| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wagner S Brum, Nicholas C Cullen, Joseph Therriault, Shorena Janelidze, Nesrine Rahmouni, Jenna Stevenson, Stijn Servaes, Andrea L Benedet, Eduardo R Zimmer, Erik Stomrud, Sebastian Palmqvist, Henrik Zetterberg, Giovanni B Frisoni, Nicholas J Ashton, Kaj Blennow, Niklas Mattsson-Carlgren, Pedro Rosa-Neto, Oskar Hansso. A blood-based biomarker workflow for optimal tau-PET referral in memory clinic settings. Nature communications. vol 15. issue 1. 2024-03-15. PMID:38486040. |
blood-based biomarkers for screening may guide tau positrion emissition tomography (pet) scan referrals to optimize prognostic evaluation in alzheimer's disease. |
2024-03-15 |
2024-03-17 |
human |
| Julian D Dallmeier, Ryan Gober, Regina T Vontell, Ayled Barreda, Daniel A Dorfsman, David A Davis, Xiaoyan Sun, Daniel Brzostowicki, Illiana Bennett, Susanna P Garamszegi, Connor M Wander, Todd Cohen, William K Scot. Corpora amylacea negatively correlate with hippocampal tau pathology in Alzheimer's disease. Frontiers in neuroscience. vol 18. 2024-03-15. PMID:38486969. |
corpora amylacea negatively correlate with hippocampal tau pathology in alzheimer's disease. |
2024-03-15 |
2024-03-17 |
Not clear |
| Julian D Dallmeier, Ryan Gober, Regina T Vontell, Ayled Barreda, Daniel A Dorfsman, David A Davis, Xiaoyan Sun, Daniel Brzostowicki, Illiana Bennett, Susanna P Garamszegi, Connor M Wander, Todd Cohen, William K Scot. Corpora amylacea negatively correlate with hippocampal tau pathology in Alzheimer's disease. Frontiers in neuroscience. vol 18. 2024-03-15. PMID:38486969. |
severity and distribution of aggregated tau and neurofibrillary tangles (nft) are strongly correlated with the clinical presentation of alzheimer's disease (ad). |
2024-03-15 |
2024-03-17 |
Not clear |
| Ali Aljassabi, Tarek Zieneldien, Janice Kim, Deepika Regmi, Chuanhai Ca. Alzheimer's Disease Immunotherapy: Current Strategies and Future Prospects. Journal of Alzheimer's disease : JAD. 2024-03-15. PMID:38489183. |
alzheimer's disease (ad) is an extremely complex and heterogeneous pathology influenced by many factors contributing to its onset and progression, including aging, amyloid-beta (aβ) plaques, tau fibril accumulation, inflammation, etc. |
2024-03-15 |
2024-03-18 |
Not clear |
| Yu Zou, Lulu Guan, Jingwang Tan, Bote Qi, Yunxiang Sun, Fengjuan Huang, Qingwen Zhan. Molecular Insights into the Differential Effects of Acetylation on the Aggregation of Tau Microtubule-Binding Repeats. Journal of chemical information and modeling. 2024-03-15. PMID:38489841. |
aggregation of tau protein into intracellular fibrillary inclusions is characterized as the hallmark of tauopathies, including alzheimer's disease and chronic traumatic encephalopathy. |
2024-03-15 |
2024-03-18 |
Not clear |
| James Naude, Meng Wang, Rebeca Leon, Eric Smith, Zahinoor Ismai. Tau-PET in early cortical Alzheimer brain regions in relation to mild behavioral impairment in older adults with either normal cognition or mild cognitive impairment. Neurobiology of aging. vol 138. 2024-03-15. PMID:38490074. |
phosphorylated tau (p-tau) is a hallmark biological manifestation of alzheimer disease (ad). |
2024-03-15 |
2024-03-18 |
human |
| Jennifer L Whitwel. Atypical clinical variants of Alzheimer's disease: are they really atypical? Frontiers in neuroscience. vol 18. 2024-03-14. PMID:38482142. |
alzheimer's disease (ad) is a neuropathological disorder defined by the deposition of the proteins, tau and β-amyloid. |
2024-03-14 |
2024-03-16 |
Not clear |
| Hong Xu, Qi Qiu, Peng Hu, Kevt'her Hoxha, Elliot Jang, Mia O'Reilly, Christopher Kim, Zhuohao He, Nicholas Marotta, Lakshmi Changolkar, Bin Zhang, Hao Wu, Gerard D Schellenberg, Brian Kraemer, Kelvin C Luk, Edward B Lee, John Q Trojanowski, Kurt R Brunden, Virginia M-Y Le. MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons. Acta neuropathologica. vol 147. issue 1. 2024-03-13. PMID:38472475. |
inclusions comprised of microtubule-associated protein tau (tau) are implicated in a group of neurodegenerative diseases, collectively known as tauopathies, that include alzheimer's disease (ad). |
2024-03-13 |
2024-03-15 |
mouse |
| Matilda Iemmolo, Giulia Bivona, Tommaso Piccoli, Aldo Nicosia, Gabriella Schiera, Carlo Maria Di Liegro, Fabrizio Di Pietra, Giulio Ghers. Effects of Cerebrospinal Fluids from Alzheimer and Non-Alzheimer Patients on Neurons-Astrocytes-Microglia Co-Culture. International journal of molecular sciences. vol 25. issue 5. 2024-03-13. PMID:38473758. |
alzheimer's disease (ad) is the most common form of dementia, characterized by the accumulation of β-amyloid plaques, tau tangles, neuroinflammation, and synaptic/neuronal loss, the latter being the strongest correlating factor with memory and cognitive impairment. |
2024-03-13 |
2024-03-15 |
Not clear |
| Kiwamu Kudo, Kamalini G Ranasinghe, Hirofumi Morise, Faatimah Syed, Kensuke Sekihara, Katherine P Rankin, Bruce L Miller, Joel Kramer, Gil Rabinovici, Keith Vossel, Heidi E Kirsch, Srikantan Nagaraja. Neurophysiological trajectories in Alzheimer's disease progression. bioRxiv : the preprint server for biology. 2024-03-12. PMID:37293044. |
alzheimer's disease (ad) is characterized by the accumulation of amyloid-β and misfolded tau proteins causing synaptic dysfunction, and progressive neurodegeneration and cognitive decline. |
2024-03-12 |
2024-03-14 |
Not clear |
| Daniel Pirici, Laurentiu Mogoanta, Daniela Adriana Ion, Samir Kumar-Sing. Fractal Analysis in Neurodegenerative Diseases. Advances in neurobiology. vol 36. 2024-03-12. PMID:38468042. |
the abnormal conformation and assembly of proteins is suggested to be the most probable cause for many of these neurodegenerative disorders, leading to the accumulation of abnormally aggregated proteins, for example, amyloid β (aβ) (alzheimer's disease and vascular dementia), tau protein (alzheimer's disease and frontotemporal lobar degeneration), α-synuclein (parkinson's disease and lewy body dementia), polyglutamine expansion diseases (huntington disease), or prion proteins (creutzfeldt-jakob disease). |
2024-03-12 |
2024-03-14 |
Not clear |
| Suzuko Ochi, Kumiko Yamada, Takashi Saito, Takaomi C Saido, Mitsuo Iinuma, Kagaku Azuma, Kin-Ya Kub. Effects of early tooth loss on chronic stress and progression of neuropathogenesis of Alzheimer's disease in adult Alzheimer's model Frontiers in aging neuroscience. vol 16. 2024-03-12. PMID:38469162. |
effects of early tooth loss on chronic stress and progression of neuropathogenesis of alzheimer's disease in adult alzheimer's model alzheimer's disease (ad), the most common neurodegenerative disease, is characterized by accumulated amyloid-β (aβ) plaques, aggregated phosphorylated tau protein, gliosis-associated neuroinflammation, synaptic dysfunction, and cognitive impairment. |
2024-03-12 |
2024-03-14 |
Not clear |
| Sadegh Ghaderi, Sana Mohammadi, Nahid Jashire Nezhad, Shaghayegh Karami, Fatemeh Sayehmir. Iron quantification in basal ganglia: quantitative susceptibility mapping as a potential biomarker for Alzheimer's disease - a systematic review and meta-analysis. Frontiers in neuroscience. vol 18. 2024-03-12. PMID:38469572. |
alzheimer's disease (ad), characterized by distinctive pathologies such as amyloid-β plaques and tau tangles, also involves deregulation of iron homeostasis, which may accelerate neurodegeneration. |
2024-03-12 |
2024-03-14 |
Not clear |
| Yu-Mi Shim, Seong-Ik Kim, So Dug Lim, Kwanghoon Lee, Eric Eunshik Kim, Jae Kyung Won, Sung-Hye Par. An Autopsy-proven Case-based Review of Autoimmune Encephalitis. Experimental neurobiology. vol 33. issue 1. 2024-03-12. PMID:38471800. |
the autopsy revealed that this patient also had alzheimer's disease, atherosclerosis, arteriolosclerosis, and aging-related tau astrogliopathy. |
2024-03-12 |
2024-03-15 |
Not clear |
| Patricia Rodriguez-Rodriguez, Luis Enrique Arroyo-Garcia, Christina Tsagkogianni, Lechuan Li, Wei Wang, Ákos Végvári, Isabella Salas-Allende, Zakary Plautz, Angel Cedazo-Minguez, Subhash C Sinha, Olga Troyanskaya, Marc Flajolet, Vicky Yao, Jean-Pierre Roussari. A cell autonomous regulator of neuronal excitability modulates tau in Alzheimer's disease vulnerable neurons. Brain : a journal of neurology. 2024-03-11. PMID:38462574. |
a cell autonomous regulator of neuronal excitability modulates tau in alzheimer's disease vulnerable neurons. |
2024-03-11 |
2024-03-14 |
mouse |
| Patricia Rodriguez-Rodriguez, Luis Enrique Arroyo-Garcia, Christina Tsagkogianni, Lechuan Li, Wei Wang, Ákos Végvári, Isabella Salas-Allende, Zakary Plautz, Angel Cedazo-Minguez, Subhash C Sinha, Olga Troyanskaya, Marc Flajolet, Vicky Yao, Jean-Pierre Roussari. A cell autonomous regulator of neuronal excitability modulates tau in Alzheimer's disease vulnerable neurons. Brain : a journal of neurology. 2024-03-11. PMID:38462574. |
neurons from layer ii of the entorhinal cortex (ecii) are the first to accumulate tau protein aggregates and degenerate during prodromal alzheimer's disease (ad). |
2024-03-11 |
2024-03-14 |
mouse |
| Hui-Yang Lei, Gui-Lin Pi, Ting He, Rui Xiong, Jing-Ru Lv, Jia-Le Liu, Dong-Qin Wu, Meng-Zhu Li, Kun Shi, Shi-Hong Li, Na-Na Yu, Yang Gao, Hui-Ling Yu, Lin-Yu Wei, Xin Wang, Qiu-Zhi Zhou, Pei-Lin Zou, Jia-Yang Zhou, Ying-Zhou Liu, Nai-Ting Shen, Jie Yang, Dan Ke, Qun Wang, Gong-Ping Liu, Xi-Fei Yang, Jian-Zhi Wang, Ying Yan. Targeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer-like social memory loss. Military Medical Research. vol 11. issue 1. 2024-03-11. PMID:38462603. |
episodic memory loss is a prominent clinical manifestation of alzheimer's disease (ad), which is closely related to tau pathology and hippocampal impairment. |
2024-03-11 |
2024-03-14 |
mouse |
| Harshini Chandrashekar, Zoltan Simandi, Heesun Choi, Han-Seul Ryu, Abraham J Waldman, Alexandria Nikish, Srikar S Muppidi, Wanfeng Gong, Dominik Paquet, Jennifer E Phillips-Cremin. A multi-looping chromatin signature predicts dysregulated gene expression in neurons with familial Alzheimer's disease mutations. bioRxiv : the preprint server for biology. 2024-03-11. PMID:38463966. |
here, using human post-mitotic neurons with rare familial alzheimer's disease (fad) mutations, we identify hundreds of reproducibly dysregulated genes and thousands of miswired loops prior to amyloid accumulation and tau phosphorylation. |
2024-03-11 |
2024-03-14 |
human |
| Yuntao Yang, Yuhan Xie, Zhao Li, Chiamaka Diala, Meer Ali, Rongbin Li, Yi Xu, Albon Wu, Pora Kim, Sayed-Rzgar Hosseini, Erfei Bi, Hongyu Zhao, W Jim Zhen. Systematic characterization of protein structural features of alternative splicing isoforms using AlphaFold 2. bioRxiv : the preprint server for biology. 2024-03-11. PMID:38464054. |
furthermore, our analysis uncovered two missense mutations in the tau protein that could influence alternative splicing, potentially contributing to the pathogenesis of alzheimer's disease. |
2024-03-11 |
2024-03-14 |
human |
| Qili Hu, Mengqiu Shi, Yunfei Li, Xiaohu Zha. Elevated plasma neurofilament light was associated with multi-modal neuroimaging features in Alzheimer's Disease signature regions and predicted future tau deposition. Research square. 2024-03-11. PMID:38464117. |
elevated plasma neurofilament light was associated with multi-modal neuroimaging features in alzheimer's disease signature regions and predicted future tau deposition. |
2024-03-11 |
2024-03-14 |
Not clear |