| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tapan Behl, Rashita Makkar, Aayush Sehgal, Neelam Sharma, Sukhbir Singh, Mohammed Albratty, Asim Najmi, Abdulkarim M Meraya, Simona Gabriela Bunga. Insights into the Explicit Protective Activity of Herbals in Management of Neurodegenerative and Cerebrovascular Disorders. Molecules (Basel, Switzerland). vol 27. issue 15. 2022-08-12. PMID:35956919. |
the treatment employed in management of these debilitating neurodegenerative disorders, such as parkinson's disease (which mainly involves the loss of dopaminergic neurons in the nigrostriatal region), alzheimer's disease (which arises due to accumulation of tau proteins causing diffusive atrophy in the brain), huntington's disease (which involves damage of striatal and spinal neurons, etc. |
2022-08-12 |
2023-08-14 |
Not clear |
| Leian Chen, Xiaoqian Niu, Yuye Wang, Shuang Lv, Xiao Zhou, Ziyuan Yang, Dantao Pen. Plasma tau proteins for the diagnosis of mild cognitive impairment and Alzheimer's disease: A systematic review and meta-analysis. Frontiers in aging neuroscience. vol 14. 2022-08-12. PMID:35959295. |
plasma tau proteins for the diagnosis of mild cognitive impairment and alzheimer's disease: a systematic review and meta-analysis. |
2022-08-12 |
2023-08-14 |
Not clear |
| Leian Chen, Xiaoqian Niu, Yuye Wang, Shuang Lv, Xiao Zhou, Ziyuan Yang, Dantao Pen. Plasma tau proteins for the diagnosis of mild cognitive impairment and Alzheimer's disease: A systematic review and meta-analysis. Frontiers in aging neuroscience. vol 14. 2022-08-12. PMID:35959295. |
we performed a systematic review and meta-analysis in order to test the accuracy of plasma tau protein in diagnosing alzheimer's disease (ad) or mild cognitive impairment (mci). |
2022-08-12 |
2023-08-14 |
Not clear |
| Mahmoud B Maina, Youssra K Al-Hilaly, Sebastian Oakley, Gunashekar Burra, Tahmida Khanon, Luca Biasetti, Kurtis Mengham, Karen Marshall, Charles R Harrington, Claude M Wischik, Louise C Serpel. Dityrosine cross-links are present in Alzheimer's disease-derived tau oligomers and paired helical filaments (PHF) which promotes the stability of the PHF-core tau (297-391) in vitro. Journal of molecular biology. 2022-08-12. PMID:35961386. |
dityrosine cross-links are present in alzheimer's disease-derived tau oligomers and paired helical filaments (phf) which promotes the stability of the phf-core tau (297-391) in vitro. |
2022-08-12 |
2023-08-14 |
Not clear |
| Mahmoud B Maina, Youssra K Al-Hilaly, Sebastian Oakley, Gunashekar Burra, Tahmida Khanon, Luca Biasetti, Kurtis Mengham, Karen Marshall, Charles R Harrington, Claude M Wischik, Louise C Serpel. Dityrosine cross-links are present in Alzheimer's disease-derived tau oligomers and paired helical filaments (PHF) which promotes the stability of the PHF-core tau (297-391) in vitro. Journal of molecular biology. 2022-08-12. PMID:35961386. |
a characteristic hallmark of alzheimer's disease (ad) is the pathological aggregation and deposition of tau into paired helical filaments (phf) in neurofibrillary tangles (nfts). |
2022-08-12 |
2023-08-14 |
Not clear |
| Tahereh Tekieh, P A Robinson, Svetlana Postnov. Cortical waste clearance in normal and restricted sleep with potential runaway tau buildup in Alzheimer's disease. Scientific reports. vol 12. issue 1. 2022-08-12. PMID:35961995. |
cortical waste clearance in normal and restricted sleep with potential runaway tau buildup in alzheimer's disease. |
2022-08-12 |
2023-08-14 |
Not clear |
| Tahereh Tekieh, P A Robinson, Svetlana Postnov. Cortical waste clearance in normal and restricted sleep with potential runaway tau buildup in Alzheimer's disease. Scientific reports. vol 12. issue 1. 2022-08-12. PMID:35961995. |
predicted tau accumulation has timescales consistent with the development of alzheimer's disease. |
2022-08-12 |
2023-08-14 |
Not clear |
| Jonathan Graff-Radford, Michelle M Mielke, Ekaterina I Hofrenning, Naomi Kouri, Timothy G Lesnick, Christina M Moloney, Alejandro Rabinstein, Janisse N Cabrera-Rodriguez, Darren M Rothberg, Scott A Przybelski, Ronald C Petersen, David S Knopman, Dennis W Dickson, Clifford R Jack, Alicia Algeciras-Schimnich, Aivi T Nguyen, Melissa E Murray, Prashanthi Vemur. Association of plasma biomarkers of amyloid and neurodegeneration with cerebrovascular disease and Alzheimer's disease. Neurobiology of aging. vol 119. 2022-08-11. PMID:35952440. |
we identified 64 participants in a population-based study with antemortem plasma markers (amyloid-β [aβ] x-42, aβx-40, neurofilament light [nfl], and total tau [t-tau]) who also had neuropathologic assessments of alzheimer's and cerebrovascular pathology. |
2022-08-11 |
2023-08-14 |
human |
| Shaney Flores, Charles D Chen, Yi Su, Aylin Dincer, Sarah J Keefe, Nicole S McKay, Angela M Paulick, Gloria Guzman Perez-Carillo, Liang Wang, Russ C Hornbeck, Manu Goyal, Andrei Vlassenko, Sally Schwarz, Michael L Nickels, Dean F Wong, Zhude Tu, Jonathan E McConathy, John C Morris, Tammie L S Benzinger, Brian A Gordo. Investigating Tau and Amyloid Tracer Skull Binding in Studies of Alzheimer disease. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2022-08-11. PMID:35953305. |
investigating tau and amyloid tracer skull binding in studies of alzheimer disease. |
2022-08-11 |
2023-08-14 |
Not clear |
| Duo Gao, Jiaqian Wan, Yu Zou, Yehong Gong, Xuewei Dong, Zhengdong Xu, Jiaxing Tang, Guanghong Wei, Qingwen Zhan. The destructive mechanism of Aβ Physical chemistry chemical physics : PCCP. 2022-08-10. PMID:35946429. |
the destructive mechanism of aβ amyloid-β (aβ) fibrillary plaques represent the main hallmarks of alzheimer's disease (ad), in addition to tau neurofibrillary tangles. |
2022-08-10 |
2023-08-14 |
Not clear |
| João Pedro Ferrari-Souza, Pâmela C L Ferreira, Bruna Bellaver, Cécile Tissot, Yi-Ting Wang, Douglas T Leffa, Wagner S Brum, Andréa L Benedet, Nicholas J Ashton, Marco Antônio De Bastiani, Andréia Rocha, Joseph Therriault, Firoza Z Lussier, Mira Chamoun, Stijn Servaes, Gleb Bezgin, Min Su Kang, Jenna Stevenson, Nesrine Rahmouni, Vanessa Pallen, Nina Margherita Poltronetti, William E Klunk, Dana L Tudorascu, Ann D Cohen, Victor L Villemagne, Serge Gauthier, Kaj Blennow, Henrik Zetterberg, Diogo O Souza, Thomas K Karikari, Eduardo R Zimmer, Pedro Rosa-Neto, Tharick A Pascoa. Astrocyte biomarker signatures of amyloid-β and tau pathologies in Alzheimer's disease. Molecular psychiatry. 2022-08-10. PMID:35948658. |
astrocyte biomarker signatures of amyloid-β and tau pathologies in alzheimer's disease. |
2022-08-10 |
2023-08-14 |
Not clear |
| Carrera-Muñoz Ismael, Barrios-López José M, Muñoz-Martínez Claudia, Romero-Fábrega Juan C, Vilchez-Carrillo Rosa M, Del Ser Quijano Teodoro, Carnero-Pardo Cristob. The cognitive performance in the Phototest is predictor of biological markers of Alzheimer's disease. International journal of geriatric psychiatry. vol 37. issue 9. 2022-08-09. PMID:35942571. |
the abnormal cerebrospinal fluid levels of biomarkers, such as β-amyloid and phosphorylated tau (ptau), support the biological diagnosis of alzheimer disease (ad) independently of its clinical stage. |
2022-08-09 |
2023-08-14 |
Not clear |
| Tiantian Guo, Xinjia Pan, Guangtong Jiang, Denghong Zhang, Jinghui Qi, Lin Shao, Zhanxiang Wang, Huaxi Xu, Yingjun Zha. Downregulating PTBP1 fails to convert astrocytes into hippocampal neurons and to alleviate symptoms in Alzheimer's mouse models. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-08-09. PMID:35944999. |
here, we demonstrate that ptbp1 downregulation using an astrocyte specific aav-mediated shrna system fails to convert hippocampal astrocytes into neurons in both male and female wt, and β-amyloid (5×fad) and tau (ps19) alzheimer's disease (ad) mouse models, and fails to reverse synaptic/cognitive deficits and ad-associated pathology in male mice. |
2022-08-09 |
2023-08-14 |
mouse |
| Adam Martersteck, Ivan Ayala, Daniel T Ohm, Callen Spencer, Christina Coventry, Sandra Weintraub, Eileen H Bigio, M -Marsel Mesulam, Changiz Geula, Emily Rogalsk. Focal amyloid and asymmetric tau in an imaging-to-autopsy case of clinical primary progressive aphasia with Alzheimer disease neuropathology. Acta neuropathologica communications. vol 10. issue 1. 2022-08-09. PMID:35945628. |
focal amyloid and asymmetric tau in an imaging-to-autopsy case of clinical primary progressive aphasia with alzheimer disease neuropathology. |
2022-08-09 |
2023-08-14 |
Not clear |
| Adam Martersteck, Ivan Ayala, Daniel T Ohm, Callen Spencer, Christina Coventry, Sandra Weintraub, Eileen H Bigio, M -Marsel Mesulam, Changiz Geula, Emily Rogalsk. Focal amyloid and asymmetric tau in an imaging-to-autopsy case of clinical primary progressive aphasia with Alzheimer disease neuropathology. Acta neuropathologica communications. vol 10. issue 1. 2022-08-09. PMID:35945628. |
quantification of in vivo amyloid and tau pet imaging relationships with postmortem measurements are critical for validating the sensitivity and specificity imaging biomarkers across clinical phenotypes with alzheimer disease neuropathologic change (adnc). |
2022-08-09 |
2023-08-14 |
Not clear |
| Juan Li, Bin Zou, Xiao-Yu Cheng, Xin-He Yang, Jia Li, Chun-Hui Zhao, Rui-Xia Ma, Ji-Xiang Tian, Yao Ya. Therapeutic effects of total saikosaponins from Frontiers in pharmacology. vol 13. 2022-08-08. PMID:35935875. |
therapeutic effects of total saikosaponins from alzheimer's disease (ad) is a neurodegenerative disease characterized by memory loss and cognitive dysfunction in the elderly, with amyloid-beta (aβ) deposition and hyperphosphorylation of tau protein as the main pathological feature. |
2022-08-08 |
2023-08-14 |
Not clear |
| Ling Wu, Zerui Wang, Shradha Lad, Nailya Gilyazova, Darren T Dougharty, Madeleine Marcus, Frances Henderson, W Keith Ray, Sandra Siedlak, Jianyong Li, Richard F Helm, Xiongwei Zhu, George S Bloom, Shih-Hsiu J Wang, Wen-Quan Zou, Bin X. Selective Detection of Misfolded Tau From Postmortem Alzheimer's Disease Brains. Frontiers in aging neuroscience. vol 14. 2022-08-08. PMID:35936779. |
selective detection of misfolded tau from postmortem alzheimer's disease brains. |
2022-08-08 |
2023-08-14 |
human |
| Ling Wu, Zerui Wang, Shradha Lad, Nailya Gilyazova, Darren T Dougharty, Madeleine Marcus, Frances Henderson, W Keith Ray, Sandra Siedlak, Jianyong Li, Richard F Helm, Xiongwei Zhu, George S Bloom, Shih-Hsiu J Wang, Wen-Quan Zou, Bin X. Selective Detection of Misfolded Tau From Postmortem Alzheimer's Disease Brains. Frontiers in aging neuroscience. vol 14. 2022-08-08. PMID:35936779. |
tau aggregates are present in multiple neurodegenerative diseases known as "tauopathies," including alzheimer's disease, pick's disease, progressive supranuclear palsy, and corticobasal degeneration. |
2022-08-08 |
2023-08-14 |
human |
| Connor M Wander, Tamy Harumy Moraes Tsujimoto, John F Ervin, Chanung Wang, Spencer M Maranto, Vanya Bhat, Julian D Dallmeier, Shih-Hsiu Jerry Wang, Feng-Chang Lin, William K Scott, David M Holtzman, Todd J Cohe. Corpora amylacea are associated with tau burden and cognitive status in Alzheimer's disease. Acta neuropathologica communications. vol 10. issue 1. 2022-08-08. PMID:35941704. |
corpora amylacea are associated with tau burden and cognitive status in alzheimer's disease. |
2022-08-08 |
2023-08-14 |
mouse |
| Xiangxiang Zhu, Zilei Zhang, Xin Yang, Longkai Qi, Yinrui Guo, Xiaocui Tang, Yizhen Xie, Diling Che. Improvement of extraction from Hericium erinaceus on the gut-brain axis in AD-like mice. Brain research. 2022-08-07. PMID:35934088. |
in this study, results showed the extractions of hericium erinaceus can ameliorate the learning and memory abilities significantly, reduce the swelling of brain tissues, neuronal apoptosis, and down-regulate the expression of alzheimer's disease intracellular markers including tau and aβ1-42. |
2022-08-07 |
2023-08-14 |
mouse |