| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yetirajam Rajesh, Thirumala-Devi Kannegant. Innate Immune Cell Death in Neuroinflammation and Alzheimer's Disease. Cells. vol 11. issue 12. 2022-06-24. PMID:35741014. |
alzheimer's disease (ad) is a neurodegenerative disorder molecularly characterized by the formation of amyloid β (aβ) plaques and type 2 microtubule-associated protein (tau) abnormalities. |
2022-06-24 |
2023-08-14 |
Not clear |
| Qianyun Chen, Jill Abrigo, Wanting Liu, Elyia Yixun Han, David Ka Wai Yeung, Lin Shi, Lisa Wing Chi Au, Min Deng, Sirong Chen, Eric Yim Lung Leung, Chi Lai Ho, Vincent Chung Tong Mok, Winnie Chiu Wing Ch. Lower Posterior Cingulate N-Acetylaspartate to Creatine Level in Early Detection of Biologically Defined Alzheimer's Disease. Brain sciences. vol 12. issue 6. 2022-06-24. PMID:35741606. |
alzheimer's disease (ad) was recently defined as a biological construct to reflect neuropathologic status, and both abnormal amyloid and tau are required for a diagnosis of ad. |
2022-06-24 |
2023-08-14 |
Not clear |
| Isidro Ferrer, Pol Andrés-Benito, Karina Ausín, Paz Cartas-Cejudo, Mercedes Lachén-Montes, José Antonio Del Rio, Joaquín Fernández-Irigoyen, Enrique Santamarí. Dysregulated Brain Protein Phosphorylation Linked to Increased Human Tau Expression in the hTau Transgenic Mouse Model. International journal of molecular sciences. vol 23. issue 12. 2022-06-24. PMID:35742871. |
altered protein phosphorylation is a major pathologic modification in tauopathies and alzheimer's disease (ad) linked to abnormal tau fibrillar deposits in neurofibrillary tangles (nfts) and pre-tangles and β-amyloid deposits in ad. |
2022-06-24 |
2023-08-14 |
mouse |
| Haijun Yang, Fantian Zeng, Yunchun Luo, Chao Zheng, Chongzhao Ran, Jian Yan. Curcumin Scaffold as a Multifunctional Tool for Alzheimer's Disease Research. Molecules (Basel, Switzerland). vol 27. issue 12. 2022-06-24. PMID:35745002. |
alzheimer's disease (ad) is one of the most common neurodegenerative disorders, which is caused by multi-factors and characterized by two histopathological hallmarks: amyloid-β (aβ) plaques and neurofibrillary tangles of tau proteins. |
2022-06-24 |
2023-08-14 |
Not clear |
| Clíona Farrell, Paige Mumford, Frances K Wisema. Rodent Modeling of Alzheimer's Disease in Down Syndrome: Frontiers in neuroscience. vol 16. 2022-06-24. PMID:35747206. |
in developed countries, the vast majority of these individuals will develop alzheimer's disease neuropathology characterized by the accumulation of amyloid-β (aβ) plaques and tau neurofibrillary tangles within the brain, which leads to the early onset of dementia (ad-ds) and reduced life-expectancy. |
2022-06-24 |
2023-08-14 |
Not clear |
| Becky C Carlyle, Robert R Kitchen, Zoe Mattingly, Amanda M Celia, Bianca A Trombetta, Sudeshna Das, Bradley T Hyman, Pia Kivisäkk, Steven E Arnol. Technical Performance Evaluation of Olink Proximity Extension Assay for Blood-Based Biomarker Discovery in Longitudinal Studies of Alzheimer's Disease. Frontiers in neurology. vol 13. 2022-06-23. PMID:35734478. |
the core alzheimer's disease (ad) cerebrospinal fluid (csf) biomarkers; amyloid-β (aß), total tau (t-tau), and phosphorylated tau (p-tau181), are strong indicators of the presence of ad pathology, but do not correlate well with disease progression, and can be difficult to implement in longitudinal studies where repeat biofluid sampling is required. |
2022-06-23 |
2023-08-14 |
Not clear |
| Laura M Wright, Matteo De Marco, Annalena Venner. Verbal fluency discrepancies as a marker of the prehippocampal stages of Alzheimer's disease. Neuropsychology. 2022-06-23. PMID:35737533. |
prior to evidence of episodic memory decline, a lengthy preclinical phase of alzheimer's disease (ad) exists characterized by the build-up of tau pathology within extrahippocampal structures. |
2022-06-23 |
2023-08-14 |
Not clear |
| Simah Mohammadi, Hashem Rafii-Tabar, Pezhman Sasanpou. A modeling study of the effect of an alternating magnetic field on magnetite nanoparticles in proximity of the neuronal microtubules: A proposed mechanism for detachment of tau proteins. Computer methods and programs in biomedicine. vol 222. 2022-06-23. PMID:35738092. |
it is known that the disintegration of microtubules in neurons occurs in response to the phosphorylation of the tau proteins that promotes the structural instability of the microtubules, as one of the factors underlying the onset of alzheimer's disease (ad). |
2022-06-23 |
2023-08-14 |
Not clear |
| Shu-Qin Cao, Yahyah Aman, Evandro F Fang, Tewin Tencomna. P. edulis Extract Protects Against Amyloid-β Toxicity in Alzheimer's Disease Models Through Maintenance of Mitochondrial Homeostasis via the FOXO3/DAF-16 Pathway. Molecular neurobiology. 2022-06-23. PMID:35739408. |
alzheimer's disease (ad) is a common and devastating disease characterized by pathological aggregations of beta-amyloid (aβ) plaques extracellularly, and tau tangles intracellularly. |
2022-06-23 |
2023-08-14 |
caenorhabditis_elegans |
| S Tok, H Maurin, C Delay, D Crauwels, N V Manyakov, W Van Der Elst, D Moechars, W H I M Drinkenbur. Pathological and neurophysiological outcomes of seeding human-derived tau pathology in the APP-KI NL-G-F and NL-NL mouse models of Alzheimer's Disease. Acta neuropathologica communications. vol 10. issue 1. 2022-06-23. PMID:35739575. |
pathological and neurophysiological outcomes of seeding human-derived tau pathology in the app-ki nl-g-f and nl-nl mouse models of alzheimer's disease. |
2022-06-23 |
2023-08-14 |
mouse |
| Mengmeng Zheng, Jiangyu Yan, Wenjuan Hao, Yuan Ren, Ming Zhou, Yunzhi Wang, Kai Wan. Worsening hearing was associated with higher β-amyloid and tau burden in age-related hearing loss. Scientific reports. vol 12. issue 1. 2022-06-21. PMID:35729211. |
β-amyloid plaques and tau accumulation in brain are hallmarks pathologic feature of alzheimer's disease (ad), which is a leading cause resulting in dementia. |
2022-06-21 |
2023-08-14 |
Not clear |
| Abdullah Al Bashit, Prakash Nepal, Theresa Connors, Derek H Oakley, Bradley T Hyman, Lin Yang, Lee Makowsk. Mapping the Spatial Distribution of Fibrillar Polymorphs in Human Brain Tissue. Frontiers in neuroscience. vol 16. 2022-06-20. PMID:35720706. |
alzheimer's disease (ad) is a neurodegenerative disorder defined by the progressive formation and spread of fibrillar aggregates of aβ peptide and tau protein. |
2022-06-20 |
2023-08-14 |
human |
| Xing Fan, Liye Xia, Zheng Zhou, Yanyan Qiu, Chenhao Zhao, Xiaomin Yin, Wei Qia. Tau Acts in Concert With Kinase/Phosphatase Underlying Synaptic Dysfunction. Frontiers in aging neuroscience. vol 14. 2022-06-17. PMID:35711910. |
alzheimer's disease (ad) is characterized by two pathological features: neurofibrillary tangles (nfts), formed by microtubule-associated protein tau, and abnormal accumulation of amyloid-β (aβ). |
2022-06-17 |
2023-08-14 |
Not clear |
| Kristian F Odfalk, Kevin F Bieniek, Sarah C Hop. Microglia: Friend and Foe in Tauopathy. Progress in neurobiology. 2022-06-17. PMID:35714860. |
the consistent spatiotemporal progression of tau pathology in alzheimer's disease (ad) led to the hypothesis that tau aggregates spread in the brain via bioactive tau "seeds" underlying advancing disease course. |
2022-06-17 |
2023-08-14 |
Not clear |
| Vrinda Kalia, Megan M Niedzwiecki, Joshua M Bradner, Fion K Lau, Faith L Anderson, Meghan L Bucher, Katherine E Manz, Alexa Puri Schlotter, Zoe Coates Fuentes, Kurt D Pennell, Martin Picard, Douglas I Walker, William T Hu, Dean P Jones, Gary W Mille. Cross-species metabolomic analysis of tau- and DDT-related toxicity. PNAS nexus. vol 1. issue 2. 2022-06-16. PMID:35707205. |
exposure to the pesticide dichlorodiphenyltrichloroethane (ddt) has been associated with increased risk of alzheimer's disease (ad), a disease also associated with hyperphosphorylated tau (p-tau) protein aggregation. |
2022-06-16 |
2023-08-14 |
Not clear |
| Nicola Spotorno, Chloé Najac, Erik Stomrud, Niklas Mattsson-Carlgren, Sebastian Palmqvist, Danielle van Westen, Itamar Ronen, Oskar Hansso. Astrocytic function is associated with both amyloid-β and tau pathology in non-demented Brain communications. vol 4. issue 3. 2022-06-15. PMID:35702728. |
astrocytic function is associated with both amyloid-β and tau pathology in non-demented a growing body of evidence suggests that astrocytes play a major role in the pathophysiology of alzheimer's disease. |
2022-06-15 |
2023-08-14 |
Not clear |
| Gemma Salvadó, Mahnaz Shekari, Carles Falcon, Grégory Operto, Marta Milà-Alomà, Gonzalo Sánchez-Benavides, Raffaele Cacciaglia, Eider Arenaza-Urquijo, Aida Niñerola-Baizán, Andrés Perissinotti, Carolina Minguillon, Karine Fauria, Gwendlyn Kollmorgen, Ivonne Suridjan, José Luis Molinuevo, Henrik Zetterberg, Kaj Blennow, Marc Suárez-Calvet, Juan Domingo Gisper. Brain alterations in the early Alzheimer's continuum with amyloid-β, tau, glial and neurodegeneration CSF markers. Brain communications. vol 4. issue 3. 2022-06-15. PMID:35702732. |
brain alterations in the early alzheimer's continuum with amyloid-β, tau, glial and neurodegeneration csf markers. |
2022-06-15 |
2023-08-14 |
Not clear |
| Amelia Hicks, Jennie L Ponsford, Gershon Spitz, Vincent Dore, Natasha Krishnadas, Caroline Roberts, Christopher C Row. Amyloid- and Tau Imaging in Chronic Traumatic Brain Injury: A Cross-sectional Study. Neurology. 2022-06-15. PMID:35705503. |
there is evidence of elevated amyloid-β and tau, the pathological hallmarks of alzheimer's disease, immediately following tbi. |
2022-06-15 |
2023-08-14 |
Not clear |
| Ning Yan, Xiao-Long Shi, Long-Qian Tang, De-Feng Wang, Xun Li, Chao Liu, Zhao-Peng Li. Synthesis and biological evaluation of thieno[3,2- Journal of enzyme inhibition and medicinal chemistry. vol 37. issue 1. 2022-06-14. PMID:35698879. |
synthesis and biological evaluation of thieno[3,2- glycogen synthase kinase 3β (gsk-3β) catalyses the hyperphosphorylation of tau protein in the alzheimer's disease (ad) pathology. |
2022-06-14 |
2023-08-14 |
Not clear |
| Amy N Zwierzchowski-Zarate, Aydé Mendoza-Oliva, Omar M Kashmer, Josue E Collazo-Lopez, Charles L White, Marc I Diamon. RNA induces unique tau strains and stabilizes Alzheimer's disease seeds. The Journal of biological chemistry. 2022-06-14. PMID:35700826. |
rna induces unique tau strains and stabilizes alzheimer's disease seeds. |
2022-06-14 |
2023-08-14 |
human |