| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria Babu, Filippo Favretto, Marija Rankovic, Markus Zweckstette. Peptidyl Prolyl Isomerase A Modulates the Liquid-Liquid Phase Separation of Proline-Rich IDPs. Journal of the American Chemical Society. 2022-08-26. PMID:36018855. |
here, we demonstrate that the most ubiquitous peptidyl prolyl isomerase, peptidyl prolyl isomerase a (ppia), concentrates inside liquid-like droplets formed by the alzheimer's disease-associated protein tau, as well as inside rna-induced coacervates of a proline-arginine dipeptide repeat protein. |
2022-08-26 |
2023-08-14 |
Not clear |
| Seda Onder, Kevser Biberoglu, Melike Yuksel, Ozden Taca. Toluidine blue O attenuates tau phosphorylation in N2a-APPSwe cells. Chemico-biological interactions. 2022-08-26. PMID:36027949. |
alzheimer's disease (ad) is characterized by extracellular amyloid plaques composed of amyloid β peptide (aβ), intracellular neurofibrillary tangles containing hyperphosphorylated tau protein and neuronal loss. |
2022-08-26 |
2023-08-14 |
mouse |
| Victoria E Bernaud, Haidyn L Bulen, Veronica L Peña, Stephanie V Koebele, Steven N Northup-Smith, Alma A Manzo, Maria Valenzuela Sanchez, Zorana Opachich, Ashley M Ruhland, Heather A Bimonte-Nelso. Task-dependent learning and memory deficits in the TgF344-AD rat model of Alzheimer's disease: three key timepoints through middle-age in females. Scientific reports. vol 12. issue 1. 2022-08-26. PMID:36028737. |
the tgf344 rat model of alzheimer's disease (ad) provides a comprehensive neuropathology presentation, with age-dependent development of tau tangles, amyloid-beta (a[formula: see text]) plaques, neuronal loss, and increased gliosis. |
2022-08-26 |
2023-08-14 |
rat |
| Mozhgan Alipour, Mahsa Motavaf, Parviz Abdolmaleki, Alireza Zali, Farzad Ashrafi, Saeid Safari, Behnam Hajipour-Verdo. Structural Analysis and Conformational Dynamics of Short Helical Hyperphosphorylated Segments of Tau Protein (Sequence 254-290) in Alzheimer's Disease: A Molecular Dynamics Simulation Study. Frontiers in molecular biosciences. vol 9. 2022-08-25. PMID:36003083. |
structural analysis and conformational dynamics of short helical hyperphosphorylated segments of tau protein (sequence 254-290) in alzheimer's disease: a molecular dynamics simulation study. |
2022-08-25 |
2023-08-14 |
Not clear |
| Pranesh Padmanabhan, Andrew Kneynsberg, Esteban Cruz, Rumelo Amor, Jean-Baptiste Sibarita, Jürgen Göt. Single-molecule imaging reveals Tau trapping at nanometer-sized dynamic hot spots near the plasma membrane that persists after microtubule perturbation and cholesterol depletion. The EMBO journal. 2022-08-25. PMID:36004506. |
accumulation of aggregates of the microtubule-binding protein tau is a pathological hallmark of alzheimer's disease. |
2022-08-25 |
2023-08-14 |
Not clear |
| Kurt Farrell, Megan A Iida, Jonathan D Cherry, Alicia Casella, Thor D Stein, Kevin F Bieniek, Jamie M Walker, Timothy E Richardson, Charles L White, Victor E Alvarez, Bertrand R Huber, Dennis W Dickson, Ricardo Insausti, Kristen Dams-O'Connor, Ann C McKee, John F Crar. Differential Vulnerability of Hippocampal Subfields in Primary Age-Related Tauopathy and Chronic Traumatic Encephalopathy. Journal of neuropathology and experimental neurology. 2022-08-25. PMID:36004533. |
in moderate to advanced cte, nfts accumulate in the hippocampus, potentially overlapping neuroanatomically with primary age-related tauopathy (part), an age-related tauopathy characterized by alzheimer disease-like tau pathology in the hippocampus devoid of amyloid plaques. |
2022-08-25 |
2023-08-14 |
human |
| Shinrye Lee, Myungjin Jo, Younghwi Kwon, Yu-Mi Jeon, Seyeon Kim, Kea Joo Lee, Hyung-Jun Ki. PTK2 regulates tau-induced neurotoxicity via phosphorylation of p62 at Ser403. Journal of neurogenetics. 2022-08-24. PMID:36000467. |
tau is a microtubule-associated protein that forms insoluble filaments that accumulate as neurofibrillary tangles in neurodegenerative diseases such as alzheimer's disease and other related tauopathies. |
2022-08-24 |
2023-08-14 |
Not clear |
| Joseph Therriault, Tharick A Pascoal, Mélissa Savard, Sulantha Mathotaarachchi, Andréa L Benedet, Mira Chamoun, Cécile Tissot, Firoza Z Lussier, Nesrine Rahmouni, Jenna Stevenson, Muhammad Naveed Iqbal Qureshi, Min Su Kang, Émilie Thomas, Paolo Vitali, Jean-Paul Soucy, Gassan Massarweh, Paramita Saha-Chaudhuri, Serge Gauthier, Pedro Rosa-Net. Intrinsic connectivity of the human brain provides scaffold for tau aggregation in clinical variants of Alzheimer's disease. Science translational medicine. vol 14. issue 659. 2022-08-24. PMID:36001678. |
intrinsic connectivity of the human brain provides scaffold for tau aggregation in clinical variants of alzheimer's disease. |
2022-08-24 |
2023-08-14 |
human |
| Marine Prissette, Wen Fury, Matthew Koss, Claudia Racioppi, Daria Fedorova, Ella Dragileva, Georgia Clarke, Taylor Pohl, John Dugan, Diana Ahrens, Joyce Chiu, Charleen Hunt, Chia-Jen Siao, Tara Young, Arijit Bhowmick, Vitaliy Rogulin, Mathieu Desclaux, Eric Y Hayden, Michael Podgorski, Min Gao, Lynn E Macdonald, David Frendewey, George D Yancopoulos, Brian Zambrowic. Disruption of nuclear envelope integrity as a possible initiating event in tauopathies. Cell reports. vol 40. issue 8. 2022-08-24. PMID:36001963. |
in alzheimer's disease and other neurodegenerative tauopathies, tau is found hyperphosphorylated and aggregated in neurofibrillary tangles. |
2022-08-24 |
2023-08-14 |
Not clear |
| Erika Taipala, Jeremiah C Pfitzer, Morgan Hellums, Miranda N Reed, Michael W Gramlic. rTg(Tau Frontiers in synaptic neuroscience. vol 14. 2022-08-22. PMID:35989711. |
rtg(tau the molecular pathways that contribute to the onset of symptoms in tauopathy models, including alzheimer's disease (ad), are difficult to distinguish because multiple changes can happen simultaneously at different stages of disease progression. |
2022-08-22 |
2023-08-14 |
Not clear |
| Kazuya Tsumagari, Yoshiaki Sato, Aki Shimozawa, Hirofumi Aoyagi, Hideyuki Okano, Junro Kuromits. Co-expression network analysis of human tau-transgenic mice reveals protein modules associated with tau-induced pathologies. iScience. vol 25. issue 8. 2022-08-22. PMID:35992067. |
abnormally accumulated tau protein aggregates are one of the hallmarks of neurodegenerative diseases, including alzheimer's disease (ad). |
2022-08-22 |
2023-08-14 |
mouse |
| Takeshi Iwatsub. Molecular Pathogenesis and Disease-modifying Therapies of Alzheimer's Disease and Related Disorders. JMA journal. vol 5. issue 3. 2022-08-22. PMID:35992282. |
the deposition of amyloid β (aβ) peptides as senile plaques and tau as neurofibrillary changes causes the hallmark neuropathological lesions of alzheimer's disease (ad), which are implicated in its pathogenesis and deemed as the prime target for disease-modifying therapies (dmts). |
2022-08-22 |
2023-08-14 |
Not clear |
| Yuto Uchida, Hirohito Kan, Keita Sakurai, Kenichi Oishi, Noriyuki Matsukaw. Quantitative susceptibility mapping as an imaging biomarker for Alzheimer's disease: The expectations and limitations. Frontiers in neuroscience. vol 16. 2022-08-22. PMID:35992906. |
meanwhile, recent clinicopathological and radiological studies have shown closer associations of tau pathology rather than β-amyloid pathology with the onset and progression of alzheimer's symptoms. |
2022-08-22 |
2023-08-14 |
Not clear |
| Emmanuel Prikas, Esmeralda Paric, Prita R Asih, Kristie Stefanoska, Holly Stefen, Thomas Fath, Anne Poljak, Arne Ittne. Tau target identification reveals NSF-dependent effects on AMPA receptor trafficking and memory formation. The EMBO journal. 2022-08-22. PMID:35993331. |
microtubule-associated protein tau is a central factor in alzheimer's disease and other tauopathies. |
2022-08-22 |
2023-08-14 |
mouse |
| Emmanuel Prikas, Esmeralda Paric, Prita R Asih, Kristie Stefanoska, Holly Stefen, Thomas Fath, Anne Poljak, Arne Ittne. Tau target identification reveals NSF-dependent effects on AMPA receptor trafficking and memory formation. The EMBO journal. 2022-08-22. PMID:35993331. |
tau interactors map onto pathways of cytoskeletal, synaptic vesicle and postsynaptic receptor regulation and show significant enrichment for parkinson's, alzheimer's and prion disease. |
2022-08-22 |
2023-08-14 |
mouse |
| Robert Lalonde, Catherine Straziell. Cocoa Flavanols and the Aging Brain. Current aging science. 2022-08-22. PMID:35993474. |
improvements are also reported in biologic markers of alzheimer's disease, in particular an increase soluble aβ and a decrease in tau hyperphosphorylation. |
2022-08-22 |
2023-08-14 |
mouse |
| Anne Fourest-Lieuvin, Angélique Vinit, Béatrice Blot, Anthime Perrot, Eric Denarier, Frédéric Saudou, Isabelle Arna. Controlled tau cleavage in cells reveals abnormal localizations of tau fragments. Neuroscience. 2022-08-22. PMID:35995336. |
in several forms of dementia, such as alzheimer's disease, the cytoskeleton-associated protein tau undergoes proteolysis, giving rise to fragments that have a toxic impact on neuronal homeostasis. |
2022-08-22 |
2023-08-14 |
Not clear |
| Alzheimer's disease-implicated protein tau puts the squeeze on microtubules. Nature chemical biology. 2022-08-22. PMID:35996002. |
alzheimer's disease-implicated protein tau puts the squeeze on microtubules. |
2022-08-22 |
2023-08-14 |
Not clear |
| Sujata Thakur, Rishika Dhapola, Phulen Sarma, Bikash Medhi, Dibbanti HariKrishna Redd. Neuroinflammation in Alzheimer's Disease: Current Progress in Molecular Signaling and Therapeutics. Inflammation. 2022-08-20. PMID:35986874. |
alzheimer's disease is marked by tau hyperphosphorylation and amyloid beta accumulation that robs people of their memories. |
2022-08-20 |
2023-08-14 |
Not clear |
| Zhen Wei, Kuan Zeng, Jichang Hu, Xing Li, Fang Huang, Bin Zhang, Jian-Zhi Wang, Rong Liu, Hong-Lian Li, Xiaochuan Wan. USP10 deubiquitinates Tau, mediating its aggregation. Cell death & disease. vol 13. issue 8. 2022-08-20. PMID:35987808. |
in alzheimer's disease (ad), tau aggregation causes it to lose these above-mentioned functions. |
2022-08-20 |
2023-08-14 |
mouse |