| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Julien Bensalem, Leanne K Hein, Sofia Hassiotis, Paul J Trim, Christopher G Proud, Leonie K Heilbronn, Timothy J Sargean. Modifying dietary protein impacts mTOR signaling and brain deposition of amyloid beta in a knock-in mouse model of Alzheimer's disease. The Journal of nutrition vol issue 2023 36870538 |
modifying dietary protein impacts mtor signaling and brain deposition of amyloid beta in a knock-in mouse model of alzheimer's disease. |
2023-03-04 |
2023-03-06 |
mouse |
| Arunkumar Subramanian, T Tamilanban, Abdulrhman Alsayari, Gobinath Ramachawolran, Ling Shing Wong, Mahendran Sekar, Siew Hua Gan, Vetriselvan Subramaniyan, Suresh V Chinni, Nur Najihah Izzati Mat Rani, Nagaraja Suryadevara, Shadma Waha. Trilateral association of autophagy, mTOR and Alzheimer's disease: Potential pathway in the development for Alzheimer's disease therapy. Frontiers in pharmacology vol 13 issue 2023 36618946 |
trilateral association of autophagy, mtor and alzheimer's disease: potential pathway in the development for alzheimer's disease therapy. |
2023-01-09 |
2023-01-30 |
human |
| Jia-Bing Li, Xiao-Yu Hu, Mu-Wen Chen, Cai-Hong Xiong, Na Zhao, Yan-Hui Ge, Hao Wang, Xiao-Ling Gao, Nan-Jie Xu, Lan-Xue Zhao, Zhi-Hua Yu, Hong-Zhuan Chen, Yu Qi. p85S6K sustains synaptic GluA1 to ameliorate cognitive deficits in Alzheimer's disease. Translational neurodegeneration vol 12 issue 1 2023 36624510 |
p70s6k, with its upstream mammalian target of rapamycin (mtor), has been shown to be involved in learning and memory and participate in the pathophysiology of alzheimer's disease (ad). |
2023-01-09 |
2023-01-30 |
Not clear |
| Cheong-Meng Chong, Yuan Tan, Jiaqi Tong, Minjing Ke, Ke Zhang, Lingli Yan, Xiaotong Cen, Jia-Hong Lu, Guobing Chen, Huanxing Su, Dajiang Qi. Presenilin-1 F105C mutation leads to tau accumulation in human neurons via the Akt/mTORC1 signaling pathway. Cell & bioscience vol 12 issue 1 2022 35965317 |
presenilin-1 (ps1) mutations account for the most common causes of familial alzheimer's disease (fad); however, whether ps1 mutation causes mtor dysregulation in human neurons remains a key unresolved issue. |
2022-08-14 |
2023-01-30 |
human |
| Cheong-Meng Chong, Yuan Tan, Jiaqi Tong, Minjing Ke, Ke Zhang, Lingli Yan, Xiaotong Cen, Jia-Hong Lu, Guobing Chen, Huanxing Su, Dajiang Qi. Presenilin-1 F105C mutation leads to tau accumulation in human neurons via the Akt/mTORC1 signaling pathway. Cell & bioscience vol 12 issue 1 2022 35965317 |
the mammalian target of rapamycin (mtor) plays a critical role in controlling cellular homeostasis, and its dysregulation has been implicated in alzheimer's disease (ad). |
2022-08-14 |
2023-01-30 |
human |
| M Perluigi, F Di Domenico, E Barone, D A Butterfiel. mTOR in Alzheimer disease and its earlier stages: Links to oxidative damage in the progression of this dementing disorder. Free radical biology & medicine vol 169 issue 2021 33933601 |
mtor in alzheimer disease and its earlier stages: links to oxidative damage in the progression of this dementing disorder. |
2021-06-28 |
2023-01-26 |
Not clear |
| Ju-Hyun Lee, Mala V Rao, Dun-Sheng Yang, Philip Stavrides, Eunju Im, Anna Pensalfini, Chunfeng Huo, Pallabi Sarkar, Tamotsu Yoshimori, Ralph A Nixo. Transgenic expression of a ratiometric autophagy probe specifically in neurons enables the interrogation of brain autophagy in vivo. Autophagy vol 15 issue 3 2020 30269645 |
abbreviations: actb: actin, beta; ad: alzheimer disease; al: autolysosomes; alp: autophagy-lysosome pathway; ap: autophagosome; app: amyloid beta (abeta) precursor protein; atg5: autophagy related 5; atg7: autophagy related 7; av: autophagic vacuoles; cns: central nervous system; ctsd: cathepsin d; cq: chloroquine; dmem: dulbecco's modified eagle's medium; gfp: green fluorescent protein; gabarap: gamma-aminobutyric acid receptor associated protein; gabarapl2/gate16: gamma-aminobutyric acid (gaba) receptor-associated protein-like 2; icc: immunocytochemistry; icv: intra-cerebroventricular; lamp2: lysosomal-associated membrane protein 2; leup: leupeptin; ly: lysosomes; map1lc3/lc3: microtubule-associated protein 1 light chain 3; mtor: mechanistic target of rapamycin kinase; rbfox3/neun: rna binding protein, fox-1 homolog (c. elegans) 3; rfp: red fluorescent protein; rps6kb1: ribosomal protein s6 kinase, polypeptide 1; sds-page: sodium dodecyl sulfate-polyacrylamide gel electrophoresis; sqstm1: sequestosome 1; tflc3: mrfp-egfp-lc3; trgl6: thy1 mrfp egfp lc3-line 6; pcr: polymerase chain reaction; pd: parkinson disease. |
2020-05-13 |
2023-01-26 |
mouse |
| Jun Araya, Kazuya Tsubouchi, Nahoko Sato, Saburo Ito, Shunsuke Minagawa, Hiromichi Hara, Yusuke Hosaka, Akihiro Ichikawa, Nayuta Saito, Tsukasa Kadota, Masahiro Yoshida, Yu Fujita, Hirofumi Utsumi, Kenji Kobayashi, Haruhiko Yanagisawa, Mitsuo Hashimoto, Hiroshi Wakui, Takeo Ishikawa, Takanori Numata, Yumi Kaneko, Hisatoshi Asano, Makoto Yamashita, Makoto Odaka, Toshiaki Morikawa, Stephen L Nishimura, Katsutoshi Nakayama, Kazuyoshi Kuwan. PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis. Autophagy vol 15 issue 3 2020 30290714 |
abbreviations: ad: alzheimer disease; aec: airway epithelial cells; balf: bronchoalveolar lavage fluid; akt: akt serine/threonine kinase; calcoco2/ndp52: calcium binding and coiled-coil domain 2; cdkn1a: cyclin dependent kinase inhibitor 1a; cdkn2a: cyclin dependent kinase inhibitor 2a; copd: chronic obstructive pulmonary disease; cs: cigarette smoke; cse: cs extract; cxcl1: c-x-c motif chemokine ligand 1; cxcl8: c-x-c motif chemokine ligand 8; hbec: human bronchial epithelial cells; 4-hne: 4-hydroxynonenal; il: interleukin; ko: knockout; lf: lung fibroblasts; lps: lipopolysaccharide; map1lc3/lc3: microtubule associated protein 1 light chain 3; mtor: mechanistic target of rapamycin kinase; 8-ohdg: 8-hydroxy-2'-deoxyguanosine; optn: optineurin; prkn: parkin rbr e3 ubiquitin protein ligase; pcd: programmed cell death; pfd: pirfenidone; pik3c: phosphatidylinositol-4:5-bisphosphate 3-kinase catalytic subunit; pink1: pten induced putative kinase 1; pten: phosphatase and tensin homolog; ra: rheumatoid arthritis; ros: reactive oxygen species; sa-glb1/\xce\xb2-gal: senescence-associated-galactosidase, beta 1; sasp: senescence-associated secretory phenotype; snp: single nucleotide polymorphism; tnf: tumor necrosis factor. |
2020-05-13 |
2023-01-26 |
mouse |
| Julian M Carosi, Timothy J Sargean. Rapamycin and Alzheimer disease: a double-edged sword? Autophagy vol 15 issue 8 2020 31066320 |
we reassess literature described by a recent perspective article calling for the use of mtor inhibition in dementia and conclude that rapamycin could be useful, but only in people who are in the earliest stages of alzheimer disease. |
2020-02-14 |
2023-01-26 |
Not clear |
| Julian M Carosi, Timothy J Sargean. Rapamycin and Alzheimer disease: a double-edged sword? Autophagy vol 15 issue 8 2020 31066320 |
numerous studies have reported that inhibition of mtor (mechanistic target of rapamycin kinase) clearly reduces alzheimer disease neuropathological hallmarks in mouse models. |
2020-02-14 |
2023-01-26 |
Not clear |
| Fabio Di Domenico, Antonella Tramutola, Cesira Foppoli, Elizabeth Head, Marzia Perluigi, D Allan Butterfiel. mTOR in Down syndrome: Role in A\\xc3\\x9f and tau neuropathology and transition to Alzheimer disease-like dementia. Free radical biology & medicine vol 114 issue 2019 28807816 |
numerous studies linked the alterations of mtor pathway to age-dependent cognitive decline, pathogenesis of alzheimer disease (ad) and ad-like dementia in down syndrome (ds). |
2019-03-13 |
2023-01-26 |
human |
| Fabio Di Domenico, Antonella Tramutola, Cesira Foppoli, Elizabeth Head, Marzia Perluigi, D Allan Butterfiel. mTOR in Down syndrome: Role in A\\xc3\\x9f and tau neuropathology and transition to Alzheimer disease-like dementia. Free radical biology & medicine vol 114 issue 2019 28807816 |
mtor in down syndrome: role in a\xc3\x9f and tau neuropathology and transition to alzheimer disease-like dementia. |
2019-03-13 |
2023-01-26 |
human |
| David Heras-Sandoval, Jazmin M P\\xc3\\xa9rez-Rojas, Jacqueline Hern\\xc3\\xa1ndez-Dami\\xc3\\xa1n, Jos\\xc3\\xa9 Pedraza-Chaverr. The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration. Cellular signalling vol 26 issue 12 2015 25173700 |
upstream of mtor the survival pi3k/akt pathway modulates mtor activity that is also altered in neurodegenerative diseases of alzheimer and parkinson. |
2015-08-06 |
2023-01-25 |
Not clear |
| Antonella Tramutola, Judy C Triplett, Fabio Di Domenico, Dana M Niedowicz, Michael P Murphy, Raffaella Coccia, Marzia Perluigi, D Allan Butterfiel. Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD. Journal of neurochemistry vol 133 issue 5 2015 25645581 |
alteration of mtor signaling occurs early in the progression of alzheimer disease (ad): analysis of brain from subjects with pre-clinical ad, amnestic mild cognitive impairment and late-stage ad. |
2015-06-24 |
2023-01-25 |
human |
| Anand M Iyer, Jackelien van Scheppingen, Ivan Milenkovic, Jasper J Anink, Homa Adle-Biassette, Gabor G Kovacs, Eleonora Aronic. mTOR Hyperactivation in down syndrome hippocampus appears early during development. Journal of neuropathology and experimental neurology vol 73 issue 7 2014 24918639 |
moreover, the expression patterns of mtor components in adult ds hippocampus support its association with alzheimer disease-related histopathologic changes. |
2014-08-06 |
2023-01-25 |
human |
| Anand M Iyer, Jackelien van Scheppingen, Ivan Milenkovic, Jasper J Anink, Homa Adle-Biassette, Gabor G Kovacs, Eleonora Aronic. mTOR Hyperactivation in down syndrome hippocampus appears early during development. Journal of neuropathology and experimental neurology vol 73 issue 7 2014 24918639 |
the expression patterns and cellular distribution of components of mtor signaling (phosphorylated s6, phosphorylated s6 kinase, phosphorylated eukaryotic initiation factor 4e binding protein 1, and phosphorylated mtor) were investigated in developing hippocampi from controls and patients with ds and from adults with ds and alzheimer disease-associated pathology using immunocytochemistry. |
2014-08-06 |
2023-01-25 |
human |
| Anand M Iyer, Jackelien van Scheppingen, Ivan Milenkovic, Jasper J Anink, Homa Adle-Biassette, Gabor G Kovacs, Eleonora Aronic. mTOR Hyperactivation in down syndrome hippocampus appears early during development. Journal of neuropathology and experimental neurology vol 73 issue 7 2014 24918639 |
prominent expression of mtor components was observed in pyramidal neurons with granulovacuolar degeneration and in neurons containing neurofibrillary tangles in the hippocampi of ds subjects with alzheimer disease pathology. |
2014-08-06 |
2023-01-25 |
human |
| Zhi Tang, Erika Bereczki, Haiyan Zhang, Shan Wang, Chunxia Li, Xinying Ji, Rui M Branca, Janne Lehti\\xc3\\xb6, Zhizhong Guan, Peter Filipcik, Shaohua Xu, Bengt Winblad, Jin-Jing Pe. Mammalian target of rapamycin (mTor) mediates tau protein dyshomeostasis: implication for Alzheimer disease. The Journal of biological chemistry vol 288 issue 22 2013 23585566 |
mammalian target of rapamycin (mtor) mediates tau protein dyshomeostasis: implication for alzheimer disease. |
2013-08-06 |
2023-01-25 |
Not clear |
| Zhi Tang, Erika Bereczki, Haiyan Zhang, Shan Wang, Chunxia Li, Xinying Ji, Rui M Branca, Janne Lehti\\xc3\\xb6, Zhizhong Guan, Peter Filipcik, Shaohua Xu, Bengt Winblad, Jin-Jing Pe. Mammalian target of rapamycin (mTor) mediates tau protein dyshomeostasis: implication for Alzheimer disease. The Journal of biological chemistry vol 288 issue 22 2013 23585566 |
previous evidence from post-mortem alzheimer disease (ad) brains and drug (especially rapamycin)-oriented in vitro and in vivo models implicated an aberrant accumulation of the mammalian target of rapamycin (mtor) in tangle-bearing neurons in ad brains and its role in the formation of abnormally hyperphosphorylated tau. |
2013-08-06 |
2023-01-25 |
Not clear |
| Salvatore Odd. The role of mTOR signaling in Alzheimer disease. Frontiers in bioscience (Scholar edition) vol 4 issue 2013 22202101 |
the role of mtor signaling in alzheimer disease. |
2013-08-05 |
2023-01-25 |
Not clear |