| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hui-Yang Lei, Gui-Lin Pi, Ting He, Rui Xiong, Jing-Ru Lv, Jia-Le Liu, Dong-Qin Wu, Meng-Zhu Li, Kun Shi, Shi-Hong Li, Na-Na Yu, Yang Gao, Hui-Ling Yu, Lin-Yu Wei, Xin Wang, Qiu-Zhi Zhou, Pei-Lin Zou, Jia-Yang Zhou, Ying-Zhou Liu, Nai-Ting Shen, Jie Yang, Dan Ke, Qun Wang, Gong-Ping Liu, Xi-Fei Yang, Jian-Zhi Wang, Ying Yan. Targeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer-like social memory loss. Military Medical Research. vol 11. issue 1. 2024-03-11. PMID:38462603. |
episodic memory loss is a prominent clinical manifestation of alzheimer's disease (ad), which is closely related to tau pathology and hippocampal impairment. |
2024-03-11 |
2024-03-14 |
mouse |
| Harshini Chandrashekar, Zoltan Simandi, Heesun Choi, Han-Seul Ryu, Abraham J Waldman, Alexandria Nikish, Srikar S Muppidi, Wanfeng Gong, Dominik Paquet, Jennifer E Phillips-Cremin. A multi-looping chromatin signature predicts dysregulated gene expression in neurons with familial Alzheimer's disease mutations. bioRxiv : the preprint server for biology. 2024-03-11. PMID:38463966. |
here, using human post-mitotic neurons with rare familial alzheimer's disease (fad) mutations, we identify hundreds of reproducibly dysregulated genes and thousands of miswired loops prior to amyloid accumulation and tau phosphorylation. |
2024-03-11 |
2024-03-14 |
human |
| Yuntao Yang, Yuhan Xie, Zhao Li, Chiamaka Diala, Meer Ali, Rongbin Li, Yi Xu, Albon Wu, Pora Kim, Sayed-Rzgar Hosseini, Erfei Bi, Hongyu Zhao, W Jim Zhen. Systematic characterization of protein structural features of alternative splicing isoforms using AlphaFold 2. bioRxiv : the preprint server for biology. 2024-03-11. PMID:38464054. |
furthermore, our analysis uncovered two missense mutations in the tau protein that could influence alternative splicing, potentially contributing to the pathogenesis of alzheimer's disease. |
2024-03-11 |
2024-03-14 |
human |
| Qili Hu, Mengqiu Shi, Yunfei Li, Xiaohu Zha. Elevated plasma neurofilament light was associated with multi-modal neuroimaging features in Alzheimer's Disease signature regions and predicted future tau deposition. Research square. 2024-03-11. PMID:38464117. |
elevated plasma neurofilament light was associated with multi-modal neuroimaging features in alzheimer's disease signature regions and predicted future tau deposition. |
2024-03-11 |
2024-03-14 |
Not clear |
| Cassis Varlow, Chester A Mathis, Neil Vasde. In vitro evaluation of [ Nuclear medicine and biology. vol 130-131. 2024-03-08. PMID:38458074. |
in vitro evaluation of [ alzheimer's disease (ad) and non-ad tauopathies such as chronic traumatic encephalopathy (cte), progressive supranuclear palsy (psp), and corticobasal degeneration (cbd) are characterized by the abnormal aggregation of three-repeat (3r) and/or four-repeat (4r) tau isoforms. |
2024-03-08 |
2024-03-11 |
human |
| Nicolas R Barthélemy, Gemma Salvadó, Suzanne E Schindler, Yingxin He, Shorena Janelidze, Lyduine E Collij, Benjamin Saef, Rachel L Henson, Charles D Chen, Brian A Gordon, Yan Li, Renaud La Joie, Tammie L S Benzinger, John C Morris, Niklas Mattsson-Carlgren, Sebastian Palmqvist, Rik Ossenkoppele, Gil D Rabinovici, Erik Stomrud, Randall J Bateman, Oskar Hansso. Highly accurate blood test for Alzheimer's disease is similar or superior to clinical cerebrospinal fluid tests. Nature medicine. 2024-03-07. PMID:38382645. |
plasma %p-tau217 (ratio of phosporylated-tau217 to non-phosphorylated tau) was analyzed by mass spectrometry in the swedish biofinder-2 cohort (n = 1,422) and the us charles f. and joanne knight alzheimer disease research center (knight adrc) cohort (n = 337). |
2024-03-07 |
2024-03-10 |
Not clear |
| Yuan-Yuan Yong, Lu Yan, Bin-Ding Wang, Dong-Sheng Fan, Min-Song Guo, Lu Yu, Jian-Ming Wu, Da-Lian Qin, Betty Yuen-Kwan Law, Vincent Kam-Wai Wong, Chong-Lin Yu, Xiao-Gang Zhou, An-Guo W. Penthorum chinense Pursh inhibits ferroptosis in cellular and Caenorhabditis elegans models of Alzheimer's disease. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 127. 2024-03-07. PMID:38452694. |
ferroptosis, a unique type of cell death triggered by iron-dependent lipid peroxidation, plays a critical role in the pathogenesis of alzheimer's disease (ad), a debilitating condition marked by memory loss and cognitive impairment due to the accumulation of beta-amyloid (aβ) and hyperphosphorylated tau protein. |
2024-03-07 |
2024-03-10 |
caenorhabditis_elegans |
| Diny Thomson, Emily Rosenich, Paul Maruff, Yen Ying Li. BDNF Val66Met moderates episodic memory decline and tau biomarker increases in early sporadic Alzheimer's disease. Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists. 2024-03-07. PMID:38454193. |
bdnf val66met moderates episodic memory decline and tau biomarker increases in early sporadic alzheimer's disease. |
2024-03-07 |
2024-03-10 |
Not clear |
| Irene Sintini, Nick Corriveau-Lecavalier, David T Jones, Mary M Machulda, Jeffrey L Gunter, Christopher G Schwarz, Hugo Botha, Arenn F Carlos, Michael G Kamykowski, Neha Atulkumar Singh, Ronald C Petersen, Clifford R Jack, Val J Lowe, Jonathan Graff-Radford, Keith A Josephs, Jennifer L Whitwel. Longitudinal default mode sub-networks in the language and visual variants of Alzheimer's disease. Brain communications. vol 6. issue 2. 2024-03-06. PMID:38444909. |
we investigated cross-sectional and 1-year longitudinal changes in default mode network sub-systems in the visual and language variants of alzheimer's disease, in relation to age and tau. |
2024-03-06 |
2024-03-08 |
human |
| J H Bentley, J I Broussar. Multimodal Gamma Stimulation Improves Activity but not Memory in Aged Tgf344-AD Rats. Current Alzheimer research. 2024-03-06. PMID:38445702. |
however, many of these models lack some of the hallmarks of alzheimer's disease, such as hyperphosphorylated tau and neuronal cell loss. |
2024-03-06 |
2024-03-08 |
mouse |
| Dibyadeep Datta, Isabella Perone, Denethi Wijegunawardana, Feng Liang, Yury M Morozov, Jon Arellano, Alvaro Duque, Zhongcong Xie, Christopher H van Dyck, Mary Kate P Joyce, Amy F T Arnste. Nanoscale imaging of pT217-tau in aged rhesus macaque entorhinal and dorsolateral prefrontal cortex: Evidence of interneuronal trafficking and early-stage neurodegeneration. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-03-06. PMID:38445818. |
tau phosphorylated at threonine-217 (pt217-tau) is a novel fluid-based biomarker that predicts onset of alzheimer's disease (ad) symptoms, but little is known about how pt217-tau arises in the brain, as soluble pt217-tau is dephosphorylated post mortem in humans. |
2024-03-06 |
2024-03-08 |
monkey |
| Ruihua Liu, Linli Guo, Yanan Zhao, Dan Wu, Jiasi Yu, Ping Li. Study on multi-target effects of the novel HDAC6 inhibitor W5 on Aβ/Cu Brain research. 2024-03-05. PMID:38442843. |
study on multi-target effects of the novel hdac6 inhibitor w5 on aβ/cu histone deacetylase 6 (hdac6) is a key therapeutic target in neurodegenerative diseases such as alzheimer's disease (ad), which has been demonstrated to play an essential role in memory function and microtubule-associated tau physiology. |
2024-03-05 |
2024-03-08 |
rat |
| Roberto Collu, Zheng Yin, Elisa Giunti, Sarah Daley, Mei Chen, Peter Morin, Richard Killick, Stephen T C Wong, Weiming Xi. Effect of the ROCK inhibitor fasudil on the brain proteomic profile in the tau transgenic mouse model of Alzheimer's disease. Frontiers in aging neuroscience. vol 16. 2024-03-05. PMID:38440100. |
effect of the rock inhibitor fasudil on the brain proteomic profile in the tau transgenic mouse model of alzheimer's disease. |
2024-03-05 |
2024-03-07 |
mouse |
| Roberto Collu, Zheng Yin, Elisa Giunti, Sarah Daley, Mei Chen, Peter Morin, Richard Killick, Stephen T C Wong, Weiming Xi. Effect of the ROCK inhibitor fasudil on the brain proteomic profile in the tau transgenic mouse model of Alzheimer's disease. Frontiers in aging neuroscience. vol 16. 2024-03-05. PMID:38440100. |
the goal of this study is to explore the pharmacological potential of the amyloid-reducing vasodilator fasudil, a selective ras homolog (rho)-associated kinases (rock) inhibitor, in the p301s tau transgenic mouse model (line ps19) of neurodegenerative tauopathy and alzheimer's disease (ad). |
2024-03-05 |
2024-03-07 |
mouse |
| Fardin Nabizadeh, Rasa Zafar. Progranulin and neuropathological features of Alzheimer's disease: longitudinal study. Aging clinical and experimental research. vol 36. issue 1. 2024-03-05. PMID:38441695. |
it has been shown that the csf level of progranulin increases in alzheimer's disease (ad) patients and is associated with the deposition of amyloid-beta (aβ) and tau in the brain tissue. |
2024-03-05 |
2024-03-07 |
Not clear |
| Junjian Zeng, Zhiqiang Liao, Hanqin Yang, Qiong Wang, Zhiyong Wu, Fuzhou Hua, Zhidong Zho. T cell infiltration mediates neurodegeneration and cognitive decline in Alzheimer's disease. Neurobiology of disease. 2024-03-04. PMID:38437992. |
alzheimer's disease (ad) is a prevalent neurodegenerative disorder with pathological features of β-amyloid (aβ) and hyperphosphorylated tau protein accumulation in the brain, often accompanied by cognitive decline. |
2024-03-04 |
2024-03-07 |
Not clear |
| Arshad Abdul Vahid, Muhammed Shafeek Oliyantakath Hassan, Allwin Ebenezer Sahayaraj, Ann Teres Babu, Safwa T Kizhakkeduth, Vinesh Vijaya. Modulation of Primary and Secondary Processes in Tau Fibril Formation by Salt-Induced Dynamics. ACS chemical neuroscience. 2024-03-04. PMID:38433380. |
the current study characterizes the aggregation pathway of two tau protein constructs that have been recently demonstrated to form alzheimer's (ad) fibril structures with divalent ions and chronic traumatic encephalopathy (cte) fibril structures with monovalent ions. |
2024-03-04 |
2024-03-06 |
Not clear |
| Yahang Liu, Qian Gao, Kecheng Wei, Chen Huang, Ce Wang, Yongfu Yu, Guoyou Qin, Tong Wan. High-dimensional generalized median adaptive lasso with application to omics data. Briefings in bioinformatics. vol 25. issue 2. 2024-03-04. PMID:38436558. |
we also utilized the gmal method on a deoxyribonucleic acid methylation dataset from the alzheimer's disease (ad) neuroimaging initiative database to investigate the association between cerebrospinal fluid tau protein levels and the severity of ad. |
2024-03-04 |
2024-03-06 |
Not clear |
| Julia Eisenhardt de Mello, Fernanda Cardoso Teixeira, Alessandra Dos Santos, Karina Luduvico, Mayara Sandrielly Soares de Aguiar, William Borges Domingues, Vinicius Farias Campos, Rejane Giacomelli Tavares, Augusto Schneider, Francieli Moro Stefanello, Roselia Maria Spanevell. Treatment with Blackberry Extract and Metformin in Sporadic Alzheimer's Disease Model: Impact on Memory, Inflammation, Redox Status, Phosphorylated Tau Protein and Insulin Signaling. Molecular neurobiology. 2024-03-02. PMID:38430352. |
treatment with blackberry extract and metformin in sporadic alzheimer's disease model: impact on memory, inflammation, redox status, phosphorylated tau protein and insulin signaling. |
2024-03-02 |
2024-03-04 |
rat |
| Wei Wang, Wen-Qing Zheng, Xian Du, Shi-Cai Chen, Yan-Han Chen, Qing-Yang Ma, Hao Wang, Shan Gao, Rui Tan, Han-Ting Zhang, Yan-Meng Zhou, Fang-Fang Zhan. Chronic pain exacerbates memory impairment and pathology of Aβ and tau by upregulating IL-1β and p-65 signaling in a mouse model of Alzheimer's disease. Brain research. 2024-03-02. PMID:38430996. |
chronic pain exacerbates memory impairment and pathology of aβ and tau by upregulating il-1β and p-65 signaling in a mouse model of alzheimer's disease. |
2024-03-02 |
2024-03-06 |
mouse |