| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qi Qin, Zhaoqian Teng, Changmei Liu, Qian Li, Yunsi Yin, Yi Tan. TREM2, microglia, and Alzheimer's disease. Mechanisms of ageing and development. vol 195. 2021-11-19. PMID:33516818. |
trem2, microglia, and alzheimer's disease. |
2021-11-19 |
2023-08-13 |
Not clear |
| Boyd Kenkhuis, Antonios Somarakis, Lorraine de Haan, Oleh Dzyubachyk, Marieke E IJsselsteijn, Noel F C C de Miranda, Boudewijn P F Lelieveldt, Jouke Dijkstra, Willeke M C van Roon-Mom, Thomas Höllt, Louise van der Weer. Iron loading is a prominent feature of activated microglia in Alzheimer's disease patients. Acta neuropathologica communications. vol 9. issue 1. 2021-11-18. PMID:33597025. |
iron loading is a prominent feature of activated microglia in alzheimer's disease patients. |
2021-11-18 |
2023-08-13 |
human |
| Boyd Kenkhuis, Antonios Somarakis, Lorraine de Haan, Oleh Dzyubachyk, Marieke E IJsselsteijn, Noel F C C de Miranda, Boudewijn P F Lelieveldt, Jouke Dijkstra, Willeke M C van Roon-Mom, Thomas Höllt, Louise van der Weer. Iron loading is a prominent feature of activated microglia in Alzheimer's disease patients. Acta neuropathologica communications. vol 9. issue 1. 2021-11-18. PMID:33597025. |
therefore, using histological methods, multispectral immunofluorescence and an automated in-house developed microglia segmentation and analysis pipeline, we studied the occurrence of iron-accumulating microglia and the effect on its activation state in human alzheimer brains. |
2021-11-18 |
2023-08-13 |
human |
| Yiyi Ma, Lei Yu, Marta Olah, Rebecca Smith, Stephanie R Oatman, Mariet Allen, Ehsan Pishva, Bin Zhang, Vilas Menon, Nilüfer Ertekin-Taner, Katie Lunnon, David A Bennett, Hans-Ulrich Klein, Philip L De Jage. EPIGENOMIC FEATURES RELATED TO MICROGLIA ARE ASSOCIATED WITH ATTENUATED EFFECT OF APOE ε4 ON ALZHEIMER'S DISEASE RISK IN HUMANS. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 16. issue Suppl 2. 2021-11-18. PMID:34393677. |
epigenomic features related to microglia are associated with attenuated effect of apoe ε4 on alzheimer's disease risk in humans. |
2021-11-18 |
2023-08-13 |
Not clear |
| Nofar Stolero, Dan Frenke. The dialog between neurons and microglia in Alzheimer's disease: The neurotransmitters view. Journal of neurochemistry. vol 158. issue 6. 2021-11-17. PMID:33314073. |
the dialog between neurons and microglia in alzheimer's disease: the neurotransmitters view. |
2021-11-17 |
2023-08-13 |
Not clear |
| Natja Haag, Hans Zempe. Persistent astrocytic IL-3 stimulation of microglia slows disease in Alzheimer's: treatment perspectives for Alzheimer's. Signal transduction and targeted therapy. vol 6. issue 1. 2021-11-17. PMID:34753904. |
persistent astrocytic il-3 stimulation of microglia slows disease in alzheimer's: treatment perspectives for alzheimer's. |
2021-11-17 |
2023-08-13 |
Not clear |
| Jannis Wißfeld, Ichiro Nozaki, Mona Mathews, Tamara Raschka, Christian Ebeling, Veit Hornung, Oliver Brüstle, Harald Neuman. Deletion of Alzheimer's disease-associated CD33 results in an inflammatory human microglia phenotype. Glia. vol 69. issue 6. 2021-11-16. PMID:33539598. |
deletion of alzheimer's disease-associated cd33 results in an inflammatory human microglia phenotype. |
2021-11-16 |
2023-08-13 |
human |
| Emma Gerrits, Nieske Brouwer, Susanne M Kooistra, Maya E Woodbury, Yannick Vermeiren, Mirjam Lambourne, Jan Mulder, Markus Kummer, Thomas Möller, Knut Biber, Wilfred F A den Dunnen, Peter P De Deyn, Bart J L Eggen, Erik W G M Boddek. Distinct amyloid-β and tau-associated microglia profiles in Alzheimer's disease. Acta neuropathologica. vol 141. issue 5. 2021-11-16. PMID:33609158. |
distinct amyloid-β and tau-associated microglia profiles in alzheimer's disease. |
2021-11-16 |
2023-08-13 |
mouse |
| Prateep Amonruttanapun, Sukumal Chongthammakun, Siriporn Chamniansawa. The effects of okadaic acid-treated SH-SY5Y cells on microglia activation and phagocytosis. Cell biology international. 2021-11-16. PMID:34748253. |
the activation of microglia is found to be associated with neurodegenerative disorders including alzheimer's disease (ad). |
2021-11-16 |
2023-08-13 |
Not clear |
| Mengmeng Wang, Yuanyuan Jiang, Zhihui Huan. Loss of C9orf72 in Microglia Drives Neuronal Injury by Enhancing Synaptic Pruning in Aged and Alzheimer's Disease Mice. Neuroscience bulletin. 2021-11-16. PMID:34783984. |
loss of c9orf72 in microglia drives neuronal injury by enhancing synaptic pruning in aged and alzheimer's disease mice. |
2021-11-16 |
2023-08-13 |
mouse |
| Akira Sobue, Okiru Komine, Yuichiro Hara, Fumito Endo, Hiroyuki Mizoguchi, Seiji Watanabe, Shigeo Murayama, Takashi Saito, Takaomi C Saido, Naruhiko Sahara, Makoto Higuchi, Tomoo Ogi, Koji Yamanak. Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer's disease. Acta neuropathologica communications. vol 9. issue 1. 2021-11-15. PMID:33402227. |
microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of alzheimer's disease. |
2021-11-15 |
2023-08-13 |
mouse |
| Miren Ettcheto, Amanda Cano, Elena Sanchez-López, Ester Verdaguer, Jaume Folch, Carme Auladell, Antoni Camin. Masitinib for the treatment of Alzheimer's disease. Neurodegenerative disease management. vol 11. issue 4. 2021-11-15. PMID:34412534. |
masitinib is a potent and selective phenylaminothiazole-type tyrosine kinase inhibitor which is currently in phase iii studies for the treatment of alzheimer's disease (ad) with the aim of modifying its evolution and with multiple pharmacological targets such as inhibition of mast cells activity, inhibition of microglia activation, modulation of aβ and tau protein signaling pathway and prevention of synaptic damage. |
2021-11-15 |
2023-08-13 |
Not clear |
| Kazuyuki Takata, Florent Ginhoux, Shun Shimoham. Roles of microglia in Alzheimer's disease and impact of new findings on microglial heterogeneity as a target for therapeutic intervention. Biochemical pharmacology. vol 192. 2021-11-15. PMID:34480881. |
roles of microglia in alzheimer's disease and impact of new findings on microglial heterogeneity as a target for therapeutic intervention. |
2021-11-15 |
2023-08-13 |
Not clear |
| Kazuyuki Takata, Florent Ginhoux, Shun Shimoham. Roles of microglia in Alzheimer's disease and impact of new findings on microglial heterogeneity as a target for therapeutic intervention. Biochemical pharmacology. vol 192. 2021-11-15. PMID:34480881. |
recent studies also revealed functions of microglia in neuroprotection and neuroinflammation, leading to the discovery that microglia are involved in several brain pathologies including alzheimer's disease (ad). |
2021-11-15 |
2023-08-13 |
Not clear |
| Qingqing Li, Yingying Wu, Jichun Chen, Aiguo Xuan, Xiao Wan. Microglia and immunotherapy in Alzheimer's disease. Acta neurologica Scandinavica. 2021-11-15. PMID:34779509. |
microglia and immunotherapy in alzheimer's disease. |
2021-11-15 |
2023-08-13 |
Not clear |
| Qingqing Li, Yingying Wu, Jichun Chen, Aiguo Xuan, Xiao Wan. Microglia and immunotherapy in Alzheimer's disease. Acta neurologica Scandinavica. 2021-11-15. PMID:34779509. |
in the pathological condition of alzheimer's disease (ad), β-amyloid peptide and a variety of pro-inflammatory factors can activate microglia, resulting in the secretion of a variety of inflammatory factors and neurotoxins. |
2021-11-15 |
2023-08-13 |
Not clear |
| Juan José Triviño, Rommy von Bernhard. The effect of aged microglia on synaptic impairment and its relevance in neurodegenerative diseases. Neurochemistry international. vol 144. 2021-11-12. PMID:33556444. |
here, we present evidence in the context of the "microglial dysregulation hypothesis", which leads to the reduction of the protective functions and increased cytotoxicity of microglia, to discuss the mechanisms involved in neurodegenerative changes and alzheimer's disease. |
2021-11-12 |
2023-08-13 |
Not clear |
| Ting Jin, Peter Rehani, Mufang Ying, Jiawei Huang, Shuang Liu, Panagiotis Roussos, Daifeng Wan. scGRNom: a computational pipeline of integrative multi-omics analyses for predicting cell-type disease genes and regulatory networks. Genome medicine. vol 13. issue 1. 2021-11-12. PMID:34044854. |
with applications to schizophrenia and alzheimer's disease, we predicted disease genes and regulatory networks for excitatory and inhibitory neurons, microglia, and oligodendrocytes. |
2021-11-12 |
2023-08-13 |
Not clear |
| Aleksandra Szykowska, Yu Chen, Thomas B Smith, Charlotta Preger, Jingjing Yang, Dongming Qian, Shubhashish M Mukhopadhyay, Edvard Wigren, Stephen J Neame, Susanne Gräslund, Helena Persson, Peter J Atkinson, Elena Di Daniel, Emma Mead, John Wang, John B Davis, Nicola A Burgess-Brown, Alex N Bulloc. Selection and structural characterization of anti-TREM2 scFvs that reduce levels of shed ectodomain. Structure (London, England : 1993). vol 29. issue 11. 2021-11-12. PMID:34233201. |
mutations in trem2, a receptor expressed by microglia in the brain, are associated with an increased risk of neurodegeneration, including alzheimer's disease. |
2021-11-12 |
2023-08-13 |
human |
| Manal Alaamery, Nour Albesher, Nora Aljawini, Moneera Alsuwailm, Salam Massadeh, Michael A Wheeler, Chun-Cheih Chao, Francisco J Quintan. Role of sphingolipid metabolism in neurodegeneration. Journal of neurochemistry. vol 158. issue 1. 2021-11-11. PMID:32402091. |
in this review, we discuss the role of sphingolipid metabolism in neurodegeneration, evaluating its direct roles in neuron development and health, and also in the induction of neurotoxic activities in cns-resident astrocytes and microglia in the context of neurologic diseases such as multiple sclerosis and alzheimer's disease. |
2021-11-11 |
2023-08-13 |
Not clear |