| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Menbere Y Wendimu, Shelley B Hook. Microglia Phenotypes in Aging and Neurodegenerative Diseases. Cells. vol 11. issue 13. 2022-07-09. PMID:35805174. |
this review provides a comprehensive overview of current research on the various microglia phenotypes and inflammatory responses in health, aging, and nds, with a special emphasis on the heterogeneous phenotypic response of microglia in acute and chronic diseases such as hemorrhagic stroke (hs), alzheimer's disease (ad), and parkinson's disease (pd). |
2022-07-09 |
2023-08-14 |
human |
| Ziyad M Althafa. Targeting Microglia in Alzheimer's Disease: From Molecular Mechanisms to Potential Therapeutic Targets for Small Molecules. Molecules (Basel, Switzerland). vol 27. issue 13. 2022-07-09. PMID:35807370. |
targeting microglia in alzheimer's disease: from molecular mechanisms to potential therapeutic targets for small molecules. |
2022-07-09 |
2023-08-14 |
Not clear |
| Mengmeng Jin, Ranjie Xu, Le Wang, Mahabub Maraj Alam, Ziyuan Ma, Sining Zhu, Alessandra C Martini, Azadeh Jadali, Matteo Bernabucci, Ping Xie, Kelvin Y Kwan, Zhiping P Pang, Elizabeth Head, Ying Liu, Ronald P Hart, Peng Jian. Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer's disease. Cell stem cell. vol 29. issue 7. 2022-07-08. PMID:35803230. |
microglia are critical in brain development and alzheimer's disease (ad) etiology. |
2022-07-08 |
2023-08-14 |
mouse |
| Jelena Stanojevic, Milorad Dragic, Ivana Stevanovic, Tihomir Ilic, Ivana Stojanovic, Milica Zeljkovic, Milica Ninkovi. Intermittent theta burst stimulation ameliorates cognitive impairment and hippocampal gliosis in the Streptozotocin-induced model of Alzheimer's disease. Behavioural brain research. 2022-07-05. PMID:35780960. |
intracerebroventricularly (icv) injected streptozotocin (stz) model of alzheimer's disease (ad) is used to explore the effect of intermittent theta burst stimulation (itbs) on astrocyte and microglia reactivity in selectively vulnerable brain regions and answer the question whether these changes are in the context of cognitive capacity. |
2022-07-05 |
2023-08-14 |
rat |
| Marie-Kim St-Pierre, Micaël Carrier, Victor Lau, Marie-Ève Trembla. Investigating Microglial Ultrastructural Alterations and Intimate Relationships with Neuronal Stress, Dystrophy, and Degeneration in Mouse Models of Alzheimer's Disease. Methods in molecular biology (Clifton, N.J.). vol 2515. 2022-07-01. PMID:35776344. |
in recent decades, microglia have taken the field of neuroscience by storm, with numerous studies identifying key roles for these cells in the pathophysiology of neurodegenerative conditions, such as alzheimer's disease (ad). |
2022-07-01 |
2023-08-14 |
mouse |
| Peng Zhao, Yuanzhong Xu, Lu-Lin Jiang, Xuejun Fan, Zhiqiang Ku, Leike Li, Xiaoye Liu, Mi Deng, Hisashi Arase, Jay-Jiguang Zhu, Timothy Y Huang, Yingjun Zhao, Chengcheng Zhang, Huaxi Xu, Qingchun Tong, Ningyan Zhang, Zhiqiang A. LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions. Molecular neurodegeneration. vol 17. issue 1. 2022-06-18. PMID:35717259. |
microglia plays crucial roles in alzheimer's disease (ad) development. |
2022-06-18 |
2023-08-14 |
Not clear |
| Yurii V Stepanov, Iuliia Golovynska, Renlong Zhang, Sergii Golovynskyi, Liudmyla I Stepanova, Oleksandr Gorbach, Taisa Dovbynchuk, Liudmyla V Garmanchuk, Tymish Y Ohulchanskyy, Junle Q. Near-infrared light reduces β-amyloid-stimulated microglial toxicity and enhances survival of neurons: mechanisms of light therapy for Alzheimer's disease. Alzheimer's research & therapy. vol 14. issue 1. 2022-06-18. PMID:35717405. |
microglia cells play a key role in the pathology of alzheimer's disease by causing chronic inflammation. |
2022-06-18 |
2023-08-14 |
Not clear |
| Sepideh Kiani Shabestari, Samuel Morabito, Emma Pascal Danhash, Amanda McQuade, Jessica Ramirez Sanchez, Emily Miyoshi, Jean Paul Chadarevian, Christel Claes, Morgan Alexandra Coburn, Jonathan Hasselmann, Jorge Hidalgo, Kayla Nhi Tran, Alessandra C Martini, Winston Chang Rothermich, Jesse Pascual, Elizabeth Head, David A Hume, Clare Pridans, Hayk Davtyan, Vivek Swarup, Mathew Blurton-Jone. Absence of microglia promotes diverse pathologies and early lethality in Alzheimer's disease mice. Cell reports. vol 39. issue 11. 2022-06-15. PMID:35705056. |
absence of microglia promotes diverse pathologies and early lethality in alzheimer's disease mice. |
2022-06-15 |
2023-08-14 |
mouse |
| Sepideh Kiani Shabestari, Samuel Morabito, Emma Pascal Danhash, Amanda McQuade, Jessica Ramirez Sanchez, Emily Miyoshi, Jean Paul Chadarevian, Christel Claes, Morgan Alexandra Coburn, Jonathan Hasselmann, Jorge Hidalgo, Kayla Nhi Tran, Alessandra C Martini, Winston Chang Rothermich, Jesse Pascual, Elizabeth Head, David A Hume, Clare Pridans, Hayk Davtyan, Vivek Swarup, Mathew Blurton-Jone. Absence of microglia promotes diverse pathologies and early lethality in Alzheimer's disease mice. Cell reports. vol 39. issue 11. 2022-06-15. PMID:35705056. |
microglia are strongly implicated in the development and progression of alzheimer's disease (ad), yet their impact on pathology and lifespan remains unclear. |
2022-06-15 |
2023-08-14 |
mouse |
| Dewan Md Sumsuzzman, Md Sahab Uddin, Md Tanvir Kabir, Sharifa Hasana, Asma Perveen, Ibtesam S Alanazi, Ghadeer M Albadrani, Mohamed M Abdel-Daim, Ghulam Md Ashra. Microglia in Alzheimer's Disease: A Favorable Cellular Target to Ameliorate Alzheimer's Pathogenesis. Mediators of inflammation. vol 2022. 2022-06-13. PMID:35693110. |
microglia in alzheimer's disease: a favorable cellular target to ameliorate alzheimer's pathogenesis. |
2022-06-13 |
2023-08-14 |
Not clear |
| Yi-Jun Xu, Ngan Pan Bennett Au, Chi Him Eddie M. Functional and Phenotypic Diversity of Microglia: Implication for Microglia-Based Therapies for Alzheimer's Disease. Frontiers in aging neuroscience. vol 14. 2022-06-13. PMID:35693341. |
functional and phenotypic diversity of microglia: implication for microglia-based therapies for alzheimer's disease. |
2022-06-13 |
2023-08-14 |
Not clear |
| Xiaowei Ma, Yizhou Zhang, Dongyun Gou, Jingle Ma, Juan Du, Chang Wang, Sha Li, Huixian Cu. Metabolic Reprogramming of Microglia Enhances Proinflammatory Cytokine Release through EphA2/p38 MAPK Pathway in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2022-06-13. PMID:35694923. |
metabolic reprogramming of microglia enhances proinflammatory cytokine release through epha2/p38 mapk pathway in alzheimer's disease. |
2022-06-13 |
2023-08-14 |
Not clear |
| Xiaowei Ma, Yizhou Zhang, Dongyun Gou, Jingle Ma, Juan Du, Chang Wang, Sha Li, Huixian Cu. Metabolic Reprogramming of Microglia Enhances Proinflammatory Cytokine Release through EphA2/p38 MAPK Pathway in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2022-06-13. PMID:35694923. |
the activation of microglia and neuroinflammation has been implicated in the pathogenesis of alzheimer's disease (ad), but the exact roles of microglia and the underlying mechanisms remain unclear. |
2022-06-13 |
2023-08-14 |
Not clear |
| Sarah M Connor, Mamunur Rashid, Katie J Ryan, Kruti Patel, Justin D Boyd, Jennifer Smith, Wassim Elyaman, David A Bennett, Elizabeth M Bradsha. GW5074 Increases Microglial Phagocytic Activities: Potential Therapeutic Direction for Alzheimer's Disease. Frontiers in cellular neuroscience. vol 16. 2022-06-09. PMID:35677758. |
microglia, the resident immune cells of the central nervous system (cns), are responsible for maintaining homeostasis in the brain by clearing debris and are suggested to be inefficient in alzheimer's disease (ad), a progressive neurodegenerative disorder for which there is no disease-modifying drug. |
2022-06-09 |
2023-08-14 |
human |
| Sanjay, Jae-Ho Shin, Miey Park, Hae-Jeung Le. Cyanidin-3-O-Glucoside Regulates the M1/M2 Polarization of Microglia via PPARγ and Aβ42 Phagocytosis Through TREM2 in an Alzheimer's Disease Model. Molecular neurobiology. 2022-06-07. PMID:35670898. |
cyanidin-3-o-glucoside regulates the m1/m2 polarization of microglia via pparγ and aβ42 phagocytosis through trem2 in an alzheimer's disease model. |
2022-06-07 |
2023-08-14 |
mouse |
| Qian Shi, Cheng Chang, Afaf Saliba, Manzoor A Bha. Microglial mTOR Activation Upregulates Trem2 and Enhances β-Amyloid Plaque Clearance in the The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-06-07. PMID:35672148. |
microglial mtor activation upregulates trem2 and enhances β-amyloid plaque clearance in the the mechanistic target of rapamycin (mtor) signaling pathway plays a major role in key cellular processes including metabolism and differentiation; however, the role of mtor in microglia and its importance in alzheimer's disease (ad) has remained largely uncharacterized. |
2022-06-07 |
2023-08-14 |
Not clear |
| Rahul Dhandapani, Marilisa Neri, Mario Bernhard, Irena Brzak, Tatjana Schweizer, Stefan Rudin, Stefanie Joller, Ramon Berth, Jasmin Kernen, Anna Neuhaus, Annick Waldt, Rachel Cuttat, Ulrike Naumann, Caroline Gubser Keller, Guglielmo Roma, Dominik Feuerbach, Derya R Shimshek, Ulf Neumann, Fabrizio Gasparini, Ivan Galimbert. Sustained Trem2 stabilization accelerates microglia heterogeneity and Aβ pathology in a mouse model of Alzheimer's disease. Cell reports. vol 39. issue 9. 2022-06-01. PMID:35649351. |
sustained trem2 stabilization accelerates microglia heterogeneity and aβ pathology in a mouse model of alzheimer's disease. |
2022-06-01 |
2023-08-13 |
mouse |
| Olumayokun A Olajide, Victoria U Iwuanyanwu, Owolabi W Banjo, Atsushi Kato, Yana B Penkova, George W J Fleet, Robert J Nas. Iminosugar Amino Acid idoBR1 Reduces Inflammatory Responses in Microglia. Molecules (Basel, Switzerland). vol 27. issue 10. 2022-05-28. PMID:35630818. |
the microglia are immune cells present in the central nervous system; their activation results in the release of inflammatory cytokines and is thought to be related to aging and neurodegenerative disorders, such as alzheimer's disease. |
2022-05-28 |
2023-08-13 |
mouse |
| Lixin Wang, Jinxia Sun, Zhulei Miao, Xin Jiang, Yuejuan Zheng, Guizhen Yan. Quercitrin improved cognitive impairment through inhibiting inflammation induced by microglia in Alzheimer's disease mice. Neuroreport. vol 33. issue 8. 2022-05-20. PMID:35594435. |
quercitrin improved cognitive impairment through inhibiting inflammation induced by microglia in alzheimer's disease mice. |
2022-05-20 |
2023-08-13 |
mouse |
| Nan Li, Jun Shu, Xiaoyan Yang, Wenshi Wei, Aijuan Ya. Exosomes Derived From M2 Microglia Cells Attenuates Neuronal Impairment and Mitochondrial Dysfunction in Alzheimer's Disease Through the PINK1/Parkin Pathway. Frontiers in cellular neuroscience. vol 16. 2022-05-16. PMID:35573832. |
exosomes derived from m2 microglia cells attenuates neuronal impairment and mitochondrial dysfunction in alzheimer's disease through the pink1/parkin pathway. |
2022-05-16 |
2023-08-13 |
mouse |