| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiqi Hu, Ya-Nan Ma, Ying Xi. Association between abnormal lipid metabolism and Alzheimer's disease: New research has revealed significant findings on the APOE4 genotype in microglia. Bioscience trends. 2024-04-17. PMID:38631884. |
association between abnormal lipid metabolism and alzheimer's disease: new research has revealed significant findings on the apoe4 genotype in microglia. |
2024-04-17 |
2024-04-20 |
Not clear |
| Zihao Li, Cun-Jin Zhan. Isolation and Culture of Mouse Primary Microglia and Oligodendrocyte Precursor Cells. Methods in molecular biology (Clifton, N.J.). vol 2782. 2024-04-15. PMID:38622401. |
microglia and oligodendrocyte precursor cells (opcs) are critical glia subsets in the central nervous system (cns) and are actively engaged in a body of diseases, such as stroke, alzheimer's disease, multiple sclerosis, etc. |
2024-04-15 |
2024-04-18 |
mouse |
| Gautham S Ramakrishnan, William L Berry, Angela Pacherille, William G Kerr, John D Chisholm, Chiara Pedicone, Mary Beth Humphre. SHIP inhibition mediates select TREM2-induced microglial functions. Molecular immunology. vol 170. 2024-04-13. PMID:38613944. |
microglia play a pivotal role in the pathology of alzheimer's disease (ad), with the triggering receptor expressed on myeloid cells 2 (trem2) central to their neuroprotective functions. |
2024-04-13 |
2024-04-16 |
mouse |
| Giusy Pizzirusso, Efthalia Preka, Julen Goikolea, Celia Aguilar-Ruiz, Patricia Rodriguez Rodriguez, Guillermo Vazquez Cabrera, Simona Laterza, Maria Latorre Leal, Francesca Eroli, Klas Blomgren, Silvia Maioli, Per Nilsson, Adamantia Fragkopoulou, André Fisahn, Luis Enrique Arroyo-Garcí. Dynamic microglia alterations associate with hippocampal network impairments: A turning point in amyloid pathology progression. Brain, behavior, and immunity. 2024-04-12. PMID:38608739. |
recent evidence highlights the role of neuroinflammation, particularly involving microglia, in alzheimer's disease onset and progression. |
2024-04-12 |
2024-04-15 |
Not clear |
| Imdadul Haq, Jason C Ngo, Nainika Roy, Richard L Pan, Nadiya Nawsheen, Rebecca Chiu, Ya Zhang, Masashi Fujita, Rajesh K Soni, Xuebing Wu, David A Bennett, Vilas Menon, Marta Olah, Falak She. An integrated toolkit for human microglia functional genomics. Stem cell research & therapy. vol 15. issue 1. 2024-04-10. PMID:38600587. |
microglia, the brain's resident immune cells, play vital roles in brain development, and disorders like alzheimer's disease (ad). |
2024-04-10 |
2024-04-13 |
human |
| Carla Cuní-López, Romal Stewart, Lotta E Oikari, Tam Hong Nguyen, Tara L Roberts, Yifan Sun, Christine C Guo, Michelle K Lupton, Anthony R White, Hazel Que. Correction: Advanced patient-specific microglia cell models for pre-clinical studies in Alzheimer's disease. Journal of neuroinflammation. vol 21. issue 1. 2024-04-10. PMID:38600570. |
correction: advanced patient-specific microglia cell models for pre-clinical studies in alzheimer's disease. |
2024-04-10 |
2024-04-13 |
Not clear |
| Izabela Lepiarz-Raba, Taufik Hidayat, Anthony J Hannan, Ali Jawai. Potential Alzheimer's disease drug targets identified through microglial biology research. Expert opinion on drug discovery. 2024-04-09. PMID:38590098. |
microglia, the primary immune cells in the brain, play multifaceted roles in alzheimer's disease (ad). |
2024-04-09 |
2024-04-11 |
Not clear |
| Yi-Kuan Chiang, Yung-Shuan Lin, Chun-Yu Chen, Jiing-Feng Lirng, Yu-Hsiu Yang, Wei-Ju Lee, Jong-Ling Fu. Different Splice Isoforms of Peripheral Triggering Receptor Expressed on Myeloid Cells 2 mRNA Expressions are Associated With Cognitive Decline in Mild Dementia Due to Alzheimer's Disease and Reflect Central Neuroinflammation. American journal of Alzheimer's disease and other dementias. vol 39. 2024-04-09. PMID:38592304. |
triggering receptor expressed on myeloid cells 2 (trem2) is upregulated in activated microglia and may be related to cognitive decline in patients with alzheimer's disease (ad). |
2024-04-09 |
2024-04-11 |
Not clear |
| Jinchao Hou, Yun Chen, Zhangying Cai, Gyu Seong Heo, Carla M Yuede, Zuoxu Wang, Kent Lin, Fareeha Saadi, Tihana Trsan, Aivi T Nguyen, Eleni Constantopoulos, Rachel A Larsen, Yiyang Zhu, Nicole D Wagner, Nolan McLaughlin, Xinyi Cynthia Kuang, Alexander D Barrow, Dian Li, Yingyue Zhou, Shoutang Wang, Susan Gilfillan, Michael L Gross, Simone Brioschi, Yongjian Liu, David M Holtzman, Marco Colonn. Antibody-mediated targeting of human microglial leukocyte Ig-like receptor B4 attenuates amyloid pathology in a mouse model. Science translational medicine. vol 16. issue 741. 2024-04-03. PMID:38569016. |
microglia help limit the progression of alzheimer's disease (ad) by constraining amyloid-β (aβ) pathology, effected through a balance of activating and inhibitory intracellular signals delivered by distinct cell surface receptors. |
2024-04-03 |
2024-04-06 |
mouse |
| Astrid Wachter, Maya E Woodbury, Sylvia Lombardo, Aicha Abdourahman, Carolin Wuest, Emily McGlame, Timothy Pastika, Joseph Tamm, Nandini Romanul, Kiran Yanamandra, Rachel Bennett, Gen Lin, Taekyung Kwon, Fan Liao, Corinna Klein, Yelena Grinberg, Methasit Jaisa-Aad, Huan Li, Matthew P Frosch, Markus P Kummer, Sudeshna Das, Tammy Dellovade, Eric H Karran, Xavier Langlois, Janina S Ried, Alberto Serrano-Pozo, Robert V Talanian, Knut Biber, Bradley T Hyma. Landscape of brain myeloid cell transcriptome along the spatiotemporal progression of Alzheimer's disease reveals distinct sequential responses to Aβ and tau. Acta neuropathologica. vol 147. issue 1. 2024-04-01. PMID:38557897. |
human microglia are critically involved in alzheimer's disease (ad) progression, as shown by genetic and molecular studies. |
2024-04-01 |
2024-04-04 |
human |
| Mengmeng Jin, Ziyuan Ma, Rui Dang, Haiwei Zhang, Rachael Kim, Haipeng Xue, Jesse Pascual, Steven Finkbeiner, Elizabeth Head, Ying Liu, Peng Jian. A Trisomy 21-linked Hematopoietic Gene Variant in Microglia Confers Resilience in Human iPSC Models of Alzheimer's Disease. bioRxiv : the preprint server for biology. 2024-04-01. PMID:38559257. |
a trisomy 21-linked hematopoietic gene variant in microglia confers resilience in human ipsc models of alzheimer's disease. |
2024-04-01 |
2024-04-04 |
human |
| Renzo Mancuso, Nicola Fattorelli, Anna Martinez-Muriana, Emma Davis, Leen Wolfs, Johanna Van Den Daele, Ivana Geric, Jessie Premereur, Paula Polanco, Baukje Bijnens, Pranav Preman, Lutgarde Serneels, Suresh Poovathingal, Sriram Balusu, Catherine Verfaillie, Mark Fiers, Bart De Stroope. Xenografted human microglia display diverse transcriptomic states in response to Alzheimer's disease-related amyloid-β pathology. Nature neuroscience. 2024-03-28. PMID:38539015. |
xenografted human microglia display diverse transcriptomic states in response to alzheimer's disease-related amyloid-β pathology. |
2024-03-28 |
2024-03-30 |
human |
| Renzo Mancuso, Nicola Fattorelli, Anna Martinez-Muriana, Emma Davis, Leen Wolfs, Johanna Van Den Daele, Ivana Geric, Jessie Premereur, Paula Polanco, Baukje Bijnens, Pranav Preman, Lutgarde Serneels, Suresh Poovathingal, Sriram Balusu, Catherine Verfaillie, Mark Fiers, Bart De Stroope. Xenografted human microglia display diverse transcriptomic states in response to Alzheimer's disease-related amyloid-β pathology. Nature neuroscience. 2024-03-28. PMID:38539015. |
microglia are central players in alzheimer's disease pathology but analyzing microglial states in human brain samples is challenging due to genetic diversity, postmortem delay and admixture of pathologies. |
2024-03-28 |
2024-03-30 |
human |
| Natascha Vidovic, Björn Spitta. Microglial Transforming Growth Factor-β Signaling in Alzheimer's Disease. International journal of molecular sciences. vol 25. issue 6. 2024-03-28. PMID:38542077. |
taken together, this review highlights the complex interaction of apolipoprotein e, the triggering receptor on myeloid cells 2, and transforming growth factor-β as part of a regulatory axis in microglia at the onset and over the course of alzheimer's disease. |
2024-03-28 |
2024-03-30 |
human |
| Álvaro Fernández-Blanco, Cèsar Sierra, Clara Tejido, Mara Diersse. Beyond Quiescent and Active: Intermediate Microglial Transcriptomic States in a Mouse Model of Down Syndrome. International journal of molecular sciences. vol 25. issue 6. 2024-03-28. PMID:38542263. |
focusing on microglia, we identified differential expression of genes associated with different microglial states, including disease-associated microglia (dams), activated response microglia (arms), and human alzheimer's disease microglia (hams), in trisomic microglia. |
2024-03-28 |
2024-03-30 |
mouse |
| Masashi Fujita, Zongmei Gao, Lu Zeng, Cristin McCabe, Charles C White, Bernard Ng, Gilad Sahar Green, Orit Rozenblatt-Rosen, Devan Phillips, Liat Amir-Zilberstein, Hyo Lee, Richard V Pearse, Atlas Khan, Badri N Vardarajan, Krzysztof Kiryluk, Chun Jimmie Ye, Hans-Ulrich Klein, Gao Wang, Aviv Regev, Naomi Habib, Julie A Schneider, Yanling Wang, Tracy Young-Pearse, Sara Mostafavi, David A Bennett, Vilas Menon, Philip L De Jage. Cell subtype-specific effects of genetic variation in the Alzheimer's disease brain. Nature genetics. 2024-03-22. PMID:38514782. |
a new variant influences apoe expression only in microglia and is associated with greater cerebral amyloid angiopathy but not alzheimer's disease pathology, after adjusting for apoeε4, providing mechanistic insights into both pathologies. |
2024-03-22 |
2024-03-24 |
Not clear |
| Jingji Wang, Yilan Zhen, Jun Yang, Shaojie Yang, Guoqi Zh. Recognizing Alzheimer's disease from perspective of oligodendrocytes: Phenomena or pathogenesis? CNS neuroscience & therapeutics. vol 30. issue 3. 2024-03-22. PMID:38516808. |
accumulation of amyloid beta, tau hyperphosphorylation, and microglia activation are the three highly acknowledged pathological factors of alzheimer's disease (ad). |
2024-03-22 |
2024-03-24 |
Not clear |
| Kristen E Fun. Measuring Antibody-Mediated Tau Fibril Uptake in Microglia by Flow Cytometry. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512680. |
microglia respond to both infectious pathogens in the brain and sterile cellular debris, including the proteinaceous aggregates that accumulate in the brains of patients with alzheimer's disease (ad). |
2024-03-21 |
2024-03-24 |
Not clear |
| Hariharakrishnan Chidambaram, Smita Eknath Desale, Subashchandrabose Chinnathamb. Purinergic Receptor P2Y12-Mediated Tau Internalization in Microglia. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512682. |
in alzheimer's disease, microglia get over activated upon the accumulation of tau and amyloid-β species in the extracellular space, ultimately leading to neurodegeneration. |
2024-03-21 |
2024-03-24 |
Not clear |
| Heng-Cai Wang, Wei Yang, Ling Xu, Yong-Hui Han, Yi Lin, Cui-Tao Lu, Kwonseop Kim, Ying-Zheng Zhao, Xi-Chong Y. BV2 Membrane-coated PEGylated-liposomes Delivered hFGF21 to Cortical and Hippocampal Microglia for Alzheimer's Disease Therapy. Advanced healthcare materials. 2024-03-21. PMID:38513154. |
bv2 membrane-coated pegylated-liposomes delivered hfgf21 to cortical and hippocampal microglia for alzheimer's disease therapy. |
2024-03-21 |
2024-03-24 |
Not clear |