All Relations between Alzheimer Disease and microglial cell

Publication Sentence Publish Date Extraction Date Species
Yuanyuan Liu, Boxi Zhang, Jiahe Liu, Chunyu Qiao, Nianyu Xue, Hongming Lv, Shize L. Mogroside V Alleviates Lipopolysaccharide-Induced Neuroinflammation via Inhibition of TLR4-MyD88 and Activation of AKT/AMPK-Nrf2 Signaling Pathway. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-05-22. PMID:34012471. as innate immune effector cells in the central nervous system (cns), microglia not only are essential for the normal development of nervous system but also act on different neurological diseases, including alzheimer's disease (ad), huntington's disease (hd), and other neuroinflammatory diseases. 2021-05-22 2023-08-13 Not clear
George B Stefano, Tobias Esch, Radek Ptacek, Richard M Krea. Dysregulation of Nitric Oxide Signaling in Microglia: Multiple Points of Functional Convergence in the Complex Pathophysiology of Alzheimer Disease. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-20. PMID:32975239. dysregulation of nitric oxide signaling in microglia: multiple points of functional convergence in the complex pathophysiology of alzheimer disease. 2021-05-20 2023-08-13 Not clear
Paul Dembny, Andrew G Newman, Manvendra Singh, Michael Hinz, Michal Szczepek, Christina Krüger, Robert Adalbert, Omar Dzaye, Thorsten Trimbuch, Thomas Wallach, Gunnar Kleinau, Katja Derkow, Bernhard C Richard, Carola Schipke, Claus Scheidereit, Harald Stachelscheid, Douglas Golenbock, Oliver Peters, Michael Coleman, Frank L Heppner, Patrick Scheerer, Victor Tarabykin, Klemens Ruprecht, Zsuzsanna Izsvák, Jens Mayer, Seija Lehnard. Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors. JCI insight. vol 5. issue 7. 2021-05-19. PMID:32271161. herv-k(hml-2) rna introduced into the cerebrospinal fluid (csf) of either c57bl/6 wild-type mice or appps1 mice, a mouse model for alzheimer's disease (ad), resulted in neurodegeneration and microglia accumulation. 2021-05-19 2023-08-13 mouse
Rajasekhar Reddy Chilakala, Aparna Lakshmi Manchikalapudi, Ashok Kumar, Aditya Sunkari. Sulforaphane Attenuates Aβ Oligomers Mediated Decrease in Phagocytic Activity of Microglial Cells. Neuroscience. vol 429. 2021-05-14. PMID:31982468. microglia are the brain mononuclear phagocytes which plays a key role in neurodegenerative diseases, like alzheimer's. 2021-05-14 2023-08-13 Not clear
Rajasekhar Reddy Chilakala, Aparna Lakshmi Manchikalapudi, Ashok Kumar, Aditya Sunkari. Sulforaphane Attenuates Aβ Oligomers Mediated Decrease in Phagocytic Activity of Microglial Cells. Neuroscience. vol 429. 2021-05-14. PMID:31982468. in alzheimer's disease (ad), microglia have been reported to clear amyloid beta (aβ) deposits via phagocytosis or release various pro-inflammatory cytokines. 2021-05-14 2023-08-13 Not clear
Shun-Fat Lau, Congping Chen, Wing-Yu Fu, Jianan Y Qu, Tom H Cheung, Amy K Y Fu, Nancy Y I. IL-33-PU.1 Transcriptome Reprogramming Drives Functional State Transition and Clearance Activity of Microglia in Alzheimer's Disease. Cell reports. vol 31. issue 3. 2021-05-14. PMID:32320664. il-33-pu.1 transcriptome reprogramming drives functional state transition and clearance activity of microglia in alzheimer's disease. 2021-05-14 2023-08-13 mouse
Hongjun Fu, Bin Liu, Liangping Li, Cynthia A Lemer. Microglia Do Not Take Up Soluble Amyloid-beta Peptides, But Partially Degrade Them by Secreting Insulin-degrading Enzyme. Neuroscience. vol 443. 2021-05-14. PMID:32697980. microglia play important roles in the pathogenesis of alzheimer's disease (ad), in part, by affecting the clearance of amyloid-β (aβ) peptides. 2021-05-14 2023-08-13 mouse
Qiu-Lan Ma, Cansheng Zhu, Marco Morselli, Trent Su, Matteo Pelligrini, Zhengqi Lu, Mychica Jones, Paul Denver, Daniel Castro, Xuelin Gu, Frances Relampagos, Kaitlin Caoili, Bruce Teter, Sally A Frautschy, Gregory M Col. The Novel Omega-6 Fatty Acid Docosapentaenoic Acid Positively Modulates Brain Innate Immune Response for Resolving Neuroinflammation at Early and Late Stages of Humanized APOE-Based Alzheimer's Disease Models. Frontiers in immunology. vol 11. 2021-05-14. PMID:33178186. neuroinflammation plays a crucial role in the development and progression of alzheimer's disease (ad), in which activated microglia are found to be associated with neurodegeneration. 2021-05-14 2023-08-13 Not clear
Alexei Verkhratsky, Robert Zore. Large-Scale Proteomics Highlights Glial Role in Neurodegeneration. Cell metabolism. vol 32. issue 1. 2021-05-13. PMID:32640242. recent quantitative mass spectrometry and coexpression network analysis of postmortem human brain samples identified protein networks responsible for sugar metabolism and function of astrocytes and microglia are altered in alzheimer's disease and other types of neurodegenerative disorders. 2021-05-13 2023-08-13 human
Daniel C Ellwanger, Shoutang Wang, Simone Brioschi, Zhifei Shao, Lydia Green, Ryan Case, Daniel Yoo, Dawn Weishuhn, Palaniswami Rathanaswami, Jodi Bradley, Sara Rao, Diana Cha, Peng Luan, Shilpa Sambashivan, Susan Gilfillan, Samuel A Hasson, Ian N Foltz, Menno van Lookeren Campagne, Marco Colonn. Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 3. 2021-05-12. PMID:33446504. prior activation state shapes the microglia response to antihuman trem2 in a mouse model of alzheimer's disease. 2021-05-12 2023-08-13 mouse
Rashmi Das, Subashchandrabose Chinnathamb. Microglial remodeling of actin network by Tau oligomers, via G protein-coupled purinergic receptor, P2Y12R-driven chemotaxis. Traffic (Copenhagen, Denmark). vol 22. issue 5. 2021-05-10. PMID:33527700. alzheimer's disease (ad) is associated with age-related neurodegeneration, synaptic deformation and chronic inflammation mediated by microglia and infiltrated macrophages in the brain. 2021-05-10 2023-08-13 Not clear
Ada Ndoja, Rohit Reja, Seung-Hye Lee, Joshua D Webster, Hai Ngu, Christopher M Rose, Donald S Kirkpatrick, Zora Modrusan, Ying-Jiun Jasmine Chen, Debra L Dugger, Vineela Gandham, Luke Xie, Kim Newton, Vishva M Dixi. Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia. Cell. vol 182. issue 5. 2021-05-07. PMID:32795415. dysregulated microglia are intimately involved in neurodegeneration, including alzheimer's disease (ad) pathogenesis, but the mechanisms controlling pathogenic microglial gene expression remain poorly understood. 2021-05-07 2023-08-13 mouse
Shashank Kumar Maurya, Neetu Bhattacharya, Suman Mishra, Amit Bhattacharya, Pratibha Banerjee, Sabyasachi Senapati, Rajnikant Mishr. Microglia Specific Drug Targeting Using Natural Products for the Regulation of Redox Imbalance in Neurodegeneration. Frontiers in pharmacology. vol 12. 2021-05-02. PMID:33927630. microglia, a type of innate immune cell of the brain, regulates neurogenesis, immunological surveillance, redox imbalance, cognitive and behavioral changes under normal and pathological conditions like alzheimer's, parkinson's, multiple sclerosis and traumatic brain injury. 2021-05-02 2023-08-13 Not clear
Shashank Kumar Maurya, Neetu Bhattacharya, Suman Mishra, Amit Bhattacharya, Pratibha Banerjee, Sabyasachi Senapati, Rajnikant Mishr. Microglia Specific Drug Targeting Using Natural Products for the Regulation of Redox Imbalance in Neurodegeneration. Frontiers in pharmacology. vol 12. 2021-05-02. PMID:33927630. the possible interventions by curcumin, resveratrol, cannabidiol, ginsenosides, flavonoids and sulforaphane on microglia specific protein iba1 suggest possibility of natural products mediated regulation of microglia phenotypes and its functions to control redox imbalance and neuroinflammation in management of alzheimer's, parkinson's and multiple sclerosis for microglia-mediated therapeutics. 2021-05-02 2023-08-13 Not clear
Edward S Wickstead, Murray A Irving, Stephen J Getting, Simon McArthu. Exploiting formyl peptide receptor 2 to promote microglial resolution: a new approach to Alzheimer's disease treatment. The FEBS journal. 2021-05-01. PMID:33811735. inflammatory activation of the primary brain immune cells, the microglia, has been implicated in alzheimer's pathogenesis through genetic, preclinical, imaging and postmortem human studies, and strategies to regulate microglial activity may hold great promise for disease modification. 2021-05-01 2023-08-13 human
Renato Socodato, Camila C Portugal, Teresa Canedo, Artur Rodrigues, Tiago O Almeida, Joana F Henriques, Sandra H Vaz, João Magalhães, Cátia M Silva, Filipa I Baptista, Renata L Alves, Vanessa Coelho-Santos, Ana Paula Silva, Roberto Paes-de-Carvalho, Ana Magalhães, Cord Brakebusch, Ana M Sebastião, Teresa Summavielle, António F Ambrósio, João B Relva. Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration. Cell reports. vol 31. issue 12. 2021-04-28. PMID:32579923. we also find that the rhoa/src signaling pathway is disrupted in microglia of the app/ps1 mouse model of alzheimer disease and that low doses of aβ oligomers trigger microglia neurotoxic polarization through the disruption of rhoa-to-src signaling. 2021-04-28 2023-08-13 mouse
Karpagam Srinivasan, Brad A Friedman, Ainhoa Etxeberria, Melanie A Huntley, Marcel P van der Brug, Oded Foreman, Jonathan S Paw, Zora Modrusan, Thomas G Beach, Geidy E Serrano, David V Hanse. Alzheimer's Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation. Cell reports. vol 31. issue 13. 2021-04-28. PMID:32610143. alzheimer's patient microglia exhibit enhanced aging and unique transcriptional activation. 2021-04-28 2023-08-13 mouse
Karpagam Srinivasan, Brad A Friedman, Ainhoa Etxeberria, Melanie A Huntley, Marcel P van der Brug, Oded Foreman, Jonathan S Paw, Zora Modrusan, Thomas G Beach, Geidy E Serrano, David V Hanse. Alzheimer's Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation. Cell reports. vol 31. issue 13. 2021-04-28. PMID:32610143. damage-associated microglia (dam) profiles observed in alzheimer's disease (ad)-related mouse models reflect an activation state that could modulate ad risk or progression. 2021-04-28 2023-08-13 mouse
Yanting Chen, Tingting Hong, Feng Chen, Yuanhong Sun, Yan Wang, Lili Cu. Interplay Between Microglia and Alzheimer's Disease-Focus on the Most Relevant Risks: APOE Genotype, Sex and Age. Frontiers in aging neuroscience. vol 13. 2021-04-28. PMID:33897406. interplay between microglia and alzheimer's disease-focus on the most relevant risks: apoe genotype, sex and age. 2021-04-28 2023-08-13 Not clear
Yanting Chen, Tingting Hong, Feng Chen, Yuanhong Sun, Yan Wang, Lili Cu. Interplay Between Microglia and Alzheimer's Disease-Focus on the Most Relevant Risks: APOE Genotype, Sex and Age. Frontiers in aging neuroscience. vol 13. 2021-04-28. PMID:33897406. uncontrolled activation of microglia is related to the course of neurodegenerative diseases such as alzheimer's disease. 2021-04-28 2023-08-13 Not clear