| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jimena Monzón-Sandoval, Elena Burlacu, Devika Agarwal, Adam E Handel, Liting Wei, John Davis, Sally A Cowley, M Zameel Cader, Caleb Webbe. Lipopolysaccharide distinctively alters human microglia transcriptomes to resemble microglia from Alzheimer's disease mouse models. Disease models & mechanisms. vol 15. issue 10. 2022-10-18. PMID:36254682. |
lipopolysaccharide distinctively alters human microglia transcriptomes to resemble microglia from alzheimer's disease mouse models. |
2022-10-18 |
2023-08-14 |
mouse |
| Jimena Monzón-Sandoval, Elena Burlacu, Devika Agarwal, Adam E Handel, Liting Wei, John Davis, Sally A Cowley, M Zameel Cader, Caleb Webbe. Lipopolysaccharide distinctively alters human microglia transcriptomes to resemble microglia from Alzheimer's disease mouse models. Disease models & mechanisms. vol 15. issue 10. 2022-10-18. PMID:36254682. |
alzheimer's disease (ad) is the most common form of dementia, and risk-influencing genetics implicates microglia and neuroimmunity in the pathogenesis of ad. |
2022-10-18 |
2023-08-14 |
mouse |
| Yi-Ge Wu, Li-Juan Song, Li-Jun Yin, Jun-Jun Yin, Qing Wang, Jie-Zhong Yu, Bao-Guo Xiao, Cun-Gen M. The effects and potential of microglial polarization and crosstalk with other cells of the central nervous system in the treatment of Alzheimer's disease. Neural regeneration research. vol 18. issue 5. 2022-10-18. PMID:36254973. |
during the pathogenesis of alzheimer's disease, stimulatory factors continuously act on the microglia causing abnormal activation and unbalanced phenotypic changes; these events have become a significant and promising area of research. |
2022-10-18 |
2023-08-14 |
Not clear |
| Yi-Ge Wu, Li-Juan Song, Li-Jun Yin, Jun-Jun Yin, Qing Wang, Jie-Zhong Yu, Bao-Guo Xiao, Cun-Gen M. The effects and potential of microglial polarization and crosstalk with other cells of the central nervous system in the treatment of Alzheimer's disease. Neural regeneration research. vol 18. issue 5. 2022-10-18. PMID:36254973. |
our literature search found that phenotypic changes occur continuously in alzheimer's disease and that microglia exhibit extensive crosstalk with astrocytes, oligodendrocytes, neurons, and penetrated peripheral innate immune cells via specific signaling pathways and cytokines. |
2022-10-18 |
2023-08-14 |
Not clear |
| Yi-Ge Wu, Li-Juan Song, Li-Jun Yin, Jun-Jun Yin, Qing Wang, Jie-Zhong Yu, Bao-Guo Xiao, Cun-Gen M. The effects and potential of microglial polarization and crosstalk with other cells of the central nervous system in the treatment of Alzheimer's disease. Neural regeneration research. vol 18. issue 5. 2022-10-18. PMID:36254973. |
collectively, unlike previous efforts to modulate microglial phenotypes at a single level, targeting the phenotypes of microglia and the crosstalk with other cells in the central nervous system may be more effective in reducing inflammation in the central nervous system in alzheimer's disease. |
2022-10-18 |
2023-08-14 |
Not clear |
| Hannah Ennerfelt, Elizabeth L Frost, Daniel A Shapiro, Coco Holliday, Kristine E Zengeler, Gabrielle Voithofer, Ashley C Bolte, Catherine R Lammert, Joshua A Kulas, Tyler K Ulland, John R Luken. SYK coordinates neuroprotective microglial responses in neurodegenerative disease. Cell. 2022-10-18. PMID:36257314. |
in our studies, we find that targeted deletion of syk in microglia leads to exacerbated aβ deposition, aggravated neuropathology, and cognitive defects in the 5xfad mouse model of alzheimer's disease (ad). |
2022-10-18 |
2023-08-14 |
mouse |
| Miao Chai, Gang Su, Juan Gao, Wei Chen, Qionghui Wu, Ying Dong, He Wang, Deyi Chen, Yonghong Li, Xin Gao, Ruixin Li, Tianfei Ma, Zhenchang Zhan. Molecular Mechanism of the Protective Effects of M2 Microglia on Neurons: A Review Focused on Exosomes and Secretory Proteins. Neurochemical research. 2022-10-12. PMID:36222957. |
m2 microglia have attracted increasing attention in recent years owing to their beneficial effects on various diseases and injuries of the cns, such as traumatic brain injury, stroke, alzheimer's disease and multiple sclerosis. |
2022-10-12 |
2023-08-14 |
Not clear |
| Yun Wei, Xianxiao L. Different phenotypes of microglia in animal models of Alzheimer disease. Immunity & ageing : I & A. vol 19. issue 1. 2022-10-08. PMID:36209099. |
different phenotypes of microglia in animal models of alzheimer disease. |
2022-10-08 |
2023-08-14 |
Not clear |
| Zi-Zhen Si, Chen-Jun Zou, Xi Mei, Xiao-Fang Li, Hu Luo, Yao Shen, Jun Hu, Xing-Xing Li, Lun Wu, Yu Li. Targeting neuroinflammation in Alzheimer's disease: from mechanisms to clinical applications. Neural regeneration research. vol 18. issue 4. 2022-10-07. PMID:36204826. |
secondly, we outlined key aspects of glial cell-associated inflammation in alzheimer's disease pathogenesis and provided the latest evidence on the roles of microglia and astrocytes in alzheimer's disease pathology. |
2022-10-07 |
2023-08-14 |
Not clear |
| Guo-Chao Yang, Yuan Shi, Chao-Nan Fan, Ying Li, Meng-Qi Yuan, Jie Pei, Yan Wu, Hai-Tao W. Spliceosomal GTPase Eftud2 regulates microglial activation and polarization. Neural regeneration research. vol 18. issue 4. 2022-10-07. PMID:36204854. |
in this study, we performed immunofluorescent staining and western blot assay and found that eftud2 was upregulated in microglia of a 5xfad transgenic mouse model of alzheimer's disease. |
2022-10-07 |
2023-08-14 |
mouse |
| Yun Li, Xiaohuan Xia, Yi Wang, Jialin C Zhen. Mitochondrial dysfunction in microglia: a novel perspective for pathogenesis of Alzheimer's disease. Journal of neuroinflammation. vol 19. issue 1. 2022-10-06. PMID:36203194. |
mitochondrial dysfunction in microglia: a novel perspective for pathogenesis of alzheimer's disease. |
2022-10-06 |
2023-08-14 |
Not clear |
| Oliver Cooper, Penny Hallett, Ole Isacso. The role of upstream lipid and metabolic systems in Alzheimer's disease, Parkinson's disease and dementias. The FEBS journal. 2022-09-27. PMID:36165619. |
using microglia as an example, we review data that suggests increased lipid concentrations cause dysfunctional inflammatory responses to immune challenges, leading to alzheimer's disease, parkinson's disease and dementia. |
2022-09-27 |
2023-08-14 |
Not clear |
| Marie-Kim St-Pierre, Micaël Carrier, Fernando González Ibáñez, Eva Šimončičová, Marie-Josée Wallman, Luc Vallières, Martin Parent, Marie-Ève Trembla. Ultrastructural characterization of dark microglia during aging in a mouse model of Alzheimer's disease pathology and in human post-mortem brain samples. Journal of neuroinflammation. vol 19. issue 1. 2022-09-27. PMID:36167544. |
ultrastructural characterization of dark microglia during aging in a mouse model of alzheimer's disease pathology and in human post-mortem brain samples. |
2022-09-27 |
2023-08-14 |
mouse |
| Marie-Kim St-Pierre, Micaël Carrier, Fernando González Ibáñez, Eva Šimončičová, Marie-Josée Wallman, Luc Vallières, Martin Parent, Marie-Ève Trembla. Ultrastructural characterization of dark microglia during aging in a mouse model of Alzheimer's disease pathology and in human post-mortem brain samples. Journal of neuroinflammation. vol 19. issue 1. 2022-09-27. PMID:36167544. |
a diverse heterogeneity of microglial cells was previously described in alzheimer's disease (ad) pathology, including dark microglia, a state characterized by ultrastructural markers of cellular stress. |
2022-09-27 |
2023-08-14 |
mouse |
| Wenliang Gao, Wei Kong, Shuaiqun Wang, Gen Wen, Yaling Y. Biomarker Genes Discovery of Alzheimer's Disease by Multi-Omics-Based Gene Regulatory Network Construction of Microglia. Brain sciences. vol 12. issue 9. 2022-09-23. PMID:36138932. |
biomarker genes discovery of alzheimer's disease by multi-omics-based gene regulatory network construction of microglia. |
2022-09-23 |
2023-08-14 |
Not clear |
| Wenliang Gao, Wei Kong, Shuaiqun Wang, Gen Wen, Yaling Y. Biomarker Genes Discovery of Alzheimer's Disease by Multi-Omics-Based Gene Regulatory Network Construction of Microglia. Brain sciences. vol 12. issue 9. 2022-09-23. PMID:36138932. |
microglia, the major immune cells in the brain, mediate neuroinflammation, increased oxidative stress, and impaired neurotransmission in alzheimer's disease (ad), in which most ad risk genes are highly expressed. |
2022-09-23 |
2023-08-14 |
Not clear |
| Helena Marcos Pasero, Aurora García Tejedor, Juan Antonio Giménez-Bastida, José Moisés Laparra Llopi. Modifiable Innate Biology within the Gut-Brain Axis for Alzheimer's Disease. Biomedicines. vol 10. issue 9. 2022-09-23. PMID:36140198. |
alzheimer's disease (ad) is a prototypical inflammation-associated loss of cognitive function, with approximately 90% of the ad burden associated with invading myeloid cells controlling the function of the resident microglia. |
2022-09-23 |
2023-08-14 |
Not clear |
| Haoran Jia, Tianwu Xi. Tracers progress for positron emission tomography imaging of glial-related disease. Journal of biomedical research. 2022-09-22. PMID:36131689. |
extensive studies have shown that astrocytes and microglia play an important role in neurodegenerative diseases, such as alzheimer's disease, parkinson's disease, huntington's disease, as well as glioma, epilepsy, ischemic stroke, and infections. |
2022-09-22 |
2023-08-14 |
human |
| Na Zhao, Wenhui Qiao, Fuyao Li, Yingxue Ren, Jiaying Zheng, Yuka A Martens, Xusheng Wang, Ling Li, Chia-Chen Liu, Kai Chen, Yiyang Zhu, Tadafumi C Ikezu, Zonghua Li, Axel D Meneses, Yunjung Jin, Joshua A Knight, Yixing Chen, Ligia Bastea, Cynthia Linares, Berkiye Sonustun, Lucy Job, Madeleine L Smith, Manling Xie, Yong U Liu, Anthony D Umpierre, Koichiro Haruwaka, Zachary S Quicksall, Peter Storz, Yan W Asmann, Long-Jun Wu, Guojun B. Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia. The Journal of experimental medicine. vol 219. issue 12. 2022-09-15. PMID:36107206. |
trem2 is exclusively expressed by microglia in the brain and is strongly linked to the risk for alzheimer's disease (ad). |
2022-09-15 |
2023-08-14 |
mouse |
| Ling-Xiao Cao, Wen-Zheng Hu, Wei Dong, Qing Yang, Jin-Hui Yin, Yue Wang, Xin Ni, Yue Huan. Neuropathological report of propionic acidemia. Neuropathology : official journal of the Japanese Society of Neuropathology. 2022-09-14. PMID:36102083. |
spongiosis, vacuolization, and the appearance of alzheimer type ii astrocytes and activated microglia were observed as well. |
2022-09-14 |
2023-08-14 |
human |