice seeded with alzheimer's disease tau. |
2022-11-18 |
2023-08-14 |
mouse |
| Stéphanie Levert, Julie Pilliod, Étienne Aumont, Sandrine Armanville, Cyntia Tremblay, Frédéric Calon, Nicole Lecler. Direct and Indirect Effects of Filamin A on Tau Pathology in Neuronal Cells. Molecular neurobiology. 2022-11-18. PMID:36399251. |
in alzheimer disease (ad), tau, an axonal microtubule-associated protein, becomes hyperphosphorylated, detaches from microtubules, accumulates, and self-aggregates in the somatodendritic (sd) compartment. |
2022-11-18 |
2023-08-14 |
Not clear |
| Geoffrey Pires, Beatrix Ueberheide, Thomas Wisniewski, Eleanor Drummon. Use of Affinity Purification-Mass Spectrometry to Identify Phosphorylated Tau Interactors in Alzheimer's Disease. Methods in molecular biology (Clifton, N.J.). vol 2561. 2022-11-18. PMID:36399275. |
use of affinity purification-mass spectrometry to identify phosphorylated tau interactors in alzheimer's disease. |
2022-11-18 |
2023-08-14 |
human |
| Geoffrey Pires, Beatrix Ueberheide, Thomas Wisniewski, Eleanor Drummon. Use of Affinity Purification-Mass Spectrometry to Identify Phosphorylated Tau Interactors in Alzheimer's Disease. Methods in molecular biology (Clifton, N.J.). vol 2561. 2022-11-18. PMID:36399275. |
phosphorylated tau is the main protein present in neurofibrillary tangles, the presence of which is a key neuropathological hallmark of alzheimer's disease (ad). |
2022-11-18 |
2023-08-14 |
human |
| Carlo Condello, Gregory E Merz, Atsushi Aoyagi, William F DeGrado, Stanley B Prusine. Aβ and Tau Prions Causing Alzheimer's Disease. Methods in molecular biology (Clifton, N.J.). vol 2561. 2022-11-18. PMID:36399277. |
aβ and tau prions causing alzheimer's disease. |
2022-11-18 |
2023-08-14 |
mouse |
| Carlo Condello, Gregory E Merz, Atsushi Aoyagi, William F DeGrado, Stanley B Prusine. Aβ and Tau Prions Causing Alzheimer's Disease. Methods in molecular biology (Clifton, N.J.). vol 2561. 2022-11-18. PMID:36399277. |
studies show that patients with alzheimer's disease (ad) have both aβ and tau prions, and thus, ad is a double-prion disease. |
2022-11-18 |
2023-08-14 |
mouse |
| Maria Rosaria Tropea, Walter Gulisano, Valeria Vacanti, Ottavio Arancio, Daniela Puzzo, Agostino Palmer. Nitric oxide/cGMP/CREB pathway and amyloid-beta crosstalk: From physiology to Alzheimer's disease. Free radical biology & medicine. 2022-11-18. PMID:36400326. |
the no/cgmp/creb signaling is downregulated during aging and neurodegenerative disorders and is affected by amyloid-β peptide (aβ) and tau protein, whose increase and deposition is considered the key pathogenic event of alzheimer's disease (ad). |
2022-11-18 |
2023-08-14 |
Not clear |
| Sravan Gopalkrishnashetty Sreenivasmurthy, Ashok Iyaswamy, Senthilkumar Krishnamoorthi, Rambabu N Reddi, Ananth Kumar Kammala, Karthick Vasudevan, Sanjib Senapati, Zhou Zhu, Cheng-Fu Su, Jia Liu, Xin-Jie Guan, Ka-Kit Chua, King-Ho Cheung, Hubiao Chen, Hong-Jie Zhang, Yuan Zhang, Ju-Xian Song, Siva Sundara Kumar Durairajan, Min L. Bromo-protopine, a novel protopine derivative, alleviates tau pathology by activating chaperone-mediated autophagy for Alzheimer's disease therapy. Frontiers in molecular biosciences. vol 9. 2022-11-17. PMID:36387280. |
bromo-protopine, a novel protopine derivative, alleviates tau pathology by activating chaperone-mediated autophagy for alzheimer's disease therapy. |
2022-11-17 |
2023-08-14 |
Not clear |
| Sravan Gopalkrishnashetty Sreenivasmurthy, Ashok Iyaswamy, Senthilkumar Krishnamoorthi, Rambabu N Reddi, Ananth Kumar Kammala, Karthick Vasudevan, Sanjib Senapati, Zhou Zhu, Cheng-Fu Su, Jia Liu, Xin-Jie Guan, Ka-Kit Chua, King-Ho Cheung, Hubiao Chen, Hong-Jie Zhang, Yuan Zhang, Ju-Xian Song, Siva Sundara Kumar Durairajan, Min L. Bromo-protopine, a novel protopine derivative, alleviates tau pathology by activating chaperone-mediated autophagy for Alzheimer's disease therapy. Frontiers in molecular biosciences. vol 9. 2022-11-17. PMID:36387280. |
emerging evidence from alzheimer's disease (ad) patients suggests that reducing tau pathology can restore cognitive and memory loss. |
2022-11-17 |
2023-08-14 |
Not clear |
| Karthikeyan Selvarasu, Abhay Kumar Singh, Ashok Iyaswamy, Sravan Gopalkrishnashetty Sreenivasmurthy, Senthilkumar Krishnamoorthi, Amal Kanti Bera, Jian-Dong Huang, Siva Sundara Kumar Durairaja. Reduction of kinesin I heavy chain decreases tau hyperphosphorylation, aggregation, and memory impairment in Alzheimer's disease and tauopathy models. Frontiers in molecular biosciences. vol 9. 2022-11-17. PMID:36387285. |
reduction of kinesin i heavy chain decreases tau hyperphosphorylation, aggregation, and memory impairment in alzheimer's disease and tauopathy models. |
2022-11-17 |
2023-08-14 |
mouse |
| Karthikeyan Selvarasu, Abhay Kumar Singh, Ashok Iyaswamy, Sravan Gopalkrishnashetty Sreenivasmurthy, Senthilkumar Krishnamoorthi, Amal Kanti Bera, Jian-Dong Huang, Siva Sundara Kumar Durairaja. Reduction of kinesin I heavy chain decreases tau hyperphosphorylation, aggregation, and memory impairment in Alzheimer's disease and tauopathy models. Frontiers in molecular biosciences. vol 9. 2022-11-17. PMID:36387285. |
many neurodegenerative diseases, such as alzheimer's disease (ad) and frontotemporal dementia with parkinsonism linked to chromosome 17, are characterized by tau pathology. |
2022-11-17 |
2023-08-14 |
mouse |
| Zhongying Gong, Lina Gao, Yi Lu, Zhiyun Wan. CSF p-tau as a potential cognition impairment biomarker in ALS. Frontiers in neurology. vol 13. 2022-11-17. PMID:36388201. |
cerebrospinal fluid (csf) and serum tau (t-tau, p-tau) are potential biomarkers for neurodegeneration in alzheimer disease (ad), but their role in amyotrophic lateral sclerosis (als) is unclear. |
2022-11-17 |
2023-08-14 |
Not clear |
| Atsuko Katsumoto, Olga N Kokiko-Cochran, Shane M Bemiller, Guixiang Xu, Richard M Ransohoff, Bruce T Lam. Triggering receptor expressed on myeloid cells 2 deficiency exacerbates injury-induced inflammation in a mouse model of tauopathy. Frontiers in immunology. vol 13. 2022-11-17. PMID:36389767. |
traumatic brain injury (tbi) promotes several alzheimer's disease-like pathological features, including microtubule-associated protein tau (mapt) accumulation within neurons. |
2022-11-17 |
2023-08-14 |
mouse |
| Oliver Goldhardt, Robert Freiberger, Tobias Dreyer, Luisa Wilner, Igor Yakushev, Marion Ortner, Hans Förstl, Janine Diehl-Schmid, Esther Milz, Josef Priller, Alfredo Ramirez, Viktor Magdolen, Markus Thaler, Timo Grimme. Herpes simplex virus alters Alzheimer's disease biomarkers - A hypothesis paper. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-11-17. PMID:36396609. |
human herpes simplex virus 1 (hsv1) is discussed to induce amyloid-β (aβ) accumulation and neurofibrillary tangles of hyperphosphorylated tau (ptau) in alzheimer's disease (ad) in cell culture and animal models. |
2022-11-17 |
2023-08-14 |
human |
| Alexandra J Weigand, Lauren E Edwards, Kelsey R Thomas, Katherine J Bangen, Mark W Bond. Comprehensive characterization of elevated tau PET signal in the absence of amyloid-beta. Brain communications. vol 4. issue 6. 2022-11-16. PMID:36382220. |
recently proposed biomarker-only diagnostic frameworks propose that amyloid-beta is necessary for placement on the alzheimer's disease continuum, whereas tau in the absence of amyloid-beta is considered to be a non-alzheimer's disease pathologic change. |
2022-11-16 |
2023-08-14 |
human |
| Alexandra J Weigand, Lauren E Edwards, Kelsey R Thomas, Katherine J Bangen, Mark W Bond. Comprehensive characterization of elevated tau PET signal in the absence of amyloid-beta. Brain communications. vol 4. issue 6. 2022-11-16. PMID:36382220. |
similarly, the pathologic designation of tau in the absence of amyloid-beta is characterized as primary age-related tauopathy and separable from alzheimer's disease. |
2022-11-16 |
2023-08-14 |
human |
| Daniel Ferreira, Rosaleena Mohanty, Melissa E Murray, Agneta Nordberg, Kejal Kantarci, Eric Westma. The hippocampal sparing subtype of Alzheimer's disease assessed in neuropathology and in vivo tau positron emission tomography: a systematic review. Acta neuropathologica communications. vol 10. issue 1. 2022-11-15. PMID:36376963. |
the hippocampal sparing subtype of alzheimer's disease assessed in neuropathology and in vivo tau positron emission tomography: a systematic review. |
2022-11-15 |
2023-08-14 |
human |
| Der-Shyang Kao, Yanyan Du, Andrew G DeMarco, Sehong Min, Mark C Hall, Jean-Christophe Rochet, W Andy Ta. Identification of novel kinases of Tau using fluorescence complementation mass spectrometry (FCMS) Molecular & cellular proteomics : MCP. 2022-11-15. PMID:36379402. |
identification of novel kinases of tau using fluorescence complementation mass spectrometry (fcms) hyperphosphorylation of the microtubule-associated protein tau is a major hallmark of alzheimer's disease (ad) and other tauopathies. |
2022-11-15 |
2023-08-14 |
human |
| Kurtis Mengham, Youssra Al-Hilaly, Sebastian Oakley, Kamillia Kasbi, Mahmoud B Maina, Louise C Serpel. Shapeshifting tau: from intrinsically disordered to paired-helical filaments. Essays in biochemistry. 2022-11-14. PMID:36373666. |
tau is an intrinsically disordered protein that has the ability to self-assemble to form paired helical and straight filaments in alzheimer's disease, as well as the ability to form additional distinct tau filaments in other tauopathies. |
2022-11-14 |
2023-08-14 |
Not clear |