| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tina Schwabe, Karpagam Srinivasan, Herve Rhin. Shifting paradigms: The central role of microglia in Alzheimer's disease. Neurobiology of disease. vol 143. 2021-08-05. PMID:32535152. |
shifting paradigms: the central role of microglia in alzheimer's disease. |
2021-08-05 |
2023-08-13 |
mouse |
| Tina Schwabe, Karpagam Srinivasan, Herve Rhin. Shifting paradigms: The central role of microglia in Alzheimer's disease. Neurobiology of disease. vol 143. 2021-08-05. PMID:32535152. |
recent human genetic studies have challenged long standing hypotheses about the chain of events in alzheimer's disease (ad), as the identification of genetic risk factors in microglial genes supports a causative role for microglia in the disease. |
2021-08-05 |
2023-08-13 |
mouse |
| Xiyu Gao, Dewei He, Dianfeng Liu, Guiqiu Hu, Yufei Zhang, Tianyu Meng, Yingchun Su, Ang Zhou, Bingxu Huang, Jian Du, Shoupeng F. Beta-naphthoflavone inhibits LPS-induced inflammation in BV-2 cells via AKT/Nrf-2/HO-1-NF-κB signaling axis. Immunobiology. vol 225. issue 4. 2021-08-05. PMID:32747020. |
numerous studies have shown that over-activation of microglia could cause neuroinflammation and release pro-inflammatory mediators, which could result in neurodegenerative diseases, like parkinson's disease, alzheimer's disease etc. |
2021-08-05 |
2023-08-13 |
mouse |
| Catia Scassellati, Antonio Carlo Galoforo, Ciro Esposito, Miriam Ciani, Giovanni Ricevuti, Cristian Bonvicin. Promising Intervention Approaches to Potentially Resolve Neuroinflammation And Steroid Hormones Alterations in Alzheimer's Disease and Its Neuropsychiatric Symptoms. Aging and disease. vol 12. issue 5. 2021-08-04. PMID:34341712. |
we described studies regarding the cross-talk among microglia and astrocytes in the neuroinflammation processes, along with the role played by the steroid hormones, and how this can reflect on cognitive decline/neurodegeneration, in particular on alzheimer's disease (ad) and its neuropsychiatric manifestations. |
2021-08-04 |
2023-08-13 |
Not clear |
| Long Li, Le Li, Jiayong Zhang, Sheng Huang, Weilin Liu, Zhifu Wang, Shengxiang Liang, Jing Tao, Lidian Che. Disease Stage-Associated Alterations in Learning and Memory through the Electroacupuncture Modulation of the Cortical Microglial M1/M2 Polarization in Mice with Alzheimer's Disease. Neural plasticity. vol 2020. 2021-08-03. PMID:32908486. |
microglia are the primary cells that exert immune function in the central nervous system, and accumulating evidence suggests that microglia act as critical players in the initiation of neurodegenerative disorders, such as alzheimer's disease (ad). |
2021-08-03 |
2023-08-13 |
mouse |
| Yujie Li, Jing Jiang, Qisheng Tang, Huiling Tian, Shun Wang, Zidong Wang, Hao Liu, Jiayi Yang, Jingyu Re. Microglia TREM2: A Potential Role in the Mechanism of Action of Electroacupuncture in an Alzheimer's Disease Animal Model. Neural plasticity. vol 2020. 2021-08-03. PMID:32952550. |
microglia trem2: a potential role in the mechanism of action of electroacupuncture in an alzheimer's disease animal model. |
2021-08-03 |
2023-08-13 |
mouse |
| Fatima El Idrissi, Bernard Gressier, David Devos, Karim Belarb. A Computational Exploration of the Molecular Network Associated to Neuroinflammation in Alzheimer's Disease. Frontiers in pharmacology. vol 12. 2021-08-03. PMID:34335238. |
neuroinflammation, as defined by the presence of classically activated microglia, is thought to play a key role in numerous neurodegenerative disorders such as alzheimer's disease. |
2021-08-03 |
2023-08-13 |
Not clear |
| Kevin Clayton, Jean Christophe Delpech, Shawn Herron, Naotoshi Iwahara, Maria Ericsson, Takashi Saito, Takaomi C Saido, Seiko Ikezu, Tsuneya Ikez. Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model. Molecular neurodegeneration. vol 16. issue 1. 2021-07-31. PMID:33752701. |
recent studies suggest that microglia contribute to tau pathology progression in alzheimer's disease. |
2021-07-31 |
2023-08-13 |
mouse |
| Cameron S McAlpine, Joseph Park, Ana Griciuc, Eunhee Kim, Se Hoon Choi, Yoshiko Iwamoto, Máté G Kiss, Kathleen A Christie, Claudio Vinegoni, Wolfram C Poller, John E Mindur, Christopher T Chan, Shun He, Henrike Janssen, Lai Ping Wong, Jeffrey Downey, Sumnima Singh, Atsushi Anzai, Florian Kahles, Mehdi Jorfi, Paolo Fumene Feruglio, Ruslan I Sadreyev, Ralph Weissleder, Benjamin P Kleinstiver, Matthias Nahrendorf, Rudolph E Tanzi, Filip K Swirsk. Astrocytic interleukin-3 programs microglia and limits Alzheimer's disease. Nature. vol 595. issue 7869. 2021-07-29. PMID:34262178. |
astrocytic interleukin-3 programs microglia and limits alzheimer's disease. |
2021-07-29 |
2023-08-13 |
Not clear |
| Annerieke Sierksma, Ashley Lu, Renzo Mancuso, Nicola Fattorelli, Nicola Thrupp, Evgenia Salta, Jesus Zoco, David Blum, Luc Buée, Bart De Strooper, Mark Fier. Novel Alzheimer risk genes determine the microglia response to amyloid-β but not to TAU pathology. EMBO molecular medicine. vol 12. issue 3. 2021-07-28. PMID:31951107. |
novel alzheimer risk genes determine the microglia response to amyloid-β but not to tau pathology. |
2021-07-28 |
2023-08-13 |
mouse |
| Kai Schlepckow, Kathryn M Monroe, Gernot Kleinberger, Ludovico Cantuti-Castelvetri, Samira Parhizkar, Dan Xia, Michael Willem, Georg Werner, Nadine Pettkus, Bettina Brunner, Alice Sülzen, Brigitte Nuscher, Heike Hampel, Xianyuan Xiang, Regina Feederle, Sabina Tahirovic, Joshua I Park, Rachel Prorok, Cathal Mahon, Chun-Chi Liang, Ju Shi, Do Jin Kim, Hanna Sabelström, Fen Huang, Gilbert Di Paolo, Mikael Simons, Joseph W Lewcock, Christian Haas. Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region. EMBO molecular medicine. vol 12. issue 4. 2021-07-28. PMID:32154671. |
moreover, in a mouse model for alzheimer's disease-related pathology, 4d9 reduced amyloidogenesis, enhanced microglial trem2 expression, and reduced a homeostatic marker, suggesting a protective function by driving microglia toward a disease-associated state. |
2021-07-28 |
2023-08-13 |
mouse |
| Stoyan Stoyanov, Weilun Sun, Henning Peter Düsedau, Carla Cangalaya, Ilseob Choi, Hadi Mirzapourdelavar, David Baidoe-Ansah, Rahul Kaushik, Jens Neumann, Ildiko Rita Dunay, Alexander Dityate. Attenuation of the extracellular matrix restores microglial activity during the early stage of amyloidosis. Glia. vol 69. issue 1. 2021-07-28. PMID:32865286. |
in the advanced stages of alzheimer's disease (ad), microglia are transformed to an activated phenotype with thickened and retracted processes, migrate to the site of amyloid-beta (aβ) plaques, and proliferate. |
2021-07-28 |
2023-08-13 |
mouse |
| Yu Xiao, Ying Dai, Li Li, Fang Geng, Yisha Xu, Jinqiu Wang, Shu Wang, Junning Zha. Tetrahydrocurcumin ameliorates Alzheimer's pathological phenotypes by inhibition of microglial cell cycle arrest and apoptosis via Ras/ERK signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 139. 2021-07-26. PMID:34243602. |
tetrahydrocurcumin ameliorates alzheimer's pathological phenotypes by inhibition of microglial cell cycle arrest and apoptosis via ras/erk signaling. |
2021-07-26 |
2023-08-13 |
mouse |
| Benxia Hu, Hyejung Won, Won Mah, Royce B Park, Bibi Kassim, Keeley Spiess, Alexey Kozlenkov, Cheynna A Crowley, Sirisha Pochareddy, Yun Li, Stella Dracheva, Nenad Sestan, Schahram Akbarian, Daniel H Geschwin. Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders. Nature communications. vol 12. issue 1. 2021-07-22. PMID:34172755. |
we find that alzheimer's disease (ad)-associated epigenetic dysregulation is linked to neurons and oligodendrocytes, whereas genetic risk factors for ad highlighted microglia, suggesting that different cell types may contribute to disease risk, via different mechanisms. |
2021-07-22 |
2023-08-13 |
human |
| Youtong Huang, Kaisa E Happonen, Patrick G Burrola, Carolyn O'Connor, Nasun Hah, Ling Huang, Axel Nimmerjahn, Greg Lemk. Microglia use TAM receptors to detect and engulf amyloid β plaques. Nature immunology. vol 22. issue 5. 2021-07-21. PMID:33859405. |
we find that in alzheimer's disease and its mouse models, induced expression of axl and mer in amyloid plaque-associated microglia was coupled to induced plaque decoration by the tam ligand gas6 and its co-ligand phosphatidylserine. |
2021-07-21 |
2023-08-13 |
mouse |
| Youtong Huang, Kaisa E Happonen, Patrick G Burrola, Carolyn O'Connor, Nasun Hah, Ling Huang, Axel Nimmerjahn, Greg Lemk. Microglia use TAM receptors to detect and engulf amyloid β plaques. Nature immunology. vol 22. issue 5. 2021-07-21. PMID:33859405. |
in the app/ps1 mouse model of alzheimer's disease, genetic ablation of axl and mer resulted in microglia that were unable to normally detect, respond to, organize or phagocytose amyloid-β plaques. |
2021-07-21 |
2023-08-13 |
mouse |
| M A Berezutsky, N A Durnova, L E Sigarev. [Neurobiological effects of tenuigenin and the opportunity of it's using in the therapy of Alzheimer's and Parkinson's diseases (literature review).] Advances in gerontology = Uspekhi gerontologii. vol 34. issue 2. 2021-07-13. PMID:34245502. |
it was noted, that the capacities of the tenuigenin to decrease the secretion of beta amyloid and to protect of neurons from damage by already made beta ameloids, to inhibit the processes of the tau proteins` hyperphosphorylation and inflammations in microglia, as well as increase the main synaptic transmission can be used by the development of effective therapeutic drugs aimed to reduce the pathogenesis of alzheimer`s disease. |
2021-07-13 |
2023-08-13 |
Not clear |
| Jenny Lutshumba, Barbara S Nikolajczyk, Adam D Bachstette. Dysregulation of Systemic Immunity in Aging and Dementia. Frontiers in cellular neuroscience. vol 15. 2021-07-10. PMID:34239415. |
although microglia have been the focus of work linking neuroinflammation and associated dementias like alzheimer's disease, the inflammatory milieu of brain is a conglomerate of cross-talk amongst microglia, systemic immune cells and soluble mediators like cytokines. |
2021-07-10 |
2023-08-13 |
human |
| Hana Lee, Jun-Ho Jang, Seok-Jun Ki. Malonic acid suppresses lipopolysaccharide-induced BV2 microglia cell activation by inhibiting the p38 MAPK/NF-κB pathway. Animal cells and systems. vol 25. issue 2. 2021-07-09. PMID:34234892. |
an inflammatory reaction caused by the activation of microglia in the brain can lead to neurodegeneration and cause diseases, such as alzheimer's and parkinson's disease. |
2021-07-09 |
2023-08-13 |
Not clear |
| Peng-Fei Zhang, Hao Hu, Lan Tan, Jin-Tai Y. Microglia Biomarkers in Alzheimer's Disease. Molecular neurobiology. vol 58. issue 7. 2021-07-06. PMID:33713018. |
microglia biomarkers in alzheimer's disease. |
2021-07-06 |
2023-08-13 |
Not clear |