| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenping Zeng, Canjun Li, Ruikun Wu, Xingguo Yang, Qingyan Wang, Bingqian Lin, Yanan Wei, Hao Li, Ge Shan, Lili Qu, Chunlei Can. Optogenetic manipulation of lysosomal physiology and autophagy-dependent clearance of amyloid beta. PLoS biology. vol 22. issue 4. 2024-04-23. PMID:38652732. |
notably, lyso-chr2 activation induces autophagy through the mtor pathway, promotes aβ clearance in an autophagy-dependent manner in cellular models, and alleviates aβ-induced paralysis in the caenorhabditis elegans model of alzheimer's disease. |
2024-04-23 |
2024-04-26 |
caenorhabditis_elegans |
| Reza Ale Mahmoud Mehraban, Parvin Babaei, Kambiz Rohampour, Adele Jafari, Zoleikha Golipoo. Metformin improves memory via AMPK/mTOR-dependent route in a rat model of Alzheimer's disease. Iranian journal of basic medical sciences. vol 27. issue 3. 2024-02-09. PMID:38333746. |
the present study evaluated whether inhibiting ampk and activating mtor could stop metformin from improving memory in rats with streptozotocin (stz) -induced alzheimer's disease. |
2024-02-09 |
2024-02-11 |
rat |
| Reddy Peera Kommaddi, Ruturaj Gowaikar, Haseena Pa, Latha Diwakar, Kunal Singh, Amrita Monda. Akt activation ameliorates deficits in hippocampal-dependent memory and activity-dependent synaptic protein synthesis in an Alzheimer's disease mouse model. The Journal of biological chemistry. 2024-01-05. PMID:38182004. |
protein kinase-b (akt) and the mechanistic target of rapamycin (mtor) signaling pathways are implicated in alzheimer's disease (ad) pathology. |
2024-01-05 |
2024-01-08 |
mouse |
| Tabea M Soelter, Timothy C Howton, Amanda D Clark, Vishal H Oza, Brittany N Lasseign. Altered Glia-Neuron Communication in Alzheimer's Disease Affects WNT, p53, and NFkB Signaling Determined by snRNA-seq. bioRxiv : the preprint server for biology. 2023-12-11. PMID:38076822. |
many signaling pathways have been proposed to be dysregulated in alzheimer's disease, including wnt, tgfβ, p53, mtor, nfkb, and pi3k/akt signaling. |
2023-12-11 |
2023-12-17 |
Not clear |
| Abdul Jalil Shah, Prince Ahad Mir, Mohd Adnan, Mitesh Patel, Mudasir Maqbool, Reyaz Hassan Mir, Mubashir Hussain Masood. Synthetic and Natural Bioactive Molecules in Balancing the Crosstalk among Common Signaling Pathways in Alzheimer's Disease: Understanding the Neurotoxic Mechanisms for Therapeutic Intervention. ACS omega. vol 8. issue 43. 2023-11-06. PMID:37929080. |
with recent discoveries, it is established that the modulation of several pathological events in alzheimer's disease (ad) due to the mammalian target of rapamycin (mtor), wnt signaling, 5'-adenosine monophosphate activated protein kinase (ampk), peroxisome proliferator-activated receptor gamma coactivator 1α (pgc-1α), and sirtuin 1 (sirt1, silent mating-type information regulator 2 homologue 1) are central to the key findings. |
2023-11-06 |
2023-11-08 |
Not clear |
| Samin Davoody, Afsaneh Asgari Taei, Pariya Khodabakhsh, Leila Dargah. mTOR signaling and Alzheimer's disease: What we know and where we are? CNS neuroscience & therapeutics. 2023-09-18. PMID:37721413. |
mtor signaling and alzheimer's disease: what we know and where we are? |
2023-09-18 |
2023-10-07 |
Not clear |
| George S Bloom, Andrés Norambuen. Dysregulation of mTOR by tau in Alzheimer's disease. Cytoskeleton (Hoboken, N.J.). 2023-08-28. PMID:37638691. |
dysregulation of mtor by tau in alzheimer's disease. |
2023-08-28 |
2023-09-07 |
Not clear |
| Hoau-Yan Wang, Zhe Pei, Kuo-Chieh Lee, Boris Nikolov, Tamara Doehner, John Puente, Nadav Friedmann, Lindsay H Burn. Simufilam suppresses overactive mTOR and restores its sensitivity to insulin in Alzheimer's disease patient lymphocytes. Frontiers in aging. vol 4. 2023-07-17. PMID:37457922. |
simufilam suppresses overactive mtor and restores its sensitivity to insulin in alzheimer's disease patient lymphocytes. |
2023-07-17 |
2023-08-14 |
Not clear |
| Hong-Yan Cai, Si-Jia Hou, Rui Wen, Qi-Fan Feng, Yu-Jia Xi, Sheng-Xiao Zhang, Jun Qiao, Mei-Na W. Causal Association Between mTOR-Dependent Protein Levels and Alzheimer's Disease: A Mendelian Randomization Study. Journal of Alzheimer's disease : JAD. 2023-07-02. PMID:37393500. |
most previous studies supported that the mammalian target of rapamycin (mtor) is over-activated in alzheimer's disease (ad) and exacerbates the development of ad. |
2023-07-02 |
2023-08-14 |
Not clear |
| Kenneth Maies. Cellular Metabolism: A Fundamental Component of Degeneration in the Nervous System. Biomolecules. vol 13. issue 5. 2023-05-27. PMID:37238686. |
critical insight into and modulation of these complex pathways are required since mtor signaling pathways, such as ampk activation, can improve memory retention in alzheimer's disease (ad) and dm, promote healthy aging, facilitate clearance of β-amyloid (aß) and tau in the brain, and control inflammation, but also may lead to cognitive loss and long-covid syndrome through mechanisms that can include oxidative stress, mitochondrial dysfunction, cytokine release, and apoe-ε4 if pathways such as autophagy and other mechanisms of programmed cell death are left unchecked. |
2023-05-27 |
2023-08-14 |
Not clear |
| Siwen Li, Chi Him Poon, Zhigang Zhang, Ming Yue, Ruijun Chen, Yalun Zhang, Md Farhad Hossain, Yining Pan, Jun Zhao, Lei Rong, Leung Wing Chu, Yat Fung Shea, Ekaterina Rogaeva, Jie Tu, Peter St George-Hyslop, Lee Wei Lim, You-Qiang Son. MicroRNA-128 suppresses tau phosphorylation and reduces amyloid-beta accumulation by inhibiting the expression of GSK3β, APPBP2, and mTOR in Alzheimer's disease. CNS neuroscience & therapeutics. 2023-03-07. PMID:36880288. |
microrna-128 suppresses tau phosphorylation and reduces amyloid-beta accumulation by inhibiting the expression of gsk3β, appbp2, and mtor in alzheimer's disease. |
2023-03-07 |
2023-08-14 |
Not clear |
| Julien Bensalem, Leanne K Hein, Sofia Hassiotis, Paul J Trim, Christopher G Proud, Leonie K Heilbronn, Timothy J Sargean. Modifying dietary protein impacts mTOR signaling and brain deposition of amyloid beta in a knock-in mouse model of Alzheimer's disease. The Journal of nutrition. 2023-03-04. PMID:36870538. |
modifying dietary protein impacts mtor signaling and brain deposition of amyloid beta in a knock-in mouse model of alzheimer's disease. |
2023-03-04 |
2023-08-14 |
mouse |
| Arunkumar Subramanian, T Tamilanban, Abdulrhman Alsayari, Gobinath Ramachawolran, Ling Shing Wong, Mahendran Sekar, Siew Hua Gan, Vetriselvan Subramaniyan, Suresh V Chinni, Nur Najihah Izzati Mat Rani, Nagaraja Suryadevara, Shadma Waha. Trilateral association of autophagy, mTOR and Alzheimer's disease: Potential pathway in the development for Alzheimer's disease therapy. Frontiers in pharmacology. vol 13. 2023-01-09. PMID:36618946. |
trilateral association of autophagy, mtor and alzheimer's disease: potential pathway in the development for alzheimer's disease therapy. |
2023-01-09 |
2023-08-14 |
human |
| Jia-Bing Li, Xiao-Yu Hu, Mu-Wen Chen, Cai-Hong Xiong, Na Zhao, Yan-Hui Ge, Hao Wang, Xiao-Ling Gao, Nan-Jie Xu, Lan-Xue Zhao, Zhi-Hua Yu, Hong-Zhuan Chen, Yu Qi. p85S6K sustains synaptic GluA1 to ameliorate cognitive deficits in Alzheimer's disease. Translational neurodegeneration. vol 12. issue 1. 2023-01-09. PMID:36624510. |
p70s6k, with its upstream mammalian target of rapamycin (mtor), has been shown to be involved in learning and memory and participate in the pathophysiology of alzheimer's disease (ad). |
2023-01-09 |
2023-08-14 |
Not clear |
| Cheong-Meng Chong, Yuan Tan, Jiaqi Tong, Minjing Ke, Ke Zhang, Lingli Yan, Xiaotong Cen, Jia-Hong Lu, Guobing Chen, Huanxing Su, Dajiang Qi. Presenilin-1 F105C mutation leads to tau accumulation in human neurons via the Akt/mTORC1 signaling pathway. Cell & bioscience. vol 12. issue 1. 2022-08-14. PMID:35965317. |
the mammalian target of rapamycin (mtor) plays a critical role in controlling cellular homeostasis, and its dysregulation has been implicated in alzheimer's disease (ad). |
2022-08-14 |
2023-08-14 |
human |
| Cheong-Meng Chong, Yuan Tan, Jiaqi Tong, Minjing Ke, Ke Zhang, Lingli Yan, Xiaotong Cen, Jia-Hong Lu, Guobing Chen, Huanxing Su, Dajiang Qi. Presenilin-1 F105C mutation leads to tau accumulation in human neurons via the Akt/mTORC1 signaling pathway. Cell & bioscience. vol 12. issue 1. 2022-08-14. PMID:35965317. |
presenilin-1 (ps1) mutations account for the most common causes of familial alzheimer's disease (fad); however, whether ps1 mutation causes mtor dysregulation in human neurons remains a key unresolved issue. |
2022-08-14 |
2023-08-14 |
human |
| Qian Shi, Cheng Chang, Afaf Saliba, Manzoor A Bha. Microglial mTOR Activation Upregulates Trem2 and Enhances β-Amyloid Plaque Clearance in the The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-06-07. PMID:35672148. |
microglial mtor activation upregulates trem2 and enhances β-amyloid plaque clearance in the the mechanistic target of rapamycin (mtor) signaling pathway plays a major role in key cellular processes including metabolism and differentiation; however, the role of mtor in microglia and its importance in alzheimer's disease (ad) has remained largely uncharacterized. |
2022-06-07 |
2023-08-14 |
Not clear |
| Deepthi Rapaka, Veera Raghavulu Bitra, Siva Reddy Challa, Paul C Adiukw. mTOR signaling as a molecular target for the alleviation of Alzheimer's disease pathogenesis. Neurochemistry international. 2022-02-26. PMID:35218870. |
mtor signaling as a molecular target for the alleviation of alzheimer's disease pathogenesis. |
2022-02-26 |
2023-08-13 |
human |
| Deepthi Rapaka, Veera Raghavulu Bitra, Siva Reddy Challa, Paul C Adiukw. mTOR signaling as a molecular target for the alleviation of Alzheimer's disease pathogenesis. Neurochemistry international. 2022-02-26. PMID:35218870. |
mtor activity was found to be altered in ad brains and rodent models, supporting the notion that aberrant mtor activity is one of the key events contributing to the onset and progression of ad hallmarks this review assesses the molecular association between the mtor signaling pathway and pathogenesis of alzheimer's disease. |
2022-02-26 |
2023-08-13 |
human |
| Chencen Lai, Zhuyi Chen, Yuanting Ding, Qian Chen, Songbai Su, Heng Liu, Ruiqing Ni, Zhi Tan. Rapamycin Attenuated Zinc-Induced Tau Phosphorylation and Oxidative Stress in Rats: Involvement of Dual mTOR/p70S6K and Nrf2/HO-1 Pathways. Frontiers in immunology. vol 13. 2022-02-24. PMID:35197970. |
the activities of mammalian target of rapamycin (mtor)/ribosomal s6 protein kinase (p70s6k) are elevated in the brains of patients with alzheimer's disease. |
2022-02-24 |
2023-08-13 |
rat |