| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Siok Lam Lim, Carlos J Rodriguez-Ortiz, Heng-Wei Hsu, Jie Wu, Joannee Zumkehr, Jason Kilian, Janielle Vidal, Pinar Ayata, Masashi Kitazaw. Chronic copper exposure directs microglia towards degenerative expression signatures in wild-type and J20 mouse model of Alzheimer's disease. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 62. 2021-08-19. PMID:32599538. |
chronic copper exposure directs microglia towards degenerative expression signatures in wild-type and j20 mouse model of alzheimer's disease. |
2021-08-19 |
2023-08-13 |
mouse |
| Keying Zhu, Melanie Pieber, Jinming Han, Klas Blomgren, Xing-Mei Zhang, Robert A Harris, Harald Lun. Absence of microglia or presence of peripherally-derived macrophages does not affect tau pathology in young or old hTau mice. Glia. vol 68. issue 7. 2021-08-18. PMID:32039516. |
microglia are implicated in the pathophysiology of several neurodegenerative disorders, including alzheimer's disease. |
2021-08-18 |
2023-08-13 |
mouse |
| Michael Ewers, Gloria Biechele, Marc Suárez-Calvet, Christian Sacher, Tanja Blume, Estrella Morenas-Rodriguez, Yuetiva Deming, Laura Piccio, Carlos Cruchaga, Gernot Kleinberger, Leslie Shaw, John Q Trojanowski, Jochen Herms, Martin Dichgans, Matthias Brendel, Christian Haass, Nicolai Franzmeie. Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation. EMBO molecular medicine. vol 12. issue 9. 2021-08-18. PMID:32790063. |
microglia activation is the brain's major immune response to amyloid plaques in alzheimer's disease (ad). |
2021-08-18 |
2023-08-13 |
Not clear |
| Diana P Benitez, Shenyi Jiang, Jack Wood, Rui Wang, Chloe M Hall, Carlijn Peerboom, Natalie Wong, Katie M Stringer, Karina S Vitanova, Victoria C Smith, Dhaval Joshi, Takashi Saito, Takaomi C Saido, John Hardy, Jörg Hanrieder, Bart De Strooper, Dervis A Salih, Takshashila Tripathi, Frances A Edwards, Damian M Cumming. Knock-in models related to Alzheimer's disease: synaptic transmission, plaques and the role of microglia. Molecular neurodegeneration. vol 16. issue 1. 2021-08-17. PMID:34266459. |
knock-in models related to alzheimer's disease: synaptic transmission, plaques and the role of microglia. |
2021-08-17 |
2023-08-13 |
mouse |
| Diana P Benitez, Shenyi Jiang, Jack Wood, Rui Wang, Chloe M Hall, Carlijn Peerboom, Natalie Wong, Katie M Stringer, Karina S Vitanova, Victoria C Smith, Dhaval Joshi, Takashi Saito, Takaomi C Saido, John Hardy, Jörg Hanrieder, Bart De Strooper, Dervis A Salih, Takshashila Tripathi, Frances A Edwards, Damian M Cumming. Knock-in models related to Alzheimer's disease: synaptic transmission, plaques and the role of microglia. Molecular neurodegeneration. vol 16. issue 1. 2021-08-17. PMID:34266459. |
microglia are active modulators of alzheimer's disease but their role in relation to amyloid plaques and synaptic changes due to rising amyloid beta is unclear. |
2021-08-17 |
2023-08-13 |
mouse |
| Rose Chesworth, Rashmi Gamage, Faheem Ullah, Sandra Sonego, Christopher Millington, Amanda Fernandez, Huazheng Liang, Tim Karl, Gerald Münch, Garry Niedermayer, Erika Gyenges. Spatial Memory and Microglia Activation in a Mouse Model of Chronic Neuroinflammation and the Anti-inflammatory Effects of Apigenin. Frontiers in neuroscience. vol 15. 2021-08-17. PMID:34393713. |
chronic neuroinflammation characterized by microglia reactivity is one of the main underlying processes in the initiation and progression of neurodegenerative diseases such as alzheimer's disease. |
2021-08-17 |
2023-08-13 |
mouse |
| Patrick Jarmo Paasila, Danielle Suzanne Davies, Greg Trevor Sutherland, Claire Goldsbur. Clustering of activated microglia occurs before the formation of dystrophic neurites in the evolution of Aβ plaques in Alzheimer's disease. Free neuropathology. vol 1. 2021-08-17. PMID:34396367. |
clustering of activated microglia occurs before the formation of dystrophic neurites in the evolution of aβ plaques in alzheimer's disease. |
2021-08-17 |
2023-08-13 |
human |
| Liang He, Jose Davila-Velderrain, Tomokazu S Sumida, David A Hafler, Manolis Kellis, Alexander M Kulminsk. NEBULA is a fast negative binomial mixed model for differential or co-expression analysis of large-scale multi-subject single-cell data. Communications biology. vol 4. issue 1. 2021-08-16. PMID:34040149. |
using nebula in alzheimer's disease cohort data sets, we found that the cell-level expression of apoe correlated with that of other genetic risk factors (including clu, cst3, trem2, c1q, and itm2b) in a cell-type-specific pattern and an isoform-dependent manner in microglia. |
2021-08-16 |
2023-08-13 |
Not clear |
| Macarena S Aloi, Katherine E Prater, Bryce Sopher, Stephanie Davidson, Suman Jayadev, Gwenn A Garde. The pro-inflammatory microRNA miR-155 influences fibrillar β-Amyloid Glia. vol 69. issue 7. 2021-08-14. PMID:33694209. |
the pro-inflammatory microrna mir-155 influences fibrillar β-amyloid microglia are the innate immune cells of the central nervous system that adopt rapid functional changes in response to damage associated molecular patterns, including aggregated β-amyloid (aβ) found in alzheimer's disease (ad). |
2021-08-14 |
2023-08-13 |
Not clear |
| Jose Henrique Ledo, Thomas Liebmann, Ran Zhang, Jerry C Chang, Estefania P Azevedo, Eitan Wong, Hernandez Moura Silva, Olga G Troyanskaya, Victor Bustos, Paul Greengar. Presenilin 1 phosphorylation regulates amyloid-β degradation by microglia. Molecular psychiatry. 2021-08-13. PMID:32792660. |
an alzheimer's mouse model containing phospho-deficient ps1 show severe aβ accumulation in microglia as well as the postsynaptic protein psd95. |
2021-08-13 |
2023-08-13 |
mouse |
| Christel Claes, Emma Pascal Danhash, Jonathan Hasselmann, Jean Paul Chadarevian, Sepideh Kiani Shabestari, Whitney E England, Tau En Lim, Jorge Luis Silva Hidalgo, Robert C Spitale, Hayk Davtyan, Mathew Blurton-Jone. Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer's disease. Molecular neurodegeneration. vol 16. issue 1. 2021-08-13. PMID:34301296. |
plaque-associated human microglia accumulate lipid droplets in a chimeric model of alzheimer's disease. |
2021-08-13 |
2023-08-13 |
mouse |
| Christel Claes, Emma Pascal Danhash, Jonathan Hasselmann, Jean Paul Chadarevian, Sepideh Kiani Shabestari, Whitney E England, Tau En Lim, Jorge Luis Silva Hidalgo, Robert C Spitale, Hayk Davtyan, Mathew Blurton-Jone. Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer's disease. Molecular neurodegeneration. vol 16. issue 1. 2021-08-13. PMID:34301296. |
disease-associated microglia (dams), that surround beta-amyloid plaques, represent a transcriptionally-distinct microglial profile in alzheimer's disease (ad). |
2021-08-13 |
2023-08-13 |
mouse |
| Maddalena Grieco, Maria Giovanna De Caris, Elisa Maggi, Federica Armeli, Roberto Coccurello, Tiziana Bisogno, Maria D'Erme, Mauro Maccarrone, Patrizia Mancini, Rita Businar. Fatty Acid Amide Hydrolase (FAAH) Inhibition Modulates Amyloid-Beta-Induced Microglia Polarization. International journal of molecular sciences. vol 22. issue 14. 2021-08-11. PMID:34299330. |
since the inhibition of fatty acid amide hydrolase (faah), the main catabolic enzyme of anandamide (aea), may provide beneficial effects in mice model of alzheimer's disease (ad)-like pathology, we aimed at determining whether the faah inhibitor urb597 might target microglia polarization and alter the cytoskeleton reorganization induced by the amyloid-β peptide (aβ). |
2021-08-11 |
2023-08-13 |
mouse |
| Tongfei Li. Human stem cell-derived microglia will be an indispensable toolbox for Alzheimer's disease research. Neural regeneration research. vol 16. issue 9. 2021-08-10. PMID:33510070. |
human stem cell-derived microglia will be an indispensable toolbox for alzheimer's disease research. |
2021-08-10 |
2023-08-13 |
human |
| Zhongqi Li, Xinyi Chen, Joaquim S L Vong, Lei Zhao, Junzhe Huang, Leo Y C Yan, Bonaventure Ip, Yun Kwok Wing, Hei-Ming Lai, Vincent C T Mok, Ho K. Systemic GLP-1R agonist treatment reverses mouse glial and neurovascular cell transcriptomic aging signatures in a genome-wide manner. Communications biology. vol 4. issue 1. 2021-08-10. PMID:34079050. |
concomitantly, alzheimer's disease (ad)-associated transcriptomic signature in microglia that arises from aging is reduced. |
2021-08-10 |
2023-08-13 |
mouse |
| Saeid Bagheri-Mohammad. Microglia in Alzheimer's Disease: The Role of Stem Cell-Microglia Interaction in Brain Homeostasis. Neurochemical research. vol 46. issue 2. 2021-08-09. PMID:33174075. |
microglia in alzheimer's disease: the role of stem cell-microglia interaction in brain homeostasis. |
2021-08-09 |
2023-08-13 |
Not clear |
| Saeid Bagheri-Mohammad. Microglia in Alzheimer's Disease: The Role of Stem Cell-Microglia Interaction in Brain Homeostasis. Neurochemical research. vol 46. issue 2. 2021-08-09. PMID:33174075. |
in alzheimer's disease (ad) condition, the deposition of amyloid-β (aβ) result in provokes the phenotypic activation of microglia and their elaboration of pro-inflammatory molecules. |
2021-08-09 |
2023-08-13 |
Not clear |
| Ou Qiao, Haixia Ji, Yi Zhang, Xinyu Zhang, Xueqian Zhang, Na Liu, Luqi Huang, Changxiao Liu, Wenyuan Ga. New insights in drug development for Alzheimer's disease based on microglia function. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 140. 2021-08-09. PMID:34083109. |
new insights in drug development for alzheimer's disease based on microglia function. |
2021-08-09 |
2023-08-13 |
Not clear |
| Eleonora Cipollari, Hannah J Szapary, Antonino Picataggi, Jeffrey T Billheimer, Catherine A Lyssenko, Gui-Shuang Ying, Leslie M Shaw, Mitchel A Kling, Rima Kaddurah-Daouk, Daniel J Rader, Domenico Praticò, Nicholas N Lyssenk. Correlates and Predictors of Cerebrospinal Fluid Cholesterol Efflux Capacity from Neural Cells, a Family of Biomarkers for Cholesterol Epidemiology in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 74. issue 2. 2021-08-05. PMID:32065798. |
basic research has implicated intracellular cholesterol in neurons, microglia, and astrocytes in the pathogenesis of alzheimer's disease (ad), but there is presently no assay to access intracellular cholesterol in neural cells in living people in the context of ad. |
2021-08-05 |
2023-08-13 |
Not clear |
| Tina Schwabe, Karpagam Srinivasan, Herve Rhin. Shifting paradigms: The central role of microglia in Alzheimer's disease. Neurobiology of disease. vol 143. 2021-08-05. PMID:32535152. |
shifting paradigms: the central role of microglia in alzheimer's disease. |
2021-08-05 |
2023-08-13 |
mouse |