| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Oscar M Muñoz, Izumi Maezawa, Lee-Way Jin, Jacopo Di Lucente, Carlito B Lebrilla, Danielle J Harvey, Angela M Zivkovi. Activated macrophages displaying an M1 phenotype have a reduced capacity to efflux cholesterol. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109138. |
microglia, specialized phagocytic cells of the brain, likewise play a critical role in the clearance of cellular debris, particularly amyloid beta, which is involved in the pathogenesis of alzheimer's disease. |
2022-02-03 |
2023-08-13 |
Not clear |
| Justin M Long, Ainsley Tran, Javier R Serrano, Xin Bao, Chao Wang, Joseph Reznikov, Anil G Cashikar, Steven M Paul, David M Holtzma. 25-Hydroxycholesterol modulates tau-mediated neurodegeneration and microglial chemotaxis and phagocytosis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109157. |
immune activation is an important component of alzheimer disease (ad) pathology, with microglia playing a critical role in driving apoe-dependent tau-mediated neurodegeneration. |
2022-02-03 |
2023-08-13 |
mouse |
| Alexandre Henriques, Pierrick Jégo, Clémence Farrugia, Noelle Callizo. Intra-hippocampal injections of Aβ oligomers induce cognitive impairments associated with neurodegeneration and activation of microglia in senescent mice: Characterization of a novel animal model of Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109200. |
intra-hippocampal injections of aβ oligomers induce cognitive impairments associated with neurodegeneration and activation of microglia in senescent mice: characterization of a novel animal model of alzheimer's disease. |
2022-02-03 |
2023-08-13 |
mouse |
| Ilaria Rossetti, Rashmi Vasundhara Gamage, Garry Niedermayer, Gerald Wolfgang Muench, Erika Gyenges. A stereological study of glial activation in GFAP-IL6 mice: A model of chronic neuroimmune conditions. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109205. |
understanding the role of chronic neuroinflammation, described by increased astro- and microglia activation, in the pathogenesis of alzheimer's disease (ad) is becoming crucial due to its role throughout the disease progression (deczkowska et al., 2018). |
2022-02-03 |
2023-08-13 |
mouse |
| Anna Fracassi, Michela Marcatti, Randy L Woltjer, Giulio Taglialatel. TREM2-induced activation of microglia contributes to synaptic resilience in non-demented individuals with Alzheimer's neuropathology. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109255. |
trem2-induced activation of microglia contributes to synaptic resilience in non-demented individuals with alzheimer's neuropathology. |
2022-02-03 |
2023-08-13 |
Not clear |
| Clara Muñoz-Castro, Ayush Noori, Colin G Magdamo, Jordan D Marks, Sudeshna Das, Bradley T Hyman, Alberto Serrano-Poz. Characterization of glial responses in Alzheimer's disease with cyclic multiplex fluorescent immunohistochemistry and machine learning. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109256. |
aβ plaques and neurofibrillary tangles in alzheimer's disease (ad) are associated with reactive astrocytes and microglia. |
2022-02-03 |
2023-08-13 |
human |
| Elizabeth Burton, Mariana Argenziano, Kieona Cook, Sumei Lu, Elisabetta Manduchi, Michelle E Leonard, Kenyaita M Hodge, Li-San Wang, Gerard D Schellenberg, Matthew E Johnson, James A Pippin, Andrew D Wells, Stewart A Anderson, Christopher D Brown, Struan F A Grant, Alessandra Ches. Variant-to-gene mapping in human microglial cell models with CRISPR validation implicates RTFDC1 at the Alzheimer's disease 'CASS4' locus. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109263. |
variant-to-gene mapping in human microglial cell models with crispr validation implicates rtfdc1 at the alzheimer's disease 'cass4' locus. |
2022-02-03 |
2023-08-13 |
human |
| Ahmed Hassan, Hannah Scott, Matt Hil. Regulation of microglial transcription factor MEF2C by Alzheimer's disease-relevant stimuli. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109321. |
in recent years, microglia have become increasingly recognized as key players in alzheimer's disease (ad)- they are thought to be protective in early ad and detrimental in late ad by producing pro-inflammatory cytokines that contribute to brain inflammation. |
2022-02-03 |
2023-08-13 |
Not clear |
| Cha-Gyun Jung, Mona Abdelhamid, Chunyu Zhou, Ferdous Taslima, Mohammad Abdullah, Makoto Michikaw. Probiotic Bifidobacterium breve decreases Aβ production via the upregulation of ADAM10 level and attenuates microglia activation in an APP knock-in mouse model of Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109373. |
probiotic bifidobacterium breve decreases aβ production via the upregulation of adam10 level and attenuates microglia activation in an app knock-in mouse model of alzheimer's disease. |
2022-02-03 |
2023-08-13 |
mouse |
| Clara Muñoz-Castro, Ayush Noori, Colin G Magdamo, Zhaozhi Li, Jordan D Marks, Matthew P Frosch, Sudeshna Das, Bradley T Hyman, Alberto Serrano-Poz. Cyclic multiplex fluorescent immunohistochemistry and machine learning reveal distinct states of astrocytes and microglia in normal aging and Alzheimer's disease. Journal of neuroinflammation. vol 19. issue 1. 2022-02-03. PMID:35109872. |
cyclic multiplex fluorescent immunohistochemistry and machine learning reveal distinct states of astrocytes and microglia in normal aging and alzheimer's disease. |
2022-02-03 |
2023-08-13 |
human |
| Clara Muñoz-Castro, Ayush Noori, Colin G Magdamo, Zhaozhi Li, Jordan D Marks, Matthew P Frosch, Sudeshna Das, Bradley T Hyman, Alberto Serrano-Poz. Cyclic multiplex fluorescent immunohistochemistry and machine learning reveal distinct states of astrocytes and microglia in normal aging and Alzheimer's disease. Journal of neuroinflammation. vol 19. issue 1. 2022-02-03. PMID:35109872. |
astrocytes and microglia react to aβ plaques, neurofibrillary tangles, and neurodegeneration in the alzheimer's disease (ad) brain. |
2022-02-03 |
2023-08-13 |
human |
| Kyu-Beom Jang, Min-Jung You, Bohyun Yang, Chan Rim, Hui-Ju Kim, Min-Soo Kwo. Persistent Acidic Environment Induces Impaired Phagocytosis via ERK in Microglia. Neurochemical research. 2022-02-01. PMID:35103911. |
acidic environment evoked by stroke, traumatic brain injury, and alzheimer's disease may change the functional properties of microglia. |
2022-02-01 |
2023-08-13 |
Not clear |
| Patrick J Paasila, Jason A Aramideh, Greg T Sutherland, Manuel B Graebe. Synapses, Microglia, and Lipids in Alzheimer's Disease. Frontiers in neuroscience. vol 15. 2022-01-31. PMID:35095394. |
synapses, microglia, and lipids in alzheimer's disease. |
2022-01-31 |
2023-08-13 |
Not clear |
| Dorota Kaniowska, Kerstin Wenk, Phil Rademacher, Ronald Weiss, Claire Fabian, Isabell Schulz, Max Guthardt, Franziska Lange, Sebastian Greiser, Matthias Schmidt, Ulf-Dietrich Braumann, Frank Emmrich, Ulrike Koehl, Yarúa Jaime. Extracellular Vesicles of Mesenchymal Stromal Cells Can be Taken Up by Microglial Cells and Partially Prevent the Stimulation Induced by β-amyloid. Stem cell reviews and reports. 2022-01-26. PMID:35080744. |
this inhibition of microglia activation may present an effective strategy for the control/therapy of neurodegenerative diseases such as alzheimer's disease. |
2022-01-26 |
2023-08-13 |
Not clear |
| Peter Hermann, Anna Villar-Piqué, Matthias Schmitz, Christian Schmidt, Daniela Varges, Stefan Goebel, Timothy Bunck, Hanna Lindemann, Carla Bogner, Isabel Santana, Inês Baldeiras, Joachim Riggert, Inga Zerr, Franc Lloren. Plasma Lipocalin 2 in Alzheimer's disease: potential utility in the differential diagnosis and relationship with other biomarkers. Alzheimer's research & therapy. vol 14. issue 1. 2022-01-14. PMID:35027079. |
in the brain, it is expressed in response to vascular and other brain injury, as well as in alzheimer's disease in reactive microglia and astrocytes. |
2022-01-14 |
2023-08-13 |
Not clear |
| Hansen Wan. Microglia Heterogeneity in Alzheimer's Disease: Insights From Single-Cell Technologies. Frontiers in synaptic neuroscience. vol 13. 2022-01-10. PMID:35002670. |
microglia heterogeneity in alzheimer's disease: insights from single-cell technologies. |
2022-01-10 |
2023-08-13 |
mouse |
| Hansen Wan. Microglia Heterogeneity in Alzheimer's Disease: Insights From Single-Cell Technologies. Frontiers in synaptic neuroscience. vol 13. 2022-01-10. PMID:35002670. |
the pathology of alzheimer's disease (ad) triggers activation of microglia. |
2022-01-10 |
2023-08-13 |
mouse |
| Juan R Perea, Marta Bolós, Raquel Cuadros, Esther García, Vega García-Escudero, Félix Hernández, Róisín M McManus, Michael T Heneka, Jesús Avil. p38 Inhibition Decreases Tau Toxicity in Microglia and Improves Their Phagocytic Function. Molecular neurobiology. 2022-01-10. PMID:35006531. |
alzheimer's disease (ad) and other tauopathies are histopathologically characterized by tau aggregation, along with a chronic inflammatory response driven by microglia. |
2022-01-10 |
2023-08-13 |
Not clear |
| Tal Ganz, Nina Fainstein, Amit Elad, Marva Lachish, Smadar Goldfarb, Ofira Einstein, Tamir Ben-Hu. Microbial pathogens induce neurodegeneration in Alzheimer's disease mice: protection by microglial regulation. Journal of neuroinflammation. vol 19. issue 1. 2022-01-07. PMID:34991645. |
we hypothesized that systemic microbial pathogens may accelerate neurodegeneration in alzheimer's disease (ad) and that microglia play a central role in this process. |
2022-01-07 |
2023-08-13 |
mouse |
| Faheem Ullah, Rashmi Gamage, Monokesh K Sen, Erika Gyenges. The Effects of Modified Curcumin Preparations on Glial Morphology in Aging and Neuroinflammation. Neurochemical research. 2022-01-06. PMID:34988899. |
neuroinflammation is characterized by reactive microglia and astrocytes (collectively called gliosis) in the central nervous system and is considered as one of the main pathological hallmarks in different neurodegenerative diseases such as alzheimer's disease, age-related dementia, and multiple sclerosis. |
2022-01-06 |
2023-08-13 |
Not clear |