| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hana Lee, Jun-Ho Jang, Seok-Jun Ki. Malonic acid suppresses lipopolysaccharide-induced BV2 microglia cell activation by inhibiting the p38 MAPK/NF-κB pathway. Animal cells and systems. vol 25. issue 2. 2021-07-09. PMID:34234892. |
an inflammatory reaction caused by the activation of microglia in the brain can lead to neurodegeneration and cause diseases, such as alzheimer's and parkinson's disease. |
2021-07-09 |
2023-08-13 |
Not clear |
| Peng-Fei Zhang, Hao Hu, Lan Tan, Jin-Tai Y. Microglia Biomarkers in Alzheimer's Disease. Molecular neurobiology. vol 58. issue 7. 2021-07-06. PMID:33713018. |
microglia biomarkers in alzheimer's disease. |
2021-07-06 |
2023-08-13 |
Not clear |
| Jia Lu, Wei Zhou, Fangfang Dou, Chenfei Wang, Zhihua Y. TRPV1 sustains microglial metabolic reprogramming in Alzheimer's disease. EMBO reports. vol 22. issue 6. 2021-06-28. PMID:33998138. |
as the brain-resident innate immune cells, reactive microglia are a major pathological feature of alzheimer's disease (ad). |
2021-06-28 |
2023-08-13 |
mouse |
| Giacomo Tondo, Leonardo Iaccarino, Silvia Paola Caminiti, Luca Presotto, Roberto Santangelo, Sandro Iannaccone, Giuseppe Magnani, Daniela Peran. The combined effects of microglia activation and brain glucose hypometabolism in early-onset Alzheimer's disease. Alzheimer's research & therapy. vol 12. issue 1. 2021-06-24. PMID:32354345. |
the combined effects of microglia activation and brain glucose hypometabolism in early-onset alzheimer's disease. |
2021-06-24 |
2023-08-13 |
human |
| Weixi Feng, Yanli Zhang, Ze Wang, Hanrong Xu, Ting Wu, Charles Marshall, Junying Gao, Ming Xia. Microglia prevent beta-amyloid plaque formation in the early stage of an Alzheimer's disease mouse model with suppression of glymphatic clearance. Alzheimer's research & therapy. vol 12. issue 1. 2021-06-24. PMID:33008458. |
microglia prevent beta-amyloid plaque formation in the early stage of an alzheimer's disease mouse model with suppression of glymphatic clearance. |
2021-06-24 |
2023-08-13 |
mouse |
| Hazel Hall-Roberts, Devika Agarwal, Juliane Obst, Thomas B Smith, Jimena Monzón-Sandoval, Elena Di Daniel, Caleb Webber, William S James, Emma Mead, John B Davis, Sally A Cowle. TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages. Alzheimer's research & therapy. vol 12. issue 1. 2021-06-24. PMID:33198789. |
trem2 is a microglial cell surface receptor, with risk mutations linked to alzheimer's disease (ad), including r47h. |
2021-06-24 |
2023-08-13 |
mouse |
| Vincent Pons, Pascal Lévesque, Marie-Michèle Plante, Serge Rives. Conditional genetic deletion of CSF1 receptor in microglia ameliorates the physiopathology of Alzheimer's disease. Alzheimer's research & therapy. vol 13. issue 1. 2021-06-24. PMID:33402196. |
conditional genetic deletion of csf1 receptor in microglia ameliorates the physiopathology of alzheimer's disease. |
2021-06-24 |
2023-08-13 |
Not clear |
| Qiuju Yuan, Xiaodong Liu, Yi Zhang, Yan-Fang Xian, Juntao Zou, Xie Zhang, Pengyun Huang, You-Qiang Song, Zhi-Xiu Li. Established Beta Amyloid Pathology Is Unaffected by TREM2 Elevation in Reactive Microglia in an Alzheimer's Disease Mouse Model. Molecules (Basel, Switzerland). vol 26. issue 9. 2021-06-24. PMID:34064330. |
established beta amyloid pathology is unaffected by trem2 elevation in reactive microglia in an alzheimer's disease mouse model. |
2021-06-24 |
2023-08-13 |
mouse |
| Yanling Hu, Gemma L Fryatt, Mohammadmersad Ghorbani, Juliane Obst, David A Menassa, Maria Martin-Estebane, Tim A O Muntslag, Adrian Olmos-Alonso, Monica Guerrero-Carrasco, Daniel Thomas, Mark S Cragg, Diego Gomez-Nicol. Replicative senescence dictates the emergence of disease-associated microglia and contributes to Aβ pathology. Cell reports. vol 35. issue 10. 2021-06-24. PMID:34107254. |
the sustained proliferation of microglia is a key hallmark of alzheimer's disease (ad), accelerating its progression. |
2021-06-24 |
2023-08-13 |
human |
| Sam C Berens, Chris M Bird, Neil A Harriso. Minocycline differentially modulates human spatial memory systems. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 13. 2021-06-23. PMID:32839527. |
microglia play a critical role in many processes fundamental to learning and memory in health and are implicated in alzheimer's pathogenesis. |
2021-06-23 |
2023-08-13 |
human |
| Marvin Reich, Iñaki Paris, Martin Ebeling, Nadine Dahm, Christophe Schweitzer, Dieter Reinhardt, Roland Schmucki, Megana Prasad, Fabian Köchl, Marcel Leist, Sally A Cowley, Jitao David Zhang, Christoph Patsch, Simon Gutbier, Markus Britschg. Alzheimer's Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia. Frontiers in immunology. vol 11. 2021-06-21. PMID:33613545. |
alzheimer's risk gene trem2 determines functional properties of new type of human ipsc-derived microglia. |
2021-06-21 |
2023-08-13 |
human |
| Marvin Reich, Iñaki Paris, Martin Ebeling, Nadine Dahm, Christophe Schweitzer, Dieter Reinhardt, Roland Schmucki, Megana Prasad, Fabian Köchl, Marcel Leist, Sally A Cowley, Jitao David Zhang, Christoph Patsch, Simon Gutbier, Markus Britschg. Alzheimer's Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia. Frontiers in immunology. vol 11. 2021-06-21. PMID:33613545. |
microglia are key in the homeostatic well-being of the brain and microglial dysfunction has been implicated in neurodegenerative disorders such as alzheimer's disease (ad). |
2021-06-21 |
2023-08-13 |
human |
| Sejal Patel, Derek Howard, Alana Man, Deborah Schwartz, Joelle Jee, Daniel Felsky, Zdenka Pausova, Tomas Paus, Leon Frenc. Donor-Specific Transcriptomic Analysis of Alzheimer's Disease-Associated Hypometabolism Highlights a Unique Donor, Ribosomal Proteins and Microglia. eNeuro. vol 7. issue 6. 2021-06-18. PMID:33234543. |
donor-specific transcriptomic analysis of alzheimer's disease-associated hypometabolism highlights a unique donor, ribosomal proteins and microglia. |
2021-06-18 |
2023-08-13 |
mouse |
| Satoshi Muraoka, Mark P Jedrychowski, Naotoshi Iwahara, Mohammad Abdullah, Kristen D Onos, Kelly J Keezer, Jianqiao Hu, Seiko Ikezu, Gareth R Howell, Steven P Gygi, Tsuneya Ikez. Enrichment of Neurodegenerative Microglia Signature in Brain-Derived Extracellular Vesicles Isolated from Alzheimer's Disease Mouse Models. Journal of proteome research. vol 20. issue 3. 2021-06-17. PMID:33534581. |
enrichment of neurodegenerative microglia signature in brain-derived extracellular vesicles isolated from alzheimer's disease mouse models. |
2021-06-17 |
2023-08-13 |
mouse |
| Maria Grazia Giovannini, Daniele Lana, Chiara Traini, Maria Giuliana Vannucch. The Microbiota-Gut-Brain Axis and Alzheimer Disease. From Dysbiosis to Neurodegeneration: Focus on the Central Nervous System Glial Cells. Journal of clinical medicine. vol 10. issue 11. 2021-06-16. PMID:34072107. |
based on this information, the role of the major microbiota products in shifting the activation profiles of astrocytes and microglia from a healthy to a diseased state will be discussed, focusing on alzheimer disease pathogenesis. |
2021-06-16 |
2023-08-13 |
Not clear |
| Nicholas F Fitz, Kyong Nyon Nam, Cody M Wolfe, Florent Letronne, Brittany E Playso, Bistra E Iordanova, Takashi D Y Kozai, Richard J Biedrzycki, Valerian E Kagan, Yulia Y Tyurina, Xianlin Han, Iliya Lefterov, Radosveta Koldamov. Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer's disease. Nature communications. vol 12. issue 1. 2021-06-15. PMID:34099706. |
phospholipids of apoe lipoproteins activate microglia in an isoform-specific manner in preclinical models of alzheimer's disease. |
2021-06-15 |
2023-08-13 |
mouse |
| Nicholas F Fitz, Kyong Nyon Nam, Cody M Wolfe, Florent Letronne, Brittany E Playso, Bistra E Iordanova, Takashi D Y Kozai, Richard J Biedrzycki, Valerian E Kagan, Yulia Y Tyurina, Xianlin Han, Iliya Lefterov, Radosveta Koldamov. Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer's disease. Nature communications. vol 12. issue 1. 2021-06-15. PMID:34099706. |
apoe and trem2 are major genetic risk factors for alzheimer's disease (ad), but how they affect microglia response to aβ remains unclear. |
2021-06-15 |
2023-08-13 |
mouse |
| Juliane Obst, Emilie Simon, Maria Martin-Estebane, Elena Pipi, Liana M Barkwill, Ivette Gonzalez-Rivera, Fergus Buchanan, Alan R Prescott, Dorte Faust, Simon Fox, Janet Brownlees, Debra Taylor, V Hugh Perry, Hugh Nuthall, Peter J Atkinson, Eric Karran, Carol Routledge, Diego Gomez-Nicol. Inhibition of IL-34 Unveils Tissue-Selectivity and Is Sufficient to Reduce Microglial Proliferation in a Model of Chronic Neurodegeneration. Frontiers in immunology. vol 11. 2021-06-14. PMID:33162994. |
the proliferation and activation of microglia, the resident macrophages in the brain, is a hallmark of many neurodegenerative diseases such as alzheimer's disease (ad) and prion disease. |
2021-06-14 |
2023-08-13 |
mouse |
| Alexandra Grubman, Xin Yi Choo, Gabriel Chew, John F Ouyang, Guizhi Sun, Nathan P Croft, Fernando J Rossello, Rebecca Simmons, Sam Buckberry, Dulce Vargas Landin, Jahnvi Pflueger, Teresa H Vandekolk, Zehra Abay, Yichen Zhou, Xiaodong Liu, Joseph Chen, Michael Larcombe, John M Haynes, Catriona McLean, Sarah Williams, Siew Yeen Chai, Trevor Wilson, Ryan Lister, Colin W Pouton, Anthony W Purcell, Owen J L Rackham, Enrico Petretto, Jose M Pol. Transcriptional signature in microglia associated with Aβ plaque phagocytosis. Nature communications. vol 12. issue 1. 2021-06-11. PMID:34021136. |
the role of microglia cells in alzheimer's disease (ad) is well recognized, however their molecular and functional diversity remain unclear. |
2021-06-11 |
2023-08-13 |
Not clear |
| Mehdi Eshraghi, Aida Adlimoghaddam, Amir Mahmoodzadeh, Farzaneh Sharifzad, Hamed Yasavoli-Sharahi, Shahrokh Lorzadeh, Benedict C Albensi, Saeid Ghavam. Alzheimer's Disease Pathogenesis: Role of Autophagy and Mitophagy Focusing in Microglia. International journal of molecular sciences. vol 22. issue 7. 2021-06-09. PMID:33805142. |
alzheimer's disease pathogenesis: role of autophagy and mitophagy focusing in microglia. |
2021-06-09 |
2023-08-13 |
Not clear |