| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ayeisha Milligan Armstrong, Tenielle Porter, Hazel Quek, Anthony White, John Haynes, Connie Jackaman, Victor Villemagne, Kylie Munyard, Simon M Laws, Giuseppe Verdile, David Grot. Chronic stress and Alzheimer's disease: the interplay between the hypothalamic-pituitary-adrenal axis, genetics and microglia. Biological reviews of the Cambridge Philosophical Society. vol 96. issue 5. 2021-10-25. PMID:34159699. |
chronic stress and alzheimer's disease: the interplay between the hypothalamic-pituitary-adrenal axis, genetics and microglia. |
2021-10-25 |
2023-08-13 |
Not clear |
| Zhong-Qing Sun, Jin-Feng Liu, Wei Luo, Ching-Hin Wong, Kwok-Fai So, Yong Hu, Kin Chi. Neural regeneration research. vol 17. issue 1. 2021-10-22. PMID:34100457. |
one of the main mechanisms of alzheimer's disease is that microglia activated by amyloid beta (aβ) transform from the resting state to an m1 state and release pro-inflammatory cytokines to the surrounding environment. |
2021-10-22 |
2023-08-13 |
Not clear |
| Christina Fröhlich, Kristin Paarmann, Johannes Steffen, Jan Stenzel, Markus Krohn, Hans-Jochen Heinze, Jens Pahnk. Genomic background-related activation of microglia and reduced β-amyloidosis in a mouse model of Alzheimer's disease. European journal of microbiology & immunology. vol 3. issue 1. 2021-10-21. PMID:23814667. |
genomic background-related activation of microglia and reduced β-amyloidosis in a mouse model of alzheimer's disease. |
2021-10-21 |
2023-08-12 |
mouse |
| R E Mrak, W St Griffi. Role of Activated Glia and of Glial Cytokines in Alzheimer's Disease: A Review. Eos (Rome, Italy). vol 16. issue 3-4. 2021-10-21. PMID:24478534. |
we review the role of activated microglia and activated astrocytes, and of glia-derived cytokines and other molecules, in the pathogenesis and pathophysiology of alzheimer's disease. |
2021-10-21 |
2023-08-12 |
Not clear |
| R E Mrak, W St Griffi. Role of Activated Glia and of Glial Cytokines in Alzheimer's Disease: A Review. Eos (Rome, Italy). vol 16. issue 3-4. 2021-10-21. PMID:24478534. |
activated microglia overexpressing the potent immune-response cytokine interleukin-1, and activated astrocytes over-expressing the neurotrophic cytokine s100β, are near-constant components of neuritic plaques in alzheimer's disease, and are frequent components of early, non-neuritic, amyloid deposits. |
2021-10-21 |
2023-08-12 |
Not clear |
| Yang Wang, Bing Xu, Jin Zhou, Jinchun Wang, Guoqing Wang, Yunpeng Ca. An Aβ3‑10‑KLH vaccine decreases Aβ plaques and astrocytes and microglia activation in the brain of APP/PS1 transgenic mice. Acta neurobiologiae experimentalis. vol 81. issue 3. 2021-10-21. PMID:34672292. |
this study aimed to investigate β‑amyloid peptide (aβ) plaques and changes of astroglia and microglia in mice with alzheimer's disease (ad). |
2021-10-21 |
2023-08-13 |
mouse |
| Toru Murakawa-Hirachi, Yoshito Mizoguchi, Masahiro Ohgidani, Yoshinori Haraguchi, Akira Monj. Effect of memantine, an anti-Alzheimer's drug, on rodent microglial cells in vitro. Scientific reports. vol 11. issue 1. 2021-10-18. PMID:33731780. |
the pathophysiology of alzheimer's disease (ad) is related to neuroinflammatory responses mediated by microglia. |
2021-10-18 |
2023-08-13 |
Not clear |
| Changhe Ren, Milian Chen, Guo Mu, Suangchun Peng, Xiangbo Liu, Cehua O. NLRP3 Inflammasome Mediates Neurodegeneration in Rats with Chronic Neuropathic Pain. Shock (Augusta, Ga.). vol 56. issue 5. 2021-10-18. PMID:34265833. |
the nod-like receptor 3 (nlrp3) inflammasome assembles inside of microglia on activation, which plays an important role in neurodegeneration such as alzheimer disease. |
2021-10-18 |
2023-08-13 |
rat |
| Si-Yi Wang, Yan Liu, Xiao-Mao Li, Adnan Mohammed Algradi, Hai Jiang, Yan-Ping Sun, Wei Guan, Juan Pan, Hai-Xue Kuang, Bing-You Yan. Discovery of Active Ingredients Targeted TREM2 by SPR Biosensor-UPLC/MS Recognition System, and Investigating the Mechanism of Anti-Neuroinflammatory Activity on the Lignin-Amides from Molecules (Basel, Switzerland). vol 26. issue 19. 2021-10-16. PMID:34641490. |
discovery of active ingredients targeted trem2 by spr biosensor-uplc/ms recognition system, and investigating the mechanism of anti-neuroinflammatory activity on the lignin-amides from as a new target protein for alzheimer's disease (ad), the triggering receptor expressed on myeloid cells 2 (trem2) was expressed on the surface of microglia, which was shown to regulate neuroinflammation, be associated with a variety of neuropathologic, and regarded as a potential indicator for monitoring ad. |
2021-10-16 |
2023-08-13 |
Not clear |
| Lushuang Xie, Yi Liu, Ning Zhang, Chenyu Li, Aaron F Sandhu, George Williams, Yan Shen, Hongying Li, Qiaofeng Wu, Shuguang Y. Electroacupuncture Improves M2 Microglia Polarization and Glia Anti-inflammation of Hippocampus in Alzheimer's Disease. Frontiers in neuroscience. vol 15. 2021-10-15. PMID:34646113. |
electroacupuncture improves m2 microglia polarization and glia anti-inflammation of hippocampus in alzheimer's disease. |
2021-10-15 |
2023-08-13 |
Not clear |
| Douglas P Wightman, Iris E Jansen, Jeanne E Savage, Alexey A Shadrin, Shahram Bahrami, Dominic Holland, Arvid Rongve, Sigrid Børte, Bendik S Winsvold, Ole Kristian Drange, Amy E Martinsen, Anne Heidi Skogholt, Cristen Willer, Geir Bråthen, Ingunn Bosnes, Jonas Bille Nielsen, Lars G Fritsche, Laurent F Thomas, Linda M Pedersen, Maiken E Gabrielsen, Marianne Bakke Johnsen, Tore Wergeland Meisingset, Wei Zhou, Petroula Proitsi, Angela Hodges, Richard Dobson, Latha Velayudhan, Karl Heilbron, Adam Auton, Julia M Sealock, Lea K Davis, Nancy L Pedersen, Chandra A Reynolds, Ida K Karlsson, Sigurdur Magnusson, Hreinn Stefansson, Steinunn Thordardottir, Palmi V Jonsson, Jon Snaedal, Anna Zettergren, Ingmar Skoog, Silke Kern, Margda Waern, Henrik Zetterberg, Kaj Blennow, Eystein Stordal, Kristian Hveem, John-Anker Zwart, Lavinia Athanasiu, Per Selnes, Ingvild Saltvedt, Sigrid B Sando, Ingun Ulstein, Srdjan Djurovic, Tormod Fladby, Dag Aarsland, Geir Selbæk, Stephan Ripke, Kari Stefansson, Ole A Andreassen, Danielle Posthum. A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease. Nature genetics. vol 53. issue 9. 2021-10-14. PMID:34493870. |
this study highlights microglia, immune cells and protein catabolism as relevant to late-onset alzheimer's disease, while identifying and prioritizing previously unidentified genes of potential interest. |
2021-10-14 |
2023-08-13 |
Not clear |
| Victoria E von Saucken, Taylor R Jay, Gary E Landret. The effect of amyloid on microglia-neuron interactions before plaque onset occurs independently of TREM2 in a mouse model of Alzheimer's disease. Neurobiology of disease. vol 145. 2021-10-12. PMID:32890775. |
genetic studies identified mutations in several immune-related genes that confer increased risk for developing alzheimer's disease (ad), suggesting a key role for microglia in ad pathology. |
2021-10-12 |
2023-08-13 |
mouse |
| Luca Muzio, Alice Viotti, Gianvito Martin. Microglia in Neuroinflammation and Neurodegeneration: From Understanding to Therapy. Frontiers in neuroscience. vol 15. 2021-10-12. PMID:34630027. |
there is solid and sound evidence suggesting that regulating microglia functions during disease pathology might represent a strategy to develop future therapies aimed at counteracting brain degeneration in multiple sclerosis, alzheimer's disease, parkinson's disease, and amyotrophic lateral sclerosis. |
2021-10-12 |
2023-08-13 |
Not clear |
| Tongya Yu, Yingying Lin, Yuzhen Xu, Yunxiao Dou, Feihong Wang, Hui Quan, Yanxin Zhao, Xueyuan Li. Repressor Element 1 Silencing Transcription Factor (REST) Governs Microglia-Like BV2 Cell Migration via Progranulin (PGRN). Neural plasticity. vol 2020. 2021-10-11. PMID:33299399. |
microglia activation contributes to alzheimer's disease (ad) etiology, and microglia migration is a fundamental function during microglia activation. |
2021-10-11 |
2023-08-13 |
Not clear |
| Thecla A van Wageningen, Emma Gerrits, Sara Palacin I Bonson, Inge Huitinga, Bart J L Eggen, Anne-Marie van Da. Exploring reported genes of microglia RNA-sequencing data: Uses and considerations. Glia. vol 69. issue 12. 2021-10-11. PMID:34409652. |
several studies describing gene expression data of microglia from alzheimer's disease or multiple sclerosis have been published, aiming to generate more insight into the role of microglia in these neurological diseases. |
2021-10-11 |
2023-08-13 |
Not clear |
| Thecla A van Wageningen, Emma Gerrits, Sara Palacin I Bonson, Inge Huitinga, Bart J L Eggen, Anne-Marie van Da. Exploring reported genes of microglia RNA-sequencing data: Uses and considerations. Glia. vol 69. issue 12. 2021-10-11. PMID:34409652. |
we observed a relatively limited overlap in reported differentially expressed genes between various microglia rna-sequencing studies from multiple sclerosis or alzheimer's diseases. |
2021-10-11 |
2023-08-13 |
Not clear |
| Naciye Magusali, Andrew C Graham, Thomas M Piers, Pantila Panichnantakul, Umran Yaman, Maryam Shoai, Regina H Reynolds, Juan A Botia, Keeley J Brookes, Tamar Guetta-Baranes, Eftychia Bellou, Sevinc Bayram, Dimitra Sokolova, Mina Ryten, Carlo Sala Frigerio, Valentina Escott-Price, Kevin Morgan, Jennifer M Pocock, John Hardy, Dervis A Sali. A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene. Brain : a journal of neurology. 2021-10-09. PMID:34619763. |
recently, we reported oligoadenylate synthetase 1 (oas1) contributed to the risk of alzheimer's disease, by its enrichment in transcriptional networks expressed by microglia. |
2021-10-09 |
2023-08-13 |
human |
| Song Cao, Daniel W Fisher, Guadalupe Rodriguez, Tian Yu, Hongxin Don. Comparisons of neuroinflammation, microglial activation, and degeneration of the locus coeruleus-norepinephrine system in APP/PS1 and aging mice. Journal of neuroinflammation. vol 18. issue 1. 2021-10-07. PMID:33407625. |
the role of microglia in alzheimer's disease (ad) pathogenesis is becoming increasingly important, as activation of these cell types likely contributes to both pathological and protective processes associated with all phases of the disease. |
2021-10-07 |
2023-08-13 |
mouse |
| Shwetha Nanjundaiah, Hariharakrishnan Chidambaram, Madhura Chandrashekar, Subashchandrabose Chinnathamb. Role of Microglia in Regulating Cholesterol and Tau Pathology in Alzheimer's Disease. Cellular and molecular neurobiology. vol 41. issue 4. 2021-10-06. PMID:32468440. |
role of microglia in regulating cholesterol and tau pathology in alzheimer's disease. |
2021-10-06 |
2023-08-13 |
Not clear |
| Qingqin S Li, Louis De Muync. Differentially expressed genes in Alzheimer's disease highlighting the roles of microglia genes including OLR1 and astrocyte gene CDK2AP1. Brain, behavior, & immunity - health. vol 13. 2021-10-01. PMID:34589742. |
differentially expressed genes in alzheimer's disease highlighting the roles of microglia genes including olr1 and astrocyte gene cdk2ap1. |
2021-10-01 |
2023-08-13 |
Not clear |