All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Jung-Lung Hsu, Yi-Chia Wei, Cheng Hong Toh, Ing-Tsung Hsiao, Kun-Ju Lin, Tzu-Chen Yen, Ming-Feng Liao, Long-Sun R. MRI images implicate glymphatic alterations mediate cognitive dysfunction in AD. Annals of neurology. 2022-10-10. PMID:36214568. the glymphatic system cleans amyloid and tau proteins from the brain in animal studies of alzheimer's disease (ad). 2022-10-10 2023-08-14 Not clear
Lin Lin, Ronald S Petralia, Lynne Holtzclaw, Ya-Xian Wang, Daniel Abebe, Dax A Hoffma. Alzheimer's disease/dementia-associated brain pathology in aging DPP6-KO mice. Neurobiology of disease. 2022-10-09. PMID:36209950. aging dpp6-ko hippocampi contained fewer total neurons and greater neuron death and had diagnostic biomarkers of alzheimer's disease present including accumulation of amyloid β and app and increase in expression of hyper-phosphorylated tau. 2022-10-09 2023-08-14 mouse
Aileen Roth, Annabelle Sander, Marleen Silke Oswald, Fabian Gärtner, Uwe Knippschild, Joachim Bischo. Comprehensive Characterization of CK1δ-Mediated Tau Phosphorylation in Alzheimer's Disease. Frontiers in molecular biosciences. vol 9. 2022-10-07. PMID:36203870. comprehensive characterization of ck1δ-mediated tau phosphorylation in alzheimer's disease. 2022-10-07 2023-08-14 Not clear
Aileen Roth, Annabelle Sander, Marleen Silke Oswald, Fabian Gärtner, Uwe Knippschild, Joachim Bischo. Comprehensive Characterization of CK1δ-Mediated Tau Phosphorylation in Alzheimer's Disease. Frontiers in molecular biosciences. vol 9. 2022-10-07. PMID:36203870. a main pathological event in alzheimer's disease is the generation of neurofibrillary tangles originating from hyperphosphorylated and subsequently aggregated tau proteins. 2022-10-07 2023-08-14 Not clear
Aileen Roth, Annabelle Sander, Marleen Silke Oswald, Fabian Gärtner, Uwe Knippschild, Joachim Bischo. Comprehensive Characterization of CK1δ-Mediated Tau Phosphorylation in Alzheimer's Disease. Frontiers in molecular biosciences. vol 9. 2022-10-07. PMID:36203870. previous reports demonstrated the critical involvement of members of the protein kinase family ck1 in the pathogenesis of alzheimer's disease by hyperphosphorylation of tau. 2022-10-07 2023-08-14 Not clear
Poosanu Thanapornsangsuth, Tatchaporn Ongphichetmetha, Watayuth Luechaipanit, Pasin Hemachudha, Thiravat Hemachudh. Elevation of plasma phosphorylated tau181 during neurological illnesses affecting consciousness and kidney dysfunction. Alzheimer's & dementia (Amsterdam, Netherlands). vol 14. issue 1. 2022-10-07. PMID:36204656. phosphorylated tau (p-tau)181 has become a promising blood-based alzheimer's disease (ad) biomarker. 2022-10-07 2023-08-14 Not clear
Zi-Zhen Si, Chen-Jun Zou, Xi Mei, Xiao-Fang Li, Hu Luo, Yao Shen, Jun Hu, Xing-Xing Li, Lun Wu, Yu Li. Targeting neuroinflammation in Alzheimer's disease: from mechanisms to clinical applications. Neural regeneration research. vol 18. issue 4. 2022-10-07. PMID:36204826. an increasing body of evidence suggests that neuroinflammation plays an important role in alzheimer's disease pathogenesis, alongside the classical pathological hallmarks such as misfolded and aggregated proteins (e.g., amyloid-beta and tau). 2022-10-07 2023-08-14 Not clear
Umang Shah, Aneri Shah, Sandip Patel, Alkesh Patel, Mehul Patel, Nilay Solanki, Swayamprakash Patel, Ashish Patel, Veena Patel, Bhavesh Pate. Atorvastatin's Reduction of Alzheimer's Disease and Possible Alteration of Cognitive Function in Midlife as well as its Treatment. CNS & neurological disorders drug targets. 2022-10-06. PMID:36200162. future directions in the research and treatment of alzheimer's disease patients include the use of antisense oligonucleotides (aso) to change target expression, and researchers discovered decreased markers of oxidative stress in tissues affected by tau pathology in response to rna interference treatment. 2022-10-06 2023-08-14 Not clear
Ihab Hajjar, Zhiyi Yang, Maureen Okafor, Chang Liu, Teresa Waligorska, Felicia C Goldstein, Leslie M Sha. Association of Plasma and Cerebrospinal Fluid Alzheimer Disease Biomarkers With Race and the Role of Genetic Ancestry, Vascular Comorbidities, and Neighborhood Factors. JAMA network open. vol 5. issue 10. 2022-10-06. PMID:36201209. differences in cerebrospinal fluid (csf) tau alzheimer dementia (ad) biomarkers by self-identified race have been observed in prior studies. 2022-10-06 2023-08-14 Not clear
Pablo Cisternas, Xavier Taylor, Pablo Martinez, Orlando Maldonado, Nur Jury, Cristian A Lasagna-Reeve. The reduction of astrocytic tau prevents amyloid-β-induced synaptotoxicity. Brain communications. vol 4. issue 5. 2022-10-05. PMID:36196088. alzheimer's disease is a neurological disorder characterized by the overproduction and aggregation of amyloid-beta and the phosphorylation and intraneuronal accumulation of tau. 2022-10-05 2023-08-14 Not clear
Pablo Cisternas, Xavier Taylor, Pablo Martinez, Orlando Maldonado, Nur Jury, Cristian A Lasagna-Reeve. The reduction of astrocytic tau prevents amyloid-β-induced synaptotoxicity. Brain communications. vol 4. issue 5. 2022-10-05. PMID:36196088. reducing endogenous astrocytic tau expression could be a potential strategy to prevent synaptic damage in alzheimer's disease and other neurological conditions. 2022-10-05 2023-08-14 Not clear
Yan Yan, Xinming Wang, Dale Chaput, Min-Kyoo Shin, Yeojung Koh, Li Gan, Andrew A Pieper, Jung-A A Woo, David E Kan. X-linked ubiquitin-specific peptidase 11 increases tauopathy vulnerability in women. Cell. 2022-10-05. PMID:36198316. although women experience significantly higher tau burden and increased risk for alzheimer's disease (ad) than men, the underlying mechanism for this vulnerability has not been explained. 2022-10-05 2023-08-14 mouse
Yu Guo, Yu-Xiang Yang, Ya-Ru Zhang, Yu-Yuan Huang, Ke-Liang Chen, Shi-Dong Chen, Prof Qiang Dong, Jin-Tai Y. Genome-wide association study of brain tau deposition as measured by Neurobiology of aging. vol 120. 2022-10-04. PMID:36195041. genome-wide association study of brain tau deposition as measured by the related genetic variants of tau deposition, a seminal pathological hallmark of alzheimer's disease, remain poorly understood. 2022-10-04 2023-08-14 Not clear
Pariya Khodabakhsh, Maryam Bazrgar, Fatemeh Mohagheghi, Siavash Parvardeh, Abolhassan Ahmadian. MicroRNA-140-5p inhibitor attenuates memory impairment induced by amyloid-ß oligomer in vivo possibly through Pin1 regulation. CNS neuroscience & therapeutics. 2022-10-03. PMID:36184817. the peptidyl-prolyl cis/trans isomerase, pin1, has a protective role in age-related neurodegeneration by targeting different phosphorylation sites of tau and the key proteins required to produce amyloid-β, which are the well-known molecular signatures of alzheimer's disease (ad) neuropathology. 2022-10-03 2023-08-14 rat
Karl Hansson, Rahil Dahlén, Oskar Hansson, Elin Pernevik, Ross Paterson, Jonathan M Schott, Nadia Magdalinou, Henrik Zetterberg, Kaj Blennow, Johan Gobo. Corrigendum to "Use of the tau protein-to-peptide ratio in CSF to improve diagnostic classification of Alzheimer's disease" [Clin. Mass Spectrom. 14 (Part B) (2019) 74-82]. Journal of mass spectrometry and advances in the clinical lab. vol 26. 2022-10-03. PMID:36187744. corrigendum to "use of the tau protein-to-peptide ratio in csf to improve diagnostic classification of alzheimer's disease" [clin. 2022-10-03 2023-08-14 Not clear
Yukiko Hori, Youhei Sohma, Motomu Kanai, Taisuke Tomit. Promotion in the Clearance of Aggregated Aβ In Vivo Using Amyloid Selective Photo-Oxygenation Technology. Neuroscience insights. vol 17. 2022-10-03. PMID:36189373. alzheimer's disease (ad) is characterized by the aggregation and deposition of 2 amyloid proteins: amyloid β peptide (aβ) and tau protein. 2022-10-03 2023-08-14 mouse
Martina P Morawe, Fan Liao, Willi Amberg, Jeroen van Bergeijk, Rui Chang, Mary Gulino, Caitlin Hamilton, Carolin Hoft, Casey Lumpkin, Bryan Mastis, Emily McGlame, Judith Nuber, Christian Plaas, Brinda Ravikumar, Kaushambi Roy, Marion Schanzenbächer, Joseph Tierno, Viktor Lakics, Tammy Dellovade, Matthew Townsen. Pharmacological mTOR-inhibition facilitates clearance of AD-related tau aggregates in the mouse brain. European journal of pharmacology. 2022-10-03. PMID:36191631. in this study we aimed to reduce tau pathology, a hallmark of alzheimer's disease (ad), by activating mtor-dependent autophagy in a transgenic mouse model of tauopathy by long-term dosing of animals with mtor-inhibitors. 2022-10-03 2023-08-14 mouse
Etsuko Imabayashi, Yuji Saitoh, Tadashi Tsukamoto, Masuhiro Sakata, Harumasa Takan. Combination of Astrogliosis and Phosphorylated Tau for the Preclinical Diagnosis of Alzheimer Disease Using 3-Dimensional Stereotactic Surface Projection Images With 18F-THK5351. Clinical nuclear medicine. 2022-09-30. PMID:36179331. combination of astrogliosis and phosphorylated tau for the preclinical diagnosis of alzheimer disease using 3-dimensional stereotactic surface projection images with 18f-thk5351. 2022-09-30 2023-08-14 Not clear
Etsuko Imabayashi, Yuji Saitoh, Tadashi Tsukamoto, Masuhiro Sakata, Harumasa Takan. Combination of Astrogliosis and Phosphorylated Tau for the Preclinical Diagnosis of Alzheimer Disease Using 3-Dimensional Stereotactic Surface Projection Images With 18F-THK5351. Clinical nuclear medicine. 2022-09-30. PMID:36179331. the alzheimer disease (ad) brain is characterized microscopically by the presence of extracellular amyloid plaques and intraneuronal neurofibrillary tangles consisting of phosphorylated tau aggregations. 2022-09-30 2023-08-14 Not clear
Helena Gossye, Sara Van Mossevelde, Anne Sieben, Maria Bjerke, Elisabeth Hendrickx Van de Craen, Julie van der Zee, Peter P De Deyn, Jan De Bleecker, Jan Versijpt, Jenneke van den Ende, Olivier Deryck, Paul Bourgeois, Jean Christophe Bier, Maarten Goethals, Rik Vandenberghe, Sebastiaan Engelborghs, Christine Van Broeckhove. Patients carrying the mutation p.R406W in MAPT present with non-conforming phenotypic spectrum. Brain : a journal of neurology. 2022-09-29. PMID:36171642. the missense mutation p.r406w in microtubule-associated protein tau leads to frontotemporal lobar degeneration with an amnestic, alzheimer's disease-like phenotype with an autosomal dominant pattern of inheritance. 2022-09-29 2023-08-14 Not clear