All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Giovanni Oliveros, Charles H Wallace, Osama Chaudry, Qiao Liu, Yue Qiu, Lei Xie, Patricia Rockwell, Maria E Figueiredo-Pereira, Peter A Serran. Repurposing ibudilast to mitigate Alzheimer's disease by targeting inflammation. Brain : a journal of neurology. 2022-04-12. PMID:35411386. this transgenic rat model is unique as it exhibits hippocampal-dependent spatial learning and memory deficits, and alzheimer's disease pathology including hippocampal amyloid plaques, tau paired-helical filaments, neuronal loss and microgliosis, in a progressive age-dependent manner that mimics the pathology observed in alzheimer's disease patients. 2022-04-12 2023-08-13 rat
Vijay K Ramanan, Michael G Heckman, Timothy G Lesnick, Scott A Przybelski, Elliot J Cahn, Matthew L Kosel, Melissa E Murray, Michelle M Mielke, Hugo Botha, Jonathan Graff-Radford, David T Jones, Val J Lowe, Mary M Machulda, Clifford R Jack, David S Knopman, Ronald C Petersen, Owen A Ross, Prashanthi Vemur. Tau polygenic risk scoring: a cost-effective aid for prognostic counseling in Alzheimer's disease. Acta neuropathologica. 2022-04-12. PMID:35412102. tau polygenic risk scoring: a cost-effective aid for prognostic counseling in alzheimer's disease. 2022-04-12 2023-08-13 Not clear
Vijay K Ramanan, Michael G Heckman, Timothy G Lesnick, Scott A Przybelski, Elliot J Cahn, Matthew L Kosel, Melissa E Murray, Michelle M Mielke, Hugo Botha, Jonathan Graff-Radford, David T Jones, Val J Lowe, Mary M Machulda, Clifford R Jack, David S Knopman, Ronald C Petersen, Owen A Ross, Prashanthi Vemur. Tau polygenic risk scoring: a cost-effective aid for prognostic counseling in Alzheimer's disease. Acta neuropathologica. 2022-04-12. PMID:35412102. tau deposition is one of two hallmark features of biologically defined alzheimer's disease (ad) and is more closely related to cognitive decline than amyloidosis. 2022-04-12 2023-08-13 Not clear
Luis Daniel Goyzueta-Mamani, Miguel Angel Chávez-Fumagalli, Karla Alvarez-Fernandez, Jorge A Aguilar-Pineda, Rita Nieto-Montesinos, Gonzalo Davila Del-Carpio, Karin J Vera-Lopez, Christian L Lino Cardena. Alzheimer's Disease: A Silent Pandemic - A Systematic Review on the Situation and Patent Landscape of the Diagnosis. Recent patents on biotechnology. 2022-04-11. PMID:35400333. alzheimer's disease (ad) is characterized by cognitive impairment, tau protein deposits, and amyloid beta plaques. 2022-04-11 2023-08-13 Not clear
Andrea Pilotto, Marta Parigi, Giulio Bonzi, Beatrice Battaglio, Elisabetta Ferrari, Lorenza Mensi, Alberto Benussi, Salvatore Caratozzolo, Maura Cosseddu, Rosanna Turrone, Silvana Archetti, Nicholas J Ashton, Henrik Zetterberg, Silvia Giliani, Alessandro Padovan. Differences Between Plasma and Cerebrospinal Fluid p-tau181 and p-tau231 in Early Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2022-04-11. PMID:35404280. plasma phosphorylated tau species have been recently proposed as peripheral markers of alzheimer's disease (ad) pathology. 2022-04-11 2023-08-13 human
Elham Yousefzadeh-Nowshahr, Gordon Winter, Peter Bohn, Katharina Kneer, Christine A F von Arnim, Markus Otto, Christoph Solbach, Sarah Anderl-Straub, Dörte Polivka, Patrick Fissler, Joachim Strobel, Peter Kletting, Matthias W Riepe, Makoto Higuchi, Gerhard Glatting, Albert Ludolph, Ambros J Bee. Quantitative analysis of regional distribution of tau pathology with 11C-PBB3-PET in a clinical setting. PloS one. vol 17. issue 4. 2022-04-11. PMID:35404966. among the tau-specific tracers, the application of 11c-pyridinyl-butadienyl-benzothiazole 3 (11c-pbb3) in pet shows high sensitivity to alzheimer disease (ad)-related tau deposition. 2022-04-11 2023-08-13 Not clear
Ying-Ying Gao, Tao Zhong, Li-Qiang Wang, Na Zhang, Yan Zeng, Ji-Ying Hu, Hai-Bin Dang, Jie Chen, Yi Lian. Zinc enhances liquid-liquid phase separation of Tau protein and aggravates mitochondrial damages in cells. International journal of biological macromolecules. 2022-04-11. PMID:35405154. intraneuronal neurofibrillary tangles composed of tau aggregates have been widely accepted as an important pathological hallmark of alzheimer's disease. 2022-04-11 2023-08-13 human
Ying-Ying Gao, Tao Zhong, Li-Qiang Wang, Na Zhang, Yan Zeng, Ji-Ying Hu, Hai-Bin Dang, Jie Chen, Yi Lian. Zinc enhances liquid-liquid phase separation of Tau protein and aggravates mitochondrial damages in cells. International journal of biological macromolecules. 2022-04-11. PMID:35405154. collectively, these results demonstrate how tau condensation and mitochondrial damages induced by tau aggregation are enhanced by zinc to deteriorate the pathogenesis of alzheimer's disease, bridging the gap between tau llps and aggregation in neuronal cells. 2022-04-11 2023-08-13 human
Christian Conze, Marina Rierola, Nataliya I Trushina, Michael Peters, Dennis Janning, Max Holzer, Jürgen J Heinisch, Thomas Arendt, Lidia Bakota, Roland Brand. Caspase-cleaved tau is senescence-associated and induces a toxic gain of function by putting a brake on axonal transport. Molecular psychiatry. 2022-04-08. PMID:35393558. the microtubule-associated protein tau plays a central role in tauopathies such as alzheimer's disease (ad). 2022-04-08 2023-08-13 mouse
Rachel A Bernier, Sarah J Banks, Matthew S Panizzon, Murray J Andrews, Emily G Jacobs, Douglas R Galasko, Alyx L Shepherd, Katerina Akassoglou, Erin E Sunderman. The neuroinflammatory marker sTNFR2 relates to worse cognition and tau in women across the Alzheimer's disease spectrum. Alzheimer's & dementia (Amsterdam, Netherlands). vol 14. issue 1. 2022-04-07. PMID:35386474. the neuroinflammatory marker stnfr2 relates to worse cognition and tau in women across the alzheimer's disease spectrum. 2022-04-07 2023-08-13 Not clear
Rachel A Bernier, Sarah J Banks, Matthew S Panizzon, Murray J Andrews, Emily G Jacobs, Douglas R Galasko, Alyx L Shepherd, Katerina Akassoglou, Erin E Sunderman. The neuroinflammatory marker sTNFR2 relates to worse cognition and tau in women across the Alzheimer's disease spectrum. Alzheimer's & dementia (Amsterdam, Netherlands). vol 14. issue 1. 2022-04-07. PMID:35386474. despite women showing greater alzheimer's disease (ad) prevalence, tau burden, and immune/neuroinflammatory response, whether neuroinflammation impacts cognition differently in women versus men and the biological basis of this impact remain unknown. 2022-04-07 2023-08-13 Not clear
Alexandra J Weigand, Anne Maass, Graham L Eglit, Mark W Bond. What's the cut-point?: a systematic investigation of tau PET thresholding methods. Alzheimer's research & therapy. vol 14. issue 1. 2022-04-06. PMID:35382866. tau positron emission tomography (pet) is increasing in popularity for biomarker characterization of alzheimer's disease (ad), and recent frameworks rely on tau pet cut-points to stage individuals along the ad continuum. 2022-04-06 2023-08-13 Not clear
Joshua Stevenson-Hoare, Amanda Heslegrave, Ganna Leonenko, Dina Fathalla, Eftychia Bellou, Lauren Luckcuck, Rachel Marshall, Rebecca Sims, Bryan Paul Morgan, John Hardy, Bart de Strooper, Julie Williams, Henrik Zetterberg, Valentina Escott-Pric. Plasma biomarkers and genetics in the diagnosis and prediction of Alzheimer's disease. Brain : a journal of neurology. 2022-04-06. PMID:35383826. plasma biomarkers for alzheimer's disease-related pathologies have undergone rapid developments during the past few years, and there are now well-validated blood tests for amyloid and tau pathology, as well as neurodegeneration and astrocytic activation. 2022-04-06 2023-08-13 Not clear
Joshua Stevenson-Hoare, Amanda Heslegrave, Ganna Leonenko, Dina Fathalla, Eftychia Bellou, Lauren Luckcuck, Rachel Marshall, Rebecca Sims, Bryan Paul Morgan, John Hardy, Bart de Strooper, Julie Williams, Henrik Zetterberg, Valentina Escott-Pric. Plasma biomarkers and genetics in the diagnosis and prediction of Alzheimer's disease. Brain : a journal of neurology. 2022-04-06. PMID:35383826. in a cohort of alzheimer's disease cases (n=1439, mean age 68 years [sd=8.2]) and screened controls (n=508, mean age 82 years [sd=6.8]), we measured plasma concentrations of the 40 and 42 amino acid-long amyloid β fragments (aβ40 and aβ42, respectively), tau phosphorylated at amino acid 181 (p-tau181), neurofilament light (nfl), and glial fibrillary acidic protein (gfap) using state-of-the-art single molecule array (simoa) technology. 2022-04-06 2023-08-13 Not clear
Olivia A Shipton, Clara S Tang, Ole Paulsen, Mariana Vargas-Caballer. Differential vulnerability of hippocampal CA3-CA1 synapses to Aβ. Acta neuropathologica communications. vol 10. issue 1. 2022-04-05. PMID:35379353. amyloid-beta (aβ) and tau protein are both involved in the pathogenesis of alzheimer's disease. 2022-04-05 2023-08-13 mouse
Engie Prifti, Eleni N Tsakiri, Ergina Vourkou, George Stamatakis, Martina Samiotaki, Efthimios M C Skoulakis, Katerina Papanikolopoulo. Mical modulates Tau toxicity via cysteine oxidation in vivo. Acta neuropathologica communications. vol 10. issue 1. 2022-04-05. PMID:35379354. tau accumulation is clearly linked to pathogenesis in alzheimer's disease and other tauopathies. 2022-04-05 2023-08-13 human
Edmarie Guzmán-Vélez, Ibai Diez, Dorothee Schoemaker, Enmanuelle Pardilla-Delgado, Clara Vila-Castelar, Joshua T Fox-Fuller, Ana Baena, Reisa A Sperling, Keith A Johnson, Francisco Lopera, Jorge Sepulcre, Yakeel T Quiro. Amyloid-β and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal-dominant Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 15. 2022-04-05. PMID:35380901. amyloid-β and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal-dominant alzheimer's disease. 2022-04-05 2023-08-13 Not clear
Edmarie Guzmán-Vélez, Ibai Diez, Dorothee Schoemaker, Enmanuelle Pardilla-Delgado, Clara Vila-Castelar, Joshua T Fox-Fuller, Ana Baena, Reisa A Sperling, Keith A Johnson, Francisco Lopera, Jorge Sepulcre, Yakeel T Quiro. Amyloid-β and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal-dominant Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 15. 2022-04-05. PMID:35380901. significanceamyloid-β and tau, hallmark pathologies of alzheimer's disease (ad), are hypothesized to spread through brain functional networks that are critical for neural communication. 2022-04-05 2023-08-13 Not clear
Amy Woodfield, Tenielle Porter, Israa Gilani, Siti Noordin, Qiao-Xin Li, Steven Collins, Ralph N Martins, Paul Maruff, Colin L Masters, Christopher C Rowe, Victor L Villemagne, Vincent Dore, Philip Newsholme, Simon M Laws, Giuseppe Verdil. Insulin resistance, cognition and Alzheimer's disease biomarkers: Evidence that CSF Aβ42 moderates the association between insulin resistance and increased CSF tau levels. Neurobiology of aging. vol 114. 2022-04-05. PMID:35381406. insulin resistance, cognition and alzheimer's disease biomarkers: evidence that csf aβ42 moderates the association between insulin resistance and increased csf tau levels. 2022-04-05 2023-08-13 Not clear
Tyler C Hammond, Ai-Ling Li. Glucose Metabolism is a Better Marker for Predicting Clinical Alzheimer's Disease than Amyloid or Tau. Journal of cellular immunology. vol 4. issue 1. 2022-04-04. PMID:35373192. glucose metabolism is a better marker for predicting clinical alzheimer's disease than amyloid or tau. 2022-04-04 2023-08-13 Not clear