| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Dietmar Rudolf Thal, Sandra O Tom\\xc3\\xa. The central role of tau in Alzheimer\'s disease: From neurofibrillary tangle maturation to the induction of cell death. Brain research bulletin. 2022-10-16. PMID:36244581.' |
the tau protein (τ) is one of the two hallmark proteins of alzheimer's disease (ad) together with the amyloid β protein (aβ). |
2022-10-16 |
2023-08-14 |
Not clear |
| Sujin Kim, Yunkwon Nam, Soo Jung Shin, Ritu Prajapati, Seong Min Shin, Min-Jeong Kim, Hyeon Soo Kim, Seol Hwa Leem, Tae-Jin Kim, Yong Ho Park, Jwa-Jin Kim, Jae Sue Choi, Minho Moo. Dual modulators of aggregation and dissociation of amyloid beta and tau: In vitro, in vivo, and in silico studies of Uncaria rhynchophylla and its bioactive components. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 156. 2022-10-15. PMID:36242849. |
a prominent characteristic of alzheimer's disease (ad) is the deposition of both amyloid-β (aβ) peptide and tau protein in the brain. |
2022-10-15 |
2023-08-14 |
Not clear |
| Lenka Hromadkova, Mohammad Khursheed Siddiqi, He Liu, Jiri G Safa. Populations of Tau Conformers Drive Prion-like Strain Effects in Alzheimer's Disease and Related Dementias. Cells. vol 11. issue 19. 2022-10-14. PMID:36230957. |
populations of tau conformers drive prion-like strain effects in alzheimer's disease and related dementias. |
2022-10-14 |
2023-08-14 |
human |
| Lenka Hromadkova, Mohammad Khursheed Siddiqi, He Liu, Jiri G Safa. Populations of Tau Conformers Drive Prion-like Strain Effects in Alzheimer's Disease and Related Dementias. Cells. vol 11. issue 19. 2022-10-14. PMID:36230957. |
recent findings of diverse populations of prion-like conformers of misfolded tau protein expand the prion concept to alzheimer's disease (ad) and monogenic frontotemporal lobar degeneration (ftld)-mapt p301l, and suggest that distinct strains of misfolded proteins drive the phenotypes and progression rates in many neurodegenerative diseases. |
2022-10-14 |
2023-08-14 |
human |
| Julia Sala-Jarque, Karolina Zimkowska, Jesús Ávila, Isidro Ferrer, José Antonio Del Rí. Towards a Mechanistic Model of Tau-Mediated Pathology in Tauopathies: What Can We Learn from Cell-Based In Vitro Assays? International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36232835. |
in alzheimer's disease, and other related tauopathies, the pattern of tau deposition follows a stereotypical progression between anatomically connected brain regions. |
2022-10-14 |
2023-08-14 |
Not clear |
| Yuta Katsumi, Deepti Putcha, Ryan Eckbo, Bonnie Wong, Megan Quimby, Scott McGinnis, Alexandra Touroutoglou, Bradford C Dickerso. Anterior dorsal attention network tau drives visual attention deficits in posterior cortical atrophy. Brain : a journal of neurology. 2022-10-14. PMID:36237170. |
posterior cortical atrophy (pca), usually an atypical clinical syndrome of alzheimer's disease, has well-characterized patterns of cortical atrophy and tau deposition that are distinct from typical amnestic presentations of alzheimer's disease. |
2022-10-14 |
2023-08-14 |
Not clear |
| Kyung Hoon Lee, Koung Mi Kan. [Association between Cerebral Small Vessel and Alzheimer's Disease]. Taehan Yongsang Uihakhoe chi. vol 83. issue 3. 2022-10-14. PMID:36238505. |
there is accumulating evidence that vascular changes may play an important role in development of alzheimer's disease (ad), and csvd lesions detected on brain mri were reported to be associated with β-amyloid and tau proteins accumulation. |
2022-10-14 |
2023-08-14 |
Not clear |
| Yu Kyeong Ki. [Recent Updates on PET Imaging in Neurodegenerative Diseases]. Taehan Yongsang Uihakhoe chi. vol 83. issue 3. 2022-10-14. PMID:36238518. |
amyloid-β and tau deposition in pet images are now key diagnostic biomarkers for the alzheimer's disease continuum. |
2022-10-14 |
2023-08-14 |
Not clear |
| Won-Jin Moo. [Alzheimer Dementia and Microvascular Pathology: Blood-Brain Barrier Permeability Imaging]. Taehan Yongsang Uihakhoe chi. vol 81. issue 3. 2022-10-14. PMID:36238621. |
accumulating evidence suggests that alzheimer's disease (ad) is not only caused by accumulation of abnormal proteins, including amyloid and tau, but is also closely associated with abnormalities in the microvascular environment including the blood-brain barrier (bbb), both of which lead to neuroinflammation and neurodegeneration. |
2022-10-14 |
2023-08-14 |
Not clear |
| Bindu D Pau. DUB'ling down uncovers an X-linked vulnerability in Alzheimer's disease. Cell. vol 185. issue 21. 2022-10-14. PMID:36240738. |
show that aberrantly high activity of x-linked usp11 deubiquitinase in women impairs clearance of tau, the principal component of neurofibrillary tangles in alzheimer's disease. |
2022-10-14 |
2023-08-14 |
Not clear |
| Emma M Coomans, Inge M W Verberk, Rik Ossenkoppele, Sander C J Verfaillie, Denise Visser, Mariam Gouda, Hayel Tuncel, Emma E Wolters, Tessa Timmers, Albert D Windhorst, Sandeep S V Golla, Philip Scheltens, Wiesje M van der Flier, Bart N M van Berckel, Charlotte E Teunisse. A head-to-head comparison between plasma pTau181 and tau-PET along the Alzheimer's disease continuum. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2022-10-13. PMID:36229187. |
both plasma tau phosphorylated at threonine-181 (ptau181) and tau positron emission tomography (tau-pet) show potential for detecting alzheimer's disease (ad) pathology and predicting clinical progression. |
2022-10-13 |
2023-08-14 |
Not clear |
| Armine Hovakimyan, Karen Zagorski, Gor Chailyan, Tatevik Antonyan, Levon Melikyan, Irina Petrushina, Dash G Batt, Olga King, Manush Ghazaryan, Aashrit Donthi, Caitlynn Foose, Nikolai Petrovsky, David H Cribbs, Michael G Agadjanyan, Anahit Ghochikya. Immunogenicity of MultiTEP platform technology-based Tau vaccine in non-human primates. NPJ vaccines. vol 7. issue 1. 2022-10-12. PMID:36224191. |
pathological forms of tau protein are directly associated with neurodegeneration and correlate with alzheimer's disease (ad) symptoms, progression, and severity. |
2022-10-12 |
2023-08-14 |
mouse |
| Chen-Ye Mou, Yan-Fei Xie, Jia-Xin Wei, Qi-Yao Wang, Jing-Yang Le, Yong-Jie Bao, Pan-Pan Zhang, Yue-Chun Mao, Xing-Han Huang, Han-Bo Pan, C Benjamin Naman, Lin Liu, Hong-Ze Liang, Xiang Wu, Jia Xu, Wei Cu. Rose Bengal inhibits β-amyloid oligomers-induced tau hyperphosphorylation via acting on Akt and CDK5 kinases. Psychopharmacology. 2022-10-11. PMID:36221038. |
tau hyperphosphorylation and aggregation is considered as a main pathological mechanism underlying alzheimer's disease (ad). |
2022-10-11 |
2023-08-14 |
drosophila_melanogaster |
| Tao-Ran Li, Di-Yang Lyu, Feng-Qi Li. Cerebrospinal Fluid sTREM2 in Alzheimer's Disease Is Associated with Both Amyloid and Tau Pathologies but not with Cognitive Status. Journal of Alzheimer's disease : JAD. 2022-10-10. PMID:36213998. |
cerebrospinal fluid strem2 in alzheimer's disease is associated with both amyloid and tau pathologies but not with cognitive status. |
2022-10-10 |
2023-08-14 |
Not clear |
| Jung-Lung Hsu, Yi-Chia Wei, Cheng Hong Toh, Ing-Tsung Hsiao, Kun-Ju Lin, Tzu-Chen Yen, Ming-Feng Liao, Long-Sun R. MRI images implicate glymphatic alterations mediate cognitive dysfunction in AD. Annals of neurology. 2022-10-10. PMID:36214568. |
the glymphatic system cleans amyloid and tau proteins from the brain in animal studies of alzheimer's disease (ad). |
2022-10-10 |
2023-08-14 |
Not clear |
| Lin Lin, Ronald S Petralia, Lynne Holtzclaw, Ya-Xian Wang, Daniel Abebe, Dax A Hoffma. Alzheimer's disease/dementia-associated brain pathology in aging DPP6-KO mice. Neurobiology of disease. 2022-10-09. PMID:36209950. |
aging dpp6-ko hippocampi contained fewer total neurons and greater neuron death and had diagnostic biomarkers of alzheimer's disease present including accumulation of amyloid β and app and increase in expression of hyper-phosphorylated tau. |
2022-10-09 |
2023-08-14 |
mouse |
| Aileen Roth, Annabelle Sander, Marleen Silke Oswald, Fabian Gärtner, Uwe Knippschild, Joachim Bischo. Comprehensive Characterization of CK1δ-Mediated Tau Phosphorylation in Alzheimer's Disease. Frontiers in molecular biosciences. vol 9. 2022-10-07. PMID:36203870. |
comprehensive characterization of ck1δ-mediated tau phosphorylation in alzheimer's disease. |
2022-10-07 |
2023-08-14 |
Not clear |
| Aileen Roth, Annabelle Sander, Marleen Silke Oswald, Fabian Gärtner, Uwe Knippschild, Joachim Bischo. Comprehensive Characterization of CK1δ-Mediated Tau Phosphorylation in Alzheimer's Disease. Frontiers in molecular biosciences. vol 9. 2022-10-07. PMID:36203870. |
a main pathological event in alzheimer's disease is the generation of neurofibrillary tangles originating from hyperphosphorylated and subsequently aggregated tau proteins. |
2022-10-07 |
2023-08-14 |
Not clear |
| Aileen Roth, Annabelle Sander, Marleen Silke Oswald, Fabian Gärtner, Uwe Knippschild, Joachim Bischo. Comprehensive Characterization of CK1δ-Mediated Tau Phosphorylation in Alzheimer's Disease. Frontiers in molecular biosciences. vol 9. 2022-10-07. PMID:36203870. |
previous reports demonstrated the critical involvement of members of the protein kinase family ck1 in the pathogenesis of alzheimer's disease by hyperphosphorylation of tau. |
2022-10-07 |
2023-08-14 |
Not clear |
| Poosanu Thanapornsangsuth, Tatchaporn Ongphichetmetha, Watayuth Luechaipanit, Pasin Hemachudha, Thiravat Hemachudh. Elevation of plasma phosphorylated tau181 during neurological illnesses affecting consciousness and kidney dysfunction. Alzheimer's & dementia (Amsterdam, Netherlands). vol 14. issue 1. 2022-10-07. PMID:36204656. |
phosphorylated tau (p-tau)181 has become a promising blood-based alzheimer's disease (ad) biomarker. |
2022-10-07 |
2023-08-14 |
Not clear |