| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christina B Young, Joseph R Winer, Kyan Younes, Karly A Cody, Tobey J Betthauser, Sterling C Johnson, Aaron Schultz, Reisa A Sperling, Michael D Greicius, Inma Cobos, Kathleen L Poston, Elizabeth C Mormin. Divergent Cortical Tau Positron Emission Tomography Patterns Among Patients With Preclinical Alzheimer Disease. JAMA neurology. 2022-04-18. PMID:35435938. |
characterization of early tau deposition in individuals with preclinical alzheimer disease (ad) is critical for prevention trials that aim to select individuals at risk for ad and halt the progression of disease. |
2022-04-18 |
2023-08-13 |
Not clear |
| Shahzaib Ahamad, Hema Kanipakam, Vijay Kumar, Dinesh Gupt. A molecular journey to check the conformational dynamics of tau tubulin kinase 2 mutations associated with Alzheimer's disease. RSC advances. vol 11. issue 3. 2022-04-15. PMID:35424125. |
a molecular journey to check the conformational dynamics of tau tubulin kinase 2 mutations associated with alzheimer's disease. |
2022-04-15 |
2023-08-13 |
human |
| Megumi Asada-Utsugi, Kengo Uemura, Takashi Ayaki, Maiko T Uemura, Sumio Minamiyama, Ryota Hikiami, Toshifumi Morimura, Akemi Shodai, Takatoshi Ueki, Ryosuke Takahashi, Ayae Kinoshita, Makoto Urushitan. Failure of DNA double-strand break repair by tau mediates Alzheimer's disease pathology in vitro. Communications biology. vol 5. issue 1. 2022-04-14. PMID:35418705. |
failure of dna double-strand break repair by tau mediates alzheimer's disease pathology in vitro. |
2022-04-14 |
2023-08-13 |
mouse |
| Megumi Asada-Utsugi, Kengo Uemura, Takashi Ayaki, Maiko T Uemura, Sumio Minamiyama, Ryota Hikiami, Toshifumi Morimura, Akemi Shodai, Takatoshi Ueki, Ryosuke Takahashi, Ayae Kinoshita, Makoto Urushitan. Failure of DNA double-strand break repair by tau mediates Alzheimer's disease pathology in vitro. Communications biology. vol 5. issue 1. 2022-04-14. PMID:35418705. |
since tau is a microtubule-associated protein, we investigate whether dsb is involved in tau pathologies in alzheimer's disease (ad). |
2022-04-14 |
2023-08-13 |
mouse |
| Joost M Riphagen, Mahanand Belathur Suresh, David H Sala. The canonical pattern of Alzheimer's disease atrophy is linked to white matter hyperintensities in normal controls, differently in normal controls compared to in AD. Neurobiology of aging. 2022-04-13. PMID:35414420. |
white matter signal abnormalities (wmsa), either hypo- or hyperintensities in mri imaging, are considered a proxy of cerebrovascular pathology and contribute to, and modulate, the clinical presentation of alzheimer's disease (ad), with cognitive dysfunction being apparent at lower levels of amyloid and/or tau pathology when lesions are present. |
2022-04-13 |
2023-08-13 |
human |
| Vincent Doré, James D Doecke, Ziad S Saad, Gallen Triana-Baltzer, Randy Slemmon, Natasha Krishnadas, Pierrick Bourgeat, Kun Huang, Samantha Burnham, Christopher Fowler, Stephanie R Rainey-Smith, Ashley I Bush, Larry Ward, Jo Robertson, Ralph N Martins, Colin L Masters, Victor L Villemagne, Jurgen Fripp, Hartmuth C Kolb, Christopher C Row. Plasma p217+tau versus NAV4694 amyloid and MK6240 tau PET across the Alzheimer's continuum. Alzheimer's & dementia (Amsterdam, Netherlands). vol 14. issue 1. 2022-04-13. PMID:35415202. |
plasma p217+tau versus nav4694 amyloid and mk6240 tau pet across the alzheimer's continuum. |
2022-04-13 |
2023-08-13 |
Not clear |
| Felix S Meier-Stephenson, Vanessa C Meier-Stephenson, Michael D Carter, Autumn R Meek, Yanfei Wang, Luzhe Pan, Qiangwei Chen, Sheila Jacobo, Fan Wu, Erhu Lu, Gordon A Simms, Laural Fisher, Alaina J McGrath, Virgil Fermo, Christopher J Barden, Harman D S Clair, Todd N Galloway, Arun Yadav, Valérie Campágna-Slater, Mark Hadden, Mark Reed, Marcia Taylor, Brendan Kelly, Elena Diez-Cecilia, Igri Kolaj, Clarissa Santos, Imindu Liyanage, Braden Sweeting, Paul Stafford, Robert Boudreau, G Andrew Reid, Ryan S Noyce, Leanne Stevens, Agnieszka Staniszewski, Hong Zhang, Mamidanna R V S Murty, Pascale Lemaire, Solenne Chardonnet, Christopher D Richardson, Valérie Gabelica, Edwin DePauw, Richard Brown, Sultan Darvesh, Ottavio Arancio, Donald F Weave. Alzheimer's disease as an autoimmune disorder of innate immunity endogenously modulated by tryptophan metabolites. Alzheimer's & dementia (New York, N. Y.). vol 8. issue 1. 2022-04-13. PMID:35415204. |
alzheimer's disease (ad) is characterized by neurotoxic immuno-inflammation concomitant with cytotoxic oligomerization of amyloid beta (aβ) and tau, culminating in concurrent, interdependent immunopathic and proteopathic pathogeneses. |
2022-04-13 |
2023-08-13 |
Not clear |
| Lisa Diez, Larisa E Kapinos, Janine Hochmair, Sabrina Huebschmann, Alvaro Dominguez-Baquero, Amelie Vogt, Marija Rankovic, Markus Zweckstetter, Roderick Y H Lim, Susanne Wegman. Phosphorylation but Not Oligomerization Drives the Accumulation of Tau with Nucleoporin Nup98. International journal of molecular sciences. vol 23. issue 7. 2022-04-12. PMID:35408855. |
in alzheimer's disease (ad) and other tauopathies, phosphorylated tau accumulates in intracellular aggregates, a pathological hallmark of these diseases. |
2022-04-12 |
2023-08-13 |
Not clear |
| Giovanni Oliveros, Charles H Wallace, Osama Chaudry, Qiao Liu, Yue Qiu, Lei Xie, Patricia Rockwell, Maria E Figueiredo-Pereira, Peter A Serran. Repurposing ibudilast to mitigate Alzheimer's disease by targeting inflammation. Brain : a journal of neurology. 2022-04-12. PMID:35411386. |
this transgenic rat model is unique as it exhibits hippocampal-dependent spatial learning and memory deficits, and alzheimer's disease pathology including hippocampal amyloid plaques, tau paired-helical filaments, neuronal loss and microgliosis, in a progressive age-dependent manner that mimics the pathology observed in alzheimer's disease patients. |
2022-04-12 |
2023-08-13 |
rat |
| Vijay K Ramanan, Michael G Heckman, Timothy G Lesnick, Scott A Przybelski, Elliot J Cahn, Matthew L Kosel, Melissa E Murray, Michelle M Mielke, Hugo Botha, Jonathan Graff-Radford, David T Jones, Val J Lowe, Mary M Machulda, Clifford R Jack, David S Knopman, Ronald C Petersen, Owen A Ross, Prashanthi Vemur. Tau polygenic risk scoring: a cost-effective aid for prognostic counseling in Alzheimer's disease. Acta neuropathologica. 2022-04-12. PMID:35412102. |
tau polygenic risk scoring: a cost-effective aid for prognostic counseling in alzheimer's disease. |
2022-04-12 |
2023-08-13 |
Not clear |
| Vijay K Ramanan, Michael G Heckman, Timothy G Lesnick, Scott A Przybelski, Elliot J Cahn, Matthew L Kosel, Melissa E Murray, Michelle M Mielke, Hugo Botha, Jonathan Graff-Radford, David T Jones, Val J Lowe, Mary M Machulda, Clifford R Jack, David S Knopman, Ronald C Petersen, Owen A Ross, Prashanthi Vemur. Tau polygenic risk scoring: a cost-effective aid for prognostic counseling in Alzheimer's disease. Acta neuropathologica. 2022-04-12. PMID:35412102. |
tau deposition is one of two hallmark features of biologically defined alzheimer's disease (ad) and is more closely related to cognitive decline than amyloidosis. |
2022-04-12 |
2023-08-13 |
Not clear |
| Luis Daniel Goyzueta-Mamani, Miguel Angel Chávez-Fumagalli, Karla Alvarez-Fernandez, Jorge A Aguilar-Pineda, Rita Nieto-Montesinos, Gonzalo Davila Del-Carpio, Karin J Vera-Lopez, Christian L Lino Cardena. Alzheimer's Disease: A Silent Pandemic - A Systematic Review on the Situation and Patent Landscape of the Diagnosis. Recent patents on biotechnology. 2022-04-11. PMID:35400333. |
alzheimer's disease (ad) is characterized by cognitive impairment, tau protein deposits, and amyloid beta plaques. |
2022-04-11 |
2023-08-13 |
Not clear |
| Andrea Pilotto, Marta Parigi, Giulio Bonzi, Beatrice Battaglio, Elisabetta Ferrari, Lorenza Mensi, Alberto Benussi, Salvatore Caratozzolo, Maura Cosseddu, Rosanna Turrone, Silvana Archetti, Nicholas J Ashton, Henrik Zetterberg, Silvia Giliani, Alessandro Padovan. Differences Between Plasma and Cerebrospinal Fluid p-tau181 and p-tau231 in Early Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2022-04-11. PMID:35404280. |
plasma phosphorylated tau species have been recently proposed as peripheral markers of alzheimer's disease (ad) pathology. |
2022-04-11 |
2023-08-13 |
human |
| Elham Yousefzadeh-Nowshahr, Gordon Winter, Peter Bohn, Katharina Kneer, Christine A F von Arnim, Markus Otto, Christoph Solbach, Sarah Anderl-Straub, Dörte Polivka, Patrick Fissler, Joachim Strobel, Peter Kletting, Matthias W Riepe, Makoto Higuchi, Gerhard Glatting, Albert Ludolph, Ambros J Bee. Quantitative analysis of regional distribution of tau pathology with 11C-PBB3-PET in a clinical setting. PloS one. vol 17. issue 4. 2022-04-11. PMID:35404966. |
among the tau-specific tracers, the application of 11c-pyridinyl-butadienyl-benzothiazole 3 (11c-pbb3) in pet shows high sensitivity to alzheimer disease (ad)-related tau deposition. |
2022-04-11 |
2023-08-13 |
Not clear |
| Ying-Ying Gao, Tao Zhong, Li-Qiang Wang, Na Zhang, Yan Zeng, Ji-Ying Hu, Hai-Bin Dang, Jie Chen, Yi Lian. Zinc enhances liquid-liquid phase separation of Tau protein and aggravates mitochondrial damages in cells. International journal of biological macromolecules. 2022-04-11. PMID:35405154. |
intraneuronal neurofibrillary tangles composed of tau aggregates have been widely accepted as an important pathological hallmark of alzheimer's disease. |
2022-04-11 |
2023-08-13 |
human |
| Ying-Ying Gao, Tao Zhong, Li-Qiang Wang, Na Zhang, Yan Zeng, Ji-Ying Hu, Hai-Bin Dang, Jie Chen, Yi Lian. Zinc enhances liquid-liquid phase separation of Tau protein and aggravates mitochondrial damages in cells. International journal of biological macromolecules. 2022-04-11. PMID:35405154. |
collectively, these results demonstrate how tau condensation and mitochondrial damages induced by tau aggregation are enhanced by zinc to deteriorate the pathogenesis of alzheimer's disease, bridging the gap between tau llps and aggregation in neuronal cells. |
2022-04-11 |
2023-08-13 |
human |
| Christian Conze, Marina Rierola, Nataliya I Trushina, Michael Peters, Dennis Janning, Max Holzer, Jürgen J Heinisch, Thomas Arendt, Lidia Bakota, Roland Brand. Caspase-cleaved tau is senescence-associated and induces a toxic gain of function by putting a brake on axonal transport. Molecular psychiatry. 2022-04-08. PMID:35393558. |
the microtubule-associated protein tau plays a central role in tauopathies such as alzheimer's disease (ad). |
2022-04-08 |
2023-08-13 |
mouse |
| Rachel A Bernier, Sarah J Banks, Matthew S Panizzon, Murray J Andrews, Emily G Jacobs, Douglas R Galasko, Alyx L Shepherd, Katerina Akassoglou, Erin E Sunderman. The neuroinflammatory marker sTNFR2 relates to worse cognition and tau in women across the Alzheimer's disease spectrum. Alzheimer's & dementia (Amsterdam, Netherlands). vol 14. issue 1. 2022-04-07. PMID:35386474. |
the neuroinflammatory marker stnfr2 relates to worse cognition and tau in women across the alzheimer's disease spectrum. |
2022-04-07 |
2023-08-13 |
Not clear |
| Rachel A Bernier, Sarah J Banks, Matthew S Panizzon, Murray J Andrews, Emily G Jacobs, Douglas R Galasko, Alyx L Shepherd, Katerina Akassoglou, Erin E Sunderman. The neuroinflammatory marker sTNFR2 relates to worse cognition and tau in women across the Alzheimer's disease spectrum. Alzheimer's & dementia (Amsterdam, Netherlands). vol 14. issue 1. 2022-04-07. PMID:35386474. |
despite women showing greater alzheimer's disease (ad) prevalence, tau burden, and immune/neuroinflammatory response, whether neuroinflammation impacts cognition differently in women versus men and the biological basis of this impact remain unknown. |
2022-04-07 |
2023-08-13 |
Not clear |
| Alexandra J Weigand, Anne Maass, Graham L Eglit, Mark W Bond. What's the cut-point?: a systematic investigation of tau PET thresholding methods. Alzheimer's research & therapy. vol 14. issue 1. 2022-04-06. PMID:35382866. |
tau positron emission tomography (pet) is increasing in popularity for biomarker characterization of alzheimer's disease (ad), and recent frameworks rely on tau pet cut-points to stage individuals along the ad continuum. |
2022-04-06 |
2023-08-13 |
Not clear |