| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Z Qiu, H Zhang, M Xia, J Gu, K Guo, H Wang, C Mia. Programmed Death of Microglia in Alzheimer's Disease: Autophagy, Ferroptosis, and Pyroptosis. The journal of prevention of Alzheimer's disease. vol 10. issue 1. 2023-01-15. PMID:36641613. |
programmed death of microglia in alzheimer's disease: autophagy, ferroptosis, and pyroptosis. |
2023-01-15 |
2023-08-14 |
Not clear |
| Hannah Ennerfelt, John R Luken. Microglia rely on SYK signalling to mount neuroprotective responses in models of Alzheimer's disease and multiple sclerosis. Clinical and translational medicine. vol 13. issue 1. 2023-01-11. PMID:36629045. |
microglia rely on syk signalling to mount neuroprotective responses in models of alzheimer's disease and multiple sclerosis. |
2023-01-11 |
2023-08-14 |
Not clear |
| Davina Biel, Marc Suárez-Calvet, Paul Hager, Anna Rubinski, Anna Dewenter, Anna Steward, Sebastian Roemer, Michael Ewers, Christian Haass, Matthias Brendel, Nicolai Franzmeie. sTREM2 is associated with amyloid-related p-tau increases and glucose hypermetabolism in Alzheimer's disease. EMBO molecular medicine. 2023-01-09. PMID:36620941. |
microglial activation occurs early in alzheimer's disease (ad) and previous studies reported both detrimental and protective effects of microglia on ad progression. |
2023-01-09 |
2023-08-14 |
Not clear |
| Marta Matuszewska, Magdalena Cieślik, Anna Wilkaniec, Marcin Strawski, Grzegorz A Czapsk. The Role of Bromodomain and Extraterminal (BET) Proteins in Controlling the Phagocytic Activity of Microglia In Vitro: Relevance to Alzheimer's Disease. International journal of molecular sciences. vol 24. issue 1. 2023-01-08. PMID:36613460. |
the role of bromodomain and extraterminal (bet) proteins in controlling the phagocytic activity of microglia in vitro: relevance to alzheimer's disease. |
2023-01-08 |
2023-08-14 |
Not clear |
| Chengwu Jin, Liang Chen, Zhulingzhi Kuang, Yiwei Sun, Dali Men. Two New Compounds Isolated from the Leaves of Ohwia Caudata and Their Neuroprotective Effect Against LPS-Induced BV2 Cells. Chemistry & biodiversity. 2023-01-08. PMID:36617501. |
previous studies on o. caudata had been reported to protect against alzheimer's disease, two new compounds were evaluated for their neuroprotective effect against lipopolysaccharide-induced bv2 microglia cells. |
2023-01-08 |
2023-08-14 |
Not clear |
| Regina T Vontell, Juan Pablo de Rivero Vaccari, Xiaoyan Sun, Sakir Humayun Gultekin, Helen M Bramlett, W Dalton Dietrich, Robert W Kean. Identification of inflammasome signaling proteins in neurons and microglia in early and intermediate stages of Alzheimer's disease. Brain pathology (Zurich, Switzerland). 2022-12-29. PMID:36579934. |
identification of inflammasome signaling proteins in neurons and microglia in early and intermediate stages of alzheimer's disease. |
2022-12-29 |
2023-08-14 |
Not clear |
| Oscar M Muñoz Herrera, Angela M Zivkovi. Microglia and Cholesterol Handling: Implications for Alzheimer's Disease. Biomedicines. vol 10. issue 12. 2022-12-23. PMID:36551857. |
microglia and cholesterol handling: implications for alzheimer's disease. |
2022-12-23 |
2023-08-14 |
Not clear |
| Harsharan Singh Bhatia, Andreas-David Brunner, Furkan Öztürk, Saketh Kapoor, Zhouyi Rong, Hongcheng Mai, Marvin Thielert, Mayar Ali, Rami Al-Maskari, Johannes Christian Paetzold, Florian Kofler, Mihail Ivilinov Todorov, Muge Molbay, Zeynep Ilgin Kolabas, Moritz Negwer, Luciano Hoeher, Hanno Steinke, Alina Dima, Basavdatta Gupta, Doris Kaltenecker, Özüm Sehnaz Caliskan, Daniel Brandt, Natalie Krahmer, Stephan Müller, Stefan Frieder Lichtenthaler, Farida Hellal, Ingo Bechmann, Bjoern Menze, Fabian Theis, Matthias Mann, Ali Ertür. Spatial proteomics in three-dimensional intact specimens. Cell. vol 185. issue 26. 2022-12-23. PMID:36563667. |
we used disco-ms to investigate microglia activation along axonal tracts after brain injury and characterized early- and late-stage individual amyloid-beta plaques in a mouse model of alzheimer's disease. |
2022-12-23 |
2023-08-14 |
mouse |
| Jinchao Hou, Yun Chen, Gary Grajales-Reyes, Marco Colonn. TREM2 dependent and independent functions of microglia in Alzheimer's disease. Molecular neurodegeneration. vol 17. issue 1. 2022-12-23. PMID:36564824. |
trem2 dependent and independent functions of microglia in alzheimer's disease. |
2022-12-23 |
2023-08-14 |
mouse |
| Jinchao Hou, Yun Chen, Gary Grajales-Reyes, Marco Colonn. TREM2 dependent and independent functions of microglia in Alzheimer's disease. Molecular neurodegeneration. vol 17. issue 1. 2022-12-23. PMID:36564824. |
microglia are central players in brain innate immunity and have been the subject of extensive research in alzheimer's disease (ad). |
2022-12-23 |
2023-08-14 |
mouse |
| b' Yunzhu Yang, Jiafa Zhang, Canhong Yang, Bo Dong, Yanhong Fu, Yuanyuan Wang, Ming Gong, Tao Liu, Pingming Qiu, Weibing Xie, Tianming L\\xc3\\xb. Sulforaphane attenuates microglia-mediated neuronal damage by down-regulating the ROS/Autophagy/NLRP3 signal axis in fibrillar A\\xce\\xb2-activated microglia. Brain research. 2022-12-20. PMID:36539049.' |
the neuroinflammatory hypothesis of alzheimer's disease (ad) posits that amyloid-beta (aβ) phagocytosis along with subsequent lysosomal damage and nlrp3 inflammasome activation plays important roles in aβ-induced microglia activation and microglia-induced neurotoxicity. |
2022-12-20 |
2023-08-14 |
Not clear |
| Dong Won Kim, Kevin J Tu, Alice Wei, Ashley J Lau, Anabel Gonzalez-Gil, Tianyu Cao, Kerstin Braunstein, Jonathan P Ling, Juan C Troncoso, Philip C Wong, Seth Blackshaw, Ronald L Schnaar, Tong L. Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes. Molecular neurodegeneration. vol 17. issue 1. 2022-12-19. PMID:36536457. |
amongst risk alleles associated with late-onset alzheimer's disease (ad), those that converged on the regulation of microglia activity have emerged as central to disease progression. |
2022-12-19 |
2023-08-14 |
Not clear |
| Ye Man Tang, Nisha S Pulimood, Stefano Stifan. Comparing the Characteristics of Microglia Preparations Generated Using Different Human iPSC-Based Differentiation Methods to Model Neurodegenerative Diseases. ASN neuro. vol 14. 2022-12-16. PMID:36524236. |
dysregulated microglia activation is a hallmark of nervous system disorders including neurodegenerative diseases such as amyotrophic lateral sclerosis (als) and alzheimer's disease. |
2022-12-16 |
2023-08-14 |
human |
| Xinyi Zhang, Peiyu Liang, Yahui Zhang, Yifan Wu, Yinghao Song, Xueyang Wang, Taoxiang Chen, Biwen Peng, Wanhong Liu, Jun Yin, Song Han, Xiaohua H. Blockade of Kv1.3 Potassium Channel Inhibits Microglia-Mediated Neuroinflammation in Epilepsy. International journal of molecular sciences. vol 23. issue 23. 2022-12-11. PMID:36499018. |
the potassium channel kv1.3 in microglia has been reported as a promising therapeutic target in neurological diseases in which neuroinflammation is involved, such as multiple sclerosis (ms), alzheimer's disease (ad), parkinson's disease (pd), and middle cerebral artery occlusion/reperfusion (mcao/r). |
2022-12-11 |
2023-08-14 |
mouse |
| Sebastiaan Moonen, Marta J Koper, Evelien Van Schoor, Jolien M Schaeverbeke, Rik Vandenberghe, Christine A F von Arnim, Thomas Tousseyn, Bart De Strooper, Dietmar Rudolf Tha. Pyroptosis in Alzheimer's disease: cell type-specific activation in microglia, astrocytes and neurons. Acta neuropathologica. 2022-12-09. PMID:36481964. |
pyroptosis in alzheimer's disease: cell type-specific activation in microglia, astrocytes and neurons. |
2022-12-09 |
2023-08-14 |
human |
| Alma S Popescu, Claire A Butler, David H Allendorf, Thomas M Piers, Anna Mallach, Julian Roewe, Peter Reinhardt, Alessandro Cinti, Loredana Redaelli, Christophe Boudesco, Laurent Pradier, Jennifer M Pocock, Peter Thornton, Guy C Brow. Alzheimer's disease-associated R47H TREM2 increases, but wild-type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss. Glia. 2022-12-08. PMID:36480007. |
triggering receptor on myeloid cells 2 (trem2) is an innate immune receptor, upregulated on the surface of microglia associated with amyloid plaques in alzheimer's disease (ad). |
2022-12-08 |
2023-08-14 |
mouse |
| Ruxin Zhang, Yanrong Song, Xuefeng S. Necroptosis and Alzheimer's Disease: Pathogenic Mechanisms and Therapeutic Opportunities. Journal of Alzheimer's disease : JAD. 2022-12-04. PMID:36463451. |
the keywords in the search included: "necroptosis", "alzheimer's disease", "signaling pathways", "aβ", aβo", "tau", "p-tau", "neuronal death", "bbb damage", "neuroinflammation", "microglia", "mitochondrial dysfunction", "granulovacuolar degeneration", "synaptic loss", "axonal degeneration", "nec-1", "nec-1s", "gsk872", "nsa", "oga", "ripk1", "ripk3", and "mlkl". |
2022-12-04 |
2023-08-14 |
Not clear |
| Bina Lee, Ingabire Ines, Jihyun Je, Eun Jung Park, Hyemin Seong, Min Gi Jo, Hwajin Kim, Seon-Hee Kim, Seong Jae Kim, Hye Jung Kim, Minkyeong Kim, Sang Won Park, Seung Pil Yu. Effect of Renal Ischemia Reperfusion on Brain Neuroinflammation. Biomedicines. vol 10. issue 11. 2022-11-26. PMID:36428560. |
the activation of microglia and astrocytes present in this area causes neuro-degenerative diseases, such as alzheimer's disease (ad) and parkinson's disease (pd). |
2022-11-26 |
2023-08-14 |
Not clear |
| Rezwanul Islam, Robin Rajan, Hadi Choudhary, Frank Vrionis, Khalid A Hanaf. Gender differences in Alzheimer's may be associated with TLR4-LYN expression in damage associated microglia and neuronal phagocytosis. Journal of cellular physiology. 2022-11-21. PMID:36409648. |
gender differences in alzheimer's may be associated with tlr4-lyn expression in damage associated microglia and neuronal phagocytosis. |
2022-11-21 |
2023-08-14 |
mouse |
| Younghun Jung, Jonathan Lopez-Benitez, Christina M Tognoni, Isabel Carreras, Alpaslan Dedeogl. Dysregulation of Sphingosine-1-Phosphate (S1P) and S1P Receptor 1 Signaling in the 5xFAD Mouse Model of Alzheimer's Disease. Brain research. 2022-11-21. PMID:36410428. |
our recent studies have shown that treatment with fingolimod, an analog of sphingosine, provides neuroprotective effects in five familiar alzheimer disease (5xfad) transgenic mice, resulting in the reduction of amyloid-β (aβ) neurotoxicity, inhibition of activation of microglia and astrocytes, increased hippocampal neurogenesis, and improved learning and memory. |
2022-11-21 |
2023-08-14 |
mouse |