| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laura Tapella, Giulia Dematteis, Federico Alessandro Ruffinatti, Luisa Ponzoni, Fabio Fiordaliso, Alessandro Corbelli, Enrico Albanese, Beatrice Pistolato, Jessica Pagano, Elettra Barberis, Emilio Marengo, Claudia Balducci, Gianluigi Forloni, Chiara Verpelli, Carlo Sala, Carla Distasi, Mariaelvina Sala, Marcello Manfredi, Armando A Genazzani, Dmitry Li. Deletion of calcineurin from astrocytes reproduces proteome signature of Alzheimer's disease and epilepsy and predisposes to seizures. Cell calcium. vol 100. 2021-12-07. PMID:34607180. |
over-represented pathways were related to protein synthesis, oxidative phosphorylation, mtor and neurological disorders, including alzheimer's disease (ad) and seizure disorder. |
2021-12-07 |
2023-08-13 |
mouse |
| Zeba Mueed, Pankaj Kumar Rai, Mohammad Amjad Kamal, Nitesh Kumar Podda. Decoding the Inter-Relationship between Sleep Disorders and Alzheimer's Disease Pathogenesis. CNS & neurological disorders drug targets. vol 20. issue 8. 2021-11-30. PMID:32885762. |
alzheimer's disease (ad), characterized by abnormally phosphorylated tau, paired helical filaments (phfs), neurofibrillary tangles (nfts), deregulated mammalian target of rapamycin (mtor), and aβ deposits, is a multifactorial disease with sleep disorders being one of the causative agents. |
2021-11-30 |
2023-08-13 |
Not clear |
| Md Sahab Uddin, Md Ataur Rahman, Md Tanvir Kabir, Tapan Behl, Bijo Mathew, Asma Perveen, George E Barreto, May N Bin-Jumah, Mohamed M Abdel-Daim, Ghulam Md Ashra. Multifarious roles of mTOR signaling in cognitive aging and cerebrovascular dysfunction of Alzheimer's disease. IUBMB life. vol 72. issue 9. 2021-11-22. PMID:32472959. |
multifarious roles of mtor signaling in cognitive aging and cerebrovascular dysfunction of alzheimer's disease. |
2021-11-22 |
2023-08-13 |
Not clear |
| Candice E Van Skike, Stacy A Hussong, Stephen F Hernandez, Andy Q Banh, Nicholas DeRosa, Veronica Galva. mTOR Attenuation with Rapamycin Reverses Neurovascular Uncoupling and Memory Deficits in Mice Modeling Alzheimer's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 19. 2021-11-22. PMID:33888602. |
mtor attenuation with rapamycin reverses neurovascular uncoupling and memory deficits in mice modeling alzheimer's disease. |
2021-11-22 |
2023-08-13 |
mouse |
| Disha Agarwal, Ruchika Kumari, Ashal Ilyas, Shweta Tyagi, Rajnish Kumar, Nitesh Kumar Podda. Crosstalk between epigenetics and mTOR as a gateway to new insights in pathophysiology and treatment of Alzheimer's disease. International journal of biological macromolecules. vol 192. 2021-11-09. PMID:34662652. |
crosstalk between epigenetics and mtor as a gateway to new insights in pathophysiology and treatment of alzheimer's disease. |
2021-11-09 |
2023-08-13 |
Not clear |
| Disha Agarwal, Ruchika Kumari, Ashal Ilyas, Shweta Tyagi, Rajnish Kumar, Nitesh Kumar Podda. Crosstalk between epigenetics and mTOR as a gateway to new insights in pathophysiology and treatment of Alzheimer's disease. International journal of biological macromolecules. vol 192. 2021-11-09. PMID:34662652. |
this review focusses on the study of the interplay of the mtor regulatory pathway with that of epigenetic machinery that may elevate the rate of early diagnosis and prove to be a gateway to the development of an efficient and novel therapeutic strategy for the treatment of alzheimer's disease at an early stage. |
2021-11-09 |
2023-08-13 |
Not clear |
| Zhongkang Zhu, Yuxi Liu, Xinyun Li, Lin Zhang, Huihui Liu, Yong Cui, Yanjie Wang, Danyu Zha. GPNMB mitigates Alzheimer's disease and enhances autophagy via suppressing the mTOR signal. Neuroscience letters. 2021-11-04. PMID:34695452. |
gpnmb mitigates alzheimer's disease and enhances autophagy via suppressing the mtor signal. |
2021-11-04 |
2023-08-13 |
mouse |
| Zhao Zhong Chong, Yan Chen Shang, Shaohui Wang, Kenneth Maies. A Critical Kinase Cascade in Neurological Disorders: PI 3-K, Akt, and mTOR. Future neurology. vol 7. issue 6. 2021-10-21. PMID:23144589. |
pi 3-k, akt, and mtor pathways are vital cellular components that determine cell fate during acute and chronic disorders, such as huntington's disease, alzheimer's disease, parkinson's disease, epilepsy, stroke, and trauma. |
2021-10-21 |
2023-08-12 |
Not clear |
| Shira Mencer, Maryam Kartawy, Felix Lendenfeld, Huda Soluh, Manish Kumar Tripathi, Igor Khaliulin, Haitham Ama. Proteomics of autism and Alzheimer's mouse models reveal common alterations in mTOR signaling pathway. Translational psychiatry. vol 11. issue 1. 2021-10-11. PMID:34535637. |
proteomics of autism and alzheimer's mouse models reveal common alterations in mtor signaling pathway. |
2021-10-11 |
2023-08-13 |
mouse |
| Jack C de la Torr. Deciphering Alzheimer's Disease Pathogenic Pathway: Role of Chronic Brain Hypoperfusion on p-Tau and mTOR. Journal of Alzheimer's disease : JAD. vol 79. issue 4. 2021-09-15. PMID:33459641. |
deciphering alzheimer's disease pathogenic pathway: role of chronic brain hypoperfusion on p-tau and mtor. |
2021-09-15 |
2023-08-13 |
mouse |
| Wenwen Zhang, Fangling Zhang, Qichao Hu, Xiaolin Xiao, Linbo Ou, Yuan Chen, Shiqing Luo, Yonghong Cheng, Yinxiao Jiang, Xiao Ma, Yanling Zha. The emerging possibility of the use of geniposide in the treatment of cerebral diseases: a review. Chinese medicine. vol 16. issue 1. 2021-09-03. PMID:34454545. |
geniposide was able to increase autophagy and inhibit apoptosis by regulating the function of mtor in treating alzheimer's disease. |
2021-09-03 |
2023-08-13 |
Not clear |
| Antonella Caccamoa Ramona Belfiore, Salvatore Odd. Retraction notice to "Genetically reducing mTOR signaling rescues central insulin dysregulation in a mouse model of Alzheimer's disease" [Neurobiology of Aging Volume 68, August 2018, Page 59-67]. Neurobiology of aging. vol 104. 2021-08-28. PMID:34162481. |
retraction notice to "genetically reducing mtor signaling rescues central insulin dysregulation in a mouse model of alzheimer's disease" [neurobiology of aging volume 68, august 2018, page 59-67]. |
2021-08-28 |
2023-08-13 |
mouse |
| Henry Querfurth, Han-Kyu Le. Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration. Molecular neurodegeneration. vol 16. issue 1. 2021-08-13. PMID:34215308. |
however, in alzheimer's disease (ad), mtor alternately plays important pathogenic roles by inhibiting both insulin signaling and autophagic removal of β-amyloid (aβ) and phospho-tau (ptau) aggregates. |
2021-08-13 |
2023-08-13 |
Not clear |
| Yuanting Ding, Heng Liu, Mofei Cen, Yuxiang Tao, Chencen Lai, Zhi Tan. Rapamycin Ameliorates Cognitive Impairments and Alzheimer's Disease-Like Pathology with Restoring Mitochondrial Abnormality in the Hippocampus of Streptozotocin-Induced Diabetic Mice. Neurochemical research. vol 46. issue 2. 2021-08-09. PMID:33140268. |
alzheimer's disease (ad) and diabetes mellitus (dm) share common pathophysiological findings, in particular, the mammalian target of rapamycin (mtor) has been strongly implied to link to ad, while it also plays a key role in the insulin signaling pathway. |
2021-08-09 |
2023-08-13 |
mouse |
| Farzad Ghafouri, Abolfazl Bahrami, Mostafa Sadeghi, Seyed Reza Miraei-Ashtiani, Maryam Bakherad, Herman W Barkema, Samantha Laros. Omics Multi-Layers Networks Provide Novel Mechanistic and Functional Insights Into Fat Storage and Lipid Metabolism in Poultry. Frontiers in genetics. vol 12. 2021-07-27. PMID:34306005. |
module finding revealed three important and functional modules, which were involved in the peroxisome proliferator-activated receptor (ppar) signaling pathway, biosynthesis of unsaturated fatty acids, alzheimer's disease metabolic pathway, adipocytokine, insulin, pi3k-akt, mtor, and ampk signaling pathway. |
2021-07-27 |
2023-08-13 |
Not clear |
| Sarah Gourmaud, David A Stewart, David J Irwin, Nicholas Roberts, Aaron J Barbour, Grace Eberwine, William T O'Brien, Robert Vassar, Delia M Talos, Frances E Jense. The role of mTORC1 activation in seizure-induced exacerbation of Alzheimer's disease. Brain : a journal of neurology. 2021-07-15. PMID:34264340. |
to elucidate our proposed bidirectional relationship between alzheimer's disease and seizures, we studied alzheimer's disease human brain samples (n = 34) and found that patients with a history of seizures (n = 14) had increased β-amyloid and tau pathology, and upregulation of the mechanistic target of rapamycin (mtor) pathway compared to cases without known seizure history (n = 20). |
2021-07-15 |
2023-08-13 |
mouse |
| Sarah Gourmaud, David A Stewart, David J Irwin, Nicholas Roberts, Aaron J Barbour, Grace Eberwine, William T O'Brien, Robert Vassar, Delia M Talos, Frances E Jense. The role of mTORC1 activation in seizure-induced exacerbation of Alzheimer's disease. Brain : a journal of neurology. 2021-07-15. PMID:34264340. |
finally, we demonstrate that administration of the mtor inhibitor rapamycin following kindled seizures rescued enhanced remote and long-term memory deficits associated with earlier kindling and prevented the seizure-induced increases in alzheimer's disease neuropathology. |
2021-07-15 |
2023-08-13 |
mouse |
| M Perluigi, F Di Domenico, E Barone, D A Butterfiel. mTOR in Alzheimer disease and its earlier stages: Links to oxidative damage in the progression of this dementing disorder. Free radical biology & medicine. vol 169. 2021-06-28. PMID:33933601. |
mtor in alzheimer disease and its earlier stages: links to oxidative damage in the progression of this dementing disorder. |
2021-06-28 |
2023-08-13 |
Not clear |
| Gabriela Dumitrita Stanciu, Razvan Nicolae Rusu, Veronica Bild, Leontina Elena Filipiuc, Bogdan-Ionel Tamba, Daniela Carmen Ababe. Systemic Actions of SGLT2 Inhibition on Chronic mTOR Activation as a Shared Pathogenic Mechanism between Alzheimer's Disease and Diabetes. Biomedicines. vol 9. issue 5. 2021-06-15. PMID:34069618. |
systemic actions of sglt2 inhibition on chronic mtor activation as a shared pathogenic mechanism between alzheimer's disease and diabetes. |
2021-06-15 |
2023-08-13 |
human |
| Zeba Mueed, Devanshu Mehta, Pankaj K Rai, Mohammad A Kamal, Nitesh K Podda. Cross-Interplay between Osmolytes and mTOR in Alzheimer's Disease Pathogenesis. Current pharmaceutical design. vol 26. issue 37. 2021-03-19. PMID:32418522. |
cross-interplay between osmolytes and mtor in alzheimer's disease pathogenesis. |
2021-03-19 |
2023-08-13 |
Not clear |