| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peng Zeng, Hong-Fei Su, Chao-Yuan Ye, Shuo-Wen Qiu, Anbing Shi, Jian-Zhi Wang, Xin-Wen Zhou, Qing Tia. A Tau Pathogenesis-Based Network Pharmacology Approach for Exploring the Protections of Frontiers in pharmacology. vol 13. 2022-05-09. PMID:35529440. |
a tau pathogenesis-based network pharmacology approach for exploring the protections of alzheimer's disease (ad) is the most common cause of neurodegenerative dementia and one of the top medical concerns worldwide. |
2022-05-09 |
2023-08-13 |
Not clear |
| Dongmei Chen, Guihua Lan, Ruomeng Li, Yingxue Mei, Xindong Shui, Xi Gu, Long Wang, Tao Zhang, Chen-Ling Gan, Yongfang Xia, Li Hu, Yuan Tian, Mi Zhang, Tae Ho Le. Melatonin ameliorates tau-related pathology via the miR-504-3p and CDK5 axis in Alzheimer's disease. Translational neurodegeneration. vol 11. issue 1. 2022-05-08. PMID:35527277. |
intracellular accumulation of the microtubule-associated protein tau and its hyperphosphorylated forms is a key neuropathological feature of alzheimer's disease (ad). |
2022-05-08 |
2023-08-13 |
Not clear |
| Abha Dangi, Abhishek Ankur Balmik, Archana Kisan Ghorpade, Nalini Vijay Gorantla, Shweta Kishor Sonawane, Subashchandrabose Chinnathambi, Udaya Kiran Marell. Residue-based propensity of aggregation in the Tau amyloidogenic hexapeptides AcPHF6* and AcPHF6. RSC advances. vol 10. issue 46. 2022-05-06. PMID:35516938. |
in alzheimer's disease and related tauopathies, the aggregation of microtubule-associated protein, tau, into fibrils occurs |
2022-05-06 |
2023-08-13 |
Not clear |
| Amy R Nelso. Peripheral Pathways to Neurovascular Unit Dysfunction, Cognitive Impairment, and Alzheimer's Disease. Frontiers in aging neuroscience. vol 14. 2022-05-06. PMID:35517047. |
although there are nuances and details continuously being unraveled, many key players were identified in the early 1900's by dr. oskar fischer and dr. alois alzheimer, including amyloid-beta (aβ), tau, vascular abnormalities, gliosis, and a possible role of infections. |
2022-05-06 |
2023-08-13 |
Not clear |
| Patricia Yuste-Checa, Andreas Bracher, F Ulrich Hart. The chaperone Clusterin in neurodegeneration-friend or foe? BioEssays : news and reviews in molecular, cellular and developmental biology. 2022-05-06. PMID:35521968. |
aggregates of the microtubule-associated protein tau are observed in alzheimer's disease and primary tauopathies. |
2022-05-06 |
2023-08-13 |
human |
| Patricia Yuste-Checa, Andreas Bracher, F Ulrich Hart. The chaperone Clusterin in neurodegeneration-friend or foe? BioEssays : news and reviews in molecular, cellular and developmental biology. 2022-05-06. PMID:35521968. |
these findings raise the possibility of a mechanistic link between clusterin upregulation observed in alzheimer's disease and the progression of tau pathology. |
2022-05-06 |
2023-08-13 |
human |
| Gurpreet Singh, Peng Liu, Katherine R Yao, Jessica M Strasser, Chris Hlynialuk, Kailee Leinonen-Wright, Peter J Teravskis, Jessica M Choquette, Junaid Ikramuddin, Merlin Bresinsky, Kathryn M Nelson, Dezhi Liao, Karen H Ashe, Michael A Walters, Steffen Pocke. Caspase-2 Inhibitor Blocks Tau Truncation and Restores Excitatory Neurotransmission in Neurons Modeling FTDP-17 Tauopathy. ACS chemical neuroscience. 2022-05-06. PMID:35522720. |
synaptic and cognitive deficits mediated by a severe reduction in excitatory neurotransmission caused by a disproportionate accumulation of the neuronal protein tau in dendritic spines is a fundamental mechanism that has been found repeatedly in models of tauopathies, including alzheimer's disease, lewy body dementia, frontotemporal dementia, and traumatic brain injury. |
2022-05-06 |
2023-08-13 |
Not clear |
| Charles Windon, Leonardo Iaccarino, Nidhi Mundada, Isabel Allen, Adam L Boxer, Desiree Byrd, Monica Rivera-Mindt, Gil D Rabinovic. Comparison of plasma and CSF biomarkers across ethnoracial groups in the ADNI. Alzheimer's & dementia (Amsterdam, Netherlands). vol 14. issue 1. 2022-05-05. PMID:35510092. |
ethnoracial differences in cerebrospinal fluid (csf; amyloid beta 42 [aβ42], total tau [t-tau], phosphorylated tau 181 [p-tau181], and plasma (p-tau181, neurofilament light [nfl]) biomarkers of alzheimer's disease (ad) are incompletely understood. |
2022-05-05 |
2023-08-13 |
Not clear |
| O G Steele, A C Stuart, L Minkley, K Shaw, O Bonnar, S Anderle, A C Penn, J Rusted, L Serpell, C Hall, S Kin. A multi-hit hypothesis for an APOE4-dependent pathophysiological state. The European journal of neuroscience. 2022-05-05. PMID:35510513. |
intriguingly, apoe4 has been associated with neuropathological and cognitive deficits in the absence of alzheimer's disease-related amyloid or tau pathology. |
2022-05-05 |
2023-08-13 |
Not clear |
| Swadesh Pal, Roderick Melni. Nonlocal models in the analysis of brain neurodegenerative protein dynamics with application to Alzheimer's disease. Scientific reports. vol 12. issue 1. 2022-05-05. PMID:35513401. |
in this paper, we focus on alzheimer's disease, where it is believed that the concentration changes in amyloid-beta and tau proteins play a central role in its onset and development. |
2022-05-05 |
2023-08-13 |
Not clear |
| Marangelie Criado-Marrero, Danielle M Blazier, Lauren A Gould, Niat T Gebru, Santiago Rodriguez Ospina, Debra S Armendariz, April L Darling, David Beaulieu-Abdelahad, Laura J Blai. Evidence against a contribution of the CCAAT-enhancer binding protein homologous protein (CHOP) in mediating neurotoxicity in rTg4510 mice. Scientific reports. vol 12. issue 1. 2022-05-05. PMID:35513476. |
tau accumulation and progressive loss of neurons are associated with alzheimer's disease (ad). |
2022-05-05 |
2023-08-13 |
mouse |
| Ian Fyf. Influence of amyloid-β on tau spread in Alzheimer disease explained. Nature reviews. Neurology. 2022-05-04. PMID:35508634. |
influence of amyloid-β on tau spread in alzheimer disease explained. |
2022-05-04 |
2023-08-13 |
Not clear |
| Panos Theofilas, Antonia M H Piergies, Ian Oh, Yoo Bin Lee, Song Hua Li, Felipe L Pereira, Cathrine Petersen, Alexander J Ehrenberg, Rana A Eser, Andrew J Ambrose, Brian Chin, Teddy Yang, Shireen Khan, Raymond Ng, Salvatore Spina, Willian W Seeley, Bruce L Miller, Michelle R Arkin, Lea T Grinber. Caspase-6-cleaved tau is relevant in Alzheimer's disease and marginal in four-repeat tauopathies: diagnostic and therapeutic implications. Neuropathology and applied neurobiology. 2022-05-04. PMID:35508761. |
caspase-6-cleaved tau is relevant in alzheimer's disease and marginal in four-repeat tauopathies: diagnostic and therapeutic implications. |
2022-05-04 |
2023-08-13 |
human |
| Panos Theofilas, Antonia M H Piergies, Ian Oh, Yoo Bin Lee, Song Hua Li, Felipe L Pereira, Cathrine Petersen, Alexander J Ehrenberg, Rana A Eser, Andrew J Ambrose, Brian Chin, Teddy Yang, Shireen Khan, Raymond Ng, Salvatore Spina, Willian W Seeley, Bruce L Miller, Michelle R Arkin, Lea T Grinber. Caspase-6-cleaved tau is relevant in Alzheimer's disease and marginal in four-repeat tauopathies: diagnostic and therapeutic implications. Neuropathology and applied neurobiology. 2022-05-04. PMID:35508761. |
yet, the relationship between acasp-6, different forms of tr-tau, and hyperphosphorylated tau (p-tau) accumulation in human brains with alzheimer's disease (ad) and other tauopathies remains unclear. |
2022-05-04 |
2023-08-13 |
human |
| Christopher Daniel Morrone, Aaron Yenhsin Lai, Jossana Bishay, Mary Elizabeth Hill, JoAnne McLauri. Parvalbumin neuroplasticity compensates for somatostatin impairment, maintaining cognitive function in Alzheimer's disease. Translational neurodegeneration. vol 11. issue 1. 2022-05-03. PMID:35501886. |
patient-to-patient variability in the degree to which β-amyloid, tau and neurodegeneration impact cognitive decline in alzheimer's disease (ad) complicates disease modeling and treatment. |
2022-05-03 |
2023-08-13 |
Not clear |
| A Harrison Brody, Sarah Helena Nies, Fulin Guan, Levi M Smith, Bandhan Mukherjee, Santiago A Salazar, Suho Lee, Tu Kiet T Lam, Stephen M Strittmatte. Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy. Molecular neurodegeneration. vol 17. issue 1. 2022-05-03. PMID:35501917. |
alzheimer risk gene product pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy. |
2022-05-03 |
2023-08-13 |
mouse |
| Hyun Kim, Alina Levine, Daniel Cohen, Philip Gehrman, Xi Zhu, Davangere P Devanand, Seonjoo Lee, Terry E Goldber. The Role of Amyloid, Tau, and APOE Genotype on the Relationship Between Informant-Reported Sleep Disturbance and Alzheimer's Disease Risks. Journal of Alzheimer's disease : JAD. 2022-05-02. PMID:35491776. |
the role of amyloid, tau, and apoe genotype on the relationship between informant-reported sleep disturbance and alzheimer's disease risks. |
2022-05-02 |
2023-08-13 |
Not clear |
| Christian LoBue, Brendan J Kelley, John Hart, Jessica Helphrey, Jeff Schaffert, C Munro Cullum, Matthew E Peters, Peter M Dougla. Mild Traumatic Brain Injury is Related to Elevated Cerebrospinal Fluid Tau in Alzheimer's Disease Dementia. Journal of Alzheimer's disease : JAD. 2022-05-02. PMID:35491792. |
mild traumatic brain injury is related to elevated cerebrospinal fluid tau in alzheimer's disease dementia. |
2022-05-02 |
2023-08-13 |
Not clear |
| Mingchao Shi, Fengna Chu, Feiqi Zhu, Jie Zh. Impact of Anti-amyloid-β Monoclonal Antibodies on the Pathology and Clinical Profile of Alzheimer's Disease: A Focus on Aducanumab and Lecanemab. Frontiers in aging neuroscience. vol 14. 2022-05-02. PMID:35493943. |
alzheimer's disease (ad) is the most prevalent form of age-related dementia in the world, and its main pathological features consist of amyloid-β (aβ) plaque deposits and neurofibrillary tangles formed by hyperphosphorylated tau protein. |
2022-05-02 |
2023-08-13 |
Not clear |
| Rebeca Lapresa, Jesus Agulla, Sonia Gonzalez-Guerrero, Juan P Bolaños, Angeles Almeid. Amyloid-β Induces Cdh1-Mediated Rock2 Stabilization Causing Neurodegeneration. Frontiers in pharmacology. vol 13. 2022-05-02. PMID:35496276. |
alzheimer's disease (ad) is a neurodegenerative disorder characterized by progressive cognitive decline, which is causally related to the accumulation of abnormally folded amyloid-β (aβ) peptide and hyperphosphorylated tau protein aggregates. |
2022-05-02 |
2023-08-13 |
mouse |