| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shalini Kanagasingam, Christopher von Ruhland, Richard Welbury, Sim K Singhra. Antimicrobial, Polarizing Light, and Paired Helical Filament Properties of Fragmented Tau Peptides of Selected Putative Gingipains. Journal of Alzheimer's disease : JAD. 2022-08-29. PMID:36031895. |
hyperphosphorylation of tau and neurofibrillary tangle (nft) formation is a defining lesion of alzheimer's disease (ad) where nft distribution is related to braak stage and disease severity. |
2022-08-29 |
2023-08-14 |
Not clear |
| Qing Wang, Chunming Xi. Microglia activation linking amyloid-β drive tau spatial propagation in Alzheimer's disease. Frontiers in neuroscience. vol 16. 2022-08-29. PMID:36033617. |
microglia activation linking amyloid-β drive tau spatial propagation in alzheimer's disease. |
2022-08-29 |
2023-08-14 |
Not clear |
| Adelaide R Tousley, Pamela W L Yeh, Hermes H Ye. Precocious emergence of cognitive and synaptic dysfunction in 3xTg-AD mice exposed prenatally to ethanol. Alcohol (Fayetteville, N.Y.). 2022-08-29. PMID:36038084. |
here we exposed a mouse model of alzheimer's disease (3xtg-ad), bearing 3 dementia associated transgenes: presenilin1 (ps1m146v), human amyloid precursor protein (appswe) and human tau (taup301s), to ethanol on gestational days 13.5-16.5 using an established binge-type maternal ethanol exposure paradigm. |
2022-08-29 |
2023-08-14 |
mouse |
| A Harrison Brody, Sarah Helena Nies, Fulin Guan, Levi M Smith, Bandhan Mukherjee, Santiago A Salazar, Suho Lee, Tu Kiet T Lam, Stephen M Strittmatte. Correction: Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy. Molecular neurodegeneration. vol 17. issue 1. 2022-08-29. PMID:36038879. |
correction: alzheimer risk gene product pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy. |
2022-08-29 |
2023-08-14 |
Not clear |
| I-Fang Wang, Pei-Chuan Ho, Kuen-Jer Tsa. MicroRNAs in Learning and Memory and Their Impact on Alzheimer's Disease. Biomedicines. vol 10. issue 8. 2022-08-26. PMID:36009403. |
we also summarize extensive studies on mirnas correlated with pathogenic tau and amyloid-β that drive the processes of alzheimer's disease (ad). |
2022-08-26 |
2023-08-14 |
mouse |
| Bisan Saleh, Kolluru D Srikanth, Tal Sneh, Lambert Yue, Steven Pelech, Evan Elliott, Hava Gil-Hen. FAK-Mediated Signaling Controls Amyloid Beta Overload, Learning and Memory Deficits in a Mouse Model of Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 16. 2022-08-26. PMID:36012331. |
using the 3xtg-ad mouse model, which carries three mutations associated with familial alzheimer's disease (app km670/671nl swedish, psen1 m146v, mapt p301l) and develops age-related progressive neuropathology including amyloid plaques and tau tangles, we describe here, for the first time, the in vivo role of fak in ad pathology. |
2022-08-26 |
2023-08-14 |
mouse |
| Ryszard Pluta, Sławomir Januszewski, Mirosław Jabłońsk. Acetylated Tau Protein: A New Piece in the Puzzle between Brain Ischemia and Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 16. 2022-08-26. PMID:36012440. |
acetylated tau protein: a new piece in the puzzle between brain ischemia and alzheimer's disease. |
2022-08-26 |
2023-08-14 |
Not clear |
| Carla Borràs, Aina Mercer, Sònia Sirisi, Daniel Alcolea, Joan Carles Escolà-Gil, Francisco Blanco-Vaca, Mireia Tond. HDL-like-Mediated Cell Cholesterol Trafficking in the Central Nervous System and Alzheimer's Disease Pathogenesis. International journal of molecular sciences. vol 23. issue 16. 2022-08-26. PMID:36012637. |
alzheimer's disease is characterized by the accumulation of extracellular amyloid beta (aβ) and abnormally hyperphosphorylated intracellular tau filaments in neurons. |
2022-08-26 |
2023-08-14 |
Not clear |
| Krzysztof Więckowski, Natalia Szałaj, Beata Gryzło, Tomasz Wichur, Izabella Góral, Emilia Sługocka, Joanna Sniecikowska, Gniewomir Latacz, Agata Siwek, Justyna Godyń, Adam Bucki, Marcin Kołaczkowski, Anna Więckowsk. Serotonin 5-HT International journal of molecular sciences. vol 23. issue 16. 2022-08-26. PMID:36012707. |
serotonin 5-ht neurodegeneration leading to alzheimer's disease results from a complex interplay of a variety of processes including misfolding and aggregation of amyloid beta and tau proteins, neuroinflammation or oxidative stress. |
2022-08-26 |
2023-08-14 |
Not clear |
| Giuseppe Di Natale, Giuseppina Sabatino, Michele Francesco Maria Sciacca, Rita Tosto, Danilo Milardi, Giuseppe Pappalard. Aβ and Tau Interact with Metal Ions, Lipid Membranes and Peptide-Based Amyloid Inhibitors: Are These Common Features Relevant in Alzheimer's Disease? Molecules (Basel, Switzerland). vol 27. issue 16. 2022-08-26. PMID:36014310. |
aβ and tau interact with metal ions, lipid membranes and peptide-based amyloid inhibitors: are these common features relevant in alzheimer's disease? |
2022-08-26 |
2023-08-14 |
Not clear |
| Maria Babu, Filippo Favretto, Marija Rankovic, Markus Zweckstette. Peptidyl Prolyl Isomerase A Modulates the Liquid-Liquid Phase Separation of Proline-Rich IDPs. Journal of the American Chemical Society. 2022-08-26. PMID:36018855. |
here, we demonstrate that the most ubiquitous peptidyl prolyl isomerase, peptidyl prolyl isomerase a (ppia), concentrates inside liquid-like droplets formed by the alzheimer's disease-associated protein tau, as well as inside rna-induced coacervates of a proline-arginine dipeptide repeat protein. |
2022-08-26 |
2023-08-14 |
Not clear |
| Seda Onder, Kevser Biberoglu, Melike Yuksel, Ozden Taca. Toluidine blue O attenuates tau phosphorylation in N2a-APPSwe cells. Chemico-biological interactions. 2022-08-26. PMID:36027949. |
alzheimer's disease (ad) is characterized by extracellular amyloid plaques composed of amyloid β peptide (aβ), intracellular neurofibrillary tangles containing hyperphosphorylated tau protein and neuronal loss. |
2022-08-26 |
2023-08-14 |
mouse |
| Victoria E Bernaud, Haidyn L Bulen, Veronica L Peña, Stephanie V Koebele, Steven N Northup-Smith, Alma A Manzo, Maria Valenzuela Sanchez, Zorana Opachich, Ashley M Ruhland, Heather A Bimonte-Nelso. Task-dependent learning and memory deficits in the TgF344-AD rat model of Alzheimer's disease: three key timepoints through middle-age in females. Scientific reports. vol 12. issue 1. 2022-08-26. PMID:36028737. |
the tgf344 rat model of alzheimer's disease (ad) provides a comprehensive neuropathology presentation, with age-dependent development of tau tangles, amyloid-beta (a[formula: see text]) plaques, neuronal loss, and increased gliosis. |
2022-08-26 |
2023-08-14 |
rat |
| Mozhgan Alipour, Mahsa Motavaf, Parviz Abdolmaleki, Alireza Zali, Farzad Ashrafi, Saeid Safari, Behnam Hajipour-Verdo. Structural Analysis and Conformational Dynamics of Short Helical Hyperphosphorylated Segments of Tau Protein (Sequence 254-290) in Alzheimer's Disease: A Molecular Dynamics Simulation Study. Frontiers in molecular biosciences. vol 9. 2022-08-25. PMID:36003083. |
structural analysis and conformational dynamics of short helical hyperphosphorylated segments of tau protein (sequence 254-290) in alzheimer's disease: a molecular dynamics simulation study. |
2022-08-25 |
2023-08-14 |
Not clear |
| Pranesh Padmanabhan, Andrew Kneynsberg, Esteban Cruz, Rumelo Amor, Jean-Baptiste Sibarita, Jürgen Göt. Single-molecule imaging reveals Tau trapping at nanometer-sized dynamic hot spots near the plasma membrane that persists after microtubule perturbation and cholesterol depletion. The EMBO journal. 2022-08-25. PMID:36004506. |
accumulation of aggregates of the microtubule-binding protein tau is a pathological hallmark of alzheimer's disease. |
2022-08-25 |
2023-08-14 |
Not clear |
| Kurt Farrell, Megan A Iida, Jonathan D Cherry, Alicia Casella, Thor D Stein, Kevin F Bieniek, Jamie M Walker, Timothy E Richardson, Charles L White, Victor E Alvarez, Bertrand R Huber, Dennis W Dickson, Ricardo Insausti, Kristen Dams-O'Connor, Ann C McKee, John F Crar. Differential Vulnerability of Hippocampal Subfields in Primary Age-Related Tauopathy and Chronic Traumatic Encephalopathy. Journal of neuropathology and experimental neurology. 2022-08-25. PMID:36004533. |
in moderate to advanced cte, nfts accumulate in the hippocampus, potentially overlapping neuroanatomically with primary age-related tauopathy (part), an age-related tauopathy characterized by alzheimer disease-like tau pathology in the hippocampus devoid of amyloid plaques. |
2022-08-25 |
2023-08-14 |
human |
| Shinrye Lee, Myungjin Jo, Younghwi Kwon, Yu-Mi Jeon, Seyeon Kim, Kea Joo Lee, Hyung-Jun Ki. PTK2 regulates tau-induced neurotoxicity via phosphorylation of p62 at Ser403. Journal of neurogenetics. 2022-08-24. PMID:36000467. |
tau is a microtubule-associated protein that forms insoluble filaments that accumulate as neurofibrillary tangles in neurodegenerative diseases such as alzheimer's disease and other related tauopathies. |
2022-08-24 |
2023-08-14 |
Not clear |
| Joseph Therriault, Tharick A Pascoal, Mélissa Savard, Sulantha Mathotaarachchi, Andréa L Benedet, Mira Chamoun, Cécile Tissot, Firoza Z Lussier, Nesrine Rahmouni, Jenna Stevenson, Muhammad Naveed Iqbal Qureshi, Min Su Kang, Émilie Thomas, Paolo Vitali, Jean-Paul Soucy, Gassan Massarweh, Paramita Saha-Chaudhuri, Serge Gauthier, Pedro Rosa-Net. Intrinsic connectivity of the human brain provides scaffold for tau aggregation in clinical variants of Alzheimer's disease. Science translational medicine. vol 14. issue 659. 2022-08-24. PMID:36001678. |
intrinsic connectivity of the human brain provides scaffold for tau aggregation in clinical variants of alzheimer's disease. |
2022-08-24 |
2023-08-14 |
human |
| Marine Prissette, Wen Fury, Matthew Koss, Claudia Racioppi, Daria Fedorova, Ella Dragileva, Georgia Clarke, Taylor Pohl, John Dugan, Diana Ahrens, Joyce Chiu, Charleen Hunt, Chia-Jen Siao, Tara Young, Arijit Bhowmick, Vitaliy Rogulin, Mathieu Desclaux, Eric Y Hayden, Michael Podgorski, Min Gao, Lynn E Macdonald, David Frendewey, George D Yancopoulos, Brian Zambrowic. Disruption of nuclear envelope integrity as a possible initiating event in tauopathies. Cell reports. vol 40. issue 8. 2022-08-24. PMID:36001963. |
in alzheimer's disease and other neurodegenerative tauopathies, tau is found hyperphosphorylated and aggregated in neurofibrillary tangles. |
2022-08-24 |
2023-08-14 |
Not clear |
| Erika Taipala, Jeremiah C Pfitzer, Morgan Hellums, Miranda N Reed, Michael W Gramlic. rTg(Tau Frontiers in synaptic neuroscience. vol 14. 2022-08-22. PMID:35989711. |
rtg(tau the molecular pathways that contribute to the onset of symptoms in tauopathy models, including alzheimer's disease (ad), are difficult to distinguish because multiple changes can happen simultaneously at different stages of disease progression. |
2022-08-22 |
2023-08-14 |
Not clear |